Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity
Аутори
Stokić, EditaHakkak, Reza
Romani, Andrea
Kupusinac, Aleksandar
Isenović, Esma R.
Tomić-Naglić, Dragana
Srdić-Galić, Biljana
Pejaković, Slađana
Radošević, Dragana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese (body mass index [BMI]: 43.5 ± 9.2 kg/m2 ) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m2 ). Obese individuals were classified into different subgroups according to medians of observed anthropometric parameters (BMI, body fat percentage, waist circumference, and trunk fat mass). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25 (OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L, p < .001). There was a negative correlation between vitamin D and anthropometric indicators of obesity: BMI: (r = - 0.64, p < .001), waist circumference (r = -0.59; p < .001), and body fat percentage (r = -0.64; p < .001) as well with fasting plasma insulin... (r = -0.35; p < .001) and homeostasis model assessment of insulin resistance (r = - 0.35; p < .001). There was a negative correlation between vitamin D level and leptin and resistin (r = -.61; p < .01), while a positive association with adiponectin concentrations were found (r = .7; p < .001). Trend estimation showed that increase in vitamin D level is accompanied by intensive increase in adiponectin concentrations (growth coefficient: 12.13). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile. In contrast, a positive trend was established between vitamin D and the protective adipocytokine adiponectin. The clinical relevance of this relationship needs to be investigated in larger studies.
Кључне речи:
Obesity / Adipose tissue / Vitamin DИзвор:
Journal of Obesity and Chronic Diseases, 2017, 1, 2Финансирање / пројекти:
- Хормонска регулација експресије и активности азот оксид синтазе и натријум-калијумове пумпе у експерименталним моделима инсулинске резистенције, дијабетеса и кардиоваскуларних поремећаја (RS-MESTD-Basic Research (BR or ON)-173033)
- Репрезентације логичких структура и формалних језика и њихове примене у рачунарству (RS-MESTD-Basic Research (BR or ON)-174026)
- Развој нових информационо-комуникационих технологија, коришћењем напредних математичких метода, са применама у медицини, телекомуникацијама, енергетици, заштитити националне баштине и образовању (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-44006)
- Provincial Secretariat for Science and Technological Development of the Autonomous Province of Vojvodina within the [project 114-451- 2856/2016]
Колекције
Институција/група
VinčaTY - JOUR AU - Stokić, Edita AU - Hakkak, Reza AU - Romani, Andrea AU - Kupusinac, Aleksandar AU - Isenović, Esma R. AU - Tomić-Naglić, Dragana AU - Srdić-Galić, Biljana AU - Pejaković, Slađana AU - Radošević, Dragana PY - 2017 UR - https://vinar.vin.bg.ac.rs/handle/123456789/12028 AB - Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese (body mass index [BMI]: 43.5 ± 9.2 kg/m2 ) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m2 ). Obese individuals were classified into different subgroups according to medians of observed anthropometric parameters (BMI, body fat percentage, waist circumference, and trunk fat mass). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25 (OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L, p < .001). There was a negative correlation between vitamin D and anthropometric indicators of obesity: BMI: (r = - 0.64, p < .001), waist circumference (r = -0.59; p < .001), and body fat percentage (r = -0.64; p < .001) as well with fasting plasma insulin (r = -0.35; p < .001) and homeostasis model assessment of insulin resistance (r = - 0.35; p < .001). There was a negative correlation between vitamin D level and leptin and resistin (r = -.61; p < .01), while a positive association with adiponectin concentrations were found (r = .7; p < .001). Trend estimation showed that increase in vitamin D level is accompanied by intensive increase in adiponectin concentrations (growth coefficient: 12.13). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile. In contrast, a positive trend was established between vitamin D and the protective adipocytokine adiponectin. The clinical relevance of this relationship needs to be investigated in larger studies. T2 - Journal of Obesity and Chronic Diseases T1 - Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity VL - 1 IS - 2 DO - 10.17756/jocd.2017-005 ER -
@article{ author = "Stokić, Edita and Hakkak, Reza and Romani, Andrea and Kupusinac, Aleksandar and Isenović, Esma R. and Tomić-Naglić, Dragana and Srdić-Galić, Biljana and Pejaković, Slađana and Radošević, Dragana", year = "2017", abstract = "Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese (body mass index [BMI]: 43.5 ± 9.2 kg/m2 ) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m2 ). Obese individuals were classified into different subgroups according to medians of observed anthropometric parameters (BMI, body fat percentage, waist circumference, and trunk fat mass). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25 (OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L, p < .001). There was a negative correlation between vitamin D and anthropometric indicators of obesity: BMI: (r = - 0.64, p < .001), waist circumference (r = -0.59; p < .001), and body fat percentage (r = -0.64; p < .001) as well with fasting plasma insulin (r = -0.35; p < .001) and homeostasis model assessment of insulin resistance (r = - 0.35; p < .001). There was a negative correlation between vitamin D level and leptin and resistin (r = -.61; p < .01), while a positive association with adiponectin concentrations were found (r = .7; p < .001). Trend estimation showed that increase in vitamin D level is accompanied by intensive increase in adiponectin concentrations (growth coefficient: 12.13). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile. In contrast, a positive trend was established between vitamin D and the protective adipocytokine adiponectin. The clinical relevance of this relationship needs to be investigated in larger studies.", journal = "Journal of Obesity and Chronic Diseases", title = "Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity", volume = "1", number = "2", doi = "10.17756/jocd.2017-005" }
Stokić, E., Hakkak, R., Romani, A., Kupusinac, A., Isenović, E. R., Tomić-Naglić, D., Srdić-Galić, B., Pejaković, S.,& Radošević, D.. (2017). Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity. in Journal of Obesity and Chronic Diseases, 1(2). https://doi.org/10.17756/jocd.2017-005
Stokić E, Hakkak R, Romani A, Kupusinac A, Isenović ER, Tomić-Naglić D, Srdić-Galić B, Pejaković S, Radošević D. Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity. in Journal of Obesity and Chronic Diseases. 2017;1(2). doi:10.17756/jocd.2017-005 .
Stokić, Edita, Hakkak, Reza, Romani, Andrea, Kupusinac, Aleksandar, Isenović, Esma R., Tomić-Naglić, Dragana, Srdić-Galić, Biljana, Pejaković, Slađana, Radošević, Dragana, "Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity" in Journal of Obesity and Chronic Diseases, 1, no. 2 (2017), https://doi.org/10.17756/jocd.2017-005 . .