Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes
2017
Autori
Rakić-Kostić, Tijana M.Bogojeski, Jovana V.
Popović, Iva A.
Nešić, Maja D.
Rajčić, Boris
Nišavić, Marija
Petković, Marijana
Veličković, Suzana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
This paper presents optimization of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer (MS) instrumental parameters for the analysis of chloro(2,2 , 2 -terpyridine) palladium(II) chloride dihydrate complex applying design of experiments methodology (DoE). This complex is of interest for potential use in the cancer therapy. DoE methodology was proved to succeed in optimization of many complex analytical problems. However, it has been poorly used for MALDI-TOF-MS optimization up to now. The theoretical mathematical relationships which explain the influence of important experimental factors (laser energy, grid voltage and number of laser shots) on the selected responses (signal to noise - S/N ratio and the resolution - R of the leading peak) is established. The optimal instrumental settings providing maximal S/N and R are identified and experimentally verified.
Ključne reči:
MALDI-TOF-MS / design of experiments (DoE) / optimization / metallo-drugsIzvor:
Hemijska industrija, 2017, 71, 4, 281-288Finansiranje / projekti:
- Modelovanje različitih hromatografskih sistema sa hemometrijskim pristupom u farmaceutskoj analizi (RS-MESTD-Basic Research (BR or ON)-172052)
- Ispitivanje mehanizma reakcija kompleksa jona prelaznih metala sa biološki značajnim molekulima (RS-MESTD-Basic Research (BR or ON)-172011)
DOI: 10.2298/HEMIND160614038R
ISSN: 0367-598X; 2217-7426
WoS: 000413180100001
Scopus: 2-s2.0-85030247844
Kolekcije
Institucija/grupa
VinčaTY - JOUR AU - Rakić-Kostić, Tijana M. AU - Bogojeski, Jovana V. AU - Popović, Iva A. AU - Nešić, Maja D. AU - Rajčić, Boris AU - Nišavić, Marija AU - Petković, Marijana AU - Veličković, Suzana PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1362 AB - This paper presents optimization of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer (MS) instrumental parameters for the analysis of chloro(2,2 , 2 -terpyridine) palladium(II) chloride dihydrate complex applying design of experiments methodology (DoE). This complex is of interest for potential use in the cancer therapy. DoE methodology was proved to succeed in optimization of many complex analytical problems. However, it has been poorly used for MALDI-TOF-MS optimization up to now. The theoretical mathematical relationships which explain the influence of important experimental factors (laser energy, grid voltage and number of laser shots) on the selected responses (signal to noise - S/N ratio and the resolution - R of the leading peak) is established. The optimal instrumental settings providing maximal S/N and R are identified and experimentally verified. T2 - Hemijska industrija T1 - Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes VL - 71 IS - 4 SP - 281 EP - 288 DO - 10.2298/HEMIND160614038R ER -
@article{ author = "Rakić-Kostić, Tijana M. and Bogojeski, Jovana V. and Popović, Iva A. and Nešić, Maja D. and Rajčić, Boris and Nišavić, Marija and Petković, Marijana and Veličković, Suzana", year = "2017", abstract = "This paper presents optimization of matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometer (MS) instrumental parameters for the analysis of chloro(2,2 , 2 -terpyridine) palladium(II) chloride dihydrate complex applying design of experiments methodology (DoE). This complex is of interest for potential use in the cancer therapy. DoE methodology was proved to succeed in optimization of many complex analytical problems. However, it has been poorly used for MALDI-TOF-MS optimization up to now. The theoretical mathematical relationships which explain the influence of important experimental factors (laser energy, grid voltage and number of laser shots) on the selected responses (signal to noise - S/N ratio and the resolution - R of the leading peak) is established. The optimal instrumental settings providing maximal S/N and R are identified and experimentally verified.", journal = "Hemijska industrija", title = "Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes", volume = "71", number = "4", pages = "281-288", doi = "10.2298/HEMIND160614038R" }
Rakić-Kostić, T. M., Bogojeski, J. V., Popović, I. A., Nešić, M. D., Rajčić, B., Nišavić, M., Petković, M.,& Veličković, S.. (2017). Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes. in Hemijska industrija, 71(4), 281-288. https://doi.org/10.2298/HEMIND160614038R
Rakić-Kostić TM, Bogojeski JV, Popović IA, Nešić MD, Rajčić B, Nišavić M, Petković M, Veličković S. Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes. in Hemijska industrija. 2017;71(4):281-288. doi:10.2298/HEMIND160614038R .
Rakić-Kostić, Tijana M., Bogojeski, Jovana V., Popović, Iva A., Nešić, Maja D., Rajčić, Boris, Nišavić, Marija, Petković, Marijana, Veličković, Suzana, "Experimental design for optimizing MALDI-TOF-MS analysis of palladium complexes" in Hemijska industrija, 71, no. 4 (2017):281-288, https://doi.org/10.2298/HEMIND160614038R . .