Nanocarriers in topical photodynamic therapy
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Аутори
Dragićević, NinaPredić-Atkinson, Jelena
Nikolić, Bojan
Pajović, Snežana B.
Ivković, Sanja
Adžić, Miroslav
Чланак у часопису (Објављена верзија)
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Приказ свих података о документуАпстракт
Introduction Photodynamic therapy (PDT) has gained significant attention due to its superiority over conventional treatments. In the context of skin cancers and nonmalignant skin diseases, topical application of photosensitizer formulations onto affected skin, followed by illumination, offers distinct advantages. Topical PDT simplifies therapy by providing easy access to the skin, increasing drug concentration within the target area, and confining residual photosensitivity to the treated skin. However, the effectiveness of topical PDT is often hindered by challenges such as limited skin penetration or photosensitizer instability. Additionally, the hypoxic tumor environment poses further limitations. Nanocarriers present a promising solution to address these challenges. Areas covered The objective of this review is to comprehensively explore and highlight the role of various nanocarriers in advancing topical PDT for the treatment of skin diseases. The primary focus is to address the c...hallenges associated with conventional topical PDT approaches and demonstrate how nanotechnology-based strategies can overcome these challenges, thereby improving the overall efficiency and efficacy of PDT. Expert opinion Nanotechnology has revolutionized the field of PDT, offering innovative tools to combat the unfavorable features of photosensitizers and hurdles in PDT. Nanocarriers enhance skin penetration and stability of photosensitizers, provide controlled drug release, reduce needed dose, increase production of reactive oxygen species, while reducing side effects, thereby improving PDT effectiveness.
Кључне речи:
nanocarriers / nanotechnology / nonmalignant skin diseases / skin cancer / topical photodynamic therapyИзвор:
Expert Opinion on Drug Delivery, 2024, 21, 2
DOI: 10.1080/17425247.2024.2318460
ISSN: 1742-5247; 1744-7593
PubMed: 38349540
Scopus: 2-s2.0-85186239760
Колекције
Институција/група
VinčaTY - JOUR AU - Dragićević, Nina AU - Predić-Atkinson, Jelena AU - Nikolić, Bojan AU - Pajović, Snežana B. AU - Ivković, Sanja AU - Adžić, Miroslav PY - 2024 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12828 AB - Introduction Photodynamic therapy (PDT) has gained significant attention due to its superiority over conventional treatments. In the context of skin cancers and nonmalignant skin diseases, topical application of photosensitizer formulations onto affected skin, followed by illumination, offers distinct advantages. Topical PDT simplifies therapy by providing easy access to the skin, increasing drug concentration within the target area, and confining residual photosensitivity to the treated skin. However, the effectiveness of topical PDT is often hindered by challenges such as limited skin penetration or photosensitizer instability. Additionally, the hypoxic tumor environment poses further limitations. Nanocarriers present a promising solution to address these challenges. Areas covered The objective of this review is to comprehensively explore and highlight the role of various nanocarriers in advancing topical PDT for the treatment of skin diseases. The primary focus is to address the challenges associated with conventional topical PDT approaches and demonstrate how nanotechnology-based strategies can overcome these challenges, thereby improving the overall efficiency and efficacy of PDT. Expert opinion Nanotechnology has revolutionized the field of PDT, offering innovative tools to combat the unfavorable features of photosensitizers and hurdles in PDT. Nanocarriers enhance skin penetration and stability of photosensitizers, provide controlled drug release, reduce needed dose, increase production of reactive oxygen species, while reducing side effects, thereby improving PDT effectiveness. T2 - Expert Opinion on Drug Delivery T1 - Nanocarriers in topical photodynamic therapy VL - 21 IS - 2 DO - 10.1080/17425247.2024.2318460 ER -
@article{ author = "Dragićević, Nina and Predić-Atkinson, Jelena and Nikolić, Bojan and Pajović, Snežana B. and Ivković, Sanja and Adžić, Miroslav", year = "2024", abstract = "Introduction Photodynamic therapy (PDT) has gained significant attention due to its superiority over conventional treatments. In the context of skin cancers and nonmalignant skin diseases, topical application of photosensitizer formulations onto affected skin, followed by illumination, offers distinct advantages. Topical PDT simplifies therapy by providing easy access to the skin, increasing drug concentration within the target area, and confining residual photosensitivity to the treated skin. However, the effectiveness of topical PDT is often hindered by challenges such as limited skin penetration or photosensitizer instability. Additionally, the hypoxic tumor environment poses further limitations. Nanocarriers present a promising solution to address these challenges. Areas covered The objective of this review is to comprehensively explore and highlight the role of various nanocarriers in advancing topical PDT for the treatment of skin diseases. The primary focus is to address the challenges associated with conventional topical PDT approaches and demonstrate how nanotechnology-based strategies can overcome these challenges, thereby improving the overall efficiency and efficacy of PDT. Expert opinion Nanotechnology has revolutionized the field of PDT, offering innovative tools to combat the unfavorable features of photosensitizers and hurdles in PDT. Nanocarriers enhance skin penetration and stability of photosensitizers, provide controlled drug release, reduce needed dose, increase production of reactive oxygen species, while reducing side effects, thereby improving PDT effectiveness.", journal = "Expert Opinion on Drug Delivery", title = "Nanocarriers in topical photodynamic therapy", volume = "21", number = "2", doi = "10.1080/17425247.2024.2318460" }
Dragićević, N., Predić-Atkinson, J., Nikolić, B., Pajović, S. B., Ivković, S.,& Adžić, M.. (2024). Nanocarriers in topical photodynamic therapy. in Expert Opinion on Drug Delivery, 21(2). https://doi.org/10.1080/17425247.2024.2318460
Dragićević N, Predić-Atkinson J, Nikolić B, Pajović SB, Ivković S, Adžić M. Nanocarriers in topical photodynamic therapy. in Expert Opinion on Drug Delivery. 2024;21(2). doi:10.1080/17425247.2024.2318460 .
Dragićević, Nina, Predić-Atkinson, Jelena, Nikolić, Bojan, Pajović, Snežana B., Ivković, Sanja, Adžić, Miroslav, "Nanocarriers in topical photodynamic therapy" in Expert Opinion on Drug Delivery, 21, no. 2 (2024), https://doi.org/10.1080/17425247.2024.2318460 . .