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Pomegranate (Punica granatum): a natural source for the development of therapeutic compositions of food supplements with anticancer activities based on electron acceptor molecular characteristics
dc.creator | Veljković, Veljko | |
dc.creator | Glišić, Sanja | |
dc.creator | Perović, Vladimir R. | |
dc.creator | Veljković, Nevena V. | |
dc.creator | Nicolson, Garth L. | |
dc.date.accessioned | 2018-03-01T17:19:53Z | |
dc.date.available | 2018-03-01T17:19:53Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 2160-3855 | |
dc.identifier.uri | https://vinar.vin.bg.ac.rs/handle/123456789/1372 | |
dc.description.abstract | Background: Numerous in vitro and in vivo studies, in addition to clinical data, demonstrate that pomegranate juice can prevent or slow-down the progression of some types of cancers. Despite the well-documented effect of pomegranate ingredients on neoplastic changes, the molecular mechanism(s) underlying this phenomenon remains elusive. Methods: For the study of pomegranate ingredients the electron-ion interaction potential (EIIP) and the average quasi valence number (AQVN) were used. These molecular descriptors can be used to describe the long-range intermolecular interactions in biological systems and can identify substances with strong electron-acceptor properties. In this study, candidate human proteins interacting with pomegranate flavonoids have been analyzed by the informational spectrum method (ISM). This represents a virtual spectroscopy method for studying protein molecular interactions. Results: Our analysis indicates that the anti-cancer properties of pomegranate juice can be ascribed to the strong electron-acceptor properties of its chemical ingredients. This analysis also suggests that pomegranate flavonoids inhibit the NF-kappaB (NF-kappa B) pathway, which plays a critical role in the pathogenesis of cancer. Conclusion: The results offer a possible explanation for an important molecular mechanism underlying the anticancer activity of pomegranate ingredients, which could also serve as a basis for the development of new therapeutic compositions of food supplements with pomegranate-like anticancer properties. | en |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173001/RS// | |
dc.rights | openAccess | en |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Functional Foods in Health and Disease | en |
dc.subject | cancer | en |
dc.subject | pomegranate | en |
dc.subject | flavonoids | en |
dc.subject | food supplement | en |
dc.subject | informational spectrum method | en |
dc.title | Pomegranate (Punica granatum): a natural source for the development of therapeutic compositions of food supplements with anticancer activities based on electron acceptor molecular characteristics | en |
dc.type | article | en |
dc.rights.license | BY | |
dcterms.abstract | Ницолсон, Гартх Л.; Вељковић Вељко; Глишић Сања; Перовић Владимир; Вељковић Невена В.; | |
dc.citation.volume | 6 | |
dc.citation.issue | 12 | |
dc.citation.spage | 769 | |
dc.citation.epage | 787 | |
dc.identifier.wos | 000391001200001 | |
dc.identifier.doi | 10.31989/ffhd.v6i12.289 | |
dc.type.version | publishedVersion | |
dc.identifier.scopus | 2-s2.0-85069938508 | |
dc.identifier.fulltext | http://vinar.vin.bg.ac.rs/bitstream/id/26387/289-1460-3-PB.pdf |
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010 - Laboratorija za fiziku
Department of Physics