Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy
Апстракт
While recognizing the differences in the pathogenesis of different malignancies, the outstanding body of evidence has been accumulated in the past few decades, implicating the role of oxidative stress in the process of cancer initiation and progression. Cancer cells exhibit an altered energy metabolism and highly efficient redox systems that enable rapid cell proliferation and survival in various conditions. The adaptation/resistance of cancer cells to chronic oxidative stress through different mechanisms usually leads to drug resistance. The specific disruption of the redox capacity with either scavenging the excessive intracellular ROS or inducing ROS generation through exogenous oxidative insult represents a promising approach for cancer therapy. A considerable research effort has been dedicated to identifying the therapeutic agents with redox-modulation capacity that may impede cancer. Based on the established knowledge in these subjects, the natural and synthetic redox modulators ...currently used or under investigation for their potential application in the oxidative stress-targeted cancer therapy are reviewed.
Кључне речи:
Oxidative stress / Redox modulators / Cancer therapy / ROS-depleting strategy / ROS-elevating strategyИзвор:
Handbook of Oxidative Stress in Cancer: Mechanistic Aspects, 2022, 2101-2121Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200017 (Универзитет у Београду, Институт за нуклеарне науке Винча, Београд-Винча) (RS-MESTD-inst-2020-200017)
DOI: 10.1007/978-981-15-9411-3_130
ISBN: 978-981-15-9410-6
Scopus: 2-s2.0-85159415274
Институција/група
VinčaTY - CHAP AU - Petrović, Sandra AU - Leskovac, Andreja PY - 2022 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10649 AB - While recognizing the differences in the pathogenesis of different malignancies, the outstanding body of evidence has been accumulated in the past few decades, implicating the role of oxidative stress in the process of cancer initiation and progression. Cancer cells exhibit an altered energy metabolism and highly efficient redox systems that enable rapid cell proliferation and survival in various conditions. The adaptation/resistance of cancer cells to chronic oxidative stress through different mechanisms usually leads to drug resistance. The specific disruption of the redox capacity with either scavenging the excessive intracellular ROS or inducing ROS generation through exogenous oxidative insult represents a promising approach for cancer therapy. A considerable research effort has been dedicated to identifying the therapeutic agents with redox-modulation capacity that may impede cancer. Based on the established knowledge in these subjects, the natural and synthetic redox modulators currently used or under investigation for their potential application in the oxidative stress-targeted cancer therapy are reviewed. T2 - Handbook of Oxidative Stress in Cancer: Mechanistic Aspects T1 - Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy SP - 2101 EP - 2121 DO - 10.1007/978-981-15-9411-3_130 ER -
@inbook{ author = "Petrović, Sandra and Leskovac, Andreja", year = "2022", abstract = "While recognizing the differences in the pathogenesis of different malignancies, the outstanding body of evidence has been accumulated in the past few decades, implicating the role of oxidative stress in the process of cancer initiation and progression. Cancer cells exhibit an altered energy metabolism and highly efficient redox systems that enable rapid cell proliferation and survival in various conditions. The adaptation/resistance of cancer cells to chronic oxidative stress through different mechanisms usually leads to drug resistance. The specific disruption of the redox capacity with either scavenging the excessive intracellular ROS or inducing ROS generation through exogenous oxidative insult represents a promising approach for cancer therapy. A considerable research effort has been dedicated to identifying the therapeutic agents with redox-modulation capacity that may impede cancer. Based on the established knowledge in these subjects, the natural and synthetic redox modulators currently used or under investigation for their potential application in the oxidative stress-targeted cancer therapy are reviewed.", journal = "Handbook of Oxidative Stress in Cancer: Mechanistic Aspects", booktitle = "Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy", pages = "2101-2121", doi = "10.1007/978-981-15-9411-3_130" }
Petrović, S.,& Leskovac, A.. (2022). Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy. in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects, 2101-2121. https://doi.org/10.1007/978-981-15-9411-3_130
Petrović S, Leskovac A. Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy. in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. 2022;:2101-2121. doi:10.1007/978-981-15-9411-3_130 .
Petrović, Sandra, Leskovac, Andreja, "Prospective Application of Natural and Synthetic Redox Modulators in Oxidative Stress-Targeted Cancer Therapy" in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects (2022):2101-2121, https://doi.org/10.1007/978-981-15-9411-3_130 . .