The IL-1β and IL-1Ra gene polymorphisms and chronic inflammation of the middle ear
Апстракт
Constitutional polymorphisms in the proinflamatory cytokine genes influence the individual cytokine secretion levels, the course and severity of inflammation. Aim of our study was to investigate the association of IL-1β +3953 C/T and IL1-Ra86 bp VNTR gene polymorphisms with the development of chronic otitis media (COM) in 144 patients and 103 controls. Frequencies of the alleles and genotypes of the IL-1Ra gene polymorphism were significantly different between the patients and controls (alleles: p=0.003; genotypes: p=0.0001). Non-carriers of IL-1Ra allele 2 had significatly higher risk for COM occurence (p=0.002; OR=2.98; ±95%CI, 1.68-5.26). This allele is a potential protective genetic marker for COM.
Кључне речи:
otitis media / gene / polymorphism / IL-1β / IL-1RaИзвор:
V Congress of the Serbian Genetic Society : Book of abstracts, 2014, 42-42Издавач:
- Belgrade : Serbian Genetic Society
Напомена:
- 5th Congress of the Serbian Genetic Society : Book of abstracts; September 28 - October 2, Kladovo, 2014.
Колекције
Институција/група
VinčaTY - CONF AU - Kolić, Ivana AU - Živković, Maja AU - Kuveljić, Jovana AU - Jesić, Snežana AU - Stanković, Aleksandra PY - 2014 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12388 AB - Constitutional polymorphisms in the proinflamatory cytokine genes influence the individual cytokine secretion levels, the course and severity of inflammation. Aim of our study was to investigate the association of IL-1β +3953 C/T and IL1-Ra86 bp VNTR gene polymorphisms with the development of chronic otitis media (COM) in 144 patients and 103 controls. Frequencies of the alleles and genotypes of the IL-1Ra gene polymorphism were significantly different between the patients and controls (alleles: p=0.003; genotypes: p=0.0001). Non-carriers of IL-1Ra allele 2 had significatly higher risk for COM occurence (p=0.002; OR=2.98; ±95%CI, 1.68-5.26). This allele is a potential protective genetic marker for COM. PB - Belgrade : Serbian Genetic Society C3 - V Congress of the Serbian Genetic Society : Book of abstracts T1 - The IL-1β and IL-1Ra gene polymorphisms and chronic inflammation of the middle ear SP - 42 EP - 42 UR - https://hdl.handle.net/21.15107/rcub_vinar_12388 ER -
@conference{ author = "Kolić, Ivana and Živković, Maja and Kuveljić, Jovana and Jesić, Snežana and Stanković, Aleksandra", year = "2014", abstract = "Constitutional polymorphisms in the proinflamatory cytokine genes influence the individual cytokine secretion levels, the course and severity of inflammation. Aim of our study was to investigate the association of IL-1β +3953 C/T and IL1-Ra86 bp VNTR gene polymorphisms with the development of chronic otitis media (COM) in 144 patients and 103 controls. Frequencies of the alleles and genotypes of the IL-1Ra gene polymorphism were significantly different between the patients and controls (alleles: p=0.003; genotypes: p=0.0001). Non-carriers of IL-1Ra allele 2 had significatly higher risk for COM occurence (p=0.002; OR=2.98; ±95%CI, 1.68-5.26). This allele is a potential protective genetic marker for COM.", publisher = "Belgrade : Serbian Genetic Society", journal = "V Congress of the Serbian Genetic Society : Book of abstracts", title = "The IL-1β and IL-1Ra gene polymorphisms and chronic inflammation of the middle ear", pages = "42-42", url = "https://hdl.handle.net/21.15107/rcub_vinar_12388" }
Kolić, I., Živković, M., Kuveljić, J., Jesić, S.,& Stanković, A.. (2014). The IL-1β and IL-1Ra gene polymorphisms and chronic inflammation of the middle ear. in V Congress of the Serbian Genetic Society : Book of abstracts Belgrade : Serbian Genetic Society., 42-42. https://hdl.handle.net/21.15107/rcub_vinar_12388
Kolić I, Živković M, Kuveljić J, Jesić S, Stanković A. The IL-1β and IL-1Ra gene polymorphisms and chronic inflammation of the middle ear. in V Congress of the Serbian Genetic Society : Book of abstracts. 2014;:42-42. https://hdl.handle.net/21.15107/rcub_vinar_12388 .
Kolić, Ivana, Živković, Maja, Kuveljić, Jovana, Jesić, Snežana, Stanković, Aleksandra, "The IL-1β and IL-1Ra gene polymorphisms and chronic inflammation of the middle ear" in V Congress of the Serbian Genetic Society : Book of abstracts (2014):42-42, https://hdl.handle.net/21.15107/rcub_vinar_12388 .