Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats
Аутори
Bobić, KatarinaTodorović, Ana
Pejić, Snežana
Veljković, Filip
Pajović, Snežana
Nedeljković, Jovan
Drakulić, Dunja
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many daily necessities, including medicine, food/ beverages, and cosmetics. Besides the numerous benefits of TiO2 NPs utilization, their use raises public concerns since humans are exposed to their toxicity. As different alterations could moderate the observed side effects of commercially available bare TiO2 NPs, we investigated whether TiO2/SA NPs (TiO2 NPs surface‑modified with salicylic acid (SA)) impact the bare TiO2 NPs-induced sensory-motor impairments and eye level of 4-hydroxynonenal (HNE) as the final product of lipid peroxidation and indicator of oxidative stress. Our results demonstrate that 14 days following single oral treatment both investigated TiO2 NPs in adult Wistar rats affected neurological functions and promoted oxidative stress to different extents. Namely, the SA modification alleviated TiO2 NPs-induced asymmetry in four limb movement, while the hind limb clasping reflex and spontaneous activity scores ...were similar between TiO2 groups. In the eye crude membrane fraction of TiO2/SA NPs-treated rats in comparison to animals treated with bare TiO2 NPs, the HNE level was downregulated. Although SA exhibits the ability to reduce some TiO2 NPs toxicity, due to still unknown mechanism of TiO2 and TiO2/SA NPs actions, further studies are required to verify herein presented findings
Извор:
Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts, 2022, 82Издавач:
- Poland : Nencki Institute of experimental biology
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Напомена:
- NEURONS 2022 : October 15-17, Krakow, Poland, 2022.
Колекције
Институција/група
VinčaTY - CONF AU - Bobić, Katarina AU - Todorović, Ana AU - Pejić, Snežana AU - Veljković, Filip AU - Pajović, Snežana AU - Nedeljković, Jovan AU - Drakulić, Dunja PY - 2022 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12741 AB - Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many daily necessities, including medicine, food/ beverages, and cosmetics. Besides the numerous benefits of TiO2 NPs utilization, their use raises public concerns since humans are exposed to their toxicity. As different alterations could moderate the observed side effects of commercially available bare TiO2 NPs, we investigated whether TiO2/SA NPs (TiO2 NPs surface‑modified with salicylic acid (SA)) impact the bare TiO2 NPs-induced sensory-motor impairments and eye level of 4-hydroxynonenal (HNE) as the final product of lipid peroxidation and indicator of oxidative stress. Our results demonstrate that 14 days following single oral treatment both investigated TiO2 NPs in adult Wistar rats affected neurological functions and promoted oxidative stress to different extents. Namely, the SA modification alleviated TiO2 NPs-induced asymmetry in four limb movement, while the hind limb clasping reflex and spontaneous activity scores were similar between TiO2 groups. In the eye crude membrane fraction of TiO2/SA NPs-treated rats in comparison to animals treated with bare TiO2 NPs, the HNE level was downregulated. Although SA exhibits the ability to reduce some TiO2 NPs toxicity, due to still unknown mechanism of TiO2 and TiO2/SA NPs actions, further studies are required to verify herein presented findings PB - Poland : Nencki Institute of experimental biology C3 - Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts T1 - Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats VL - 82 UR - https://hdl.handle.net/21.15107/rcub_vinar_12741 ER -
@conference{ author = "Bobić, Katarina and Todorović, Ana and Pejić, Snežana and Veljković, Filip and Pajović, Snežana and Nedeljković, Jovan and Drakulić, Dunja", year = "2022", abstract = "Titanium dioxide nanoparticles (TiO2 NPs) are widely used in many daily necessities, including medicine, food/ beverages, and cosmetics. Besides the numerous benefits of TiO2 NPs utilization, their use raises public concerns since humans are exposed to their toxicity. As different alterations could moderate the observed side effects of commercially available bare TiO2 NPs, we investigated whether TiO2/SA NPs (TiO2 NPs surface‑modified with salicylic acid (SA)) impact the bare TiO2 NPs-induced sensory-motor impairments and eye level of 4-hydroxynonenal (HNE) as the final product of lipid peroxidation and indicator of oxidative stress. Our results demonstrate that 14 days following single oral treatment both investigated TiO2 NPs in adult Wistar rats affected neurological functions and promoted oxidative stress to different extents. Namely, the SA modification alleviated TiO2 NPs-induced asymmetry in four limb movement, while the hind limb clasping reflex and spontaneous activity scores were similar between TiO2 groups. In the eye crude membrane fraction of TiO2/SA NPs-treated rats in comparison to animals treated with bare TiO2 NPs, the HNE level was downregulated. Although SA exhibits the ability to reduce some TiO2 NPs toxicity, due to still unknown mechanism of TiO2 and TiO2/SA NPs actions, further studies are required to verify herein presented findings", publisher = "Poland : Nencki Institute of experimental biology", journal = "Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts", title = "Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats", volume = "82", url = "https://hdl.handle.net/21.15107/rcub_vinar_12741" }
Bobić, K., Todorović, A., Pejić, S., Veljković, F., Pajović, S., Nedeljković, J.,& Drakulić, D.. (2022). Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats. in Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts Poland : Nencki Institute of experimental biology., 82. https://hdl.handle.net/21.15107/rcub_vinar_12741
Bobić K, Todorović A, Pejić S, Veljković F, Pajović S, Nedeljković J, Drakulić D. Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats. in Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts. 2022;82. https://hdl.handle.net/21.15107/rcub_vinar_12741 .
Bobić, Katarina, Todorović, Ana, Pejić, Snežana, Veljković, Filip, Pajović, Snežana, Nedeljković, Jovan, Drakulić, Dunja, "Surface modification of TiO2 nanoparticles moderates neurological impairments and upregulated oxidative stress indicator in eyes of adult Wistar rats" in Acta Neurobiologiae experimentalis : NEURONUS 2022 : 12th Neuronus 2022 Neuroscience Forum : Abstracts, 82 (2022), https://hdl.handle.net/21.15107/rcub_vinar_12741 .