Cytotoxicity of copper(II)-complexes with some S-alkyl derivatives of thiosalicylic acid. Crystal structure of the binuclear copper(II)-complex with S-ethyl derivative of thiosalicylic acid
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AuthorsNikolie, Milos V.
Mijajlovic, Marina Z.
Jevtic, Verica V.
Ratkovic, Zoran R.
Novaković, Slađana B.
Bogdanović, Goran A.
Trifunovic, Srecko R.
Radic, Gordana P.
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The spectroscopically predicted structure of the obtained copper(II)-complex with S-ethyl derivative of thiosalicylic acid was confirmed by X-ray structural study and compared to previously reported crystal structure of the Cu complex with S-methyl derivative. Single crystals suitable for X-ray measurements were obtained by slow crystallization from a water solution. Cytotoxic effects of S-alkyl (R = benzyl (L1), methyl (12), ethyl (L3), propyl (IA) and butyl (L5)) derivatives of thiosalicylic acid and the corresponding binuclear copper(II)-complexes on murine colon carcinoma cell lines, 026 and CT26.CL25 and human colon carcinoma cell line HCT-116 were reported here. The analysis of cancer cell viability showed that all the tested complexes had low cytotoxic effect on murine colon carcinoma cell lines, but several times higher cytotoxicity on normal human colon carcinoma cells. (C) 2016 Elsevier B.V. All rights reserved.
Keywords:Binuclear copper(II)-complexes / Crystal structure / Cytotoxicity
Source:Journal of Molecular Structure, 2016, 1116, 264-271
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- Faculty of Medical Sciences [MP 2014/01]