Effects of chronic oral D-galactose treatment on general health status in male Wistar rats
Аутори
Martinović, JelenaGuševac Stojanović, Ivana
Zarić, M.
Todorović, Ana
Veljković, Filip
Pejić, Snežana
Stojanović, Zoran
Mitrović, N.
Grković, Ivana
Drakulić, Dunja
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
D-galactose (d-gal) is an important physiological nutrient. According to thewidely accepted aging metabolic theory d-gal at high levels can be convertedinto aldose and hydroperoxide, resulting in the overproduction of reactiveoxygen species (ROS). Increased ROS levels may subsequently cause oxidative stress, inflammation, mitochondrial dysfunction, and apoptosis which are hallmarks of natural senescence as well as various pathological conditions. We investigated the effects of chronic oral d-gal intake (200 mg/kg and 500 mg/kg for 6 weeks) on physiological, neurological and toxicity parameters in 3 months old male Wistar rats. The obtained results indicate that body weight, food intake, serum glucose, neurological and toxicity status remained unaffected while urine proteins were significantly increased in d-gal treated rats. Although there was no effect on the general health status of the animals, our findings suggest that chronic oral d-gal administration may lead to renal dysfunction....
Кључне речи:
D-galactose / reactive oxygen species / health statusИзвор:
7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry, 2021, 115-118Издавач:
- Belgrade : Vinča Institute of Nuclear Sciences
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Колекције
Институција/група
VinčaTY - CONF AU - Martinović, Jelena AU - Guševac Stojanović, Ivana AU - Zarić, M. AU - Todorović, Ana AU - Veljković, Filip AU - Pejić, Snežana AU - Stojanović, Zoran AU - Mitrović, N. AU - Grković, Ivana AU - Drakulić, Dunja PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/11399 AB - D-galactose (d-gal) is an important physiological nutrient. According to thewidely accepted aging metabolic theory d-gal at high levels can be convertedinto aldose and hydroperoxide, resulting in the overproduction of reactiveoxygen species (ROS). Increased ROS levels may subsequently cause oxidative stress, inflammation, mitochondrial dysfunction, and apoptosis which are hallmarks of natural senescence as well as various pathological conditions. We investigated the effects of chronic oral d-gal intake (200 mg/kg and 500 mg/kg for 6 weeks) on physiological, neurological and toxicity parameters in 3 months old male Wistar rats. The obtained results indicate that body weight, food intake, serum glucose, neurological and toxicity status remained unaffected while urine proteins were significantly increased in d-gal treated rats. Although there was no effect on the general health status of the animals, our findings suggest that chronic oral d-gal administration may lead to renal dysfunction. PB - Belgrade : Vinča Institute of Nuclear Sciences C3 - 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry T1 - Effects of chronic oral D-galactose treatment on general health status in male Wistar rats SP - 115 EP - 118 UR - https://hdl.handle.net/21.15107/rcub_vinar_11399 ER -
@conference{ author = "Martinović, Jelena and Guševac Stojanović, Ivana and Zarić, M. and Todorović, Ana and Veljković, Filip and Pejić, Snežana and Stojanović, Zoran and Mitrović, N. and Grković, Ivana and Drakulić, Dunja", year = "2021", abstract = "D-galactose (d-gal) is an important physiological nutrient. According to thewidely accepted aging metabolic theory d-gal at high levels can be convertedinto aldose and hydroperoxide, resulting in the overproduction of reactiveoxygen species (ROS). Increased ROS levels may subsequently cause oxidative stress, inflammation, mitochondrial dysfunction, and apoptosis which are hallmarks of natural senescence as well as various pathological conditions. We investigated the effects of chronic oral d-gal intake (200 mg/kg and 500 mg/kg for 6 weeks) on physiological, neurological and toxicity parameters in 3 months old male Wistar rats. The obtained results indicate that body weight, food intake, serum glucose, neurological and toxicity status remained unaffected while urine proteins were significantly increased in d-gal treated rats. Although there was no effect on the general health status of the animals, our findings suggest that chronic oral d-gal administration may lead to renal dysfunction.", publisher = "Belgrade : Vinča Institute of Nuclear Sciences", journal = "7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry", title = "Effects of chronic oral D-galactose treatment on general health status in male Wistar rats", pages = "115-118", url = "https://hdl.handle.net/21.15107/rcub_vinar_11399" }
Martinović, J., Guševac Stojanović, I., Zarić, M., Todorović, A., Veljković, F., Pejić, S., Stojanović, Z., Mitrović, N., Grković, I.,& Drakulić, D.. (2021). Effects of chronic oral D-galactose treatment on general health status in male Wistar rats. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry Belgrade : Vinča Institute of Nuclear Sciences., 115-118. https://hdl.handle.net/21.15107/rcub_vinar_11399
Martinović J, Guševac Stojanović I, Zarić M, Todorović A, Veljković F, Pejić S, Stojanović Z, Mitrović N, Grković I, Drakulić D. Effects of chronic oral D-galactose treatment on general health status in male Wistar rats. in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry. 2021;:115-118. https://hdl.handle.net/21.15107/rcub_vinar_11399 .
Martinović, Jelena, Guševac Stojanović, Ivana, Zarić, M., Todorović, Ana, Veljković, Filip, Pejić, Snežana, Stojanović, Zoran, Mitrović, N., Grković, Ivana, Drakulić, Dunja, "Effects of chronic oral D-galactose treatment on general health status in male Wistar rats" in 7th Workshop Specific Methods for Food Safety and Quality, September 22nd, 2021, Belgrade, Serbia, 15th International Conference on Fundamental and Applied Aspects of Physical Chemistry - Physical Chemistry (2021):115-118, https://hdl.handle.net/21.15107/rcub_vinar_11399 .