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dc.creatorNešić, Maja A.
dc.creatorPopović, Iva A.
dc.creatorLeskovac, Andreja
dc.creatorPetković, Marijana
dc.date.accessioned2018-03-01T17:10:58Z
dc.date.available2018-03-01T17:10:58Z
dc.date.issued2016
dc.identifier.issn0966-0844 (print)
dc.identifier.issn1572-8773 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1271
dc.description.abstractRuthenium compounds are highly regarded as metallo-drug candidates. Many studies have focused their attention on the interaction between ruthenium complexes with their possible biological targets. The interaction of ruthenium complexes with transport proteins, enzymes and peptides is of great importance for understanding their biodistribution and mechanism of action, therefore, the development of an anti-cancer therapy involving ruthenium complexes has recently shifted from DNA targeting towards protein targeting. With the aim of gaining insight into possible interactions between ruthenium complexes with biologically relevant proteins, we have studied the interaction of cis-dichlorobis(2,2-bipyridyl-4,4-dicarboxylic acid)ruthenium(II) complex [Ru(II)(dcbpy)(2)Cl-2], which previously showed good potency in photo-dynamic chemotherapy, with bovine serum albumin (BSA), phospholipase A(2) (PLA(2)) and glutathione (GSH). Binding constants and possible number of binding sites to mentioned proteins and peptide are investigated by ultraviolet-visible spectroscopy and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI TOF MS). The complex binding affinities were in the following order: PLA(2) GT BSA GT GSH. Moreover, genotoxic profile of the complex, tested on peripheral blood lymphocytes as a model system, was also promising.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172023/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172011/RS//
dc.rightsrestrictedAccessen
dc.sourceBiometalsen
dc.subjectRuthenium (II) complexen
dc.subjectPotential metallo-drugen
dc.subjectBiological targetsen
dc.subjectProteinsen
dc.subjectGlutathioneen
dc.titleBiological activity and binding properties of [Ru(II)(dcbpy)(2)Cl-2] complex to bovine serum albumin, phospholipase A(2) and glutathioneen
dc.typearticleen
dcterms.abstractНесиц, Маја; Поповић Ива; Лесковац Aндреја; Петковић Маријана;
dc.citation.volume29
dc.citation.issue5
dc.citation.spage921
dc.citation.epage933
dc.identifier.wos000385252400015
dc.identifier.doi10.1007/s10534-016-9964-y
dc.citation.rankM23
dc.identifier.pmid27515969
dc.identifier.scopus2-s2.0-84981486939


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