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dc.creatorRakić-Kostić, Tijana M.
dc.creatorBogojeski, Jovana V.
dc.creatorPopović, Iva A.
dc.creatorNešić, Maja D.
dc.creatorRajčić, Boris
dc.creatorNišavić, Marija
dc.creatorPetković, Marijana
dc.creatorVeličković, Suzana
dc.date.accessioned2018-03-01T17:18:59Z
dc.date.available2018-03-01T17:18:59Z
dc.date.issued2017
dc.identifier.issn0367-598X (print)
dc.identifier.issn2217-7426 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1362
dc.description.abstractThis paper presents optimization of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer (MS) instrumental parameters for the analysis of chloro(2,2 , 2 -terpyridine) palladium(II) chloride dihydrate complex applying design of experiments methodology (DoE). This complex is of interest for potential use in the cancer therapy. DoE methodology was proved to succeed in optimization of many complex analytical problems. However, it has been poorly used for MALDI-TOF-MS optimization up to now. The theoretical mathematical relationships which explain the influence of important experimental factors (laser energy, grid voltage and number of laser shots) on the selected responses (signal to noise - S/N ratio and the resolution - R of the leading peak) is established. The optimal instrumental settings providing maximal S/N and R are identified and experimentally verified.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172052/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172011/RS//
dc.rightsopenAccessen
dc.sourceHemijska industrijaen
dc.subjectMALDI-TOF-MSen
dc.subjectdesign of experiments (DoE)en
dc.subjectoptimizationen
dc.subjectmetallo-drugsen
dc.titleExperimental design for optimizing MALDI-TOF-MS analysis of palladium complexesen
dc.typearticleen
dcterms.abstractРакиц-Костиц, Тијана М.; Поповић Ива; Богојески, Јована В.; Рајчић Борис; Несиц, Маја Д.; Нишавић Марија; Петковић Маријана; Величковић Сузана;
dc.citation.volume71
dc.citation.issue4
dc.citation.spage281
dc.citation.epage288
dc.identifier.wos000413180100001
dc.identifier.doi10.2298/HEMIND160614038R
dc.identifier.scopus2-s2.0-85030247844
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/11743/1358.pdf


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