Matrix metalloproteinase-9 gene polymorphism-1562 C/T as susceptibility factor for carotid atherosclerotic plaque development
Нема приказа
Аутори
Kolaković, AnaStojković, Ljiljana
Radak, Đorđe
Đurić, Tamara
Radak, Sandra
Stanković, Aleksandra
Alavantić, Dragan
Živković, Maja
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The matrix metalloproteinase 9 (MMP-9) has been shown to play role in VSMC migration and proliferation by degradation of the basement membrane. MMP-9 expression is increased after vascular injury. The MMP-9 -1562 C/T gene polymorphism results in higher promoter activity of the T allele. The higher prevalence of –1562T allele was associated with coronary artery stenosis. The aim was to investigate the association of the MMP-9 -1562C/T polymorphism and susceptibility for development of carotid plaques. Genomic DNA was isolated from blood cells of 278 control subjects and 136 patients with carotid atherosclerosis. The genotypes were determined by tetra-primer ARMS PCR method previously developed by us and visualized by MADGE. We did not find the significant difference in genotype frequencies between controls: CC 70.82%, CT 27.05%, TT 2.14%, and patients: CC 74.26%, CT 25.74%, TT 0%. The allele frequencies didn’t differ as well (controls: C 0.84, T 0.16, patients: 0.87, 0.13. MMP-9 gene po...lymorphism -1562C/T is not the susceptibility factor for development of carotid atherosclerotic plaques in population of Serbia.
Извор:
IV Congress of the Serbian Genetic Society : Book of abstracts, 2009, 90-90Издавач:
- Belgrade : Serbian Genetic Society
Напомена:
- 4th Congress of the serbian genetic society : Tara, Serbia, June 01-05, 2009.
- Content available: https://www.dgsgenetika.org.rs/abstrakti/zbornik-iv-kongres-en.htm#Rad68
Колекције
Институција/група
VinčaTY - CONF AU - Kolaković, Ana AU - Stojković, Ljiljana AU - Radak, Đorđe AU - Đurić, Tamara AU - Radak, Sandra AU - Stanković, Aleksandra AU - Alavantić, Dragan AU - Živković, Maja PY - 2009 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12780 AB - The matrix metalloproteinase 9 (MMP-9) has been shown to play role in VSMC migration and proliferation by degradation of the basement membrane. MMP-9 expression is increased after vascular injury. The MMP-9 -1562 C/T gene polymorphism results in higher promoter activity of the T allele. The higher prevalence of –1562T allele was associated with coronary artery stenosis. The aim was to investigate the association of the MMP-9 -1562C/T polymorphism and susceptibility for development of carotid plaques. Genomic DNA was isolated from blood cells of 278 control subjects and 136 patients with carotid atherosclerosis. The genotypes were determined by tetra-primer ARMS PCR method previously developed by us and visualized by MADGE. We did not find the significant difference in genotype frequencies between controls: CC 70.82%, CT 27.05%, TT 2.14%, and patients: CC 74.26%, CT 25.74%, TT 0%. The allele frequencies didn’t differ as well (controls: C 0.84, T 0.16, patients: 0.87, 0.13. MMP-9 gene polymorphism -1562C/T is not the susceptibility factor for development of carotid atherosclerotic plaques in population of Serbia. PB - Belgrade : Serbian Genetic Society C3 - IV Congress of the Serbian Genetic Society : Book of abstracts T1 - Matrix metalloproteinase-9 gene polymorphism-1562 C/T as susceptibility factor for carotid atherosclerotic plaque development SP - 90 EP - 90 UR - https://hdl.handle.net/21.15107/rcub_vinar_12780 ER -
@conference{ author = "Kolaković, Ana and Stojković, Ljiljana and Radak, Đorđe and Đurić, Tamara and Radak, Sandra and Stanković, Aleksandra and Alavantić, Dragan and Živković, Maja", year = "2009", abstract = "The matrix metalloproteinase 9 (MMP-9) has been shown to play role in VSMC migration and proliferation by degradation of the basement membrane. MMP-9 expression is increased after vascular injury. The MMP-9 -1562 C/T gene polymorphism results in higher promoter activity of the T allele. The higher prevalence of –1562T allele was associated with coronary artery stenosis. The aim was to investigate the association of the MMP-9 -1562C/T polymorphism and susceptibility for development of carotid plaques. Genomic DNA was isolated from blood cells of 278 control subjects and 136 patients with carotid atherosclerosis. The genotypes were determined by tetra-primer ARMS PCR method previously developed by us and visualized by MADGE. We did not find the significant difference in genotype frequencies between controls: CC 70.82%, CT 27.05%, TT 2.14%, and patients: CC 74.26%, CT 25.74%, TT 0%. The allele frequencies didn’t differ as well (controls: C 0.84, T 0.16, patients: 0.87, 0.13. MMP-9 gene polymorphism -1562C/T is not the susceptibility factor for development of carotid atherosclerotic plaques in population of Serbia.", publisher = "Belgrade : Serbian Genetic Society", journal = "IV Congress of the Serbian Genetic Society : Book of abstracts", title = "Matrix metalloproteinase-9 gene polymorphism-1562 C/T as susceptibility factor for carotid atherosclerotic plaque development", pages = "90-90", url = "https://hdl.handle.net/21.15107/rcub_vinar_12780" }
Kolaković, A., Stojković, L., Radak, Đ., Đurić, T., Radak, S., Stanković, A., Alavantić, D.,& Živković, M.. (2009). Matrix metalloproteinase-9 gene polymorphism-1562 C/T as susceptibility factor for carotid atherosclerotic plaque development. in IV Congress of the Serbian Genetic Society : Book of abstracts Belgrade : Serbian Genetic Society., 90-90. https://hdl.handle.net/21.15107/rcub_vinar_12780
Kolaković A, Stojković L, Radak Đ, Đurić T, Radak S, Stanković A, Alavantić D, Živković M. Matrix metalloproteinase-9 gene polymorphism-1562 C/T as susceptibility factor for carotid atherosclerotic plaque development. in IV Congress of the Serbian Genetic Society : Book of abstracts. 2009;:90-90. https://hdl.handle.net/21.15107/rcub_vinar_12780 .
Kolaković, Ana, Stojković, Ljiljana, Radak, Đorđe, Đurić, Tamara, Radak, Sandra, Stanković, Aleksandra, Alavantić, Dragan, Živković, Maja, "Matrix metalloproteinase-9 gene polymorphism-1562 C/T as susceptibility factor for carotid atherosclerotic plaque development" in IV Congress of the Serbian Genetic Society : Book of abstracts (2009):90-90, https://hdl.handle.net/21.15107/rcub_vinar_12780 .