Multiple Roles of the RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical Implications
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: Hepatocellular carcinoma (HCC) is one of the most frequent cancers in humans, characterised by a high resistance to conventional chemotherapy, late diagnosis, and a high mortality rate. It is necessary to elucidate the molecular mechanisms involved in hepatocarcinogenesis to improve diagnosis and treatment outcomes. The Runt-related (RUNX) family of transcription factors (RUNX1, RUNX2, and RUNX3) participates in cardinal biological processes and plays paramount roles in the pathogenesis of numerous human malignancies. Their role is often controversial as they can act as oncogenes or tumour suppressors and depends on cellular context. Evidence shows that deregulated RUNX genes may be involved in hepatocarcinogenesis from the earliest to the latest stages. In this review, we summarise the topical evidence on the roles of RUNX gene family members in HCC. We discuss their possible application as non-invasive molecular markers for early diagnosis, prognosis, and development of novel treat...ment strategies in HCC patients.
Кључне речи:
RUNX / hepatocellular carcinoma / oncogenes / tumour suppressors / biomarkersИзвор:
Cells, 2023, 12, 18, 2303-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
DOI: 10.3390/cells12182303
ISSN: 2073-4409
PubMed: 37759525
Scopus: 2-s2.0-85172803048
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Институција/група
VinčaTY - JOUR AU - Krajnović, Milena M. AU - Kožik, Bojana AU - Božović, Ana M. AU - Jovanović-Ćupić, Snežana PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11625 AB - : Hepatocellular carcinoma (HCC) is one of the most frequent cancers in humans, characterised by a high resistance to conventional chemotherapy, late diagnosis, and a high mortality rate. It is necessary to elucidate the molecular mechanisms involved in hepatocarcinogenesis to improve diagnosis and treatment outcomes. The Runt-related (RUNX) family of transcription factors (RUNX1, RUNX2, and RUNX3) participates in cardinal biological processes and plays paramount roles in the pathogenesis of numerous human malignancies. Their role is often controversial as they can act as oncogenes or tumour suppressors and depends on cellular context. Evidence shows that deregulated RUNX genes may be involved in hepatocarcinogenesis from the earliest to the latest stages. In this review, we summarise the topical evidence on the roles of RUNX gene family members in HCC. We discuss their possible application as non-invasive molecular markers for early diagnosis, prognosis, and development of novel treatment strategies in HCC patients. T2 - Cells T1 - Multiple Roles of the RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical Implications VL - 12 IS - 18 SP - 2303 DO - 10.3390/cells12182303 ER -
@article{ author = "Krajnović, Milena M. and Kožik, Bojana and Božović, Ana M. and Jovanović-Ćupić, Snežana", year = "2023", abstract = ": Hepatocellular carcinoma (HCC) is one of the most frequent cancers in humans, characterised by a high resistance to conventional chemotherapy, late diagnosis, and a high mortality rate. It is necessary to elucidate the molecular mechanisms involved in hepatocarcinogenesis to improve diagnosis and treatment outcomes. The Runt-related (RUNX) family of transcription factors (RUNX1, RUNX2, and RUNX3) participates in cardinal biological processes and plays paramount roles in the pathogenesis of numerous human malignancies. Their role is often controversial as they can act as oncogenes or tumour suppressors and depends on cellular context. Evidence shows that deregulated RUNX genes may be involved in hepatocarcinogenesis from the earliest to the latest stages. In this review, we summarise the topical evidence on the roles of RUNX gene family members in HCC. We discuss their possible application as non-invasive molecular markers for early diagnosis, prognosis, and development of novel treatment strategies in HCC patients.", journal = "Cells", title = "Multiple Roles of the RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical Implications", volume = "12", number = "18", pages = "2303", doi = "10.3390/cells12182303" }
Krajnović, M. M., Kožik, B., Božović, A. M.,& Jovanović-Ćupić, S.. (2023). Multiple Roles of the RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical Implications. in Cells, 12(18), 2303. https://doi.org/10.3390/cells12182303
Krajnović MM, Kožik B, Božović AM, Jovanović-Ćupić S. Multiple Roles of the RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical Implications. in Cells. 2023;12(18):2303. doi:10.3390/cells12182303 .
Krajnović, Milena M., Kožik, Bojana, Božović, Ana M., Jovanović-Ćupić, Snežana, "Multiple Roles of the RUNX Gene Family in Hepatocellular Carcinoma and Their Potential Clinical Implications" in Cells, 12, no. 18 (2023):2303, https://doi.org/10.3390/cells12182303 . .