Quercetin decreases fructose drinking in model of fructose-induced insulin resistance. Unexpected uric acid and TBARS lowering effect of methyl cellulose vehicle and fructose combination
Аутори
Korićanac, GoranHricovíniová, Jana
Romić, Snježana
Dobrocsyova, Viktoria
Stojiljković, Mojca
Kršková, Katarína
Ivković, Tamara
Zorad, Štefan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to improve insulin sensitivity in fructose-treated animals by ingestion of flavonoid quercetin. Several signs of insulin resistance have been developed in rats by drinking 10% fructose solution for 9 weeks. The effect of 6-week-gavage-administrated quercetin (20 mg/kg/day in 1% methyl cellulose solution) was monitored. Rats of the control groups received methyl cellulose vehicle as well. The most striking result of the quercetin treatment was the normalization of the fructose solution drinking to the level of drinking water intake. In addition, quercetin supplementation considerably decreased the plasma glucose and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index in rats consuming fructose. Surprisingly, fructose ingestion did not elevate plasma uric acid, thiobarbituric acid reactive substances, nitrotyrosine, or advanced glycation end products fluorescence. Instead, a reduction of the above parameters was observed. In summary, these result...s indicate that quercetin supplementation reduces fructose drinking and decreases plasma glucose and the HOMA-IR index. Furthermore, methyl cellulose, in combination with fructose, causes uric acid – lowering, antioxidant and anti-glycation effects. Thus, methyl cellulose possibly shifts fructose metabolism in favor of the utilization of antioxidant features of fructose. Our results call for using methyl cellulose in sweetened beverages and other sweetened food.
Кључне речи:
Quercetin / Fructose-rich diet / Methyl cellulose / Uric acid / TBARSИзвор:
General physiology and biophysics, 2024, 43, 3, 221-230Финансирање / пројекти:
- Slovak Research and Development Agency [grant APVV-20-0421]
- Ministry of Education, Science, Research and Sport of the Slovak Republic [grant VEGA 2/0105/24]
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Колекције
Институција/група
VinčaTY - JOUR AU - Korićanac, Goran AU - Hricovíniová, Jana AU - Romić, Snježana AU - Dobrocsyova, Viktoria AU - Stojiljković, Mojca AU - Kršková, Katarína AU - Ivković, Tamara AU - Zorad, Štefan PY - 2024 UR - https://vinar.vin.bg.ac.rs/handle/123456789/13298 AB - The aim of this study was to improve insulin sensitivity in fructose-treated animals by ingestion of flavonoid quercetin. Several signs of insulin resistance have been developed in rats by drinking 10% fructose solution for 9 weeks. The effect of 6-week-gavage-administrated quercetin (20 mg/kg/day in 1% methyl cellulose solution) was monitored. Rats of the control groups received methyl cellulose vehicle as well. The most striking result of the quercetin treatment was the normalization of the fructose solution drinking to the level of drinking water intake. In addition, quercetin supplementation considerably decreased the plasma glucose and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index in rats consuming fructose. Surprisingly, fructose ingestion did not elevate plasma uric acid, thiobarbituric acid reactive substances, nitrotyrosine, or advanced glycation end products fluorescence. Instead, a reduction of the above parameters was observed. In summary, these results indicate that quercetin supplementation reduces fructose drinking and decreases plasma glucose and the HOMA-IR index. Furthermore, methyl cellulose, in combination with fructose, causes uric acid – lowering, antioxidant and anti-glycation effects. Thus, methyl cellulose possibly shifts fructose metabolism in favor of the utilization of antioxidant features of fructose. Our results call for using methyl cellulose in sweetened beverages and other sweetened food. T2 - General physiology and biophysics T1 - Quercetin decreases fructose drinking in model of fructose-induced insulin resistance. Unexpected uric acid and TBARS lowering effect of methyl cellulose vehicle and fructose combination VL - 43 IS - 3 SP - 221 EP - 230 DO - 10.4149/gpb_2024003 ER -
@article{ author = "Korićanac, Goran and Hricovíniová, Jana and Romić, Snježana and Dobrocsyova, Viktoria and Stojiljković, Mojca and Kršková, Katarína and Ivković, Tamara and Zorad, Štefan", year = "2024", abstract = "The aim of this study was to improve insulin sensitivity in fructose-treated animals by ingestion of flavonoid quercetin. Several signs of insulin resistance have been developed in rats by drinking 10% fructose solution for 9 weeks. The effect of 6-week-gavage-administrated quercetin (20 mg/kg/day in 1% methyl cellulose solution) was monitored. Rats of the control groups received methyl cellulose vehicle as well. The most striking result of the quercetin treatment was the normalization of the fructose solution drinking to the level of drinking water intake. In addition, quercetin supplementation considerably decreased the plasma glucose and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index in rats consuming fructose. Surprisingly, fructose ingestion did not elevate plasma uric acid, thiobarbituric acid reactive substances, nitrotyrosine, or advanced glycation end products fluorescence. Instead, a reduction of the above parameters was observed. In summary, these results indicate that quercetin supplementation reduces fructose drinking and decreases plasma glucose and the HOMA-IR index. Furthermore, methyl cellulose, in combination with fructose, causes uric acid – lowering, antioxidant and anti-glycation effects. Thus, methyl cellulose possibly shifts fructose metabolism in favor of the utilization of antioxidant features of fructose. Our results call for using methyl cellulose in sweetened beverages and other sweetened food.", journal = "General physiology and biophysics", title = "Quercetin decreases fructose drinking in model of fructose-induced insulin resistance. Unexpected uric acid and TBARS lowering effect of methyl cellulose vehicle and fructose combination", volume = "43", number = "3", pages = "221-230", doi = "10.4149/gpb_2024003" }
Korićanac, G., Hricovíniová, J., Romić, S., Dobrocsyova, V., Stojiljković, M., Kršková, K., Ivković, T.,& Zorad, Š.. (2024). Quercetin decreases fructose drinking in model of fructose-induced insulin resistance. Unexpected uric acid and TBARS lowering effect of methyl cellulose vehicle and fructose combination. in General physiology and biophysics, 43(3), 221-230. https://doi.org/10.4149/gpb_2024003
Korićanac G, Hricovíniová J, Romić S, Dobrocsyova V, Stojiljković M, Kršková K, Ivković T, Zorad Š. Quercetin decreases fructose drinking in model of fructose-induced insulin resistance. Unexpected uric acid and TBARS lowering effect of methyl cellulose vehicle and fructose combination. in General physiology and biophysics. 2024;43(3):221-230. doi:10.4149/gpb_2024003 .
Korićanac, Goran, Hricovíniová, Jana, Romić, Snježana, Dobrocsyova, Viktoria, Stojiljković, Mojca, Kršková, Katarína, Ivković, Tamara, Zorad, Štefan, "Quercetin decreases fructose drinking in model of fructose-induced insulin resistance. Unexpected uric acid and TBARS lowering effect of methyl cellulose vehicle and fructose combination" in General physiology and biophysics, 43, no. 3 (2024):221-230, https://doi.org/10.4149/gpb_2024003 . .