Engineering multi-core flower-like magnetic nanoparticles with high intrinsic loss power
Аутори
Ognjanović, MilošRadović, Magdalena
Mirković, Marija
Vranješ-Đurić, Sanja
Dojčinović, Biljana
Stanković, Dalibor
Antić, Bratislav
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In the last decades, self-heating magnetic nanoparticles (MNPs) were engineered and investigated for magnetic hyperthermia (MH) and other applications such as catalysis and chemical synthesis. To be applied as nanoheaters for in vivo MH in cancer therapy, MNPs should have high heating efficiency expressed by Intrinsic Loss Power (ILP). One of the requirements for in vivo applications of MNPs is their non-toxicity. Hence, the most investigated MNPs for MH are based on iron oxides (magnetite and maghemite), which are non-toxic or slightly toxic. This work aimed to apply thepolyol-mediated protocol to engineer mixed Zn1-xMnxFe2O4 and analyze their heating abilities. To obtain a series of Zn1-xMnxFe2O4 samples with a specific nominal composition, the initial components, salts of Zn, Mn and Fe, were mixed in the appropriate stoichiometric ratio. The deviation from the target stoichiometry and the formation of samples with polyvalent ions and possibly vacancies were determined after ICP anal...ysis. By analyzing TEM micrographs, we found that the change in the chemical composition does not affect the morphology. Multicore flower-like nanostructures with a size in the range of 47-63 nm were obtained. They consist of many cores (crystallites or nanoparticles) with a size of \textasciitilde10 nm. The samples show good colloidal stability, which is significant for their medical applications. Magnetization measurements in different DC fields showed that the samples are superparamagnetic at 300K and that the saturation magnetization values are in the range of \textasciitilde59-73 emu/g. The hyperthermic efficiency of the synthesized samples was tested in an external ac field of 252 kHz and a field strength of 15.9 kA/m. Significantly different values were obtained for the ILP parameter (in units nHm2/Kg): 5.77 (Zn0.098Mn0.447Fe2.455O4) ˃ 3.22 (Mn0.624Fe2.376O4) ˃ 2.04 (Zn0.182Mn0.344Fe2.474O4) ˃ 1.36 (Zn0.309Mn0.240Fe2.451O4) ˃ 1.01 (Zn0.394Mn0.138Fe2.468O4) ˃ 0.34 (Zn0.640Fe2.360O4). To explain the values of the ILP parameter, additional research is required, which includes the analysis of the influence of local defects and cation distribution on the magnetism of the investigated nanostructures. Also, significantly high ILP values indicate that some samples can be selected and further tested for in vitro/in vivo applications.
Кључне речи:
magnetic nanoparticles / polyol synthesis / nanoflowers / magnetic hyperthermiaИзвор:
26th Congress of the Society of Chemists and Technologists of Macedonia : the book of abstracts; September 20-23, Ohrid, Macedonia, 2023, 185-Издавач:
- Society of Chemists and Technologists of Macedonia
Институција/група
VinčaTY - CONF AU - Ognjanović, Miloš AU - Radović, Magdalena AU - Mirković, Marija AU - Vranješ-Đurić, Sanja AU - Dojčinović, Biljana AU - Stanković, Dalibor AU - Antić, Bratislav PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11671 AB - In the last decades, self-heating magnetic nanoparticles (MNPs) were engineered and investigated for magnetic hyperthermia (MH) and other applications such as catalysis and chemical synthesis. To be applied as nanoheaters for in vivo MH in cancer therapy, MNPs should have high heating efficiency expressed by Intrinsic Loss Power (ILP). One of the requirements for in vivo applications of MNPs is their non-toxicity. Hence, the most investigated MNPs for MH are based on iron oxides (magnetite and maghemite), which are non-toxic or slightly toxic. This work aimed to apply thepolyol-mediated protocol to engineer mixed Zn1-xMnxFe2O4 and analyze their heating abilities. To obtain a series of Zn1-xMnxFe2O4 samples with a specific nominal composition, the initial components, salts of Zn, Mn and Fe, were mixed in the appropriate stoichiometric ratio. The deviation from the target stoichiometry and the formation of samples with polyvalent ions and possibly vacancies were determined after ICP analysis. By analyzing TEM micrographs, we found that the change in the chemical composition does not affect the morphology. Multicore flower-like nanostructures with a size in the range of 47-63 nm were obtained. They consist of many cores (crystallites or nanoparticles) with a size of \textasciitilde10 nm. The samples show good colloidal stability, which is significant for their medical applications. Magnetization measurements in different DC fields showed that the samples are superparamagnetic at 300K and that the saturation magnetization values are in the range of \textasciitilde59-73 emu/g. The hyperthermic efficiency of the synthesized samples was tested in an external ac field of 252 kHz and a field strength of 15.9 kA/m. Significantly different values were obtained for the ILP parameter (in units nHm2/Kg): 5.77 (Zn0.098Mn0.447Fe2.455O4) ˃ 3.22 (Mn0.624Fe2.376O4) ˃ 2.04 (Zn0.182Mn0.344Fe2.474O4) ˃ 1.36 (Zn0.309Mn0.240Fe2.451O4) ˃ 1.01 (Zn0.394Mn0.138Fe2.468O4) ˃ 0.34 (Zn0.640Fe2.360O4). To explain the values of the ILP parameter, additional research is required, which includes the analysis of the influence of local defects and cation distribution on the magnetism of the investigated nanostructures. Also, significantly high ILP values indicate that some samples can be selected and further tested for in vitro/in vivo applications. PB - Society of Chemists and Technologists of Macedonia C3 - 26th Congress of the Society of Chemists and Technologists of Macedonia : the book of abstracts; September 20-23, Ohrid, Macedonia T1 - Engineering multi-core flower-like magnetic nanoparticles with high intrinsic loss power SP - 185 UR - https://hdl.handle.net/21.15107/rcub_vinar_11671 ER -
@conference{ author = "Ognjanović, Miloš and Radović, Magdalena and Mirković, Marija and Vranješ-Đurić, Sanja and Dojčinović, Biljana and Stanković, Dalibor and Antić, Bratislav", year = "2023", abstract = "In the last decades, self-heating magnetic nanoparticles (MNPs) were engineered and investigated for magnetic hyperthermia (MH) and other applications such as catalysis and chemical synthesis. To be applied as nanoheaters for in vivo MH in cancer therapy, MNPs should have high heating efficiency expressed by Intrinsic Loss Power (ILP). One of the requirements for in vivo applications of MNPs is their non-toxicity. Hence, the most investigated MNPs for MH are based on iron oxides (magnetite and maghemite), which are non-toxic or slightly toxic. This work aimed to apply thepolyol-mediated protocol to engineer mixed Zn1-xMnxFe2O4 and analyze their heating abilities. To obtain a series of Zn1-xMnxFe2O4 samples with a specific nominal composition, the initial components, salts of Zn, Mn and Fe, were mixed in the appropriate stoichiometric ratio. The deviation from the target stoichiometry and the formation of samples with polyvalent ions and possibly vacancies were determined after ICP analysis. By analyzing TEM micrographs, we found that the change in the chemical composition does not affect the morphology. Multicore flower-like nanostructures with a size in the range of 47-63 nm were obtained. They consist of many cores (crystallites or nanoparticles) with a size of \textasciitilde10 nm. The samples show good colloidal stability, which is significant for their medical applications. Magnetization measurements in different DC fields showed that the samples are superparamagnetic at 300K and that the saturation magnetization values are in the range of \textasciitilde59-73 emu/g. The hyperthermic efficiency of the synthesized samples was tested in an external ac field of 252 kHz and a field strength of 15.9 kA/m. Significantly different values were obtained for the ILP parameter (in units nHm2/Kg): 5.77 (Zn0.098Mn0.447Fe2.455O4) ˃ 3.22 (Mn0.624Fe2.376O4) ˃ 2.04 (Zn0.182Mn0.344Fe2.474O4) ˃ 1.36 (Zn0.309Mn0.240Fe2.451O4) ˃ 1.01 (Zn0.394Mn0.138Fe2.468O4) ˃ 0.34 (Zn0.640Fe2.360O4). To explain the values of the ILP parameter, additional research is required, which includes the analysis of the influence of local defects and cation distribution on the magnetism of the investigated nanostructures. Also, significantly high ILP values indicate that some samples can be selected and further tested for in vitro/in vivo applications.", publisher = "Society of Chemists and Technologists of Macedonia", journal = "26th Congress of the Society of Chemists and Technologists of Macedonia : the book of abstracts; September 20-23, Ohrid, Macedonia", title = "Engineering multi-core flower-like magnetic nanoparticles with high intrinsic loss power", pages = "185", url = "https://hdl.handle.net/21.15107/rcub_vinar_11671" }
Ognjanović, M., Radović, M., Mirković, M., Vranješ-Đurić, S., Dojčinović, B., Stanković, D.,& Antić, B.. (2023). Engineering multi-core flower-like magnetic nanoparticles with high intrinsic loss power. in 26th Congress of the Society of Chemists and Technologists of Macedonia : the book of abstracts; September 20-23, Ohrid, Macedonia Society of Chemists and Technologists of Macedonia., 185. https://hdl.handle.net/21.15107/rcub_vinar_11671
Ognjanović M, Radović M, Mirković M, Vranješ-Đurić S, Dojčinović B, Stanković D, Antić B. Engineering multi-core flower-like magnetic nanoparticles with high intrinsic loss power. in 26th Congress of the Society of Chemists and Technologists of Macedonia : the book of abstracts; September 20-23, Ohrid, Macedonia. 2023;:185. https://hdl.handle.net/21.15107/rcub_vinar_11671 .
Ognjanović, Miloš, Radović, Magdalena, Mirković, Marija, Vranješ-Đurić, Sanja, Dojčinović, Biljana, Stanković, Dalibor, Antić, Bratislav, "Engineering multi-core flower-like magnetic nanoparticles with high intrinsic loss power" in 26th Congress of the Society of Chemists and Technologists of Macedonia : the book of abstracts; September 20-23, Ohrid, Macedonia (2023):185, https://hdl.handle.net/21.15107/rcub_vinar_11671 .