90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours
Нема приказа
Аутори
Vukadinović, AleksandarMilanović, Zorana
Ognjanović, Miloš
Janković, Drina
Radović, Magdalena
Mirković, Marija D.
Karageorgou, Maria-Argyro
Bouziotis, Penelope
Erić, Slavica
Vranješ-Đurić, Sanja
Antić, Bratislav
Prijović, Željko
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) are a promising nanomaterial for the development of dual radiation/hyperthermia cancer therapy. To that purpose, flower-shaped SPIONs with an exceptional heating capability were synthesised and coated with citrate, dextran or (3-aminopropyl)triethoxysilane. Both non-coated and coated SPIONs were nontoxic to CT-26 mouse colon cancer cells up to 1.0 mg ml−1 in vitro. In an oscillating magnetic field, citrate-coated SPIONs (CA/SPIONs) displayed the highest heating rate (SAR ∼ 253 W g−1) and the strongest hyperthermia effects against CT-26 cells. Labelling of the CA/SPIONs by the 90Y radionuclide, emitting β− radiation with an average/maximum energy of 0.94/2.23 MeV, and deep tissue penetration generated 90Y-CA/SPIONs intended for the therapy of solid tumours. However, intravenous injection of 90Y-CA/SPIONs in CT-26 xenograft-bearing mice resulted in low tumour accumulation. On the contrary, intratumoural injection resulted ...in long-term retention at the injection site. A single intratumoural injection of 0.25 mg CA/SPIONs followed by 30-min courses of magnetic hyperthermia for four consecutive days caused a moderate antitumour effect against CT-26 and 4T1 mouse tumour xenografts. Intratumoural application of 1.85 MBq/0.25 mg 90Y-CA/SPIONs, alone or combined with hyperthermia, caused a significant (P ≤ 0.01) antitumour effect without signs of systemic toxicity. The results confirm the suitability of 90Y-CA/SPIONs for monotherapy or dual magnetic hyperthermia-radionuclide nanobrachytherapy (NBT) of solid tumours.
Кључне речи:
cancer therapy / hyperthermia / magnetic nanoparticles / nanobrachytherapy / radionuclide therapyИзвор:
Nanotechnology, 2022, 33, 40, 405102-
DOI: 10.1088/1361-6528/ac7ac0
ISSN: 0957-4484
WoS: 00082585670000
Scopus: 2-s2.0-85134444611
Институција/група
VinčaTY - JOUR AU - Vukadinović, Aleksandar AU - Milanović, Zorana AU - Ognjanović, Miloš AU - Janković, Drina AU - Radović, Magdalena AU - Mirković, Marija D. AU - Karageorgou, Maria-Argyro AU - Bouziotis, Penelope AU - Erić, Slavica AU - Vranješ-Đurić, Sanja AU - Antić, Bratislav AU - Prijović, Željko PY - 2022 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10368 AB - Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) are a promising nanomaterial for the development of dual radiation/hyperthermia cancer therapy. To that purpose, flower-shaped SPIONs with an exceptional heating capability were synthesised and coated with citrate, dextran or (3-aminopropyl)triethoxysilane. Both non-coated and coated SPIONs were nontoxic to CT-26 mouse colon cancer cells up to 1.0 mg ml−1 in vitro. In an oscillating magnetic field, citrate-coated SPIONs (CA/SPIONs) displayed the highest heating rate (SAR ∼ 253 W g−1) and the strongest hyperthermia effects against CT-26 cells. Labelling of the CA/SPIONs by the 90Y radionuclide, emitting β− radiation with an average/maximum energy of 0.94/2.23 MeV, and deep tissue penetration generated 90Y-CA/SPIONs intended for the therapy of solid tumours. However, intravenous injection of 90Y-CA/SPIONs in CT-26 xenograft-bearing mice resulted in low tumour accumulation. On the contrary, intratumoural injection resulted in long-term retention at the injection site. A single intratumoural injection of 0.25 mg CA/SPIONs followed by 30-min courses of magnetic hyperthermia for four consecutive days caused a moderate antitumour effect against CT-26 and 4T1 mouse tumour xenografts. Intratumoural application of 1.85 MBq/0.25 mg 90Y-CA/SPIONs, alone or combined with hyperthermia, caused a significant (P ≤ 0.01) antitumour effect without signs of systemic toxicity. The results confirm the suitability of 90Y-CA/SPIONs for monotherapy or dual magnetic hyperthermia-radionuclide nanobrachytherapy (NBT) of solid tumours. T2 - Nanotechnology T1 - 90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours VL - 33 IS - 40 SP - 405102 DO - 10.1088/1361-6528/ac7ac0 ER -
@article{ author = "Vukadinović, Aleksandar and Milanović, Zorana and Ognjanović, Miloš and Janković, Drina and Radović, Magdalena and Mirković, Marija D. and Karageorgou, Maria-Argyro and Bouziotis, Penelope and Erić, Slavica and Vranješ-Đurić, Sanja and Antić, Bratislav and Prijović, Željko", year = "2022", abstract = "Radiolabelled superparamagnetic iron oxide nanoparticles (SPIONs) are a promising nanomaterial for the development of dual radiation/hyperthermia cancer therapy. To that purpose, flower-shaped SPIONs with an exceptional heating capability were synthesised and coated with citrate, dextran or (3-aminopropyl)triethoxysilane. Both non-coated and coated SPIONs were nontoxic to CT-26 mouse colon cancer cells up to 1.0 mg ml−1 in vitro. In an oscillating magnetic field, citrate-coated SPIONs (CA/SPIONs) displayed the highest heating rate (SAR ∼ 253 W g−1) and the strongest hyperthermia effects against CT-26 cells. Labelling of the CA/SPIONs by the 90Y radionuclide, emitting β− radiation with an average/maximum energy of 0.94/2.23 MeV, and deep tissue penetration generated 90Y-CA/SPIONs intended for the therapy of solid tumours. However, intravenous injection of 90Y-CA/SPIONs in CT-26 xenograft-bearing mice resulted in low tumour accumulation. On the contrary, intratumoural injection resulted in long-term retention at the injection site. A single intratumoural injection of 0.25 mg CA/SPIONs followed by 30-min courses of magnetic hyperthermia for four consecutive days caused a moderate antitumour effect against CT-26 and 4T1 mouse tumour xenografts. Intratumoural application of 1.85 MBq/0.25 mg 90Y-CA/SPIONs, alone or combined with hyperthermia, caused a significant (P ≤ 0.01) antitumour effect without signs of systemic toxicity. The results confirm the suitability of 90Y-CA/SPIONs for monotherapy or dual magnetic hyperthermia-radionuclide nanobrachytherapy (NBT) of solid tumours.", journal = "Nanotechnology", title = "90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours", volume = "33", number = "40", pages = "405102", doi = "10.1088/1361-6528/ac7ac0" }
Vukadinović, A., Milanović, Z., Ognjanović, M., Janković, D., Radović, M., Mirković, M. D., Karageorgou, M., Bouziotis, P., Erić, S., Vranješ-Đurić, S., Antić, B.,& Prijović, Ž.. (2022). 90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours. in Nanotechnology, 33(40), 405102. https://doi.org/10.1088/1361-6528/ac7ac0
Vukadinović A, Milanović Z, Ognjanović M, Janković D, Radović M, Mirković MD, Karageorgou M, Bouziotis P, Erić S, Vranješ-Đurić S, Antić B, Prijović Ž. 90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours. in Nanotechnology. 2022;33(40):405102. doi:10.1088/1361-6528/ac7ac0 .
Vukadinović, Aleksandar, Milanović, Zorana, Ognjanović, Miloš, Janković, Drina, Radović, Magdalena, Mirković, Marija D., Karageorgou, Maria-Argyro, Bouziotis, Penelope, Erić, Slavica, Vranješ-Đurić, Sanja, Antić, Bratislav, Prijović, Željko, "90Y-CA/SPIONs for dual magnetic hyperthermia-radionuclide nanobrachytherapy of solid tumours" in Nanotechnology, 33, no. 40 (2022):405102, https://doi.org/10.1088/1361-6528/ac7ac0 . .