Cholecalciferol affects cardiac proteins regulating malonyl-CoA availability and intracellular calcium level
Аутори
Ivković, TamaraTepavčević, Snežana
Romić, Snježana Đ.
Stojiljković, Mojca D.
Kostić, Milan
Stanišić, Jelena
Korićanac, Goran
Ćulafić, Tijana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Cholecalciferol improves insulin signaling and glucose metabolism in the heart and reduces
circulating non-esterified fatty acids. Cholecalciferol effects on the cardiac fatty acid (FA) metabolism
and the consequences on calcium handling were examined. Blood lipid profile was determined.
Western blot and qRT-PCR were used to examine protein and mRNA expression. Cholecalciferoltreated rats had increased acetyl CoA carboxylase 2 protein expression and decreased expression of
malonyl CoA decarboxylase. In addition, the expression of uncoupling protein 3 was elevated. Also,
the level of peroxisome proliferator-activated receptor-gamma coactivator in the nucleus of heart
cells was increased along with the level of sarcoplasmic/endoplasmic reticulum Ca2+ATPase in the
microsomal fraction. In parallel, the L-type calcium channel and ryanodine receptor expression was
reduced. In the heart of healthy rats, cholecalciferol affects proteins regulating malonyl CoA availability and intracell...ular Ca2+ handling proteins.
Кључне речи:
Vitamin D / Heart / Fatty acid metabolism / Calcium handlingИзвор:
General physiology and biophysics, 2023, 42, 03, 241-250Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
Институција/група
VinčaTY - JOUR AU - Ivković, Tamara AU - Tepavčević, Snežana AU - Romić, Snježana Đ. AU - Stojiljković, Mojca D. AU - Kostić, Milan AU - Stanišić, Jelena AU - Korićanac, Goran AU - Ćulafić, Tijana PY - 2023 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10924 AB - Cholecalciferol improves insulin signaling and glucose metabolism in the heart and reduces circulating non-esterified fatty acids. Cholecalciferol effects on the cardiac fatty acid (FA) metabolism and the consequences on calcium handling were examined. Blood lipid profile was determined. Western blot and qRT-PCR were used to examine protein and mRNA expression. Cholecalciferoltreated rats had increased acetyl CoA carboxylase 2 protein expression and decreased expression of malonyl CoA decarboxylase. In addition, the expression of uncoupling protein 3 was elevated. Also, the level of peroxisome proliferator-activated receptor-gamma coactivator in the nucleus of heart cells was increased along with the level of sarcoplasmic/endoplasmic reticulum Ca2+ATPase in the microsomal fraction. In parallel, the L-type calcium channel and ryanodine receptor expression was reduced. In the heart of healthy rats, cholecalciferol affects proteins regulating malonyl CoA availability and intracellular Ca2+ handling proteins. T2 - General physiology and biophysics T1 - Cholecalciferol affects cardiac proteins regulating malonyl-CoA availability and intracellular calcium level VL - 42 IS - 03 SP - 241 EP - 250 DO - 10.4149/gpb_2023005 ER -
@article{ author = "Ivković, Tamara and Tepavčević, Snežana and Romić, Snježana Đ. and Stojiljković, Mojca D. and Kostić, Milan and Stanišić, Jelena and Korićanac, Goran and Ćulafić, Tijana", year = "2023", abstract = "Cholecalciferol improves insulin signaling and glucose metabolism in the heart and reduces circulating non-esterified fatty acids. Cholecalciferol effects on the cardiac fatty acid (FA) metabolism and the consequences on calcium handling were examined. Blood lipid profile was determined. Western blot and qRT-PCR were used to examine protein and mRNA expression. Cholecalciferoltreated rats had increased acetyl CoA carboxylase 2 protein expression and decreased expression of malonyl CoA decarboxylase. In addition, the expression of uncoupling protein 3 was elevated. Also, the level of peroxisome proliferator-activated receptor-gamma coactivator in the nucleus of heart cells was increased along with the level of sarcoplasmic/endoplasmic reticulum Ca2+ATPase in the microsomal fraction. In parallel, the L-type calcium channel and ryanodine receptor expression was reduced. In the heart of healthy rats, cholecalciferol affects proteins regulating malonyl CoA availability and intracellular Ca2+ handling proteins.", journal = "General physiology and biophysics", title = "Cholecalciferol affects cardiac proteins regulating malonyl-CoA availability and intracellular calcium level", volume = "42", number = "03", pages = "241-250", doi = "10.4149/gpb_2023005" }
Ivković, T., Tepavčević, S., Romić, S. Đ., Stojiljković, M. D., Kostić, M., Stanišić, J., Korićanac, G.,& Ćulafić, T.. (2023). Cholecalciferol affects cardiac proteins regulating malonyl-CoA availability and intracellular calcium level. in General physiology and biophysics, 42(03), 241-250. https://doi.org/10.4149/gpb_2023005
Ivković T, Tepavčević S, Romić SĐ, Stojiljković MD, Kostić M, Stanišić J, Korićanac G, Ćulafić T. Cholecalciferol affects cardiac proteins regulating malonyl-CoA availability and intracellular calcium level. in General physiology and biophysics. 2023;42(03):241-250. doi:10.4149/gpb_2023005 .
Ivković, Tamara, Tepavčević, Snežana, Romić, Snježana Đ., Stojiljković, Mojca D., Kostić, Milan, Stanišić, Jelena, Korićanac, Goran, Ćulafić, Tijana, "Cholecalciferol affects cardiac proteins regulating malonyl-CoA availability and intracellular calcium level" in General physiology and biophysics, 42, no. 03 (2023):241-250, https://doi.org/10.4149/gpb_2023005 . .