Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results
Аутори
Životić, IvanĐorđević, Ana
Đurić, Tamara
Končar, Igor
Alavantić, Dragan
Stanković, Aleksandra
Živković, Maja
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Genome wide association studies have recognized the 9p21 rs10757278 polymorphism as a significant independent genetic prognostic marker for coronary artery disease. The aim of this study was to explore possible association of the rs10757278 polymorphism with advanced carotid atherosclerosis (CA) in the population of Serbia. The study group included 147 controls and 428 patients consecutively admitted for carotid endarterectomy. 9p21 rs10757278 polymorphism was genotyped using TaqMan technology on 7500 ABI Real Time PCR. There was no significant association of this polymorphism and CA, either in study group overall or in males. The GG genotype, according to recessive model of inheritance (AA+AG vs. GG), was significantly associated with advanced CA in females only (OR=2.15, 95% CI 1.07- 4.29, p=0.03). Preliminary results in this study suggest that rs10757278 GG genotype might be a significant predictive sex-specific marker for advanced CA in the population of Serbia.
Кључне речи:
carotid atherosclerosis / 9p21 / polymorphismИзвор:
V Congress of the Serbian Genetic Society : Book of abstracts, 2014, 56-56Издавач:
- Belgrade : Serbian Physiological Society
Напомена:
- 5th Congress of the Serbian Genetic Society : Book of abstracts; September 28 - October 2, Kladovo, 2014.
Колекције
Институција/група
VinčaTY - CONF AU - Životić, Ivan AU - Đorđević, Ana AU - Đurić, Tamara AU - Končar, Igor AU - Alavantić, Dragan AU - Stanković, Aleksandra AU - Živković, Maja PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12811 AB - Genome wide association studies have recognized the 9p21 rs10757278 polymorphism as a significant independent genetic prognostic marker for coronary artery disease. The aim of this study was to explore possible association of the rs10757278 polymorphism with advanced carotid atherosclerosis (CA) in the population of Serbia. The study group included 147 controls and 428 patients consecutively admitted for carotid endarterectomy. 9p21 rs10757278 polymorphism was genotyped using TaqMan technology on 7500 ABI Real Time PCR. There was no significant association of this polymorphism and CA, either in study group overall or in males. The GG genotype, according to recessive model of inheritance (AA+AG vs. GG), was significantly associated with advanced CA in females only (OR=2.15, 95% CI 1.07- 4.29, p=0.03). Preliminary results in this study suggest that rs10757278 GG genotype might be a significant predictive sex-specific marker for advanced CA in the population of Serbia. PB - Belgrade : Serbian Physiological Society C3 - V Congress of the Serbian Genetic Society : Book of abstracts T1 - Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results SP - 56 EP - 56 UR - https://hdl.handle.net/21.15107/rcub_vinar_12811 ER -
@conference{ author = "Životić, Ivan and Đorđević, Ana and Đurić, Tamara and Končar, Igor and Alavantić, Dragan and Stanković, Aleksandra and Živković, Maja", year = "2014", abstract = "Genome wide association studies have recognized the 9p21 rs10757278 polymorphism as a significant independent genetic prognostic marker for coronary artery disease. The aim of this study was to explore possible association of the rs10757278 polymorphism with advanced carotid atherosclerosis (CA) in the population of Serbia. The study group included 147 controls and 428 patients consecutively admitted for carotid endarterectomy. 9p21 rs10757278 polymorphism was genotyped using TaqMan technology on 7500 ABI Real Time PCR. There was no significant association of this polymorphism and CA, either in study group overall or in males. The GG genotype, according to recessive model of inheritance (AA+AG vs. GG), was significantly associated with advanced CA in females only (OR=2.15, 95% CI 1.07- 4.29, p=0.03). Preliminary results in this study suggest that rs10757278 GG genotype might be a significant predictive sex-specific marker for advanced CA in the population of Serbia.", publisher = "Belgrade : Serbian Physiological Society", journal = "V Congress of the Serbian Genetic Society : Book of abstracts", title = "Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results", pages = "56-56", url = "https://hdl.handle.net/21.15107/rcub_vinar_12811" }
Životić, I., Đorđević, A., Đurić, T., Končar, I., Alavantić, D., Stanković, A.,& Živković, M.. (2014). Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results. in V Congress of the Serbian Genetic Society : Book of abstracts Belgrade : Serbian Physiological Society., 56-56. https://hdl.handle.net/21.15107/rcub_vinar_12811
Životić I, Đorđević A, Đurić T, Končar I, Alavantić D, Stanković A, Živković M. Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results. in V Congress of the Serbian Genetic Society : Book of abstracts. 2014;:56-56. https://hdl.handle.net/21.15107/rcub_vinar_12811 .
Životić, Ivan, Đorđević, Ana, Đurić, Tamara, Končar, Igor, Alavantić, Dragan, Stanković, Aleksandra, Živković, Maja, "Polymorphism rs10757278 in 9p21 region is associated with severe carotid atherosclerosis in sex specific manner: Preliminary results" in V Congress of the Serbian Genetic Society : Book of abstracts (2014):56-56, https://hdl.handle.net/21.15107/rcub_vinar_12811 .