Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors
Аутори
Todorović, LidijaKožik, Bojana
Božović, Ana
Mandušić, Vesna
Stanojević, Boban
Živaljević, Vladan
Paunović, Ivan
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Adrenocortical tumors (ACTs) are heterogeneous neoplasms with incompletely understood pathogenesis. Correct differential diagnosis between adrenocortical adenoma (ACA) and localized adrenocortical carcinoma (ACC), as well as improved prognostic stratification of ACC patients, are of great clinical importance. Alterations in gene expression patterns have been found in adrenocortical neoplasms compared to normal tissue. In addition to having a role in tumorigenesis, distinct gene expression signatures may help to distinguish different ACT types. The combined expression patterns of PINK1, DLGAP5 and BUB1B have been suggested as malignancy and outcome predictors in previous studies. In order to validate their diagnostic/prognostic potential, we investigated the expression levels of these three genes and their association with clinico-pathological parameters in a cohort of 47 ACC and 15 ACA patients from Serbia. In addition, we analyzed the association of their expression levels with surviv...al data in an independent ACC cohort of 79 patients from The Cancer Genome Atlas (TCGA) database. The results showed that high expression levels of BUB1B and DLGAP5, and low expression levels of PINK1 significantly associated with ACC. Moreover, combined expression of both DLGAP5 and BUB1B with PINK1 were significantly higher in localized ACC compared with ACA. The results from the TCGA cohort showed that expression alterations of these genes were strong predictors of disease-free and overall survival in ACC patients. These results are consistent with the previously reported results and confirm that the expression patterns of PINK1, DLGAP5 and BUB1B might have value as molecular predictors of malignancy and/or survival in ACC patients.
Извор:
The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts, 2022, A39-Издавач:
- Poland : The National Institute of Cardiology
Напомена:
- The 21st ENS@T and 1st COST-HARMONIS@TION meeting; September 28-30, Warsaw, Poland, 2022.
Колекције
Институција/група
VinčaTY - CONF AU - Todorović, Lidija AU - Kožik, Bojana AU - Božović, Ana AU - Mandušić, Vesna AU - Stanojević, Boban AU - Živaljević, Vladan AU - Paunović, Ivan PY - 2022 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12509 AB - Adrenocortical tumors (ACTs) are heterogeneous neoplasms with incompletely understood pathogenesis. Correct differential diagnosis between adrenocortical adenoma (ACA) and localized adrenocortical carcinoma (ACC), as well as improved prognostic stratification of ACC patients, are of great clinical importance. Alterations in gene expression patterns have been found in adrenocortical neoplasms compared to normal tissue. In addition to having a role in tumorigenesis, distinct gene expression signatures may help to distinguish different ACT types. The combined expression patterns of PINK1, DLGAP5 and BUB1B have been suggested as malignancy and outcome predictors in previous studies. In order to validate their diagnostic/prognostic potential, we investigated the expression levels of these three genes and their association with clinico-pathological parameters in a cohort of 47 ACC and 15 ACA patients from Serbia. In addition, we analyzed the association of their expression levels with survival data in an independent ACC cohort of 79 patients from The Cancer Genome Atlas (TCGA) database. The results showed that high expression levels of BUB1B and DLGAP5, and low expression levels of PINK1 significantly associated with ACC. Moreover, combined expression of both DLGAP5 and BUB1B with PINK1 were significantly higher in localized ACC compared with ACA. The results from the TCGA cohort showed that expression alterations of these genes were strong predictors of disease-free and overall survival in ACC patients. These results are consistent with the previously reported results and confirm that the expression patterns of PINK1, DLGAP5 and BUB1B might have value as molecular predictors of malignancy and/or survival in ACC patients. PB - Poland : The National Institute of Cardiology C3 - The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts T1 - Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors SP - A39 UR - https://hdl.handle.net/21.15107/rcub_vinar_12509 ER -
@conference{ author = "Todorović, Lidija and Kožik, Bojana and Božović, Ana and Mandušić, Vesna and Stanojević, Boban and Živaljević, Vladan and Paunović, Ivan", year = "2022", abstract = "Adrenocortical tumors (ACTs) are heterogeneous neoplasms with incompletely understood pathogenesis. Correct differential diagnosis between adrenocortical adenoma (ACA) and localized adrenocortical carcinoma (ACC), as well as improved prognostic stratification of ACC patients, are of great clinical importance. Alterations in gene expression patterns have been found in adrenocortical neoplasms compared to normal tissue. In addition to having a role in tumorigenesis, distinct gene expression signatures may help to distinguish different ACT types. The combined expression patterns of PINK1, DLGAP5 and BUB1B have been suggested as malignancy and outcome predictors in previous studies. In order to validate their diagnostic/prognostic potential, we investigated the expression levels of these three genes and their association with clinico-pathological parameters in a cohort of 47 ACC and 15 ACA patients from Serbia. In addition, we analyzed the association of their expression levels with survival data in an independent ACC cohort of 79 patients from The Cancer Genome Atlas (TCGA) database. The results showed that high expression levels of BUB1B and DLGAP5, and low expression levels of PINK1 significantly associated with ACC. Moreover, combined expression of both DLGAP5 and BUB1B with PINK1 were significantly higher in localized ACC compared with ACA. The results from the TCGA cohort showed that expression alterations of these genes were strong predictors of disease-free and overall survival in ACC patients. These results are consistent with the previously reported results and confirm that the expression patterns of PINK1, DLGAP5 and BUB1B might have value as molecular predictors of malignancy and/or survival in ACC patients.", publisher = "Poland : The National Institute of Cardiology", journal = "The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts", title = "Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors", pages = "A39", url = "https://hdl.handle.net/21.15107/rcub_vinar_12509" }
Todorović, L., Kožik, B., Božović, A., Mandušić, V., Stanojević, B., Živaljević, V.,& Paunović, I.. (2022). Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts Poland : The National Institute of Cardiology., A39. https://hdl.handle.net/21.15107/rcub_vinar_12509
Todorović L, Kožik B, Božović A, Mandušić V, Stanojević B, Živaljević V, Paunović I. Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors. in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts. 2022;:A39. https://hdl.handle.net/21.15107/rcub_vinar_12509 .
Todorović, Lidija, Kožik, Bojana, Božović, Ana, Mandušić, Vesna, Stanojević, Boban, Živaljević, Vladan, Paunović, Ivan, "Validation of diagnostic and prognostic potential of PINK1, DLGAP5 and BUB1B expression patterns in adrenocortical tumors" in The 21st ENS@T and 1st COST-HARMONIS@TION meeting : Book of abstracts (2022):A39, https://hdl.handle.net/21.15107/rcub_vinar_12509 .