Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines
Само за регистроване кориснике
2016
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A small library of novel 2-oxo-1,2,3,4-tetrahydropyrimidines was synthesized via a one-pot multicomponent Biginelli reaction. Copper complex which was used for the first time as a homogeneous and heterogeneous catalyst, makes this a facile and efficient reaction at room temperature. All the obtained products fall out of the solution in pure form and are easily isolated via filtration in good-to-excellent yields. The molecular structure of one of the products, ethyl 6-methyl-2-oxo-4-(4-isopropoxy-3-methoxyphenyl) - 1,2,3,4 - tetrahydropyrimidine-5- carboxylate, has been determined by X-ray crystallography. All non-hydrogen atoms in the heterocyclic, six-membered ring are determined to be approximately coplanar.
Кључне речи:
Homogeneous catalysis / Heterogeneous catalysis / Multicomponent reactions (MCRs) / HeterocyclesИзвор:
Molecular Diversity, 2016, 20, 3, 591-604Финансирање / пројекти:
- Испитивање механизма реакција комплекса јона прелазних метала са биолошки значајним молекулима (RS-MESTD-Basic Research (BR or ON)-172011)
- Нове електрохемијске и хемијске методе у синтези органских једињења од интереса за медицину и хемију материјала (RS-MESTD-Basic Research (BR or ON)-172034)
DOI: 10.1007/s11030-016-9658-y
ISSN: 1381-1991; 1573-501X
PubMed: 26829937
WoS: 000379259200002
Scopus: 2-s2.0-84977450850
Колекције
Институција/група
VinčaTY - JOUR AU - Muškinja, Jovana AU - Janković, Nenad AU - Ratković, Zoran R. AU - Bogdanović, Goran A. AU - Bugarčič, Zorica M. PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1163 AB - A small library of novel 2-oxo-1,2,3,4-tetrahydropyrimidines was synthesized via a one-pot multicomponent Biginelli reaction. Copper complex which was used for the first time as a homogeneous and heterogeneous catalyst, makes this a facile and efficient reaction at room temperature. All the obtained products fall out of the solution in pure form and are easily isolated via filtration in good-to-excellent yields. The molecular structure of one of the products, ethyl 6-methyl-2-oxo-4-(4-isopropoxy-3-methoxyphenyl) - 1,2,3,4 - tetrahydropyrimidine-5- carboxylate, has been determined by X-ray crystallography. All non-hydrogen atoms in the heterocyclic, six-membered ring are determined to be approximately coplanar. T2 - Molecular Diversity T1 - Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines VL - 20 IS - 3 SP - 591 EP - 604 DO - 10.1007/s11030-016-9658-y ER -
@article{ author = "Muškinja, Jovana and Janković, Nenad and Ratković, Zoran R. and Bogdanović, Goran A. and Bugarčič, Zorica M.", year = "2016", abstract = "A small library of novel 2-oxo-1,2,3,4-tetrahydropyrimidines was synthesized via a one-pot multicomponent Biginelli reaction. Copper complex which was used for the first time as a homogeneous and heterogeneous catalyst, makes this a facile and efficient reaction at room temperature. All the obtained products fall out of the solution in pure form and are easily isolated via filtration in good-to-excellent yields. The molecular structure of one of the products, ethyl 6-methyl-2-oxo-4-(4-isopropoxy-3-methoxyphenyl) - 1,2,3,4 - tetrahydropyrimidine-5- carboxylate, has been determined by X-ray crystallography. All non-hydrogen atoms in the heterocyclic, six-membered ring are determined to be approximately coplanar.", journal = "Molecular Diversity", title = "Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines", volume = "20", number = "3", pages = "591-604", doi = "10.1007/s11030-016-9658-y" }
Muškinja, J., Janković, N., Ratković, Z. R., Bogdanović, G. A.,& Bugarčič, Z. M.. (2016). Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines. in Molecular Diversity, 20(3), 591-604. https://doi.org/10.1007/s11030-016-9658-y
Muškinja J, Janković N, Ratković ZR, Bogdanović GA, Bugarčič ZM. Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines. in Molecular Diversity. 2016;20(3):591-604. doi:10.1007/s11030-016-9658-y .
Muškinja, Jovana, Janković, Nenad, Ratković, Zoran R., Bogdanović, Goran A., Bugarčič, Zorica M., "Vanillic aldehydes for the one-pot synthesis of novel 2-oxo-1,2,3,4-tetrahydropyrimidines" in Molecular Diversity, 20, no. 3 (2016):591-604, https://doi.org/10.1007/s11030-016-9658-y . .