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An integral study to identify the regional genetic and environmental risk factors for the common noncommunicable diseases in the human population of Serbia - INGEMA_S

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info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41028/RS//

An integral study to identify the regional genetic and environmental risk factors for the common noncommunicable diseases in the human population of Serbia - INGEMA_S (en)
Интегрална студија идентификације регионалних генетских фактора ризика и фактора ризика животне средине за масовне незаразне болести хумане популације у Србији - INGEMA_S (sr)
Integralna studija identifikacije regionalnih genetskih faktora rizika i faktora rizika životne sredine za masovne nezarazne bolesti humane populacije u Srbiji - INGEMA_S (sr_RS)
Authors

Publications

Comparison of fine particulate matter level, chemical content and oxidative potential derived from two dissimilar urban environments

Jovanović, Maja; Savić, Jasmina; Kovačević, Renata; Tasić, Viša; Todorović, Žaklina; Stevanović, Svetlana; Manojlović, Dragan D.; Jovašević-Stojanović, Milena

(2020)

TY  - JOUR
AU  - Jovanović, Maja
AU  - Savić, Jasmina
AU  - Kovačević, Renata
AU  - Tasić, Viša
AU  - Todorović, Žaklina
AU  - Stevanović, Svetlana
AU  - Manojlović, Dragan D.
AU  - Jovašević-Stojanović, Milena
PY  - 2020
UR  - http://cherry.chem.bg.ac.rs/handle/123456789/3820
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8750
AB  - Urban airborne particles contain a wide spectrum of components, known to have harmful effects on human health. This study reports a detailed investigation of fine particulate matter (PM2.5), chemical content and oxidative potential derived from two different urban environments. During summer and winter, 20-day campaigns were conducted at Belgrade city center (urban-background site – UB) and Bor (urban-industrial site – UI). Using various analytical techniques, carbonaceous compounds, water-soluble inorganic ions, major and trace elements were determined, while the oxidative potential of PM2.5 was estimated by dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay (OPDCFH values). The mean PM2.5 concentrations in both urban environments were above the recommended daily value, and the dominant PM2.5 mass contributor was organic matter (29–55%). The OC/EC ratio was significantly higher at UB site during winter, which was an indication of a considerable contribution of secondary organic carbon to the overall organic carbon (OC). Water-soluble organic carbon (WSOC) was also higher at UB than at UI site, and it probably came from the same sources as OC. In general, the different partition of secondary organic aerosol (SOA) in warm and cold periods affected the number of organic components. Sulfates and nitrates were the most abundant ions at both sites and they counted approximately 40% (summer) and 50% (winter) of total ions. Further, the concentrations of the most elements, particularly some potentially carcinogenic elements such as As, Cd and Pb were significantly higher at UI, due to the emissions from the copper smelter complex in the vicinity. The mean OPDCFH values were similar during the summer at both sampling sites, whereas a statistically significant difference between sites was noticed in favor of UB environment in winter.
T2  - Science of the Total Environment
T1  - Comparison of fine particulate matter level, chemical content and oxidative potential derived from two dissimilar urban environments
VL  - 708
SP  - 135209
DO  - 10.1016/j.scitotenv.2019.135209
ER  - 
@article{
author = "Jovanović, Maja and Savić, Jasmina and Kovačević, Renata and Tasić, Viša and Todorović, Žaklina and Stevanović, Svetlana and Manojlović, Dragan D. and Jovašević-Stojanović, Milena",
year = "2020",
url = "http://cherry.chem.bg.ac.rs/handle/123456789/3820, http://vinar.vin.bg.ac.rs/handle/123456789/8750",
abstract = "Urban airborne particles contain a wide spectrum of components, known to have harmful effects on human health. This study reports a detailed investigation of fine particulate matter (PM2.5), chemical content and oxidative potential derived from two different urban environments. During summer and winter, 20-day campaigns were conducted at Belgrade city center (urban-background site – UB) and Bor (urban-industrial site – UI). Using various analytical techniques, carbonaceous compounds, water-soluble inorganic ions, major and trace elements were determined, while the oxidative potential of PM2.5 was estimated by dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay (OPDCFH values). The mean PM2.5 concentrations in both urban environments were above the recommended daily value, and the dominant PM2.5 mass contributor was organic matter (29–55%). The OC/EC ratio was significantly higher at UB site during winter, which was an indication of a considerable contribution of secondary organic carbon to the overall organic carbon (OC). Water-soluble organic carbon (WSOC) was also higher at UB than at UI site, and it probably came from the same sources as OC. In general, the different partition of secondary organic aerosol (SOA) in warm and cold periods affected the number of organic components. Sulfates and nitrates were the most abundant ions at both sites and they counted approximately 40% (summer) and 50% (winter) of total ions. Further, the concentrations of the most elements, particularly some potentially carcinogenic elements such as As, Cd and Pb were significantly higher at UI, due to the emissions from the copper smelter complex in the vicinity. The mean OPDCFH values were similar during the summer at both sampling sites, whereas a statistically significant difference between sites was noticed in favor of UB environment in winter.",
journal = "Science of the Total Environment",
title = "Comparison of fine particulate matter level, chemical content and oxidative potential derived from two dissimilar urban environments",
volume = "708",
pages = "135209",
doi = "10.1016/j.scitotenv.2019.135209"
}
1

Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling

Matić, Zoran; Platiša, Mirjana M.; Kalauzi, Aleksandar; Bojić, Tijana

(2020)

TY  - JOUR
AU  - Matić, Zoran
AU  - Platiša, Mirjana M.
AU  - Kalauzi, Aleksandar
AU  - Bojić, Tijana
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8848
AB  - Objective: We explored the physiological background of the non-linear operating mode of cardiorespiratory oscillators as the fundamental question of cardiorespiratory homeodynamics and as a prerequisite for the understanding of neurocardiovascular diseases. We investigated 20 healthy human subjects for changes using electrocardiac RR interval (RRI) and respiratory signal (Resp) Detrended Fluctuation Analysis (DFA, α1RRI, α2RRI, α1Resp, α2Resp), Multiple Scaling Entropy (MSERRI1−4, MSERRI5−10, MSEResp1−4, MSEResp5−10), spectral coherence (CohRRI−Resp), cross DFA (ρ1 and ρ2) and cross MSE (XMSE1−4 and XMSE5−10) indices in four physiological conditions: supine with spontaneous breathing, standing with spontaneous breathing, supine with 0.1 Hz breathing and standing with 0.1 Hz breathing. Main results: Standing is primarily characterized by the change of RRI parameters, insensitivity to change with respiratory parameters, decrease of CohRRI−Resp and insensitivity to change of in ρ1, ρ2, XMSE1−4, and XMSE5−10. Slow breathing in supine position was characterized by the change of the linear and non-linear parameters of both signals, reflecting the dominant vagal RRI modulation and the impact of slow 0.1 Hz breathing on Resp parameters. CohRRI−Resp did not change with respect to supine position, while ρ1 increased. Slow breathing in standing reflected the qualitatively specific state of autonomic regulation with striking impact on both cardiac and respiratory parameters, with specific patterns of cardiorespiratory coupling. Significance: Our results show that cardiac and respiratory short term and long term complexity parameters have different, state dependent patterns. Sympathovagal non-linear interactions are dependent on the pattern of their activation, having different scaling properties when individually activated with respect to the state of their joint activation. All investigated states induced a change of α1 vs. α2 relationship, which can be accurately expressed by the proposed measure—inter-fractal angle θ. Short scale (α1 vs. MSE1−4) and long scale (α2 vs. MSE5−10) complexity measures had reciprocal interrelation in standing with 0.1 Hz breathing, with specific cardiorespiratory coupling pattern (ρ1 vs. XMSE1−4). These results support the hypothesis of hierarchical organization of cardiorespiratory complexity mechanisms and their recruitment in ascendant manner with respect to the increase of behavioral challenge complexity. Specific and comprehensive cardiorespiratory regulation in standing with 0.1 Hz breathing suggests this state as the potentially most beneficial maneuver for cardiorespiratory conditioning. © Copyright © 2020 Matić, Platiša, Kalauzi and Bojić.
T2  - Frontiers in Physiology
T1  - Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling
VL  - 11
SP  - 24
DO  - 10.3389/fphys.2020.00024
ER  - 
@article{
author = "Matić, Zoran and Platiša, Mirjana M. and Kalauzi, Aleksandar and Bojić, Tijana",
year = "2020",
url = "https://vinar.vin.bg.ac.rs/handle/123456789/8848",
abstract = "Objective: We explored the physiological background of the non-linear operating mode of cardiorespiratory oscillators as the fundamental question of cardiorespiratory homeodynamics and as a prerequisite for the understanding of neurocardiovascular diseases. We investigated 20 healthy human subjects for changes using electrocardiac RR interval (RRI) and respiratory signal (Resp) Detrended Fluctuation Analysis (DFA, α1RRI, α2RRI, α1Resp, α2Resp), Multiple Scaling Entropy (MSERRI1−4, MSERRI5−10, MSEResp1−4, MSEResp5−10), spectral coherence (CohRRI−Resp), cross DFA (ρ1 and ρ2) and cross MSE (XMSE1−4 and XMSE5−10) indices in four physiological conditions: supine with spontaneous breathing, standing with spontaneous breathing, supine with 0.1 Hz breathing and standing with 0.1 Hz breathing. Main results: Standing is primarily characterized by the change of RRI parameters, insensitivity to change with respiratory parameters, decrease of CohRRI−Resp and insensitivity to change of in ρ1, ρ2, XMSE1−4, and XMSE5−10. Slow breathing in supine position was characterized by the change of the linear and non-linear parameters of both signals, reflecting the dominant vagal RRI modulation and the impact of slow 0.1 Hz breathing on Resp parameters. CohRRI−Resp did not change with respect to supine position, while ρ1 increased. Slow breathing in standing reflected the qualitatively specific state of autonomic regulation with striking impact on both cardiac and respiratory parameters, with specific patterns of cardiorespiratory coupling. Significance: Our results show that cardiac and respiratory short term and long term complexity parameters have different, state dependent patterns. Sympathovagal non-linear interactions are dependent on the pattern of their activation, having different scaling properties when individually activated with respect to the state of their joint activation. All investigated states induced a change of α1 vs. α2 relationship, which can be accurately expressed by the proposed measure—inter-fractal angle θ. Short scale (α1 vs. MSE1−4) and long scale (α2 vs. MSE5−10) complexity measures had reciprocal interrelation in standing with 0.1 Hz breathing, with specific cardiorespiratory coupling pattern (ρ1 vs. XMSE1−4). These results support the hypothesis of hierarchical organization of cardiorespiratory complexity mechanisms and their recruitment in ascendant manner with respect to the increase of behavioral challenge complexity. Specific and comprehensive cardiorespiratory regulation in standing with 0.1 Hz breathing suggests this state as the potentially most beneficial maneuver for cardiorespiratory conditioning. © Copyright © 2020 Matić, Platiša, Kalauzi and Bojić.",
journal = "Frontiers in Physiology",
title = "Slow 0.1 Hz Breathing and Body Posture Induced Perturbations of RRI and Respiratory Signal Complexity and Cardiorespiratory Coupling",
volume = "11",
pages = "24",
doi = "10.3389/fphys.2020.00024"
}
2

Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis

Kolić, Ivana; Stojković, Ljiljana S.; Dinčić, Evica; Jovanović, Ivan G.; Stanković, Aleksandra; Živković, Maja

(2020)

TY  - JOUR
AU  - Kolić, Ivana
AU  - Stojković, Ljiljana S.
AU  - Dinčić, Evica
AU  - Jovanović, Ivan G.
AU  - Stanković, Aleksandra
AU  - Živković, Maja
PY  - 2020
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8618
AB  - Leptin (LEP) may contribute to the pathogenesis of multiple sclerosis (MS) by its immunomodulatory, proinflammatory and prooxidant effects. Therefore, plasma LEP levels and mRNA expression of five genes related to the LEP signaling pathway (LEP, LEP receptor (LEPR), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1A), superoxide dismutase 2, tumor necrosis factor-alpha) were investigated in relapsing-remitting MS. In patients (N = 64), compared to healthy subjects (N = 62), relative LEP mRNA levels were significantly increased (p = 0,01), while LEPR and PGC1A mRNA levels were decreased (p = 0,001 and p = 0,04, respectively). Significant positive correlation was observed between LEPR mRNA levels and clinical parameters of MS progression (EDSS, MSSS). © 2019
T2  - Journal of Neuroimmunology
T1  - Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis
VL  - 338
SP  - 577090
DO  - 10.1016/j.jneuroim.2019.577090
ER  - 
@article{
author = "Kolić, Ivana and Stojković, Ljiljana S. and Dinčić, Evica and Jovanović, Ivan G. and Stanković, Aleksandra and Živković, Maja",
year = "2020",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8618",
abstract = "Leptin (LEP) may contribute to the pathogenesis of multiple sclerosis (MS) by its immunomodulatory, proinflammatory and prooxidant effects. Therefore, plasma LEP levels and mRNA expression of five genes related to the LEP signaling pathway (LEP, LEP receptor (LEPR), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC1A), superoxide dismutase 2, tumor necrosis factor-alpha) were investigated in relapsing-remitting MS. In patients (N = 64), compared to healthy subjects (N = 62), relative LEP mRNA levels were significantly increased (p = 0,01), while LEPR and PGC1A mRNA levels were decreased (p = 0,001 and p = 0,04, respectively). Significant positive correlation was observed between LEPR mRNA levels and clinical parameters of MS progression (EDSS, MSSS). © 2019",
journal = "Journal of Neuroimmunology",
title = "Expression of LEP, LEPR and PGC1A genes is altered in peripheral blood mononuclear cells of patients with relapsing-remitting multiple sclerosis",
volume = "338",
pages = "577090",
doi = "10.1016/j.jneuroim.2019.577090"
}
1

Renal Dysfunction Following Elective Endovascular Aortic Aneurysm Repair

Radak, Đorđe J.; Nešković, Mihailo; Otašević, Petar; Isenović, Esma R.

(2019)

TY  - JOUR
AU  - Radak, Đorđe J.
AU  - Nešković, Mihailo
AU  - Otašević, Petar
AU  - Isenović, Esma R.
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8038
AB  - Abdominal Aortic Aneurysm (AAA) is a degenerative disease of the aortic wall with potentially fatal complications. Open Repair (OR) was considered the gold standard, until the emergence of Endovascular Aneurysm Repair (EVAR), which is less invasive and equally (if not more) effective. As the popularity of endovascular procedures grows, related complications become more evident, with kidney damage being one of them. Although Acute Kidney Injury (AKI) following EVAR is relatively common, its true incidence is still uncertain. Also, there is insufficient data concerning long-term renal outcomes after EVAR, especially with repeated contrast agent exposure. Despite the lack of firm evidence on the effectiveness of individual strategies, it is evident that prevention of AKI following EVAR requires a multifactorial approach. This review focuses on recent findings based on human studies regarding the current evidence of renal impairment after EVAR, its quantification and strategies for its prevention. © 2019 Bentham Science Publishers.
T2  - Current Vascular Pharmacology
T1  - Renal Dysfunction Following Elective Endovascular Aortic Aneurysm Repair
VL  - 17
IS  - 2
SP  - 133
EP  - 140
DO  - 10.2174/1570161115666171116163203
ER  - 
@article{
author = "Radak, Đorđe J. and Nešković, Mihailo and Otašević, Petar and Isenović, Esma R.",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8038",
abstract = "Abdominal Aortic Aneurysm (AAA) is a degenerative disease of the aortic wall with potentially fatal complications. Open Repair (OR) was considered the gold standard, until the emergence of Endovascular Aneurysm Repair (EVAR), which is less invasive and equally (if not more) effective. As the popularity of endovascular procedures grows, related complications become more evident, with kidney damage being one of them. Although Acute Kidney Injury (AKI) following EVAR is relatively common, its true incidence is still uncertain. Also, there is insufficient data concerning long-term renal outcomes after EVAR, especially with repeated contrast agent exposure. Despite the lack of firm evidence on the effectiveness of individual strategies, it is evident that prevention of AKI following EVAR requires a multifactorial approach. This review focuses on recent findings based on human studies regarding the current evidence of renal impairment after EVAR, its quantification and strategies for its prevention. © 2019 Bentham Science Publishers.",
journal = "Current Vascular Pharmacology",
title = "Renal Dysfunction Following Elective Endovascular Aortic Aneurysm Repair",
volume = "17",
number = "2",
pages = "133-140",
doi = "10.2174/1570161115666171116163203"
}
2
3
3

Renal Dysfunction Following Elective Endovascular Aortic Aneurysm Repair

Radak, Đorđe J.; Nešković, Mihailo; Otašević, Petar; Isenović, Esma R.

(2019)

TY  - JOUR
AU  - Radak, Đorđe J.
AU  - Nešković, Mihailo
AU  - Otašević, Petar
AU  - Isenović, Esma R.
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8040
AB  - Abdominal Aortic Aneurysm (AAA) is a degenerative disease of the aortic wall with potentially fatal complications. Open Repair (OR) was considered the gold standard, until the emergence of Endovascular Aneurysm Repair (EVAR), which is less invasive and equally (if not more) effective. As the popularity of endovascular procedures grows, related complications become more evident, with kidney damage being one of them. Although Acute Kidney Injury (AKI) following EVAR is relatively common, its true incidence is still uncertain. Also, there is insufficient data concerning long-term renal outcomes after EVAR, especially with repeated contrast agent exposure. Despite the lack of firm evidence on the effectiveness of individual strategies, it is evident that prevention of AKI following EVAR requires a multifactorial approach. This review focuses on recent findings based on human studies regarding the current evidence of renal impairment after EVAR, its quantification and strategies for its prevention. © 2019 Bentham Science Publishers.
T2  - Current Vascular Pharmacology
T1  - Renal Dysfunction Following Elective Endovascular Aortic Aneurysm Repair
VL  - 17
IS  - 2
SP  - 133
EP  - 140
DO  - 10.2174/1570161115666171116163203
ER  - 
@article{
author = "Radak, Đorđe J. and Nešković, Mihailo and Otašević, Petar and Isenović, Esma R.",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8040",
abstract = "Abdominal Aortic Aneurysm (AAA) is a degenerative disease of the aortic wall with potentially fatal complications. Open Repair (OR) was considered the gold standard, until the emergence of Endovascular Aneurysm Repair (EVAR), which is less invasive and equally (if not more) effective. As the popularity of endovascular procedures grows, related complications become more evident, with kidney damage being one of them. Although Acute Kidney Injury (AKI) following EVAR is relatively common, its true incidence is still uncertain. Also, there is insufficient data concerning long-term renal outcomes after EVAR, especially with repeated contrast agent exposure. Despite the lack of firm evidence on the effectiveness of individual strategies, it is evident that prevention of AKI following EVAR requires a multifactorial approach. This review focuses on recent findings based on human studies regarding the current evidence of renal impairment after EVAR, its quantification and strategies for its prevention. © 2019 Bentham Science Publishers.",
journal = "Current Vascular Pharmacology",
title = "Renal Dysfunction Following Elective Endovascular Aortic Aneurysm Repair",
volume = "17",
number = "2",
pages = "133-140",
doi = "10.2174/1570161115666171116163203"
}
2
3
3

In search of an optimal in-field calibration method of low-cost gas sensors for ambient air pollutants: Comparison of linear, multilinear and artificial neural network approaches

Topalović, Dušan; Davidović, Miloš D.; Jovanović, Maja; Bartonova, Alena; Ristovski, Zoran; Jovašević-Stojanović, Milena

(2019)

TY  - JOUR
AU  - Topalović, Dušan
AU  - Davidović, Miloš D.
AU  - Jovanović, Maja
AU  - Bartonova, Alena
AU  - Ristovski, Zoran
AU  - Jovašević-Stojanović, Milena
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8372
AB  - The current compliance networks of automatic air-quality monitoring stations in large urban environments are not sufficient to provide spatial and temporal measurement resolution for realistic assessment of personal exposure to pollutants. Small low-cost sensor platforms with greater mobility and expected lower maintenance costs, are increasingly being used as a supplement to compliance monitoring stations. However, low-cost sensor platforms usually provide data with uncertain precision. To improve the precision, these sensor platforms require in-field calibration. Our paper aims to demonstrate that data from each individual sensor system can be corrected using that sensor system's own data to achieve much improved data quality compared to a reference. However, in this procedure, there are practical difficulties such as individual sensor outputs from the multi-sensor system not being sufficiently available due to malfunctions for instance. We explore how this can be dealt with. In our opinion, this is a novel approach, of practical importance both to users and manufacturers. We present a detailed comparative analysis of Linear Regression (univariate), Multivariate Linear Regression and Artificial Neural Networks used with a specific aim of calibrating field-deployed low-cost CO and O3 sensors. For Artificial Neural Network models, the performance of three common training algorithms was compared (Levenberg-Marquardt, Resilient back-propagation and Conjugate Gradient Powell-Beale algorithm). Data for this study were obtained from two campaigns conducted with 25 multi-sensor AQMESH v.3.5 platforms used within the activities of the CITI-SENSE project. The platforms were co-located to reference gas monitors at the Automatic Monitoring Station Stari Grad, in Belgrade, Serbia. This paper demonstrates that Multivariate Linear Regression and Artificial Neural Network calibration models can improve the output signal. This improvement can be measured by changes in the median and interquartile ranges of statistical parameters used for model evaluation. Artificial Neural Networks showed the best results compared to Linear Regression and Multivariate Linear Regression models. The best predictors for CO, in addition to CO low-cost sensor data, were PM2.5 and NO2, while for O3, in addition to O3 low-cost sensor data, the most suitable input predictors were NO and aH. Based on residual error analysis, we have shown that for CO and O3, a certain range of concentrations exists in which calibrated values differ by less than 10% from the reference method results. In addition, it was noted that for all models, CO sensors consistently showed lower variability between platforms compared to O3 sensors. © 2019 Elsevier Ltd
T2  - Atmospheric Environment
T1  - In search of an optimal in-field calibration method of low-cost gas sensors for ambient air pollutants: Comparison of linear, multilinear and artificial neural network approaches
VL  - 213
SP  - 640
EP  - 658
DO  - 10.1016/j.atmosenv.2019.06.028
ER  - 
@article{
author = "Topalović, Dušan and Davidović, Miloš D. and Jovanović, Maja and Bartonova, Alena and Ristovski, Zoran and Jovašević-Stojanović, Milena",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8372",
abstract = "The current compliance networks of automatic air-quality monitoring stations in large urban environments are not sufficient to provide spatial and temporal measurement resolution for realistic assessment of personal exposure to pollutants. Small low-cost sensor platforms with greater mobility and expected lower maintenance costs, are increasingly being used as a supplement to compliance monitoring stations. However, low-cost sensor platforms usually provide data with uncertain precision. To improve the precision, these sensor platforms require in-field calibration. Our paper aims to demonstrate that data from each individual sensor system can be corrected using that sensor system's own data to achieve much improved data quality compared to a reference. However, in this procedure, there are practical difficulties such as individual sensor outputs from the multi-sensor system not being sufficiently available due to malfunctions for instance. We explore how this can be dealt with. In our opinion, this is a novel approach, of practical importance both to users and manufacturers. We present a detailed comparative analysis of Linear Regression (univariate), Multivariate Linear Regression and Artificial Neural Networks used with a specific aim of calibrating field-deployed low-cost CO and O3 sensors. For Artificial Neural Network models, the performance of three common training algorithms was compared (Levenberg-Marquardt, Resilient back-propagation and Conjugate Gradient Powell-Beale algorithm). Data for this study were obtained from two campaigns conducted with 25 multi-sensor AQMESH v.3.5 platforms used within the activities of the CITI-SENSE project. The platforms were co-located to reference gas monitors at the Automatic Monitoring Station Stari Grad, in Belgrade, Serbia. This paper demonstrates that Multivariate Linear Regression and Artificial Neural Network calibration models can improve the output signal. This improvement can be measured by changes in the median and interquartile ranges of statistical parameters used for model evaluation. Artificial Neural Networks showed the best results compared to Linear Regression and Multivariate Linear Regression models. The best predictors for CO, in addition to CO low-cost sensor data, were PM2.5 and NO2, while for O3, in addition to O3 low-cost sensor data, the most suitable input predictors were NO and aH. Based on residual error analysis, we have shown that for CO and O3, a certain range of concentrations exists in which calibrated values differ by less than 10% from the reference method results. In addition, it was noted that for all models, CO sensors consistently showed lower variability between platforms compared to O3 sensors. © 2019 Elsevier Ltd",
journal = "Atmospheric Environment",
title = "In search of an optimal in-field calibration method of low-cost gas sensors for ambient air pollutants: Comparison of linear, multilinear and artificial neural network approaches",
volume = "213",
pages = "640-658",
doi = "10.1016/j.atmosenv.2019.06.028"
}
9
4
6

Measurements of Oxidative Potential of Particulate Matter at Belgrade Tunnel; Comparison of BPEAnit, DTT and DCFH Assays

Jovanović, Maja; Savić, Jasmina; Salimi, Farhad; Stevanović, Svetlana; Brown, Reece A.; Jovašević-Stojanović, Milena; Manojlovic, Dragan; Bartonova, Alena; Bottle, Steven; Ristovski, Zoran

(2019)

TY  - JOUR
AU  - Jovanović, Maja
AU  - Savić, Jasmina
AU  - Salimi, Farhad
AU  - Stevanović, Svetlana
AU  - Brown, Reece A.
AU  - Jovašević-Stojanović, Milena
AU  - Manojlovic, Dragan
AU  - Bartonova, Alena
AU  - Bottle, Steven
AU  - Ristovski, Zoran
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8677
AB  - To estimate the oxidative potential (OP) of particulate matter (PM), two commonly used cell-free, molecular probes were applied: dithiothreitol (DTT) and dichloro-dihydro-fluorescein diacetate (DCFH-DA), and their performance was compared with 9,10-bis (phenylethynyl) anthracene-nitroxide (BPEAnit). To the best of our knowledge, this is the first study in which the performance of the DTT and DCFH has been compared with the BPEAnit probe. The average concentrations of PM, organic carbon (OC) and elemental carbon (EC) for fine (PM2.5) and coarse (PM10) particles were determined. The results were 44.8 ± 13.7, 9.8 ± 5.1 and 9.3 ± 4.8 µg·m−3 for PM2.5 and 75.5 ± 25.1, 16.3 ± 8.7 and 11.8 ± 5.3 µg·m−3 for PM10, respectively, for PM, OC and EC. The water-soluble organic carbon (WSOC) fraction accounted for 42 ± 14% and 28 ± 9% of organic carbon in PM2.5 and PM10, respectively. The average volume normalized OP values for the three assays depended on both the sampling periods and the PM fractions. The OPBPEAnit had its peak at 2 p.m.; in the afternoon, it was three times higher compared to the morning and late afternoon values. The DCFH and BPEAnit results were correlated (r = 0.64), while there was no good agreement between the BPEAnit and the DTT (r = 0.14). The total organic content of PM does not necessarily represent oxidative capacity and it shows varying correlation with the OP. With respect to the two PM fractions studied, the OP was mostly associated with smaller particles.
T2  - International Journal of Environmental Research and Public Health
T1  - Measurements of Oxidative Potential of Particulate Matter at Belgrade Tunnel; Comparison of BPEAnit, DTT and DCFH Assays
VL  - 16
IS  - 24
SP  - 4906
DO  - 10.3390/ijerph16244906
ER  - 
@article{
author = "Jovanović, Maja and Savić, Jasmina and Salimi, Farhad and Stevanović, Svetlana and Brown, Reece A. and Jovašević-Stojanović, Milena and Manojlovic, Dragan and Bartonova, Alena and Bottle, Steven and Ristovski, Zoran",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8677",
abstract = "To estimate the oxidative potential (OP) of particulate matter (PM), two commonly used cell-free, molecular probes were applied: dithiothreitol (DTT) and dichloro-dihydro-fluorescein diacetate (DCFH-DA), and their performance was compared with 9,10-bis (phenylethynyl) anthracene-nitroxide (BPEAnit). To the best of our knowledge, this is the first study in which the performance of the DTT and DCFH has been compared with the BPEAnit probe. The average concentrations of PM, organic carbon (OC) and elemental carbon (EC) for fine (PM2.5) and coarse (PM10) particles were determined. The results were 44.8 ± 13.7, 9.8 ± 5.1 and 9.3 ± 4.8 µg·m−3 for PM2.5 and 75.5 ± 25.1, 16.3 ± 8.7 and 11.8 ± 5.3 µg·m−3 for PM10, respectively, for PM, OC and EC. The water-soluble organic carbon (WSOC) fraction accounted for 42 ± 14% and 28 ± 9% of organic carbon in PM2.5 and PM10, respectively. The average volume normalized OP values for the three assays depended on both the sampling periods and the PM fractions. The OPBPEAnit had its peak at 2 p.m.; in the afternoon, it was three times higher compared to the morning and late afternoon values. The DCFH and BPEAnit results were correlated (r = 0.64), while there was no good agreement between the BPEAnit and the DTT (r = 0.14). The total organic content of PM does not necessarily represent oxidative capacity and it shows varying correlation with the OP. With respect to the two PM fractions studied, the OP was mostly associated with smaller particles.",
journal = "International Journal of Environmental Research and Public Health",
title = "Measurements of Oxidative Potential of Particulate Matter at Belgrade Tunnel; Comparison of BPEAnit, DTT and DCFH Assays",
volume = "16",
number = "24",
pages = "4906",
doi = "10.3390/ijerph16244906"
}
2
1
4

Sjenica, a newly identified radon priority area in Serbia, and radon data correlated with geological parameters using the multiple linear regression model

Žunić, Zora S.; Stojanovska, Zdenka A.; Boev, Blažo; Šorša, Ajka; Čeliković, Igor T.; Ćurguz, Zoran; Ronnquist, Tryggve; Janićijević, Aco; Alavantić, Dragan

(2019)

TY  - JOUR
AU  - Žunić, Zora S.
AU  - Stojanovska, Zdenka A.
AU  - Boev, Blažo
AU  - Šorša, Ajka
AU  - Čeliković, Igor T.
AU  - Ćurguz, Zoran
AU  - Ronnquist, Tryggve
AU  - Janićijević, Aco
AU  - Alavantić, Dragan
PY  - 2019
UR  - http://cjees.ro/viewTopic.php?topicId=797
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8026
AB  - The paper deals with the analysis of the annual indoor radon concentrations variations due to different geological parameters of Sjenica community, Western Serbia. The measured 222Rn concentrations were ranging from 10 to 1130 Bq/m3. In 14% of the buildings, the radon action level of 300 Bq/m3 is exceeded, indicating that Sjenica community could be characterized as a radon priority area. Each of 35 measuring location was georeferenced and corresponding lithostratigraphic units and geological period was assigned. Data were analyzed using the multiple linear regression (MLR) method and two predictive models were developed. The MLR model generated by the geological periods explained 17% of the radon variability while, the better one, was the lithostratigraphic MLR model, which explained 52% of the radon variability. Analysis has shown that lithostratigraphic units are important parameters in the prediction of radon levels. © 2019 Carpathian Journal of Earth and Environmental Sciences.
T2  - Carpathian Journal of Earth and Environmental Sciences
T1  - Sjenica, a newly identified radon priority area in Serbia, and radon data correlated with geological parameters using the multiple linear regression model
VL  - 14
IS  - 1
SP  - 235
EP  - 244
DO  - 10.26471/cjees/2019/014/075
ER  - 
@article{
author = "Žunić, Zora S. and Stojanovska, Zdenka A. and Boev, Blažo and Šorša, Ajka and Čeliković, Igor T. and Ćurguz, Zoran and Ronnquist, Tryggve and Janićijević, Aco and Alavantić, Dragan",
year = "2019",
url = "http://cjees.ro/viewTopic.php?topicId=797, http://vinar.vin.bg.ac.rs/handle/123456789/8026",
abstract = "The paper deals with the analysis of the annual indoor radon concentrations variations due to different geological parameters of Sjenica community, Western Serbia. The measured 222Rn concentrations were ranging from 10 to 1130 Bq/m3. In 14% of the buildings, the radon action level of 300 Bq/m3 is exceeded, indicating that Sjenica community could be characterized as a radon priority area. Each of 35 measuring location was georeferenced and corresponding lithostratigraphic units and geological period was assigned. Data were analyzed using the multiple linear regression (MLR) method and two predictive models were developed. The MLR model generated by the geological periods explained 17% of the radon variability while, the better one, was the lithostratigraphic MLR model, which explained 52% of the radon variability. Analysis has shown that lithostratigraphic units are important parameters in the prediction of radon levels. © 2019 Carpathian Journal of Earth and Environmental Sciences.",
journal = "Carpathian Journal of Earth and Environmental Sciences",
title = "Sjenica, a newly identified radon priority area in Serbia, and radon data correlated with geological parameters using the multiple linear regression model",
volume = "14",
number = "1",
pages = "235-244",
doi = "10.26471/cjees/2019/014/075"
}

Asocijacija genskih varijanti na hromozomu 9p21 i transkripcije gena za CDKN2B i HACD4 sa nastankom ateroskleroze i njenim kliničkim komplikacijama kod čoveka

Životić, Ivan

(Универзитет у Београду, Биолошки факултет, 2019)

@phdthesis{
author = "Životić, Ivan",
year = "2019",
url = "http://nardus.mpn.gov.rs/handle/123456789/11534, http://eteze.bg.ac.rs/application/showtheses?thesesId=6931, https://fedorabg.bg.ac.rs/fedora/get/o:20301/bdef:Content/download, https://plus.sr.cobiss.net/opac7/bib/1025217714, http://vinar.vin.bg.ac.rs/handle/123456789/8727",
abstract = "Ateroskleroza je kompleksna, hronična i progresivna bolest arterijskih krvnih sudova koja se razvija tokom života i najčešće se klinički manifestuje u kasnijem životnom dobu. Dve najznačajnije kliničke komplikacije su ishemijski moždni i srčani udar (IM), na čiji nastanak utiču sredinski i nasledni faktori (genetska predispozicija). U ovoj studiji ispitana je asocijacija četiri genetičke varijante prisutne u hromozomskom regionu 9p21 (rs10757278 i rs518394 u genu ANRIL, i rs36212560 i rs2275888 u genu HACD4), sa rizikom za nastanak IM, karotidnog plaka (KP) i kliničkih komplikacija KP (ultrasonografski definisan tip plaka, simptomatska karotidna bolest, prisustvo ulceracije na plaku). Ispitana je transkripcija gena CDKN2B i HACD4 kao i nivo iRNK u tkivu karotidnog aterosklerotskog plaka i mononuklearnim ćelijama periferne krvi (MĆPK) bolesnika koji su doživeli prvi IM, 6 meseci nakon infarkta. Nivo iRNK ispitan je u odnosu na genotipove i tip karotidnog plaka.Utvrđena je značajna asocijacija rs10757278 sa rizikom za nastanak KP kod žena. Utvrđeno je da je haplotip genetičkih varijanti rs36212560 i rs2275888 značajno asociran sa rizikom za nastanak KP i IM. Rezutlat je pokazao polno specifičnu asocijaciju (kod muškaraca) kao i značajnu asocijaciju varijante rs36212560 testirane van haplotipa. Nije detektovana značajna asocijacija genetičkih varijanti rs2275888 i rs518394 sa rizikom za razvoj karotidnog plaka, ali je ustanovljena značajna, nezavisna asocijacija varijante rs2275888 sa rizikom za nastanak IM. Varijanta rs10757278 je značajno asocirana sa tipom karotidnog aterosklerotskog plaka. Ustanovljeno je da je haplotip varijanti rs36212560 i rs2275888 značajno asociran sa rizikom za razvoj ulceracije karotidnog plaka, i sa simptomatskom karotidnom bolešću u grupi bolesnika sa KP, kao i da polno specifična asocijacija sa haplotipom postoji kod muškaraca.Razlika u nivoima ekspresije merena je na nivou iRNK u odnosu na genotipove ispitivanih varijanti. U tkivu KP nije detektovana razlika u nivou iRNK za CDKN2B u odnosu na genotipove ispitivanih varijanti, ali je ustanovljen statistički trend u asocijaciji sa genotipom varijante rs1075278. Varijanta rs2275888 je prethodno okarakterisan kao eQTL (eng. expression Quantitative Trait Locus) za gen FOCAD gen u tibijalnoj arteriji..., Atherosclerosis is a complex, chronic and progeressive disease of arterial blood vessels that develops during the life and usualy with clinical manifestations at later age. Two most singnifficant clinical manifestations are stroke and myocardial infarction (MI), which development is affected by the median and hereditary factors (genetic predisposition). In this study, association of four genetic variants from chromosome region 9p21 have been investigated (rs10757278 and rs518394 in the ANRIL gene, and rs36212560 and rs2275888 in the HACD4 gene) with the risk for development of MI, the carotid plaque (CP) and its clinical complications (ultrasonographicaly deffined plaque type, symphtomatic disease, presence of carotid plaque ulceration). The transcription of genes CDKN2B and HACD4 at the mRNA level was examined in the CP tissue and peripheral blood mononuclear cells (PBMC) of patients who sustained first MI, six months after the infarction. Level of mRNA was examined in relation to genotypes and CP type.Signifficant association was determined for rs10757278 with the risk for CP development among females. It was determined that haplotype of gene variants rs36212560 and rs2275888 is significantly associated with the risk for CP and MI development. Result has shown gender specific association (among males) as well as association of rs36212560 with CP and MI when tested independently. It wasn’t detected signifficant association of gene variants rs2275888 and rs518394 with the risk for the development of CP, but, the signifficant idependant association of rs2275888 variant with the risk for MI. Variant rs10757278 is signifficantly associated with the carotid atherosclerotic plaque type. Haplotype of rs36212560 and rs2275888 variants is signifficantly associated with the carotid plaque ulceration, as well as with simpthomatic carotid disease in the group of CP patients., and in addition, the gender speciffic association with the haplotype exist in males.Diference in expression levels was measured at the level of mRNA in relation to genotypes of tested variants. In CP tissue difference in CDKN2B mRNK level wasn’t detected in relation to tested variants according to genotype, but statistical trend was detected in association with rs10757278 genotypes...",
publisher = "Универзитет у Београду, Биолошки факултет",
journal = "Универзитет у Београду",
title = "Asocijacija genskih varijanti na hromozomu 9p21 i transkripcije gena za CDKN2B i HACD4 sa nastankom ateroskleroze i njenim kliničkim komplikacijama kod čoveka"
}

The Significance of Pain in Chronic Venous Disease and its Medical Treatment

Radak, Đorđe J.; Atanasijević, Igor; Nešković, Mihailo; Isenović, Esma R.

(2019)

TY  - JOUR
AU  - Radak, Đorđe J.
AU  - Atanasijević, Igor
AU  - Nešković, Mihailo
AU  - Isenović, Esma R.
PY  - 2019
UR  - http://www.eurekaselect.com/159661/article
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8098
AB  - Chronic venous disease (CVeD) is a highly prevalent condition in the general population, and it has a significant impact on quality of life. While it is usually manifested by obvious signs, such as varicose veins and venous ulcers, other symptoms of the disease are less specific. Among the other symptoms, which include heaviness, swelling, muscle cramps and restless legs, pain is the symptom that most frequently compels CVeD patients to seek medical aid. However, there is a substantial discrepancy between pain severity and clinically detectable signs of CVeD, questioned by several opposing studies. Further evaluation is needed to clarify this subject, and to analyse whether pain development predicts objective CVeD progression. General management of CVeD starts with advising lifestyle changes, such as lowering body mass index and treating comorbidities. However, the mainstay of treatment is compression therapy, with the additional use of pharmacological substances. Venoactive drugs proved to be the drugs of choice for symptom alleviation and slowing the progression of CVeD, with micronized purified flavonoid fraction being the most effective one. Interventional therapy is reserved for advanced stages of the disease.
T2  - Current Vascular Pharmacology
T1  - The Significance of Pain in Chronic Venous Disease and its Medical Treatment
VL  - 17
IS  - 3
SP  - 291
EP  - 297
DO  - 10.2174/1570161116666180209111826
ER  - 
@article{
author = "Radak, Đorđe J. and Atanasijević, Igor and Nešković, Mihailo and Isenović, Esma R.",
year = "2019",
url = "http://www.eurekaselect.com/159661/article, http://vinar.vin.bg.ac.rs/handle/123456789/8098",
abstract = "Chronic venous disease (CVeD) is a highly prevalent condition in the general population, and it has a significant impact on quality of life. While it is usually manifested by obvious signs, such as varicose veins and venous ulcers, other symptoms of the disease are less specific. Among the other symptoms, which include heaviness, swelling, muscle cramps and restless legs, pain is the symptom that most frequently compels CVeD patients to seek medical aid. However, there is a substantial discrepancy between pain severity and clinically detectable signs of CVeD, questioned by several opposing studies. Further evaluation is needed to clarify this subject, and to analyse whether pain development predicts objective CVeD progression. General management of CVeD starts with advising lifestyle changes, such as lowering body mass index and treating comorbidities. However, the mainstay of treatment is compression therapy, with the additional use of pharmacological substances. Venoactive drugs proved to be the drugs of choice for symptom alleviation and slowing the progression of CVeD, with micronized purified flavonoid fraction being the most effective one. Interventional therapy is reserved for advanced stages of the disease.",
journal = "Current Vascular Pharmacology",
title = "The Significance of Pain in Chronic Venous Disease and its Medical Treatment",
volume = "17",
number = "3",
pages = "291-297",
doi = "10.2174/1570161116666180209111826"
}
1
1
1

PHACTR1 haplotypes are associated with carotid plaque presence and affect PHACTR1 mRNA expression in carotid plaque tissue

Kuveljić, Jovana; Đurić, Tamara; Stanković, Aleksandra; Končar, Igor; Alavantić, Dragan; Živković, Maja

(2019)

TY  - JOUR
AU  - Kuveljić, Jovana
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
AU  - Končar, Igor
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8348
AB  - Background: Carotid plaque is a hallmark of advanced carotid atherosclerosis and there is evidence of phosphatase and actin regulator 1 (PHACTR1) involvement in the processes that lead to atherosclerosis. PHACTR1 intronic variants have been associated with coronary artery disease and carotid dissection. Up to date the PHACTR1 haplotypes were not investigated in association with carotid plaque presence (CPP). So, the aims of this study were to investigate possible association of PHACTR1 haplotypes inferred from the intronic variants rs9349379, rs2026458 and rs2876300 with CPP in patients with advanced carotid atherosclerosis and to analyze their possible effect on PHACTR1 relative mRNA expression in carotid plaque tissue specimens. Methods: The study group consisted of 501 patients with evidence of carotid plaque presence admitted for carotid endarterectomy and 310 healthy controls. PHACTR1 rs9349379, rs2026458, rs2876300 and relative mRNA expression were detected by TaqMan® technology. Results: We have found significant and independent association of haplotype ACA with the CPP, compared to the referent haplotype GTA (adjusted OR = 1.54 95% CI = 1.07–2.21, p = 0.02). The OR was adjusted for gender, age, BMI, hypertension and total cholesterol. The relative expression of PHACTR1 mRNA in carotid plaque tissue proved to be significantly higher in carriers of the ACG haplotype compared to the referent haplotype GTA (p = 0.03). Conclusion: Our results suggest that PHACTR1 haplotypes inferred from the variants rs9349379, rs2026458 and rs2876300 affect PHACTR1 mRNA and bear the risk for CPP in patients with advanced carotid atherosclerosis. Further replication and validation studies are inevitable. © 2019 Elsevier B.V.
T2  - Gene
T1  - PHACTR1 haplotypes are associated with carotid plaque presence and affect PHACTR1 mRNA expression in carotid plaque tissue
VL  - 710
SP  - 273
EP  - 278
DO  - 10.1016/j.gene.2019.06.020
ER  - 
@article{
author = "Kuveljić, Jovana and Đurić, Tamara and Stanković, Aleksandra and Končar, Igor and Alavantić, Dragan and Živković, Maja",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8348",
abstract = "Background: Carotid plaque is a hallmark of advanced carotid atherosclerosis and there is evidence of phosphatase and actin regulator 1 (PHACTR1) involvement in the processes that lead to atherosclerosis. PHACTR1 intronic variants have been associated with coronary artery disease and carotid dissection. Up to date the PHACTR1 haplotypes were not investigated in association with carotid plaque presence (CPP). So, the aims of this study were to investigate possible association of PHACTR1 haplotypes inferred from the intronic variants rs9349379, rs2026458 and rs2876300 with CPP in patients with advanced carotid atherosclerosis and to analyze their possible effect on PHACTR1 relative mRNA expression in carotid plaque tissue specimens. Methods: The study group consisted of 501 patients with evidence of carotid plaque presence admitted for carotid endarterectomy and 310 healthy controls. PHACTR1 rs9349379, rs2026458, rs2876300 and relative mRNA expression were detected by TaqMan® technology. Results: We have found significant and independent association of haplotype ACA with the CPP, compared to the referent haplotype GTA (adjusted OR = 1.54 95% CI = 1.07–2.21, p = 0.02). The OR was adjusted for gender, age, BMI, hypertension and total cholesterol. The relative expression of PHACTR1 mRNA in carotid plaque tissue proved to be significantly higher in carriers of the ACG haplotype compared to the referent haplotype GTA (p = 0.03). Conclusion: Our results suggest that PHACTR1 haplotypes inferred from the variants rs9349379, rs2026458 and rs2876300 affect PHACTR1 mRNA and bear the risk for CPP in patients with advanced carotid atherosclerosis. Further replication and validation studies are inevitable. © 2019 Elsevier B.V.",
journal = "Gene",
title = "PHACTR1 haplotypes are associated with carotid plaque presence and affect PHACTR1 mRNA expression in carotid plaque tissue",
volume = "710",
pages = "273-278",
doi = "10.1016/j.gene.2019.06.020"
}

Measurement of uranium in urine, hair and nails in subjects of Niska Banja town, a high natural background radiation area of Serbia

Žunić, Zora S.; Benedik, Ljudmila; Kritsananuwat, Rawiwan; Veselinović, Nenad; Tokonami, Shinji; Arae, Hideki; Stojanovska, Zdenka A.; Sahoo, Sarata Kumar

(2019)

TY  - JOUR
AU  - Žunić, Zora S.
AU  - Benedik, Ljudmila
AU  - Kritsananuwat, Rawiwan
AU  - Veselinović, Nenad
AU  - Tokonami, Shinji
AU  - Arae, Hideki
AU  - Stojanovska, Zdenka A.
AU  - Sahoo, Sarata Kumar
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8621
AB  - Urine, hair and nail samples were collected from a population of both sex aged from 40 to 87 years in Niška Banja (227 km south of Belgrade, Serbia) with a high level of natural radioactivity (HLNRA). To assess and monitor the public exposure, urine samples for each subject (24 h period) were collected and concentration of uranium (U) was analysed using alpha-particle spectrometry. Human hair and nails considered as bio-indicators of the public exposure to radionuclides over a long period of months or even years and concentration of U was determined using inductively coupled plasma-mass spectrometry. The mean concentrations of U in urine, hair and nail were 123 ng/L, 17 ng/g and 8 ng/g, respectively. There was a large variation and may be due to geological origin.
T2  - Radiation Protection Dosimetry
T1  - Measurement of uranium in urine, hair and nails in subjects of Niska Banja town, a high natural background radiation area of Serbia
VL  - 184
IS  - 3-4
SP  - 319
EP  - 323
DO  - 10.1093/rpd/ncz120
ER  - 
@article{
author = "Žunić, Zora S. and Benedik, Ljudmila and Kritsananuwat, Rawiwan and Veselinović, Nenad and Tokonami, Shinji and Arae, Hideki and Stojanovska, Zdenka A. and Sahoo, Sarata Kumar",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8621",
abstract = "Urine, hair and nail samples were collected from a population of both sex aged from 40 to 87 years in Niška Banja (227 km south of Belgrade, Serbia) with a high level of natural radioactivity (HLNRA). To assess and monitor the public exposure, urine samples for each subject (24 h period) were collected and concentration of uranium (U) was analysed using alpha-particle spectrometry. Human hair and nails considered as bio-indicators of the public exposure to radionuclides over a long period of months or even years and concentration of U was determined using inductively coupled plasma-mass spectrometry. The mean concentrations of U in urine, hair and nail were 123 ng/L, 17 ng/g and 8 ng/g, respectively. There was a large variation and may be due to geological origin.",
journal = "Radiation Protection Dosimetry",
title = "Measurement of uranium in urine, hair and nails in subjects of Niska Banja town, a high natural background radiation area of Serbia",
volume = "184",
number = "3-4",
pages = "319-323",
doi = "10.1093/rpd/ncz120"
}

Effective Doses Estimated from the Results of Direct Radon and Thoron Progeny Sensors (DRPS/DTPS), Exposed in Selected Region of Balkans

Žunić, Zora S.; Mishra, Rosaline; Čeliković, Igor T.; Stojanovska, Zdenka A.; Yarmoshenko, Ilia V.; Malinovsky, Georgy; Veselinović, Nenad; Gulan, Ljiljana; Ćurguz, Zoran; Vaupotič, Janja; Ujic, Predrag; Kolarž, Predrag M.; Milić, Gordana; Kovacs, Tibor; Sapra, Balvindar K.; Kavasi, Norbert; Sahoo, Sarata Kumar

(2019)

TY  - JOUR
AU  - Žunić, Zora S.
AU  - Mishra, Rosaline
AU  - Čeliković, Igor T.
AU  - Stojanovska, Zdenka A.
AU  - Yarmoshenko, Ilia V.
AU  - Malinovsky, Georgy
AU  - Veselinović, Nenad
AU  - Gulan, Ljiljana
AU  - Ćurguz, Zoran
AU  - Vaupotič, Janja
AU  - Ujic, Predrag
AU  - Kolarž, Predrag M.
AU  - Milić, Gordana
AU  - Kovacs, Tibor
AU  - Sapra, Balvindar K.
AU  - Kavasi, Norbert
AU  - Sahoo, Sarata Kumar
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8481
AB  - The main contribution to population exposure is due to radon and thoron progenies and not radon itself. The aim of this study was therefore to estimate annual effective dose using the results of Direct Radon and Thoron Progeny Sensors were exposed in 69 selected schools and 319 dwellings in several regions of Balkans: in Serbia: regions of Sokobanja and Kosovo and Metohija, Republic of Macedonia, Republic of Srpska and Slovenia. Obtained average total effective doses are in the range from 0.22 mSv a-1 (schools in Republic of Srpska) to 2.5 mSv a-1 (dwellings in Kosovo) and are below the reference level of 10 mSv a-1 recommended by International Commission on Radiological Protection. © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
T2  - Radiation Protection Dosimetry
T1  - Effective Doses Estimated from the Results of Direct Radon and Thoron Progeny Sensors (DRPS/DTPS), Exposed in Selected Region of Balkans
VL  - 185
IS  - 3
SP  - 387
EP  - 390
DO  - 10.1093/rpd/ncz025
ER  - 
@article{
author = "Žunić, Zora S. and Mishra, Rosaline and Čeliković, Igor T. and Stojanovska, Zdenka A. and Yarmoshenko, Ilia V. and Malinovsky, Georgy and Veselinović, Nenad and Gulan, Ljiljana and Ćurguz, Zoran and Vaupotič, Janja and Ujic, Predrag and Kolarž, Predrag M. and Milić, Gordana and Kovacs, Tibor and Sapra, Balvindar K. and Kavasi, Norbert and Sahoo, Sarata Kumar",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8481",
abstract = "The main contribution to population exposure is due to radon and thoron progenies and not radon itself. The aim of this study was therefore to estimate annual effective dose using the results of Direct Radon and Thoron Progeny Sensors were exposed in 69 selected schools and 319 dwellings in several regions of Balkans: in Serbia: regions of Sokobanja and Kosovo and Metohija, Republic of Macedonia, Republic of Srpska and Slovenia. Obtained average total effective doses are in the range from 0.22 mSv a-1 (schools in Republic of Srpska) to 2.5 mSv a-1 (dwellings in Kosovo) and are below the reference level of 10 mSv a-1 recommended by International Commission on Radiological Protection. © The Author(s) 2019. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.",
journal = "Radiation Protection Dosimetry",
title = "Effective Doses Estimated from the Results of Direct Radon and Thoron Progeny Sensors (DRPS/DTPS), Exposed in Selected Region of Balkans",
volume = "185",
number = "3",
pages = "387-390",
doi = "10.1093/rpd/ncz025"
}
1
1

Factors affecting indoor radon variations: A case study in schools of eastern macedonia

Stojanovska, Zdenka A.; Boev, Blažo; Žunić, Zora S.; Ivanova, K; Šorša, Ajka; Boev, Ivan; Ćurguz, Zoran; Kolarž, Predrag M.

(2019)

TY  - JOUR
AU  - Stojanovska, Zdenka A.
AU  - Boev, Blažo
AU  - Žunić, Zora S.
AU  - Ivanova, K
AU  - Šorša, Ajka
AU  - Boev, Ivan
AU  - Ćurguz, Zoran
AU  - Kolarž, Predrag M.
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8108
AB  - The subject of this study is the radon concentrations variations, measured with a nuclear track detectors in a total of 58 premises in all 29 primary schools of 4 municipalities in the Eastern part of the Republic of Macedonia. Despite a relatively small territory, the variability of radon concentrations proved to be significant. The geometric means (geometric standard deviations) of radon concentrations in the examined municipalities were in the range from GM = 71 Bq/m 3 (GSD = 2.08) to GM = 162 Bq/m 3 (GSD = 2.69), while for the entire region it was: GM = 96 Bq/m 3 (GSD = 2.47). The influence of the geographical and geological features of the school site as well as the building characteristics on the radon variations were investigated. The analysis showed that type of municipality, building materials, basement and geology have significant effects and respectively describe 6%, 16%, 22%, 39% of the radon total variability.
T2  - Romanian Journal of Physics
T1  - Factors affecting indoor radon variations: A case study in schools of eastern macedonia
VL  - 64
IS  - 1-2
ER  - 
@article{
author = "Stojanovska, Zdenka A. and Boev, Blažo and Žunić, Zora S. and Ivanova, K and Šorša, Ajka and Boev, Ivan and Ćurguz, Zoran and Kolarž, Predrag M.",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8108",
abstract = "The subject of this study is the radon concentrations variations, measured with a nuclear track detectors in a total of 58 premises in all 29 primary schools of 4 municipalities in the Eastern part of the Republic of Macedonia. Despite a relatively small territory, the variability of radon concentrations proved to be significant. The geometric means (geometric standard deviations) of radon concentrations in the examined municipalities were in the range from GM = 71 Bq/m 3 (GSD = 2.08) to GM = 162 Bq/m 3 (GSD = 2.69), while for the entire region it was: GM = 96 Bq/m 3 (GSD = 2.47). The influence of the geographical and geological features of the school site as well as the building characteristics on the radon variations were investigated. The analysis showed that type of municipality, building materials, basement and geology have significant effects and respectively describe 6%, 16%, 22%, 39% of the radon total variability.",
journal = "Romanian Journal of Physics",
title = "Factors affecting indoor radon variations: A case study in schools of eastern macedonia",
volume = "64",
number = "1-2"
}

Confined electron states in two-dimensional HgTe in magnetic field: Quantum dot versus quantum ring behavior

Topalović, Dušan; Arsoski, Vladimir; Tadić, Milan Ž.; Peeters, François M.

(2019)

TY  - JOUR
AU  - Topalović, Dušan
AU  - Arsoski, Vladimir
AU  - Tadić, Milan Ž.
AU  - Peeters, François M.
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8534
AB  - We investigate the electron states and optical absorption in square- and hexagonal-shaped two-dimensional (2D) HgTe quantum dots and quantum rings in the presence of a perpendicular magnetic field. The electronic structure is modeled by means of the sp3d5s∗ tight-binding method within the nearest-neighbor approximation. Both bulklike and edge states appear in the energy spectrum. The bulklike states in quantum rings exhibit Aharonov-Bohm oscillations in magnetic field, whereas no such oscillations are found in quantum dots, which is ascribed to the different topology of the two systems. When magnetic field varies, all the edge states in square quantum dots appear as quasibands composed of almost fully flat levels, whereas some edge states in quantum rings are found to oscillate with magnetic field. However, the edge states in hexagonal quantum dots are localized like in rings. The absorption spectra of all the structures consist of numerous absorption lines, which substantially overlap even for small line broadening. The absorption lines in the infrared are found to originate from transitions between edge states. It is shown that the magnetic field can be used to efficiently tune the optical absorption of HgTe 2D quantum dot and quantum ring systems. © 2019 American Physical Society.
T2  - Physical Review B
T1  - Confined electron states in two-dimensional HgTe in magnetic field: Quantum dot versus quantum ring behavior
VL  - 100
IS  - 12
SP  - 125304
DO  - 10.1103/PhysRevB.100.125304
ER  - 
@article{
author = "Topalović, Dušan and Arsoski, Vladimir and Tadić, Milan Ž. and Peeters, François M.",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8534",
abstract = "We investigate the electron states and optical absorption in square- and hexagonal-shaped two-dimensional (2D) HgTe quantum dots and quantum rings in the presence of a perpendicular magnetic field. The electronic structure is modeled by means of the sp3d5s∗ tight-binding method within the nearest-neighbor approximation. Both bulklike and edge states appear in the energy spectrum. The bulklike states in quantum rings exhibit Aharonov-Bohm oscillations in magnetic field, whereas no such oscillations are found in quantum dots, which is ascribed to the different topology of the two systems. When magnetic field varies, all the edge states in square quantum dots appear as quasibands composed of almost fully flat levels, whereas some edge states in quantum rings are found to oscillate with magnetic field. However, the edge states in hexagonal quantum dots are localized like in rings. The absorption spectra of all the structures consist of numerous absorption lines, which substantially overlap even for small line broadening. The absorption lines in the infrared are found to originate from transitions between edge states. It is shown that the magnetic field can be used to efficiently tune the optical absorption of HgTe 2D quantum dot and quantum ring systems. © 2019 American Physical Society.",
journal = "Physical Review B",
title = "Confined electron states in two-dimensional HgTe in magnetic field: Quantum dot versus quantum ring behavior",
volume = "100",
number = "12",
pages = "125304",
doi = "10.1103/PhysRevB.100.125304"
}
1

CDKN2B gene expression is affected by 9p21.3 rs10757278 in CAD patients, six months after the MI

Životić, Ivan; Đurić, Tamara; Stanković, Aleksandra; Milašinović, Dejan; Stanković, Goran; Dekleva, Milica; Marković-Nikolić, Nataša; Alavantić, Dragan; Živković, Maja

(2019)

TY  - JOUR
AU  - Životić, Ivan
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
AU  - Milašinović, Dejan
AU  - Stanković, Goran
AU  - Dekleva, Milica
AU  - Marković-Nikolić, Nataša
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2019
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/8432
AB  - Background: Chromosomal region 9p21.3 is most robustly associated with coronary artery disease (CAD) in western European populations. However, heterogeneity in CAD phenotypes leads to uncertainty whether 9p21.3 is associated with stable and/or acute clinical presentations of CAD. 9p21.3 is rich in regulatory elements, but the underlying mechanisms of its actions in CAD remain unclear. We investigate the association of 9p21.3 two haplotype blocks lead variants (rs10757278 and rs518394) with first-ever non-fatal myocardial infarction (MI) in CAD patients and their association with CDKN2B mRNA expression in peripheral blood mononuclear cells 6 months after the event. Methods: We included CAD patients with sustained first MI (n = 523) and controls (n = 583). Gene expression was assessed in 72 patients 6 months after MI and 43 healthy controls. TaqMan® technology was used for the gene expression and genotyping analysis. Results: CDKN2B mRNA was significantly lower in MI patients compared with the controls (p = 0.002) and in patients carrying the rs10757278 G risk allele versus AA homozygotes (p = 0.012) 6 months after the event. While we confirmed the association of rs10757278 with CDKN2B expression in MI patients, we failed to find an association between the investigated variants and MI or disease burden. Conclusions: We suggest a dysregulation of gene expression in the 9p21.3 region six months after acute MI, which is affected by a genetic variant in patients. The rs10757278 rare allele is one factor that might lead to prolonged risk for proatherogenic complications. © 2019 The Canadian Society of Clinical Chemists
T2  - Clinical Biochemistry
T1  - CDKN2B gene expression is affected by 9p21.3 rs10757278 in CAD patients, six months after the MI
VL  - 73
SP  - 70
EP  - 76
DO  - 10.1016/j.clinbiochem.2019.08.003
ER  - 
@article{
author = "Životić, Ivan and Đurić, Tamara and Stanković, Aleksandra and Milašinović, Dejan and Stanković, Goran and Dekleva, Milica and Marković-Nikolić, Nataša and Alavantić, Dragan and Živković, Maja",
year = "2019",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/8432",
abstract = "Background: Chromosomal region 9p21.3 is most robustly associated with coronary artery disease (CAD) in western European populations. However, heterogeneity in CAD phenotypes leads to uncertainty whether 9p21.3 is associated with stable and/or acute clinical presentations of CAD. 9p21.3 is rich in regulatory elements, but the underlying mechanisms of its actions in CAD remain unclear. We investigate the association of 9p21.3 two haplotype blocks lead variants (rs10757278 and rs518394) with first-ever non-fatal myocardial infarction (MI) in CAD patients and their association with CDKN2B mRNA expression in peripheral blood mononuclear cells 6 months after the event. Methods: We included CAD patients with sustained first MI (n = 523) and controls (n = 583). Gene expression was assessed in 72 patients 6 months after MI and 43 healthy controls. TaqMan® technology was used for the gene expression and genotyping analysis. Results: CDKN2B mRNA was significantly lower in MI patients compared with the controls (p = 0.002) and in patients carrying the rs10757278 G risk allele versus AA homozygotes (p = 0.012) 6 months after the event. While we confirmed the association of rs10757278 with CDKN2B expression in MI patients, we failed to find an association between the investigated variants and MI or disease burden. Conclusions: We suggest a dysregulation of gene expression in the 9p21.3 region six months after acute MI, which is affected by a genetic variant in patients. The rs10757278 rare allele is one factor that might lead to prolonged risk for proatherogenic complications. © 2019 The Canadian Society of Clinical Chemists",
journal = "Clinical Biochemistry",
title = "CDKN2B gene expression is affected by 9p21.3 rs10757278 in CAD patients, six months after the MI",
volume = "73",
pages = "70-76",
doi = "10.1016/j.clinbiochem.2019.08.003"
}

Editorial: Neurocardiovascular Diseases: New Aspects of the Old Issues

Bojić, Tijana

(2019)

@article{
author = "Bojić, Tijana",
year = "2019",
url = "https://www.frontiersin.org/article/10.3389/fnins.2018.01032/full, http://vinar.vin.bg.ac.rs/handle/123456789/8179",
journal = "Frontiers in Neuroscience",
title = "Editorial: Neurocardiovascular Diseases: New Aspects of the Old Issues",
volume = "12",
number = "JAN",
doi = "10.3389/fnins.2018.01032"
}
1
1
1
1

Regulation of hepatic Na+/K+-ATPase in obese female and male rats: involvement of ERK1/2, AMPK, and Rho/ROCK

(2018)

TY  - JOUR
PY  - 2018
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7581
AB  - In this study, we assessed whether the disturbed regulation of sodium/potassium-adenosine-triphosphatase (Na+/K+-ATPase) occurs as a consequence of obesity-induced IR in sex-specific manner. We also assessed whether alterations of IRS/PI3K/Akt, ERK1/2, AMPK alpha, and RhoA/ROCK signaling cascades have an important role in this pathology. Female and male Wistar rats (150-200 g, 8 weeks old) were fed a standard laboratory diet or a high-fat (HF) diet (42% fat) for 10 weeks. The activity of hepatic Na+/K+-ATPase and Rho, and the association of IRS-1/p85 were assessed in liver. Furthermore, the protein level of alpha(1) Na+/K+-ATPase in plasma membrane fractions, and protein levels of IRS-1, PI3K-p85, -p110, RhoA, ROCK1, ROCK2, ERK1/2, AMPK alpha, ER alpha, and ER beta in liver lysates were assessed. The expression of hepatic alpha(1) Na+/K+-ATPase mRNA was also analyzed by qRT-PCR. The results show that HF-fed female rats exhibited an increase in hepatic ERK1/2 (p < 0.05) and AMPK alpha (p < 0.05) phosphorylation levels, unchanged level of Na+/K+-ATPase alpha(1) mRNA, decreased level of Na+/K+-ATPase activity (p < 0.05), and decreased alpha(1) Na+/K+-ATPase protein expression (p < 0.01). In liver of HF-fed male rats, results show decreased levels of Na+/K+-ATPase activity (p < 0.01), both protein and mRNA of alpha(1) subunit (p < 0.05), but significant increase in Rho activity (p < 0.05). Our results indicate significant sex differences in alpha(1) Na+/K+-ATPase mRNA expression and activation of ERK1/2, AMPK alpha, and Rho in the liver. Exploring the sex-specific factors and pathways that promote obesity-related diseases may lead to a better understanding of pathogenesis and discovering new therapeutic targets.
T2  - Molecular and Cellular Biochemistry
T1  - Regulation of hepatic Na+/K+-ATPase in obese female and male rats: involvement of ERK1/2, AMPK, and Rho/ROCK
VL  - 440
SP  - 77
EP  - 88
DO  - 10.1007/s11010-017-3157-z
ER  - 
@article{
year = "2018",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7581",
abstract = "In this study, we assessed whether the disturbed regulation of sodium/potassium-adenosine-triphosphatase (Na+/K+-ATPase) occurs as a consequence of obesity-induced IR in sex-specific manner. We also assessed whether alterations of IRS/PI3K/Akt, ERK1/2, AMPK alpha, and RhoA/ROCK signaling cascades have an important role in this pathology. Female and male Wistar rats (150-200 g, 8 weeks old) were fed a standard laboratory diet or a high-fat (HF) diet (42% fat) for 10 weeks. The activity of hepatic Na+/K+-ATPase and Rho, and the association of IRS-1/p85 were assessed in liver. Furthermore, the protein level of alpha(1) Na+/K+-ATPase in plasma membrane fractions, and protein levels of IRS-1, PI3K-p85, -p110, RhoA, ROCK1, ROCK2, ERK1/2, AMPK alpha, ER alpha, and ER beta in liver lysates were assessed. The expression of hepatic alpha(1) Na+/K+-ATPase mRNA was also analyzed by qRT-PCR. The results show that HF-fed female rats exhibited an increase in hepatic ERK1/2 (p < 0.05) and AMPK alpha (p < 0.05) phosphorylation levels, unchanged level of Na+/K+-ATPase alpha(1) mRNA, decreased level of Na+/K+-ATPase activity (p < 0.05), and decreased alpha(1) Na+/K+-ATPase protein expression (p < 0.01). In liver of HF-fed male rats, results show decreased levels of Na+/K+-ATPase activity (p < 0.01), both protein and mRNA of alpha(1) subunit (p < 0.05), but significant increase in Rho activity (p < 0.05). Our results indicate significant sex differences in alpha(1) Na+/K+-ATPase mRNA expression and activation of ERK1/2, AMPK alpha, and Rho in the liver. Exploring the sex-specific factors and pathways that promote obesity-related diseases may lead to a better understanding of pathogenesis and discovering new therapeutic targets.",
journal = "Molecular and Cellular Biochemistry",
title = "Regulation of hepatic Na+/K+-ATPase in obese female and male rats: involvement of ERK1/2, AMPK, and Rho/ROCK",
volume = "440",
pages = "77-88",
doi = "10.1007/s11010-017-3157-z"
}
7
5
3

Transcriptome-driven integrative exploration of functional state of ureter tissue affected by CAKUT

Jovanović, Ivan G.; Živković, Maja; Kostić, Mirjana M.; Krstić, Zoran; Đurić, Tamara; Licastro, Danilo; Meroni, Germana; Alavantić, Dragan; Stanković, Aleksandra

(2018)

TY  - JOUR
AU  - Jovanović, Ivan G.
AU  - Živković, Maja
AU  - Kostić, Mirjana M.
AU  - Krstić, Zoran
AU  - Đurić, Tamara
AU  - Licastro, Danilo
AU  - Meroni, Germana
AU  - Alavantić, Dragan
AU  - Stanković, Aleksandra
PY  - 2018
UR  - https://linkinghub.elsevier.com/retrieve/pii/S0024320518305940
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7891
AB  - Aims: (1) to identify the most dysregulated genes in ureter tissue affected by congenital anomalies of the kidney and urinary tract (CAKUT) and to extract the biological meaning of these markers; (2) to describe the key molecular networks in CAKUT and to provide expression validation of the genes selected from these networks. Main methods: Transcriptome data was obtained from ureter samples of CAKUT patients and controls by Illumina iScan microarray. Identification of differentially expressed genes was coupled with subsequent bioinformatics analyses. Expression of candidate genes was validated by qRT-PCR. Key findings: Analysis of the transcriptome led to the identification of 78 commonly dysregulated genes in CAKUT tissue compared to controls. Integrative bioinformatic analyses of differentially expressed genes identified 7 major networks. The targets for qRT-PCR validation were selected as members of the major molecular networks in CAKUT, which had both, the significant high fold change and biological relevance for CAKUT. By qRT-PCR the substantial increase of LCN2, PROM1, SOSTDC1, and decrease of INA, RASD1 and TAC3 mRNA levels was confirmed. Significance: Since CAKUT is a leading cause of end-stage renal disease in children, the search for molecular targets for postnatal therapy is of particular interest. Data described in this study represents the gene expression profile and significant molecular networks specific to human ureter affected by CAKUT. The discovery of impaired molecular factors and processes is the step towards the uncovering of the key mechanisms that reflect CAKUT postnatally and could lead to the affected tissue deterioration and end organ damage. © 2018 Elsevier Inc.
T2  - Life Sciences
T1  - Transcriptome-driven integrative exploration of functional state of ureter tissue affected by CAKUT
VL  - 212
SP  - 1
EP  - 8
DO  - 10.1016/j.lfs.2018.09.042
ER  - 
@article{
author = "Jovanović, Ivan G. and Živković, Maja and Kostić, Mirjana M. and Krstić, Zoran and Đurić, Tamara and Licastro, Danilo and Meroni, Germana and Alavantić, Dragan and Stanković, Aleksandra",
year = "2018",
url = "https://linkinghub.elsevier.com/retrieve/pii/S0024320518305940, http://vinar.vin.bg.ac.rs/handle/123456789/7891",
abstract = "Aims: (1) to identify the most dysregulated genes in ureter tissue affected by congenital anomalies of the kidney and urinary tract (CAKUT) and to extract the biological meaning of these markers; (2) to describe the key molecular networks in CAKUT and to provide expression validation of the genes selected from these networks. Main methods: Transcriptome data was obtained from ureter samples of CAKUT patients and controls by Illumina iScan microarray. Identification of differentially expressed genes was coupled with subsequent bioinformatics analyses. Expression of candidate genes was validated by qRT-PCR. Key findings: Analysis of the transcriptome led to the identification of 78 commonly dysregulated genes in CAKUT tissue compared to controls. Integrative bioinformatic analyses of differentially expressed genes identified 7 major networks. The targets for qRT-PCR validation were selected as members of the major molecular networks in CAKUT, which had both, the significant high fold change and biological relevance for CAKUT. By qRT-PCR the substantial increase of LCN2, PROM1, SOSTDC1, and decrease of INA, RASD1 and TAC3 mRNA levels was confirmed. Significance: Since CAKUT is a leading cause of end-stage renal disease in children, the search for molecular targets for postnatal therapy is of particular interest. Data described in this study represents the gene expression profile and significant molecular networks specific to human ureter affected by CAKUT. The discovery of impaired molecular factors and processes is the step towards the uncovering of the key mechanisms that reflect CAKUT postnatally and could lead to the affected tissue deterioration and end organ damage. © 2018 Elsevier Inc.",
journal = "Life Sciences",
title = "Transcriptome-driven integrative exploration of functional state of ureter tissue affected by CAKUT",
volume = "212",
pages = "1-8",
doi = "10.1016/j.lfs.2018.09.042"
}
1
4
3
2

Left ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective study

Đorđević, Ana; Dekleva, Milica; Živković, Maja; Stanković, Aleksandra; Marković-Nikolić, Nataša; Alavantić, Dragan; Đurić, Tamara

(2018)

TY  - JOUR
AU  - Đorđević, Ana
AU  - Dekleva, Milica
AU  - Živković, Maja
AU  - Stanković, Aleksandra
AU  - Marković-Nikolić, Nataša
AU  - Alavantić, Dragan
AU  - Đurić, Tamara
PY  - 2018
UR  - http://link.springer.com/10.1007/s11033-018-4384-4
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7958
AB  - Post-infarct left ventricular remodeling (LVR) process increases the risk of heart failure (HF). Circulating galectin-3 has been associated with fibrosis, inflammation and cardiac dysfunction during the remodeling process after myocardial infarction (MI). The aims of this prospective case study were to investigate the association of potentially functional variants in the vicinity of LGALS-3 locus, rs2274273 and rs17128183 with maladaptive LVR and whether these variants could affect LGALS-3 mRNA expression in peripheral blood mononuclear cells of patients 6 months after the first MI. This study encompassed 167 patients with acute MI that were followed up for 6 months. Evidence of LVR was obtained by repeated 2D Doppler echocardiography. Rs2274273, rs17128183 and LGALS-3 mRNA expression were detected by TaqMan® technology. Rs2274273 and rs17128183 rare allele bearing genotypes, according to the dominant model (CT+TT vs. CC and AG+GG vs. AA, respectively), were significantly and independently associated with maladaptive LVR (adjusted OR = 3.02, P = 0.016; adjusted OR = 3.14, P = 0.019, respectively) and higher LGALS-3 mRNA expression (fold induction 1.203, P = 0.03 and 1.214, P = 0.03, respectively). Our exploratory results suggest that rs2274273 and rs17128183 variants affect LGALS-3 mRNA and bear the risk for maladaptive LVR post-MI remodeling. Further replication and validation in a larger group of patients is inevitable. © 2018, Springer Nature B.V.
T2  - Molecular Biology Reports
T1  - Left ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective study
VL  - 45
IS  - 6
SP  - 2227
EP  - 2236
DO  - 10.1007/s11033-018-4384-4
ER  - 
@article{
author = "Đorđević, Ana and Dekleva, Milica and Živković, Maja and Stanković, Aleksandra and Marković-Nikolić, Nataša and Alavantić, Dragan and Đurić, Tamara",
year = "2018",
url = "http://link.springer.com/10.1007/s11033-018-4384-4, http://vinar.vin.bg.ac.rs/handle/123456789/7958",
abstract = "Post-infarct left ventricular remodeling (LVR) process increases the risk of heart failure (HF). Circulating galectin-3 has been associated with fibrosis, inflammation and cardiac dysfunction during the remodeling process after myocardial infarction (MI). The aims of this prospective case study were to investigate the association of potentially functional variants in the vicinity of LGALS-3 locus, rs2274273 and rs17128183 with maladaptive LVR and whether these variants could affect LGALS-3 mRNA expression in peripheral blood mononuclear cells of patients 6 months after the first MI. This study encompassed 167 patients with acute MI that were followed up for 6 months. Evidence of LVR was obtained by repeated 2D Doppler echocardiography. Rs2274273, rs17128183 and LGALS-3 mRNA expression were detected by TaqMan® technology. Rs2274273 and rs17128183 rare allele bearing genotypes, according to the dominant model (CT+TT vs. CC and AG+GG vs. AA, respectively), were significantly and independently associated with maladaptive LVR (adjusted OR = 3.02, P = 0.016; adjusted OR = 3.14, P = 0.019, respectively) and higher LGALS-3 mRNA expression (fold induction 1.203, P = 0.03 and 1.214, P = 0.03, respectively). Our exploratory results suggest that rs2274273 and rs17128183 variants affect LGALS-3 mRNA and bear the risk for maladaptive LVR post-MI remodeling. Further replication and validation in a larger group of patients is inevitable. © 2018, Springer Nature B.V.",
journal = "Molecular Biology Reports",
title = "Left ventricular remodeling after the first myocardial infarction in association with LGALS-3 neighbouring variants rs2274273 and rs17128183 and its relative mRNA expression: a prospective study",
volume = "45",
number = "6",
pages = "2227-2236",
doi = "10.1007/s11033-018-4384-4"
}
1
1
1

New complexity measures reveal that topographic loops of human alpha phase potentials are more complex in drowsy than in wake

Kalauzi, Aleksandar; Vučković, Aleksandra; Bojić, Tijana

(2018)

TY  - JOUR
AU  - Kalauzi, Aleksandar
AU  - Vučković, Aleksandra
AU  - Bojić, Tijana
PY  - 2018
UR  - http://link.springer.com/10.1007/s11517-017-1746-3
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7746
AB  - A number of measures, stemming from nonlinear dynamics, exist to estimate complexity of biomedical objects. In most cases they are appropriate, but sometimes unconventional measures, more suited for specific objects, are needed to perform the task. In our present work, we propose three new complexity measures to quantify complexity of topographic closed loops of alpha carrier frequency phase potentials (CFPP) of healthy humans in wake and drowsy states. EEG of ten adult individuals was recorded in both states, using a 14-channel montage. For each subject and each state, a topographic loop (circular directed graph) was constructed according to CFPP values. Circular complexity measure was obtained by summing angles which directed graph edges (arrows) form with the topographic center. Longitudinal complexity was defined as the sum of all arrow lengths, while intersecting complexity was introduced by counting the number of intersections of graph edges. Wilcoxon's signed-ranks test was used on the sets of these three measures, as well as on fractal dimension values of some loop properties, to test differences between loops obtained in wake vs. drowsy. While fractal dimension values were not significantly different, longitudinal and intersecting complexities, as well as anticlockwise circularity, were significantly increased in drowsy.
T2  - Medical & Biological Engineering & Computing
T1  - New complexity measures reveal that topographic loops of human alpha phase potentials are more complex in drowsy than in wake
VL  - 56
IS  - 6
SP  - 967
EP  - 978
DO  - 10.1007/s11517-017-1746-3
ER  - 
@article{
author = "Kalauzi, Aleksandar and Vučković, Aleksandra and Bojić, Tijana",
year = "2018",
url = "http://link.springer.com/10.1007/s11517-017-1746-3, http://vinar.vin.bg.ac.rs/handle/123456789/7746",
abstract = "A number of measures, stemming from nonlinear dynamics, exist to estimate complexity of biomedical objects. In most cases they are appropriate, but sometimes unconventional measures, more suited for specific objects, are needed to perform the task. In our present work, we propose three new complexity measures to quantify complexity of topographic closed loops of alpha carrier frequency phase potentials (CFPP) of healthy humans in wake and drowsy states. EEG of ten adult individuals was recorded in both states, using a 14-channel montage. For each subject and each state, a topographic loop (circular directed graph) was constructed according to CFPP values. Circular complexity measure was obtained by summing angles which directed graph edges (arrows) form with the topographic center. Longitudinal complexity was defined as the sum of all arrow lengths, while intersecting complexity was introduced by counting the number of intersections of graph edges. Wilcoxon's signed-ranks test was used on the sets of these three measures, as well as on fractal dimension values of some loop properties, to test differences between loops obtained in wake vs. drowsy. While fractal dimension values were not significantly different, longitudinal and intersecting complexities, as well as anticlockwise circularity, were significantly increased in drowsy.",
journal = "Medical & Biological Engineering & Computing",
title = "New complexity measures reveal that topographic loops of human alpha phase potentials are more complex in drowsy than in wake",
volume = "56",
number = "6",
pages = "967-978",
doi = "10.1007/s11517-017-1746-3"
}

The HACD4 haplotype as a risk factor for atherosclerosis in males

Životić, Ivan; Đurić, Tamara; Stanković, Aleksandra; Ivancevic, Ilija; Končar, Igor; Milašinović, Dejan; Stanković, Goran; Alavantić, Dragan; Živković, Maja

(2018)

TY  - JOUR
AU  - Životić, Ivan
AU  - Đurić, Tamara
AU  - Stanković, Aleksandra
AU  - Ivancevic, Ilija
AU  - Končar, Igor
AU  - Milašinović, Dejan
AU  - Stanković, Goran
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2018
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1843
AB  - The 9p21.3 region is rich in regulatory elements and the variants in this region had been robustly associated with carotid plaque (CP) and coronary artery disease (CAD). Recently, the HACD4 was detected as one of the six 9p21.3 differentially expressed genes associated with accelerated atherosclerosis and greater mean lesion area in the Athsq1 congenic mice. We aimed to investigate association of two potentially regulatory HACD4 variants (rs36212560 I/D, rs2275888 T/C) and their haplotypes with CP occurrence and the level of HACD4 and FOCAD mRNA in human CP tissue. Association study was replicated in CAD patients who suffered the first myocardial infarction. Study included 477 CP patients, 303 healthy controls and replication sample of 224 CAD males from the population of Serbia. Genotypes were determined by polymerase chain reaction (PCR) and real-time PCR using TaqMan (R) technology. The gene expression was detected with TaqMan (R) technology. We have found significant and independent association of DT haplotype with CP presence in men (adjusted OR = 1.64 CI = 1.12-2.42, p = 0.011). The result was replicated in CAD males (adjusted OR = 1.84 CI = 1.21-2.80, p = 0.004). We have found significant effect of the HACD4 rs2275888 on FOCAD mRNA level in human CP tissue. Correction for multiple testing was performed. Independent association of HACD4 haplotypes with atherosclerotic phenotypes connotes a further validation and replication in larger cohorts as well as functional studies to enlighten the potential mechanism of its action in pathophysiology of atherosclerosis.
T2  - Gene
T1  - The HACD4 haplotype as a risk factor for atherosclerosis in males
VL  - 641
SP  - 35
EP  - 40
DO  - 10.1016/j.gene.2017.10.030
ER  - 
@article{
author = "Životić, Ivan and Đurić, Tamara and Stanković, Aleksandra and Ivancevic, Ilija and Končar, Igor and Milašinović, Dejan and Stanković, Goran and Alavantić, Dragan and Živković, Maja",
year = "2018",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1843",
abstract = "The 9p21.3 region is rich in regulatory elements and the variants in this region had been robustly associated with carotid plaque (CP) and coronary artery disease (CAD). Recently, the HACD4 was detected as one of the six 9p21.3 differentially expressed genes associated with accelerated atherosclerosis and greater mean lesion area in the Athsq1 congenic mice. We aimed to investigate association of two potentially regulatory HACD4 variants (rs36212560 I/D, rs2275888 T/C) and their haplotypes with CP occurrence and the level of HACD4 and FOCAD mRNA in human CP tissue. Association study was replicated in CAD patients who suffered the first myocardial infarction. Study included 477 CP patients, 303 healthy controls and replication sample of 224 CAD males from the population of Serbia. Genotypes were determined by polymerase chain reaction (PCR) and real-time PCR using TaqMan (R) technology. The gene expression was detected with TaqMan (R) technology. We have found significant and independent association of DT haplotype with CP presence in men (adjusted OR = 1.64 CI = 1.12-2.42, p = 0.011). The result was replicated in CAD males (adjusted OR = 1.84 CI = 1.21-2.80, p = 0.004). We have found significant effect of the HACD4 rs2275888 on FOCAD mRNA level in human CP tissue. Correction for multiple testing was performed. Independent association of HACD4 haplotypes with atherosclerotic phenotypes connotes a further validation and replication in larger cohorts as well as functional studies to enlighten the potential mechanism of its action in pathophysiology of atherosclerosis.",
journal = "Gene",
title = "The HACD4 haplotype as a risk factor for atherosclerosis in males",
volume = "641",
pages = "35-40",
doi = "10.1016/j.gene.2017.10.030"
}

Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high-fat diet

Jovanović, Aleksandra; Obradović, Milan M.; Sudar, Emina; Stewart, Alan J.; Pitt, Samantha J.; Alavantić, Dragan; Aleksić, Ema; Isenović, Esma R.

(2017)

TY  - JOUR
AU  - Jovanović, Aleksandra
AU  - Obradović, Milan M.
AU  - Sudar, Emina
AU  - Stewart, Alan J.
AU  - Pitt, Samantha J.
AU  - Alavantić, Dragan
AU  - Aleksić, Ema
AU  - Isenović, Esma R.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/1812
AB  - The aim of this study was to investigate whether the presence of endogenous estradiol alters the effects of a high-fat (HF) diet on activity/expression of the cardiac Na+/K+-ATPase, via PI3K/IRS and RhoA/ROCK signalling cascades in female rats. For this study, female Wistar rats (8 weeks old, 150-200 g) were fed a standard diet or a HF diet (balanced diet for laboratory rats enriched with 42% fat) for 10 weeks. The results show that rats fed a HF diet exhibited a decrease in phosphorylation of the alpha(1) subunit of Na+/K+-ATPase by 30% (p LT 0.05), expression of total alpha(1) subunit of Na+/K+-ATPase by 31% (p LT 0.05), and association of IRS1 with p85 subunit of PI3K by 42% (p LT 0.05), while the levels of cardiac RhoA and ROCK2 were significantly increased by 84% (p LT 0.01) and 62% (p LT 0.05), respectively. Our results suggest that a HF diet alters cardiac Na+/K+-ATPase expression via molecular mechanisms involving RhoA/ROCK and IRS-1/PI3K signalling in female rats.
T2  - Molecular and Cellular Biochemistry
T1  - Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high-fat diet
VL  - 436
IS  - 1-2
SP  - 49
EP  - 58
DO  - 10.1007/s11010-017-3077-y
ER  - 
@article{
author = "Jovanović, Aleksandra and Obradović, Milan M. and Sudar, Emina and Stewart, Alan J. and Pitt, Samantha J. and Alavantić, Dragan and Aleksić, Ema and Isenović, Esma R.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/1812",
abstract = "The aim of this study was to investigate whether the presence of endogenous estradiol alters the effects of a high-fat (HF) diet on activity/expression of the cardiac Na+/K+-ATPase, via PI3K/IRS and RhoA/ROCK signalling cascades in female rats. For this study, female Wistar rats (8 weeks old, 150-200 g) were fed a standard diet or a HF diet (balanced diet for laboratory rats enriched with 42% fat) for 10 weeks. The results show that rats fed a HF diet exhibited a decrease in phosphorylation of the alpha(1) subunit of Na+/K+-ATPase by 30% (p LT 0.05), expression of total alpha(1) subunit of Na+/K+-ATPase by 31% (p LT 0.05), and association of IRS1 with p85 subunit of PI3K by 42% (p LT 0.05), while the levels of cardiac RhoA and ROCK2 were significantly increased by 84% (p LT 0.01) and 62% (p LT 0.05), respectively. Our results suggest that a HF diet alters cardiac Na+/K+-ATPase expression via molecular mechanisms involving RhoA/ROCK and IRS-1/PI3K signalling in female rats.",
journal = "Molecular and Cellular Biochemistry",
title = "Changes in cardiac Na+/K+-ATPase expression and activity in female rats fed a high-fat diet",
volume = "436",
number = "1-2",
pages = "49-58",
doi = "10.1007/s11010-017-3077-y"
}

Thoron, radon and air ions spatial distribution in indoor air

Kolarž, Predrag M.; Vaupotič, Janja; Kobal, Ivan; Ujić, Predrag; Stojanovska, Zdenka A.; Žunić, Zora S.

(2017)

TY  - JOUR
AU  - Kolarž, Predrag M.
AU  - Vaupotič, Janja
AU  - Kobal, Ivan
AU  - Ujić, Predrag
AU  - Stojanovska, Zdenka A.
AU  - Žunić, Zora S.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7163
AB  - Spatial distribution of radioactive gasses thoron (Tn) and radon (Rn) in indoor air of 9 houses mostly during winter period of 2013 has been studied. According to properties of alpha decay of both elements, air ionization was also measured. Simultaneous continual measurements using three Rn/an and three air-ion active instruments deployed on to three different distances from the wall surface have shown various outcomes. It has turned out that Tn and air ions concentrations decrease with the distance increase, while Rn remained uniformly distributed. Exponential fittings function for Tn variation with distance was used for the diffusion length and constant as well as the exhalation rate determination. The obtained values were similar with experimental data reported in the literature. Concentrations of air ions were found to be in relation with Rn and obvious, but to a lesser extent, with Tn. (C) 2016 Elsevier Ltd. All rights reserved.
T2  - Journal of Environmental Radioactivity
T1  - Thoron, radon and air ions spatial distribution in indoor air
VL  - 173
SP  - 70
EP  - 74
DO  - 10.1016/j.jenvrad.2016.11.006
ER  - 
@article{
author = "Kolarž, Predrag M. and Vaupotič, Janja and Kobal, Ivan and Ujić, Predrag and Stojanovska, Zdenka A. and Žunić, Zora S.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7163",
abstract = "Spatial distribution of radioactive gasses thoron (Tn) and radon (Rn) in indoor air of 9 houses mostly during winter period of 2013 has been studied. According to properties of alpha decay of both elements, air ionization was also measured. Simultaneous continual measurements using three Rn/an and three air-ion active instruments deployed on to three different distances from the wall surface have shown various outcomes. It has turned out that Tn and air ions concentrations decrease with the distance increase, while Rn remained uniformly distributed. Exponential fittings function for Tn variation with distance was used for the diffusion length and constant as well as the exhalation rate determination. The obtained values were similar with experimental data reported in the literature. Concentrations of air ions were found to be in relation with Rn and obvious, but to a lesser extent, with Tn. (C) 2016 Elsevier Ltd. All rights reserved.",
journal = "Journal of Environmental Radioactivity",
title = "Thoron, radon and air ions spatial distribution in indoor air",
volume = "173",
pages = "70-74",
doi = "10.1016/j.jenvrad.2016.11.006"
}
4
4
4

Indoor Radon, Thoron and Their Progeny Concentrations in High Thoron Rural Serbia Environments

Žunić, Zora S.; Stojanovska, Zdenka A.; Veselinovic, N.; Mishra, R.; Yarmoshenko, Ilia V.; Sapra, B. K.; Ishikawa, Tetsuo; Omori, Y.; Ćurguz, Zoran; Bossew, Peter; Udovicic, V.; Ramola, R. C.

(2017)

TY  - JOUR
AU  - Žunić, Zora S.
AU  - Stojanovska, Zdenka A.
AU  - Veselinovic, N.
AU  - Mishra, R.
AU  - Yarmoshenko, Ilia V.
AU  - Sapra, B. K.
AU  - Ishikawa, Tetsuo
AU  - Omori, Y.
AU  - Ćurguz, Zoran
AU  - Bossew, Peter
AU  - Udovicic, V.
AU  - Ramola, R. C.
PY  - 2017
UR  - http://vinar.vin.bg.ac.rs/handle/123456789/7195
AB  - This article deals with the variation of radon (Rn), thoron (Tn) and their progeny concentrations expressed in terms of equilibrium equivalent concentrations (EERC and EETC), in 40 houses, in four villages of Sokobanja municipality, Southern Serbia. Two types of passive detectors were used: (1) discriminative radon-thoron detector for simultaneous Rn and Tn gases measurements and (2) direct Tn and Rn progeny sensors (DRPS/DTPS) for measuring Rn and Tn progeny concentrations. Detectors were exposed simultaneously for a single period of 12 months. Variations of Tn and EETC appear higher than those of Rn and EERC. Analysis of the spatial variation of the measured concentrations is also reported. This work is part of a wider survey of Rn, Tn and their progeny concentrations in indoor environments throughout the Balkan region started in 2011 year.
T2  - Radiation Protection Dosimetry
T1  - Indoor Radon, Thoron and Their Progeny Concentrations in High Thoron Rural Serbia Environments
VL  - 177
IS  - 1-2
SP  - 36
EP  - 39
DO  - 10.1093/rpd/ncx167
ER  - 
@article{
author = "Žunić, Zora S. and Stojanovska, Zdenka A. and Veselinovic, N. and Mishra, R. and Yarmoshenko, Ilia V. and Sapra, B. K. and Ishikawa, Tetsuo and Omori, Y. and Ćurguz, Zoran and Bossew, Peter and Udovicic, V. and Ramola, R. C.",
year = "2017",
url = "http://vinar.vin.bg.ac.rs/handle/123456789/7195",
abstract = "This article deals with the variation of radon (Rn), thoron (Tn) and their progeny concentrations expressed in terms of equilibrium equivalent concentrations (EERC and EETC), in 40 houses, in four villages of Sokobanja municipality, Southern Serbia. Two types of passive detectors were used: (1) discriminative radon-thoron detector for simultaneous Rn and Tn gases measurements and (2) direct Tn and Rn progeny sensors (DRPS/DTPS) for measuring Rn and Tn progeny concentrations. Detectors were exposed simultaneously for a single period of 12 months. Variations of Tn and EETC appear higher than those of Rn and EERC. Analysis of the spatial variation of the measured concentrations is also reported. This work is part of a wider survey of Rn, Tn and their progeny concentrations in indoor environments throughout the Balkan region started in 2011 year.",
journal = "Radiation Protection Dosimetry",
title = "Indoor Radon, Thoron and Their Progeny Concentrations in High Thoron Rural Serbia Environments",
volume = "177",
number = "1-2",
pages = "36-39",
doi = "10.1093/rpd/ncx167"
}
6
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5