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dc.creatorJokanović, Vukoman R.
dc.creatorČolović, Božana M.
dc.creatorMarkovic, Dejan
dc.creatorPetrovic, Milan
dc.creatorJokanović, Milan
dc.creatorMilosavljevic, Petar
dc.creatorSopta, Jelena
dc.date.accessioned2018-03-01T16:50:54Z
dc.date.available2018-03-01T16:50:54Z
dc.date.issued2016
dc.identifier.issn1687-4110 (print)
dc.identifier.issn1687-4129 (electronic)
dc.identifier.urihttp://vinar.vin.bg.ac.rs/handle/123456789/1040
dc.description.abstractA synthetic bone substitute based on calcium hydroxyapatite (CHA) and poly(lactic-co-glycolic) acid (PLGA), described in this paper, was synthesized to fulfill specific requirements like biodegradability, satisfying mechanical properties, optimal porosity and nanotopology, osteoinductive and osteoconductive properties, and so forth. Structural and morphological properties of the new scaffold were analyzed by micro computed tomography and scanning electron microscopy, while its physicochemical properties were investigated by X-ray diffraction and infrared spectroscopy. In vivo biological investigations of the synthesized scaffold were conducted over the cutaneous irritation and biofunctionality assays on rabbits and the test of acute systemic toxicity on mice. The results showed that the scaffold is not irritant and that it does not exhibit any symptoms of acute toxicity. Biofunctionality assays which include evaluation of the presence of various cells of immune response, the presence of neoangiogenesis, percentage of mineralization of newly formed bone, and fibroplasia in the tissue indicated that the new scaffold is suitable for the application in maxillofacial and dental surgery as a bone substitute. Also, it showed significant advantages over commercial product Geistlich Bio-Oss(R) from the aspect of some parameters of immunological response.en
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172026/RS//
dc.rightsopenAccessen
dc.sourceJournal of Nanomaterialsen
dc.titleIn Vivo Investigation of ALBO-OS Scaffold Based on Hydroxyapatite and PLGAen
dc.typearticleen
dcterms.abstractПетровиц, Милан; Јокановић Вукоман Р.; Јокановиц, Милан; Чоловић Божана; Милосављевиц, Петар; Сопта, Јелена; Марковиц, Дејан;
dc.identifier.wos000374899500001
dc.identifier.doi10.1155/2016/3948768
dc.citation.otherArticle Number: 3948768
dc.citation.rankM22
dc.identifier.scopus2-s2.0-84969790689
dc.identifier.fulltexthttp://vinar.vin.bg.ac.rs//bitstream/id/11459/1036.pdf


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