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dc.creatorPejić, Snežana
dc.creatorStojiljković, Vesna
dc.creatorTodorović, Ana
dc.creatorGavrilović, Ljubica
dc.creatorPavlović, Ivan
dc.creatorPopović, Nataša M.
dc.creatorPajović, Snežana B.
dc.date.accessioned2018-03-01T17:13:37Z
dc.date.available2018-03-01T17:13:37Z
dc.date.issued2016
dc.identifier.issn0015-5497 (print)
dc.identifier.issn1734-9168 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1301
dc.description.abstractThe study deals with manganese superoxide dismutase, copper, zinc superoxide dismutase, and catalase activities in brain cortex of Wistar rats exposed to acute stress (immobilization or cold for 2 h), chronic stress (long-term isolation or long-term forced swimming for 21 days), or to combined chronic/acute stress. We observed that i) single episodes of acute stress by immobilization increased activity of both superoxide dismutases; ii) both types of chronic stresses significantly elevated activities of all examined enzymes; iii) chronic social isolation was a much stronger stressor than physical stress by swimming; iv) in animals pre-exposed to chronic isolation, additional stress by immobilization or cold significantly decreased previously elevated activities of all enzymes, while after chronic swimming, acute immobilization lowered only catalase activity. The obtained results indicate that stress conditions most probably altered the cell redox equilibrium, thus influencing the antioxidant response in brain cortex. Further investigation of neuronal prooxidant/antioxidant cellular conditions is needed to improve the prevention and treatment of various stress induced diseases.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41027/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41022/RS//
dc.rightsrestrictedAccessen
dc.sourceFolia Biologica, Krakowen
dc.subjectAntioxidant enzymesen
dc.subjectreactive oxygen speciesen
dc.subjectacute stressen
dc.subjectchronic stressen
dc.subjectbrain cortexen
dc.titleAntioxidant Enzymes in Brain Cortex of Rats Exposed to Acute, Chronic and Combined Stressen
dc.typearticleen
dcterms.abstractПајовиц, Снезана Б.; Пејић Снежана; Стојиљковић Весна; Тодоровић Aна; Гавриловић Љубица; Павловић Иван; Поповић Наташа;
dc.citation.volume64
dc.citation.issue3
dc.citation.spage189
dc.citation.epage195
dc.identifier.wos000387737300006
dc.identifier.doi10.3409/fb64_3.189
dc.citation.rankM23
dc.identifier.scopus2-s2.0-85006048069


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