Neodymium-Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep-Tissue Photothermal Therapy
Нема приказа
Аутори
del Rosal, BlancaPerez-Delgado, Alberto
Carrasco, Elisa
Jovanović, Dragana J.
Dramićanin, Miroslav
Dražić, Goran
Juarranz de la Fuente, Angeles
Sanz-Rodriguez, Francisco
Jaque, Daniel
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Nanoparticle-mediated photothermal therapy (NP-PTT) constitutes a flexible, highly selective, cost effective, and accurate tool for cancer treatment alone or in combination with other therapies such as radiotherapy or chemotherapy. The future application of NP-PTT in real life mainly depends on the design and synthesis of novel multifunctional nanoparticles that could overcome the current limitations of NP-PTT such as limited penetration depth and absence of therapy control. In this work, ultrasmall (approximate to 2.4 nm) NdVO4 stoichiometric (100% constituent Nd3+ ions) nanoparticles are reported, which are capable of in vivo sub-tissue localized heating under 808 nm optical excitation while providing, simultaneously, the possibility of high penetration near-infrared fluorescence imaging. Ultrasmall stoichiometric NdVO4 nanoparticles have evidenced a superior light-to-heat conversion efficiency. This is explained in terms of their large absorption cross-section at 808 nm (consequence... of the particular spectroscopic properties of neodymium ions in NdVO4 and of the high neodymium content) as well as to their ultrasmall size that leads to large nonradiative decay rates. Results included in this work introduce ultrasmall, NdVO4 stoichiometric nanoparticles to the scientific community as multifunctional photothermal agents that could be considered as an alternative to traditional systems such as metallic, organic, or carbon-based nanoparticles.
Извор:
Advanced Optical Materials, 2016, 4, 5, 782-789Финансирање / пројекти:
- Материјали редуковане димензионалности за ефикасну апсорпцију светлости и конверзију енергије (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45020)
- Spanish Ministerio de Economia y Competitividad [MAT2013-47395-C4-1-R], Instituto de Salud Carlos III (FIS) [PI15/00974], Comunidad Autonoma de Madrid (CAM, Skin-Model) [S2010/BMD-2359], Universidad Autonoma de Madrid, Slovenian Research Agency (ARRS) [P2-0148], [J2-6754]
Напомена:
- Peer-reviewed article: https://vinar.vin.bg.ac.rs/handle/123456789/9686
DOI: 10.1002/adom.201500726
ISSN: 2195-1071
WoS: 000377598900020
Scopus: 2-s2.0-84959870262
Колекције
Институција/група
VinčaTY - JOUR AU - del Rosal, Blanca AU - Perez-Delgado, Alberto AU - Carrasco, Elisa AU - Jovanović, Dragana J. AU - Dramićanin, Miroslav AU - Dražić, Goran AU - Juarranz de la Fuente, Angeles AU - Sanz-Rodriguez, Francisco AU - Jaque, Daniel PY - 2016 UR - https://vinar.vin.bg.ac.rs/handle/123456789/1113 AB - Nanoparticle-mediated photothermal therapy (NP-PTT) constitutes a flexible, highly selective, cost effective, and accurate tool for cancer treatment alone or in combination with other therapies such as radiotherapy or chemotherapy. The future application of NP-PTT in real life mainly depends on the design and synthesis of novel multifunctional nanoparticles that could overcome the current limitations of NP-PTT such as limited penetration depth and absence of therapy control. In this work, ultrasmall (approximate to 2.4 nm) NdVO4 stoichiometric (100% constituent Nd3+ ions) nanoparticles are reported, which are capable of in vivo sub-tissue localized heating under 808 nm optical excitation while providing, simultaneously, the possibility of high penetration near-infrared fluorescence imaging. Ultrasmall stoichiometric NdVO4 nanoparticles have evidenced a superior light-to-heat conversion efficiency. This is explained in terms of their large absorption cross-section at 808 nm (consequence of the particular spectroscopic properties of neodymium ions in NdVO4 and of the high neodymium content) as well as to their ultrasmall size that leads to large nonradiative decay rates. Results included in this work introduce ultrasmall, NdVO4 stoichiometric nanoparticles to the scientific community as multifunctional photothermal agents that could be considered as an alternative to traditional systems such as metallic, organic, or carbon-based nanoparticles. T2 - Advanced Optical Materials T1 - Neodymium-Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep-Tissue Photothermal Therapy VL - 4 IS - 5 SP - 782 EP - 789 DO - 10.1002/adom.201500726 ER -
@article{ author = "del Rosal, Blanca and Perez-Delgado, Alberto and Carrasco, Elisa and Jovanović, Dragana J. and Dramićanin, Miroslav and Dražić, Goran and Juarranz de la Fuente, Angeles and Sanz-Rodriguez, Francisco and Jaque, Daniel", year = "2016", abstract = "Nanoparticle-mediated photothermal therapy (NP-PTT) constitutes a flexible, highly selective, cost effective, and accurate tool for cancer treatment alone or in combination with other therapies such as radiotherapy or chemotherapy. The future application of NP-PTT in real life mainly depends on the design and synthesis of novel multifunctional nanoparticles that could overcome the current limitations of NP-PTT such as limited penetration depth and absence of therapy control. In this work, ultrasmall (approximate to 2.4 nm) NdVO4 stoichiometric (100% constituent Nd3+ ions) nanoparticles are reported, which are capable of in vivo sub-tissue localized heating under 808 nm optical excitation while providing, simultaneously, the possibility of high penetration near-infrared fluorescence imaging. Ultrasmall stoichiometric NdVO4 nanoparticles have evidenced a superior light-to-heat conversion efficiency. This is explained in terms of their large absorption cross-section at 808 nm (consequence of the particular spectroscopic properties of neodymium ions in NdVO4 and of the high neodymium content) as well as to their ultrasmall size that leads to large nonradiative decay rates. Results included in this work introduce ultrasmall, NdVO4 stoichiometric nanoparticles to the scientific community as multifunctional photothermal agents that could be considered as an alternative to traditional systems such as metallic, organic, or carbon-based nanoparticles.", journal = "Advanced Optical Materials", title = "Neodymium-Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep-Tissue Photothermal Therapy", volume = "4", number = "5", pages = "782-789", doi = "10.1002/adom.201500726" }
del Rosal, B., Perez-Delgado, A., Carrasco, E., Jovanović, D. J., Dramićanin, M., Dražić, G., Juarranz de la Fuente, A., Sanz-Rodriguez, F.,& Jaque, D.. (2016). Neodymium-Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep-Tissue Photothermal Therapy. in Advanced Optical Materials, 4(5), 782-789. https://doi.org/10.1002/adom.201500726
del Rosal B, Perez-Delgado A, Carrasco E, Jovanović DJ, Dramićanin M, Dražić G, Juarranz de la Fuente A, Sanz-Rodriguez F, Jaque D. Neodymium-Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep-Tissue Photothermal Therapy. in Advanced Optical Materials. 2016;4(5):782-789. doi:10.1002/adom.201500726 .
del Rosal, Blanca, Perez-Delgado, Alberto, Carrasco, Elisa, Jovanović, Dragana J., Dramićanin, Miroslav, Dražić, Goran, Juarranz de la Fuente, Angeles, Sanz-Rodriguez, Francisco, Jaque, Daniel, "Neodymium-Based Stoichiometric Ultrasmall Nanoparticles for Multifunctional Deep-Tissue Photothermal Therapy" in Advanced Optical Materials, 4, no. 5 (2016):782-789, https://doi.org/10.1002/adom.201500726 . .