Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma
Аутори
Theodosiou, MariaSakellis, Elias
Boukos, Nikos
Kusigerski, Vladan
Kalska-Szostko, Beata
Efthimiadou, Eleni
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Magnetic hyperthermia (MHT) is in the spotlight of nanomedical research for the treatment of cancer employing magnetic iron oxide nanoparticles and their intrinsic capability for heat dissipation under an alternating magnetic field (AMF). Herein we focus on the synthesis of iron oxide nanoflowers (Nfs) of different sizes (15 and 35 nm) and coatings (bare, citrate, and Rhodamine B) while comparing their physicochemical and magnetothermal properties. We encapsulated colloidally stable citrate coated Nfs, of both sizes, in thermosensitive liposomes via extrusion, and RhB was loaded in the lipid bilayer. All formulations proved hemocompatible and cytocompatible. We found that 35 nm Nfs, at lower concentrations than 15 nm Nfs, served better as nanoheaters for magnetic hyperthermia applications. In vitro, magnetic hyperthermia results showed promising therapeutic and imaging potential for RhB loaded magnetoliposomes containing 35 nm Nfs against LLC and CULA cell lines of lung adenocarcinoma.
Кључне речи:
Cancer / Chemistry / Drug discovery / Materials scienceИзвор:
Scientific Reports, 2022, 12, 1, 8697-Финансирање / пројекти:
- HFRI and GSRT [GA. no. 14650]
- ERANETs 2021A, Action: ΕRANET RUS PLUS [project “Rational design of novel magnetic nanocarriers for targeted vascular therapies” MIS 5161147]
DOI: 10.1038/s41598-022-12687-3
ISSN: 2045-2322
WoS: 00079997580003
Scopus: 2-s2.0-85130712785
Колекције
Институција/група
VinčaTY - JOUR AU - Theodosiou, Maria AU - Sakellis, Elias AU - Boukos, Nikos AU - Kusigerski, Vladan AU - Kalska-Szostko, Beata AU - Efthimiadou, Eleni PY - 2022 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10346 AB - Magnetic hyperthermia (MHT) is in the spotlight of nanomedical research for the treatment of cancer employing magnetic iron oxide nanoparticles and their intrinsic capability for heat dissipation under an alternating magnetic field (AMF). Herein we focus on the synthesis of iron oxide nanoflowers (Nfs) of different sizes (15 and 35 nm) and coatings (bare, citrate, and Rhodamine B) while comparing their physicochemical and magnetothermal properties. We encapsulated colloidally stable citrate coated Nfs, of both sizes, in thermosensitive liposomes via extrusion, and RhB was loaded in the lipid bilayer. All formulations proved hemocompatible and cytocompatible. We found that 35 nm Nfs, at lower concentrations than 15 nm Nfs, served better as nanoheaters for magnetic hyperthermia applications. In vitro, magnetic hyperthermia results showed promising therapeutic and imaging potential for RhB loaded magnetoliposomes containing 35 nm Nfs against LLC and CULA cell lines of lung adenocarcinoma. T2 - Scientific Reports T1 - Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma VL - 12 IS - 1 SP - 8697 DO - 10.1038/s41598-022-12687-3 ER -
@article{ author = "Theodosiou, Maria and Sakellis, Elias and Boukos, Nikos and Kusigerski, Vladan and Kalska-Szostko, Beata and Efthimiadou, Eleni", year = "2022", abstract = "Magnetic hyperthermia (MHT) is in the spotlight of nanomedical research for the treatment of cancer employing magnetic iron oxide nanoparticles and their intrinsic capability for heat dissipation under an alternating magnetic field (AMF). Herein we focus on the synthesis of iron oxide nanoflowers (Nfs) of different sizes (15 and 35 nm) and coatings (bare, citrate, and Rhodamine B) while comparing their physicochemical and magnetothermal properties. We encapsulated colloidally stable citrate coated Nfs, of both sizes, in thermosensitive liposomes via extrusion, and RhB was loaded in the lipid bilayer. All formulations proved hemocompatible and cytocompatible. We found that 35 nm Nfs, at lower concentrations than 15 nm Nfs, served better as nanoheaters for magnetic hyperthermia applications. In vitro, magnetic hyperthermia results showed promising therapeutic and imaging potential for RhB loaded magnetoliposomes containing 35 nm Nfs against LLC and CULA cell lines of lung adenocarcinoma.", journal = "Scientific Reports", title = "Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma", volume = "12", number = "1", pages = "8697", doi = "10.1038/s41598-022-12687-3" }
Theodosiou, M., Sakellis, E., Boukos, N., Kusigerski, V., Kalska-Szostko, B.,& Efthimiadou, E.. (2022). Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma. in Scientific Reports, 12(1), 8697. https://doi.org/10.1038/s41598-022-12687-3
Theodosiou M, Sakellis E, Boukos N, Kusigerski V, Kalska-Szostko B, Efthimiadou E. Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma. in Scientific Reports. 2022;12(1):8697. doi:10.1038/s41598-022-12687-3 .
Theodosiou, Maria, Sakellis, Elias, Boukos, Nikos, Kusigerski, Vladan, Kalska-Szostko, Beata, Efthimiadou, Eleni, "Iron oxide nanoflowers encapsulated in thermosensitive fluorescent liposomes for hyperthermia treatment of lung adenocarcinoma" in Scientific Reports, 12, no. 1 (2022):8697, https://doi.org/10.1038/s41598-022-12687-3 . .