Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study
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2016
Authors
Čabarkapa, AndreaŽivković, Lada
Borozan, Sunčica Z.
Zlatković-Svenda, Mirjana
Dekanski, Dragana
Jancic, Ivan
Radak-Perović, Marija
Bajić, Vladan P.
Spremo-Potparević, Biljana
Article (Published version)
,
© 2016 John Wiley & Sons, Ltd.
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The effects of co-administration of dry olive leaf extract (DOLE) with standard methotrexate (MTX) therapy on the parameters of cell damage and inflammation in patients with early and long-term rheumatoid arthritis (RA) were evaluated at baseline, 3 and 6weeks. Patients were assigned to groups: the early phase RA group on MTX monotherapy (E MTX), and the two RA groups that received co-treatment with DOLE and MTX: early (E MTX+DOLE) and long-term phase patients (L-t MTX+ DOLE). Baseline values indicated increased parameters of cell damage and disruption of redox balance in all groups. After three weeks the E MTX+DOLE group maintained high catalase activity, exhibited decrease of lipid peroxidation and protein damage indicatorsthiols and nitrites, while levels of DNA damage and pro-inflammatory interleukin-6 were significantly reduced. In E MTX group catalase activity remained unaltered while significant lipid peroxidation and DNA damage reductions were seen only after six weeks. L-t MTX...+DOLE group showed only modest alterations of cell damage parameters during six weeks. Combined administration of DOLE with MTX contributes to faster reduction of cell damage, restores oxidative balance and improves interleukin-6 suppression during high disease activity in early phase RA, but not in long term patients. Copyright (c) 2016 John Wiley and Sons, Ltd.
Keywords:
dry olive leaf extract / methotrexate / inflammation / oxidative stress / cell damageSource:
Phytotherapy Research, 2016, 30, 10, 1615-1623Funding / projects:
- Cell Cycle Aberrations and the Impact of Oxidative Stress in Neurodegenerative Processes and Malignant Transformation of the Cell (RS-MESTD-Basic Research (BR or ON)-173034)
DOI: 10.1002/ptr.5662
ISSN: 0951-418X; 1099-1573
PubMed: 27271301
WoS: 000385700400007
Scopus: 2-s2.0-84973563650
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VinčaTY - JOUR AU - Čabarkapa, Andrea AU - Živković, Lada AU - Borozan, Sunčica Z. AU - Zlatković-Svenda, Mirjana AU - Dekanski, Dragana AU - Jancic, Ivan AU - Radak-Perović, Marija AU - Bajić, Vladan P. AU - Spremo-Potparević, Biljana PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1282 AB - The effects of co-administration of dry olive leaf extract (DOLE) with standard methotrexate (MTX) therapy on the parameters of cell damage and inflammation in patients with early and long-term rheumatoid arthritis (RA) were evaluated at baseline, 3 and 6weeks. Patients were assigned to groups: the early phase RA group on MTX monotherapy (E MTX), and the two RA groups that received co-treatment with DOLE and MTX: early (E MTX+DOLE) and long-term phase patients (L-t MTX+ DOLE). Baseline values indicated increased parameters of cell damage and disruption of redox balance in all groups. After three weeks the E MTX+DOLE group maintained high catalase activity, exhibited decrease of lipid peroxidation and protein damage indicatorsthiols and nitrites, while levels of DNA damage and pro-inflammatory interleukin-6 were significantly reduced. In E MTX group catalase activity remained unaltered while significant lipid peroxidation and DNA damage reductions were seen only after six weeks. L-t MTX+DOLE group showed only modest alterations of cell damage parameters during six weeks. Combined administration of DOLE with MTX contributes to faster reduction of cell damage, restores oxidative balance and improves interleukin-6 suppression during high disease activity in early phase RA, but not in long term patients. Copyright (c) 2016 John Wiley and Sons, Ltd. T2 - Phytotherapy Research T1 - Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study VL - 30 IS - 10 SP - 1615 EP - 1623 DO - 10.1002/ptr.5662 ER -
@article{ author = "Čabarkapa, Andrea and Živković, Lada and Borozan, Sunčica Z. and Zlatković-Svenda, Mirjana and Dekanski, Dragana and Jancic, Ivan and Radak-Perović, Marija and Bajić, Vladan P. and Spremo-Potparević, Biljana", year = "2016", abstract = "The effects of co-administration of dry olive leaf extract (DOLE) with standard methotrexate (MTX) therapy on the parameters of cell damage and inflammation in patients with early and long-term rheumatoid arthritis (RA) were evaluated at baseline, 3 and 6weeks. Patients were assigned to groups: the early phase RA group on MTX monotherapy (E MTX), and the two RA groups that received co-treatment with DOLE and MTX: early (E MTX+DOLE) and long-term phase patients (L-t MTX+ DOLE). Baseline values indicated increased parameters of cell damage and disruption of redox balance in all groups. After three weeks the E MTX+DOLE group maintained high catalase activity, exhibited decrease of lipid peroxidation and protein damage indicatorsthiols and nitrites, while levels of DNA damage and pro-inflammatory interleukin-6 were significantly reduced. In E MTX group catalase activity remained unaltered while significant lipid peroxidation and DNA damage reductions were seen only after six weeks. L-t MTX+DOLE group showed only modest alterations of cell damage parameters during six weeks. Combined administration of DOLE with MTX contributes to faster reduction of cell damage, restores oxidative balance and improves interleukin-6 suppression during high disease activity in early phase RA, but not in long term patients. Copyright (c) 2016 John Wiley and Sons, Ltd.", journal = "Phytotherapy Research", title = "Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study", volume = "30", number = "10", pages = "1615-1623", doi = "10.1002/ptr.5662" }
Čabarkapa, A., Živković, L., Borozan, S. Z., Zlatković-Svenda, M., Dekanski, D., Jancic, I., Radak-Perović, M., Bajić, V. P.,& Spremo-Potparević, B.. (2016). Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study. in Phytotherapy Research, 30(10), 1615-1623. https://doi.org/10.1002/ptr.5662
Čabarkapa A, Živković L, Borozan SZ, Zlatković-Svenda M, Dekanski D, Jancic I, Radak-Perović M, Bajić VP, Spremo-Potparević B. Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study. in Phytotherapy Research. 2016;30(10):1615-1623. doi:10.1002/ptr.5662 .
Čabarkapa, Andrea, Živković, Lada, Borozan, Sunčica Z., Zlatković-Svenda, Mirjana, Dekanski, Dragana, Jancic, Ivan, Radak-Perović, Marija, Bajić, Vladan P., Spremo-Potparević, Biljana, "Dry Olive Leaf Extract in Combination with Methotrexate Reduces Cell Damage in Early Rheumatoid Arthritis PatientsA Pilot Study" in Phytotherapy Research, 30, no. 10 (2016):1615-1623, https://doi.org/10.1002/ptr.5662 . .