Magnetically induced controlled release from glucose-modified liposomes loaded with Fe3O4 nanoparticles
Само за регистроване кориснике
2021
Аутори
Cvjetinović, ĐorđeMilanović, Zorana
Mirković, Marija D.
Petrović, Jelena
Vesković, Ana
Popović-Bijelić, Ana
Prijović, Željko
Janković, Drina
Vranješ-Đurić, Sanja
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Small glucose-modified liposomes (GMLs) were loaded with magnetic Fe3O4 nanoparticles (MNPs) and fluorescein using a standard thin layer preparation procedure and a varying lipid/MNPs ratio. The liposomes were characterized with TEM and DLS measurements, and MNPs encapsulation rate was determined using ICP-OES. Prepared liposomes were stored at 5 °C for 30 days and subsequently exposed to an external magnetic field (20 mT) with varying exposure times (2‒20 min), at room temperature. The release of fluorescein from GMLs induced by the magnetic field exposures was quantified, showing a high release rate (25‒85%) depending on the concentration of MNPs in GMLs. EPR measurements were conducted during the liposomes storage period in order to provide semi-quantitative information of possible MNPs oxidation from Fe3O4 to Fe2O3 inside the liposomes, impacting MNPs magnetic properties. In contrast to the MNPs water dispersion, no significant change in the EPR signal of MNPs encapsulated inside G...MLs was detected over the course of 30 days. The data presented in this study indicate that GMLs loaded with MNPs maintain a high stability for prolonged periods of time and that this delivery system may be used for magnetically assisted controlled drug release.
Извор:
Journal of Nanoparticle Research, 2021, 23, 11, 252-Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200146 (Универзитет у Београду, Факултет за физичку хемију) (RS-MESTD-inst-2020-200146)
DOI: 10.1007/s11051-021-05375-2
ISSN: 1572-896X
WoS: 000721867100001
Scopus: 2-s2.0-85119824031
Колекције
Институција/група
VinčaTY - JOUR AU - Cvjetinović, Đorđe AU - Milanović, Zorana AU - Mirković, Marija D. AU - Petrović, Jelena AU - Vesković, Ana AU - Popović-Bijelić, Ana AU - Prijović, Željko AU - Janković, Drina AU - Vranješ-Đurić, Sanja PY - 2021 UR - https://vinar.vin.bg.ac.rs/handle/123456789/10063 AB - Small glucose-modified liposomes (GMLs) were loaded with magnetic Fe3O4 nanoparticles (MNPs) and fluorescein using a standard thin layer preparation procedure and a varying lipid/MNPs ratio. The liposomes were characterized with TEM and DLS measurements, and MNPs encapsulation rate was determined using ICP-OES. Prepared liposomes were stored at 5 °C for 30 days and subsequently exposed to an external magnetic field (20 mT) with varying exposure times (2‒20 min), at room temperature. The release of fluorescein from GMLs induced by the magnetic field exposures was quantified, showing a high release rate (25‒85%) depending on the concentration of MNPs in GMLs. EPR measurements were conducted during the liposomes storage period in order to provide semi-quantitative information of possible MNPs oxidation from Fe3O4 to Fe2O3 inside the liposomes, impacting MNPs magnetic properties. In contrast to the MNPs water dispersion, no significant change in the EPR signal of MNPs encapsulated inside GMLs was detected over the course of 30 days. The data presented in this study indicate that GMLs loaded with MNPs maintain a high stability for prolonged periods of time and that this delivery system may be used for magnetically assisted controlled drug release. T2 - Journal of Nanoparticle Research T1 - Magnetically induced controlled release from glucose-modified liposomes loaded with Fe3O4 nanoparticles VL - 23 IS - 11 SP - 252 DO - 10.1007/s11051-021-05375-2 ER -
@article{ author = "Cvjetinović, Đorđe and Milanović, Zorana and Mirković, Marija D. and Petrović, Jelena and Vesković, Ana and Popović-Bijelić, Ana and Prijović, Željko and Janković, Drina and Vranješ-Đurić, Sanja", year = "2021", abstract = "Small glucose-modified liposomes (GMLs) were loaded with magnetic Fe3O4 nanoparticles (MNPs) and fluorescein using a standard thin layer preparation procedure and a varying lipid/MNPs ratio. The liposomes were characterized with TEM and DLS measurements, and MNPs encapsulation rate was determined using ICP-OES. Prepared liposomes were stored at 5 °C for 30 days and subsequently exposed to an external magnetic field (20 mT) with varying exposure times (2‒20 min), at room temperature. The release of fluorescein from GMLs induced by the magnetic field exposures was quantified, showing a high release rate (25‒85%) depending on the concentration of MNPs in GMLs. EPR measurements were conducted during the liposomes storage period in order to provide semi-quantitative information of possible MNPs oxidation from Fe3O4 to Fe2O3 inside the liposomes, impacting MNPs magnetic properties. In contrast to the MNPs water dispersion, no significant change in the EPR signal of MNPs encapsulated inside GMLs was detected over the course of 30 days. The data presented in this study indicate that GMLs loaded with MNPs maintain a high stability for prolonged periods of time and that this delivery system may be used for magnetically assisted controlled drug release.", journal = "Journal of Nanoparticle Research", title = "Magnetically induced controlled release from glucose-modified liposomes loaded with Fe3O4 nanoparticles", volume = "23", number = "11", pages = "252", doi = "10.1007/s11051-021-05375-2" }
Cvjetinović, Đ., Milanović, Z., Mirković, M. D., Petrović, J., Vesković, A., Popović-Bijelić, A., Prijović, Ž., Janković, D.,& Vranješ-Đurić, S.. (2021). Magnetically induced controlled release from glucose-modified liposomes loaded with Fe3O4 nanoparticles. in Journal of Nanoparticle Research, 23(11), 252. https://doi.org/10.1007/s11051-021-05375-2
Cvjetinović Đ, Milanović Z, Mirković MD, Petrović J, Vesković A, Popović-Bijelić A, Prijović Ž, Janković D, Vranješ-Đurić S. Magnetically induced controlled release from glucose-modified liposomes loaded with Fe3O4 nanoparticles. in Journal of Nanoparticle Research. 2021;23(11):252. doi:10.1007/s11051-021-05375-2 .
Cvjetinović, Đorđe, Milanović, Zorana, Mirković, Marija D., Petrović, Jelena, Vesković, Ana, Popović-Bijelić, Ana, Prijović, Željko, Janković, Drina, Vranješ-Đurić, Sanja, "Magnetically induced controlled release from glucose-modified liposomes loaded with Fe3O4 nanoparticles" in Journal of Nanoparticle Research, 23, no. 11 (2021):252, https://doi.org/10.1007/s11051-021-05375-2 . .