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dc.creatorBukonjic, Andriana M.
dc.creatorTomovic, Dugan Lj.
dc.creatorNikolic, Milos V.
dc.creatorMijajlovic, Marina Z.
dc.creatorJevtic, Verica V.
dc.creatorRatkovic, Zoran R.
dc.creatorNovaković, Slađana B.
dc.creatorBogdanović, Goran A.
dc.creatorRadojevic, Ivana D.
dc.creatorMaksimovic, Jovana Z.
dc.creatorVasic, Sava M.
dc.creatorComic, Ljiljana R.
dc.creatorTrifunovic, Srecko R.
dc.creatorRadic, Gordana P.
dc.date.accessioned2018-03-01T17:13:11Z
dc.date.available2018-03-01T17:13:11Z
dc.date.issued2017
dc.identifier.issn0022-2860 (print)
dc.identifier.issn1872-8014 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1296
dc.description.abstractThe spectroscopically predicted structure of the obtained copper(II)-complex with S-propyl derivative of thiosalicylic acid was confirmed by X-ray structural study. The binuclear copper(II)-complex with S-propyl derivative of thiosalicylic acid crystallized in two polymorphic forms with main structural difference in the orientation of phenyl rings relative to corresponding carboxylate groups. The antibacterial activity was tested determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) by using microdilution method. The influence on bacterial biofilm formation was determined by tissue culture plate method. In general, the copper(II)-complexes manifested a selective and moderate activity. The most sensitive bacteria to the effects of Cu(II)-complexes was a clinical isolate of Pseudomonas aeruginosa. For this bacteria MIC and biofilm inhibitory concentration (BIC) values for all tested complexes were in the range or better than the positive control, doxycycline. Also, for the established biofilm of clinical isolate Staphylococcus aureus, BIC values for the copper(II)-complex with S-ethyl derivative of thiosalicylic acid, [Cu-2(S-et-thiosal)(4)(H2O)(2)] (C3) and copper(II)-complex with S-butyl derivative of thiosalicylic acid, [Cu-2(S-bu-thiosal)(4)(H2O)(2)] (C5) were in range or better than the positive control. All the complexes acted better against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus aureus ATCC 25923) than Gram-negative bacteria (Proteus mirabilis ATCC 12453, Pseudomonas aeruginosa, and P. aeruginosa. ATCC 27855). The complexes showed weak antioxidative properties tested by two methods (1,1-diphenyl-2-picrylhydrazyl (DPPH) and reducing power assay). (C) 2016 Elsevier B.V. All rights reserved.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172016/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172034/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS//
dc.rightsrestrictedAccessen
dc.sourceJournal of Molecular Structureen
dc.subjectBinuclear copper(II)-complexen
dc.subjectCrystal structureen
dc.subjectBiological activityen
dc.titleAntibacterial, antibiofilm and antioxidant screening of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-propyl derivative of thiosalicylic aciden
dc.typearticleen
dcterms.abstractНиколиц, Милос В.; Јевтиц, Верица В.; Томовиц, Дуган Љ.; Новаковић Слађана; Букоњиц, Aндриана М.; Богдановић Горан; Ратковиц, Зоран Р.; Радојевиц, Ивана Д.; Мијајловиц, Марина З.; Максимовиц, Јована З.; Цомиц, Љиљана Р.; Васиц, Сава М.; Радиц, Гордана П.; Трифуновиц, Срецко Р.;
dc.citation.volume1128
dc.citation.spage330
dc.citation.epage337
dc.identifier.wos000387194600041
dc.identifier.doi10.1016/j.molstruc.2016.08.086
dc.identifier.scopus2-s2.0-84986277738


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