Thermal, mechanical, and dielectric properties of radiation sterilized mesomorphic PP: Comparison between gamma and electron beam irradiation modalities
Само за регистроване кориснике
2024
Аутори
Suljovrujić, EdinMiličević, Dejan
Stolić, Anđelka
Dudić, Duško
Vašalić, Dragan
Džunuzović, Enis
Stamboliev, Georgi
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Polypropylene (PP) is widely used in the medical industry to produce syringes, vials, and numerous other singleuse biopharmaceutical devices. The need to sterilize these products has led to intensive use of high-energy radiation, even though PP is known to undergo excessive oxidative degradation and deterioration in properties upon irradiation in air. In recent years, a shortage in 60Co supply, as a main source for gamma sterilization, is pushing radiation sterilization of polymeric medical products to electron beam (EB) and/or X-ray modalities as preferable. Some questions related to the equivalence of these methods remain open and are mostly related to changes in the material structure caused by different types of radiation and processing conditions, such as dose rates. This research compares electron beam and gamma irradiation modalities employed on the low crystalline (quenched) PP. In the case of EB irradiation, the typical dose rates are on the order of 104 kGy/h, while in the ca...se of gamma radiation dose rates are lower for three or more orders of magnitude. Since gamma irradiation covers a wide range of dose rates, the difference between samples gamma irradiated with relatively fast (8 kGy/ h) and slow (0.08 kGy/h) dose rates was also analyzed in detail. Comparative investigation of crystallinity, oxidative degradation, thermal, dielectric, and mechanical properties provide a clearer picture of the impact of different modalities and dose rates on mesomorphic PP and are of interest in the practical application of ionizing radiation in the sterilization of PP-based medical devices.
Кључне речи:
Ionizing radiation / Sterilization / Gamma / Electron beam / Radiation modalities / PolypropyleneИзвор:
Polymer Degradation and Stability, 2024, 229, 110940-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
- Research Project titled “Comparative study of e-beam and gamma radiation effects in polyolefins commonly used in medical devices” [IAEA Research Contract No: 24728] which forms a part of the IAEA Coordinated Research Project F23035, entitled “Radiation Effect on Polymer Materials Commonly Used in Medical Devices”
DOI: 10.1016/j.polymdegradstab.2024.110940
ISSN: 0141-3910
Scopus: 2-s2.0-85200963335
Колекције
Институција/група
VinčaTY - JOUR AU - Suljovrujić, Edin AU - Miličević, Dejan AU - Stolić, Anđelka AU - Dudić, Duško AU - Vašalić, Dragan AU - Džunuzović, Enis AU - Stamboliev, Georgi PY - 2024 UR - https://vinar.vin.bg.ac.rs/handle/123456789/13668 AB - Polypropylene (PP) is widely used in the medical industry to produce syringes, vials, and numerous other singleuse biopharmaceutical devices. The need to sterilize these products has led to intensive use of high-energy radiation, even though PP is known to undergo excessive oxidative degradation and deterioration in properties upon irradiation in air. In recent years, a shortage in 60Co supply, as a main source for gamma sterilization, is pushing radiation sterilization of polymeric medical products to electron beam (EB) and/or X-ray modalities as preferable. Some questions related to the equivalence of these methods remain open and are mostly related to changes in the material structure caused by different types of radiation and processing conditions, such as dose rates. This research compares electron beam and gamma irradiation modalities employed on the low crystalline (quenched) PP. In the case of EB irradiation, the typical dose rates are on the order of 104 kGy/h, while in the case of gamma radiation dose rates are lower for three or more orders of magnitude. Since gamma irradiation covers a wide range of dose rates, the difference between samples gamma irradiated with relatively fast (8 kGy/ h) and slow (0.08 kGy/h) dose rates was also analyzed in detail. Comparative investigation of crystallinity, oxidative degradation, thermal, dielectric, and mechanical properties provide a clearer picture of the impact of different modalities and dose rates on mesomorphic PP and are of interest in the practical application of ionizing radiation in the sterilization of PP-based medical devices. T2 - Polymer Degradation and Stability T1 - Thermal, mechanical, and dielectric properties of radiation sterilized mesomorphic PP: Comparison between gamma and electron beam irradiation modalities VL - 229 SP - 110940 DO - 10.1016/j.polymdegradstab.2024.110940 ER -
@article{ author = "Suljovrujić, Edin and Miličević, Dejan and Stolić, Anđelka and Dudić, Duško and Vašalić, Dragan and Džunuzović, Enis and Stamboliev, Georgi", year = "2024", abstract = "Polypropylene (PP) is widely used in the medical industry to produce syringes, vials, and numerous other singleuse biopharmaceutical devices. The need to sterilize these products has led to intensive use of high-energy radiation, even though PP is known to undergo excessive oxidative degradation and deterioration in properties upon irradiation in air. In recent years, a shortage in 60Co supply, as a main source for gamma sterilization, is pushing radiation sterilization of polymeric medical products to electron beam (EB) and/or X-ray modalities as preferable. Some questions related to the equivalence of these methods remain open and are mostly related to changes in the material structure caused by different types of radiation and processing conditions, such as dose rates. This research compares electron beam and gamma irradiation modalities employed on the low crystalline (quenched) PP. In the case of EB irradiation, the typical dose rates are on the order of 104 kGy/h, while in the case of gamma radiation dose rates are lower for three or more orders of magnitude. Since gamma irradiation covers a wide range of dose rates, the difference between samples gamma irradiated with relatively fast (8 kGy/ h) and slow (0.08 kGy/h) dose rates was also analyzed in detail. Comparative investigation of crystallinity, oxidative degradation, thermal, dielectric, and mechanical properties provide a clearer picture of the impact of different modalities and dose rates on mesomorphic PP and are of interest in the practical application of ionizing radiation in the sterilization of PP-based medical devices.", journal = "Polymer Degradation and Stability", title = "Thermal, mechanical, and dielectric properties of radiation sterilized mesomorphic PP: Comparison between gamma and electron beam irradiation modalities", volume = "229", pages = "110940", doi = "10.1016/j.polymdegradstab.2024.110940" }
Suljovrujić, E., Miličević, D., Stolić, A., Dudić, D., Vašalić, D., Džunuzović, E.,& Stamboliev, G.. (2024). Thermal, mechanical, and dielectric properties of radiation sterilized mesomorphic PP: Comparison between gamma and electron beam irradiation modalities. in Polymer Degradation and Stability, 229, 110940. https://doi.org/10.1016/j.polymdegradstab.2024.110940
Suljovrujić E, Miličević D, Stolić A, Dudić D, Vašalić D, Džunuzović E, Stamboliev G. Thermal, mechanical, and dielectric properties of radiation sterilized mesomorphic PP: Comparison between gamma and electron beam irradiation modalities. in Polymer Degradation and Stability. 2024;229:110940. doi:10.1016/j.polymdegradstab.2024.110940 .
Suljovrujić, Edin, Miličević, Dejan, Stolić, Anđelka, Dudić, Duško, Vašalić, Dragan, Džunuzović, Enis, Stamboliev, Georgi, "Thermal, mechanical, and dielectric properties of radiation sterilized mesomorphic PP: Comparison between gamma and electron beam irradiation modalities" in Polymer Degradation and Stability, 229 (2024):110940, https://doi.org/10.1016/j.polymdegradstab.2024.110940 . .