Приказ основних података о документу

dc.creatorSekulić, Dalibor L.
dc.creatorSatarić, Bogdan M.
dc.creatorZdravković, Slobodan
dc.creatorBugay, Aleksandr N.
dc.creatorSatarić, Miljko V.
dc.date.accessioned2018-03-01T17:06:58Z
dc.date.available2018-03-01T17:06:58Z
dc.date.issued2016
dc.identifier.issn1054-1500
dc.identifier.issn1089-7682
dc.identifier.urihttps://vinar.vin.bg.ac.rs/handle/123456789/1225
dc.description.abstractThe mechanical and electrical properties, and information processing capabilities of microtubules are the permanent subject of interest for carrying out experiments in vitro and in silico, as well as for theoretical attempts to elucidate the underlying processes. In this paper, we developed a new model of the mechano-electrical waves elicited in the rows of very flexible C-terminal tails which decorate the outer surface of each microtubule. The fact that C-terminal tails play very diverse roles in many cellular functions, such as recruitment of motor proteins and microtubule-associated proteins, motivated us to consider their collective dynamics as the source of localized waves aimed for communication between microtubule and associated proteins. Our approach is based on the ferroelectric liquid crystal model and it leads to the effective asymmetric double-well potential which brings about the conditions for the appearance of kink-waves conducted by intrinsic electric fields embedded in microtubules. These kinks can serve as the signals for control and regulation of intracellular traffic along microtubules performed by processive motions of motor proteins, primarly from kinesin and dynein families. On the other hand, they can be precursors for initiation of dynamical instability of microtubules by recruiting the proper proteins responsible for the depolymerization process. Published by AIP Publishing.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/171009/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43008/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45010/RS//
dc.relationProvincial Secretariat of Science and Technological Development of AP Vojvodina [114-451-2708/2016-03]
dc.relationRussian Foundation for Basic Research [16-02-00453a]
dc.relationJoint Institute for Nuclear Research, Dubna, Russian Federation
dc.relationMinistry of Science, Education and Technological Development of the Republic of Serbia
dc.rightsrestrictedAccessen
dc.sourceChaosen
dc.titleNonlinear dynamics of C-terminal tails in cellular microtubulesen
dc.typearticleen
dc.rights.licenseARR
dcterms.abstractСатариц, Миљко В.; Здравковић Слободан; Сатариц, Богдан М.; Секулиц, Далибор Л.; Бугаy, Aлександр Н.;
dc.citation.volume26
dc.citation.issue7
dc.identifier.wos000382404700019
dc.identifier.doi10.1063/1.4959802
dc.citation.otherArticle Number: 073119
dc.citation.rankM21a
dc.identifier.pmid27475079
dc.type.versionpublishedVersion
dc.identifier.scopus2-s2.0-85026628470


Документи

ДатотекеВеличинаФорматПреглед

Уз овај запис нема датотека.

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу