Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid
Нема приказа
Аутори
Bobić, Katarina![](/themes/MirageVinar/images/orcid.png)
Todorović, Ana
![](/themes/MirageVinar/images/orcid.png)
Pejić, Snežana
![](/themes/MirageVinar/images/orcid.png)
Veljković, Filip
![](/themes/MirageVinar/images/orcid.png)
Pajović, Snežana
![](/themes/MirageVinar/images/orcid.png)
Nedeljković, Jovan
![](/themes/MirageVinar/images/orcid.png)
Drakulić, Dunja
![](/themes/MirageVinar/images/orcid.png)
Конференцијски прилог (Објављена верзија)
![](/themes/MirageVinar//images/creativecommons/arr.png)
Метаподаци
Приказ свих података о документуАпстракт
Titanium dioxide nanoparticles (Ti02 NPs) are widely used in different cosmetic products, food additives and pharmaceuticals. Their accumulation within the body is associated with adverse health effects. Since animal studies indicate that their outcomes could be ameliorated by different modifications, we tested the impact of Ti02 NPs surface-modified with 5-aminosalicylic acid (Ti02/5-ASA NPs) in female adult Wistar rats. For the purpose of this experiment,14 days following the acute oral intake, the effects of commercially available Ti02 NPs and i02/5-ASA NPs were compared, using well defined methods, to assess the signs of acute toxicity (agitation, convulsion, and mortality) and neurological function (visual placing,
spontaneous activity, and pacing/circling) along with the levels of end products of lipid peroxidation (LPP) in eyes. Our results indicate that following the treatments, spontaneous activity was disturbed while mortality, convulsion and visual placing were unaltered. T...he modification decreased Ti02 NPs-induced
impairment of agitation and pacing/circling. The insight into biomolecules in the eyes, more precisely into a marker of oxidative stress (LPP), showed that it was decreased after treatment with Ti02/5-ASA NPs in comparison to Ti02 NPs, indicating that this type of modification might mitigate Ti02 NPs-induced oxidative stress. According to obtained results, even though the exact mechanism of the actions is still unknown, the modification with 5-aminosalicylic acid alleviates toxic effects of commercially available Ti02 NPs.
Извор:
18th YSA PhD Symposium 2023 : Book of abstracts, 2023Издавач:
- Vienna : Young Scientist Association
Напомена:
- Young Scientist Association PhD Symposium : May 28-29, Vienna, Austria, 2023.
Колекције
Институција/група
VinčaTY - CONF AU - Bobić, Katarina AU - Todorović, Ana AU - Pejić, Snežana AU - Veljković, Filip AU - Pajović, Snežana AU - Nedeljković, Jovan AU - Drakulić, Dunja PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12810 AB - Titanium dioxide nanoparticles (Ti02 NPs) are widely used in different cosmetic products, food additives and pharmaceuticals. Their accumulation within the body is associated with adverse health effects. Since animal studies indicate that their outcomes could be ameliorated by different modifications, we tested the impact of Ti02 NPs surface-modified with 5-aminosalicylic acid (Ti02/5-ASA NPs) in female adult Wistar rats. For the purpose of this experiment,14 days following the acute oral intake, the effects of commercially available Ti02 NPs and i02/5-ASA NPs were compared, using well defined methods, to assess the signs of acute toxicity (agitation, convulsion, and mortality) and neurological function (visual placing, spontaneous activity, and pacing/circling) along with the levels of end products of lipid peroxidation (LPP) in eyes. Our results indicate that following the treatments, spontaneous activity was disturbed while mortality, convulsion and visual placing were unaltered. The modification decreased Ti02 NPs-induced impairment of agitation and pacing/circling. The insight into biomolecules in the eyes, more precisely into a marker of oxidative stress (LPP), showed that it was decreased after treatment with Ti02/5-ASA NPs in comparison to Ti02 NPs, indicating that this type of modification might mitigate Ti02 NPs-induced oxidative stress. According to obtained results, even though the exact mechanism of the actions is still unknown, the modification with 5-aminosalicylic acid alleviates toxic effects of commercially available Ti02 NPs. PB - Vienna : Young Scientist Association C3 - 18th YSA PhD Symposium 2023 : Book of abstracts T1 - Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid UR - https://hdl.handle.net/21.15107/rcub_vinar_12810 ER -
@conference{ author = "Bobić, Katarina and Todorović, Ana and Pejić, Snežana and Veljković, Filip and Pajović, Snežana and Nedeljković, Jovan and Drakulić, Dunja", year = "2023", abstract = "Titanium dioxide nanoparticles (Ti02 NPs) are widely used in different cosmetic products, food additives and pharmaceuticals. Their accumulation within the body is associated with adverse health effects. Since animal studies indicate that their outcomes could be ameliorated by different modifications, we tested the impact of Ti02 NPs surface-modified with 5-aminosalicylic acid (Ti02/5-ASA NPs) in female adult Wistar rats. For the purpose of this experiment,14 days following the acute oral intake, the effects of commercially available Ti02 NPs and i02/5-ASA NPs were compared, using well defined methods, to assess the signs of acute toxicity (agitation, convulsion, and mortality) and neurological function (visual placing, spontaneous activity, and pacing/circling) along with the levels of end products of lipid peroxidation (LPP) in eyes. Our results indicate that following the treatments, spontaneous activity was disturbed while mortality, convulsion and visual placing were unaltered. The modification decreased Ti02 NPs-induced impairment of agitation and pacing/circling. The insight into biomolecules in the eyes, more precisely into a marker of oxidative stress (LPP), showed that it was decreased after treatment with Ti02/5-ASA NPs in comparison to Ti02 NPs, indicating that this type of modification might mitigate Ti02 NPs-induced oxidative stress. According to obtained results, even though the exact mechanism of the actions is still unknown, the modification with 5-aminosalicylic acid alleviates toxic effects of commercially available Ti02 NPs.", publisher = "Vienna : Young Scientist Association", journal = "18th YSA PhD Symposium 2023 : Book of abstracts", title = "Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid", url = "https://hdl.handle.net/21.15107/rcub_vinar_12810" }
Bobić, K., Todorović, A., Pejić, S., Veljković, F., Pajović, S., Nedeljković, J.,& Drakulić, D.. (2023). Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid. in 18th YSA PhD Symposium 2023 : Book of abstracts Vienna : Young Scientist Association.. https://hdl.handle.net/21.15107/rcub_vinar_12810
Bobić K, Todorović A, Pejić S, Veljković F, Pajović S, Nedeljković J, Drakulić D. Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid. in 18th YSA PhD Symposium 2023 : Book of abstracts. 2023;. https://hdl.handle.net/21.15107/rcub_vinar_12810 .
Bobić, Katarina, Todorović, Ana, Pejić, Snežana, Veljković, Filip, Pajović, Snežana, Nedeljković, Jovan, Drakulić, Dunja, "Rat toxicity study of orally administrated titanium dioxide nanoparticles modified with 5-aminosalicylic acid" in 18th YSA PhD Symposium 2023 : Book of abstracts (2023), https://hdl.handle.net/21.15107/rcub_vinar_12810 .