TY  - JOUR
AU  - Houdova, Dominika
AU  - Popović, Iva A.
AU  - Dellinger, Thomas
AU  - Nešić, Maja D.
AU  - Petković, Marijana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10135
AB  - The endangered loggerhead sea turtles (Caretta caretta) are a relatively abundant sea turtle species in Madeiran waters, where they encounter various environmental stressors: from natural to anthropogenic. The physiological stress response is increased corticosterone (CS) level in the blood, achieving 2 ng/mL. Although there are various analytical methods for determining the CS concentration in turtle blood, most of them require tedious procedures for the preparation. In this work, we have tested the possibility of using matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI TOF MS) for fast screening and detection of CS in blood from a turtle captured at the coast of Madeira Island. MALDI does not require sample derivatization and is suitable for low sample volume. The linearity, precision, and limit of detection and quantification with three organic MALDI matrices were investigated in this study. The signal-to-noise ratio of the CS-derived signal was used as a parameter for quantification. Isotopically labelled corticosterone was added as a correction factor at fixed concentration to achieve better linearity and precision. Our results demonstrate that this method has the potential for quantification of CS in turtle blood. However, the lowest concentration of CS extracted from plasma that was still detectable by MALDI TOF MS was about 0.04 mg/mL, which is about ten times higher than the expected CS concentration in blood.
T2  - International Journal of Mass Spectrometry
T1  - Potential of MALDI TOF mass spectrometry for detection and quantification of corticosterone in the blood of loggerhead sea turtles
VL  - 473
SP  - 116796
DO  - 10.1016/j.ijms.2022.116796
ER  - 

@article{
author = "Houdova, Dominika and Popović, Iva A. and Dellinger, Thomas and Nešić, Maja D. and Petković, Marijana",
year = "2022",
abstract = "The endangered loggerhead sea turtles (Caretta caretta) are a relatively abundant sea turtle species in Madeiran waters, where they encounter various environmental stressors: from natural to anthropogenic. The physiological stress response is increased corticosterone (CS) level in the blood, achieving 2 ng/mL. Although there are various analytical methods for determining the CS concentration in turtle blood, most of them require tedious procedures for the preparation. In this work, we have tested the possibility of using matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI TOF MS) for fast screening and detection of CS in blood from a turtle captured at the coast of Madeira Island. MALDI does not require sample derivatization and is suitable for low sample volume. The linearity, precision, and limit of detection and quantification with three organic MALDI matrices were investigated in this study. The signal-to-noise ratio of the CS-derived signal was used as a parameter for quantification. Isotopically labelled corticosterone was added as a correction factor at fixed concentration to achieve better linearity and precision. Our results demonstrate that this method has the potential for quantification of CS in turtle blood. However, the lowest concentration of CS extracted from plasma that was still detectable by MALDI TOF MS was about 0.04 mg/mL, which is about ten times higher than the expected CS concentration in blood.",
journal = "International Journal of Mass Spectrometry",
title = "Potential of MALDI TOF mass spectrometry for detection and quantification of corticosterone in the blood of loggerhead sea turtles",
volume = "473",
pages = "116796",
doi = "10.1016/j.ijms.2022.116796"
}

Houdova, D., Popović, I. A., Dellinger, T., Nešić, M. D.,& Petković, M.. (2022). Potential of MALDI TOF mass spectrometry for detection and quantification of corticosterone in the blood of loggerhead sea turtles. in International Journal of Mass Spectrometry, 473, 116796.
https://doi.org/10.1016/j.ijms.2022.116796

Houdova D, Popović IA, Dellinger T, Nešić MD, Petković M. Potential of MALDI TOF mass spectrometry for detection and quantification of corticosterone in the blood of loggerhead sea turtles. in International Journal of Mass Spectrometry. 2022;473:116796.
doi:10.1016/j.ijms.2022.116796 .

Houdova, Dominika, Popović, Iva A., Dellinger, Thomas, Nešić, Maja D., Petković, Marijana, "Potential of MALDI TOF mass spectrometry for detection and quantification of corticosterone in the blood of loggerhead sea turtles" in International Journal of Mass Spectrometry, 473 (2022):116796,
https://doi.org/10.1016/j.ijms.2022.116796 . .

TY  - JOUR
AU  - Nešić, Maja D.
AU  - Dučić, Tanja
AU  - Algarra, Manuel
AU  - Popović, Iva A.
AU  - Stepić, Milutin
AU  - Gonçalves, Mara
AU  - Petković, Marijana
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10184
AB  - In the last decade, targeting membrane lipids in cancer cells has been a promising approach that deserves attention in the field of anticancer drug development. To get a comprehensive understanding of the effect of the drug [Ru(η5-Cp)(PPh3)2CN] (RuCN) on cell lipidic components, we combine complementary analytical approaches, matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI TOF MS) and synchrotron radiation-based Fourier transform infrared (SR-FTIR) spectroscopy. Techniques are used for screening the effect of potential metallodrug, RuCN, without and with drug carriers (carbon dots (CDs) and nitrogen-doped carbon dots (N-CDs)) on the lipids of the human ovarian cancer cell line A2780. MALDI TOF MS results revealed that the lysis of ovarian cancer membrane lipids is promoted by RuCN and not by drug carriers (CDs and N-CDs). Furthermore, SR-FTIR results strongly suggested that the phospholipids of cancer cells undergo oxidative stress after the treatment with RuCN that was accompanied by the disordering of the fatty acid chains. On the other hand, using (N-)CDs as RuCN nanocarriers prevented the oxidative stress caused by RuCN but did not prevent the disordering of the fatty acid chain packing. Finally, we demonstrated that RuCN and RuCN/(N-)CDs alter the hydration of the membrane surface in the membrane–water interface region.
T2  - Cancers
T1  - Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study
VL  - 14
IS  - 5
SP  - 1182
DO  - 10.3390/cancers14051182
ER  - 

@article{
author = "Nešić, Maja D. and Dučić, Tanja and Algarra, Manuel and Popović, Iva A. and Stepić, Milutin and Gonçalves, Mara and Petković, Marijana",
year = "2022",
abstract = "In the last decade, targeting membrane lipids in cancer cells has been a promising approach that deserves attention in the field of anticancer drug development. To get a comprehensive understanding of the effect of the drug [Ru(η5-Cp)(PPh3)2CN] (RuCN) on cell lipidic components, we combine complementary analytical approaches, matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI TOF MS) and synchrotron radiation-based Fourier transform infrared (SR-FTIR) spectroscopy. Techniques are used for screening the effect of potential metallodrug, RuCN, without and with drug carriers (carbon dots (CDs) and nitrogen-doped carbon dots (N-CDs)) on the lipids of the human ovarian cancer cell line A2780. MALDI TOF MS results revealed that the lysis of ovarian cancer membrane lipids is promoted by RuCN and not by drug carriers (CDs and N-CDs). Furthermore, SR-FTIR results strongly suggested that the phospholipids of cancer cells undergo oxidative stress after the treatment with RuCN that was accompanied by the disordering of the fatty acid chains. On the other hand, using (N-)CDs as RuCN nanocarriers prevented the oxidative stress caused by RuCN but did not prevent the disordering of the fatty acid chain packing. Finally, we demonstrated that RuCN and RuCN/(N-)CDs alter the hydration of the membrane surface in the membrane–water interface region.",
journal = "Cancers",
title = "Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study",
volume = "14",
number = "5",
pages = "1182",
doi = "10.3390/cancers14051182"
}

Nešić, M. D., Dučić, T., Algarra, M., Popović, I. A., Stepić, M., Gonçalves, M.,& Petković, M.. (2022). Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study. in Cancers, 14(5), 1182.
https://doi.org/10.3390/cancers14051182

Nešić MD, Dučić T, Algarra M, Popović IA, Stepić M, Gonçalves M, Petković M. Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study. in Cancers. 2022;14(5):1182.
doi:10.3390/cancers14051182 .

Nešić, Maja D., Dučić, Tanja, Algarra, Manuel, Popović, Iva A., Stepić, Milutin, Gonçalves, Mara, Petković, Marijana, "Lipid Status of A2780 Ovarian Cancer Cells after Treatment with Ruthenium Complex Modified with Carbon Dot Nanocarriers: A Multimodal SR-FTIR Spectroscopy and MALDI TOF Mass Spectrometry Study" in Cancers, 14, no. 5 (2022):1182,
https://doi.org/10.3390/cancers14051182 . .

TY  - JOUR
AU  - Dučić, Tanja
AU  - Alves, Carla S.
AU  - Vučinić, Željko
AU  - Lázaro-Martínez, Juan M.
AU  - Petković, Marijana
AU  - Soto, Juan
AU  - Mutavdžić, Dragosav
AU  - Valle Martínez de Yuso, M.
AU  - Radotić, Ksenija
AU  - Algarra, Manuel
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10277
AB  - S and N-doped carbon dots (S-CDs and N-CDs) and their cisplatin (cis-Pt) derivatives. (S-CDs@cis-Pt and N-CDs@cis-Pt) were tested on two ovarian cancer cell lines: A2780 and A2780 cells resistant to cis-Pt (A2780R). Several spectroscopic techniques were employed to check S-CDs@cis-Pt and N-CDs@cis-Pt: solid- and solution-state nuclear magnetic resonance, matrix-assisted laser desorption, ionization time-of-flight mass spectrometry, and X-ray photoelectron spectroscopy. In addition, synchrotron-based Fourier Transformed Infrared spectro-microscopy was used to evaluate the biochemical changes in cells after treatment with cis-Pt, S-CDs, N-CDs, or S-CDs@cis-Pt and N-CDs@cis-Pt, respectively. Computational chemistry was applied to establish the model for the most stable bond between S-CDs and N-CDs and cis-Pt. The results revealed the successful modification of S-CDs and N-CDs with cis-Pt and the formation of a stable composite system that can be used for drug delivery to cancer cells and likewise to overcome acquired cis-Pt resistance. Nanoparticle treatment of A2780 and A2780R cells led to the changes in their structure of lipids, proteins, and nucleic acids depending on the treatment. The results showed the S-CDs@cis-Pt and N-CDs@cis-Pt might be used in the combination with cis-Pt to treat the adenocarcinoma, thus having a potential to be further developed as drug delivery systems.
T2  - Journal of Colloid and Interface Science
T1  - S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach
VL  - 623
SP  - 226
EP  - 237
DO  - 10.1016/j.jcis.2022.05.005
ER  - 

@article{
author = "Dučić, Tanja and Alves, Carla S. and Vučinić, Željko and Lázaro-Martínez, Juan M. and Petković, Marijana and Soto, Juan and Mutavdžić, Dragosav and Valle Martínez de Yuso, M. and Radotić, Ksenija and Algarra, Manuel",
year = "2022",
abstract = "S and N-doped carbon dots (S-CDs and N-CDs) and their cisplatin (cis-Pt) derivatives. (S-CDs@cis-Pt and N-CDs@cis-Pt) were tested on two ovarian cancer cell lines: A2780 and A2780 cells resistant to cis-Pt (A2780R). Several spectroscopic techniques were employed to check S-CDs@cis-Pt and N-CDs@cis-Pt: solid- and solution-state nuclear magnetic resonance, matrix-assisted laser desorption, ionization time-of-flight mass spectrometry, and X-ray photoelectron spectroscopy. In addition, synchrotron-based Fourier Transformed Infrared spectro-microscopy was used to evaluate the biochemical changes in cells after treatment with cis-Pt, S-CDs, N-CDs, or S-CDs@cis-Pt and N-CDs@cis-Pt, respectively. Computational chemistry was applied to establish the model for the most stable bond between S-CDs and N-CDs and cis-Pt. The results revealed the successful modification of S-CDs and N-CDs with cis-Pt and the formation of a stable composite system that can be used for drug delivery to cancer cells and likewise to overcome acquired cis-Pt resistance. Nanoparticle treatment of A2780 and A2780R cells led to the changes in their structure of lipids, proteins, and nucleic acids depending on the treatment. The results showed the S-CDs@cis-Pt and N-CDs@cis-Pt might be used in the combination with cis-Pt to treat the adenocarcinoma, thus having a potential to be further developed as drug delivery systems.",
journal = "Journal of Colloid and Interface Science",
title = "S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach",
volume = "623",
pages = "226-237",
doi = "10.1016/j.jcis.2022.05.005"
}

Dučić, T., Alves, C. S., Vučinić, Ž., Lázaro-Martínez, J. M., Petković, M., Soto, J., Mutavdžić, D., Valle Martínez de Yuso, M., Radotić, K.,& Algarra, M.. (2022). S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach. in Journal of Colloid and Interface Science, 623, 226-237.
https://doi.org/10.1016/j.jcis.2022.05.005

Dučić T, Alves CS, Vučinić Ž, Lázaro-Martínez JM, Petković M, Soto J, Mutavdžić D, Valle Martínez de Yuso M, Radotić K, Algarra M. S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach. in Journal of Colloid and Interface Science. 2022;623:226-237.
doi:10.1016/j.jcis.2022.05.005 .

Dučić, Tanja, Alves, Carla S., Vučinić, Željko, Lázaro-Martínez, Juan M., Petković, Marijana, Soto, Juan, Mutavdžić, Dragosav, Valle Martínez de Yuso, M., Radotić, Ksenija, Algarra, Manuel, "S, N-doped carbon dots-based cisplatin delivery system in adenocarcinoma cells: Spectroscopical and computational approach" in Journal of Colloid and Interface Science, 623 (2022):226-237,
https://doi.org/10.1016/j.jcis.2022.05.005 . .

TY  - JOUR
AU  - Nunes, Nadia
AU  - Popović, Iva
AU  - Abreu, Elder
AU  - Maciel, Dina
AU  - Rodrigues, João
AU  - Soto, Juan
AU  - Algarra, Manuel
AU  - Petković, Marijana
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13317
AB  - We studied the possibility of detection of [Ru(η5-C5H5)(PPh3)2Cl] (abbreviated by RuCp) complex as a model system for Ru-based metallodrugs in human urine by using matrix-assisted laser desorption/ionization time-of- flight mass spectrometry (MALDI-TOF MS) without previous purification or removal of inorganic salts. Inorganic salts might prevent the detection of RuCp by MALDI-TOF MS, most likely through the increased number and intensity of background/organic matrix signals. This problem might be overcome by the acquisition of matrix- free spectra and the addition of nanoparticles, such as carbon dots, to the urine solution. Our results suggest that RuCp is easily detectable by MALDI-TOF MS in all acquisition conditions, with the CHCA matrix being the best for acquisition in phosphate-containing solutions, whereas in urine, DHB and matrix-free approach demonstrated the highest sensitivity, precision, and reproducibility. The sensitivity of matrix-free MALDI detection of RuCp could be increased by the addition of carbon dots to the urine. Based on theoretical calculations for all matrix/analyte combinations, the model for the interaction of RuCp with carbon dots was established, and higher sensitivity explained.
T2  - Talanta
T1  - Detection of Ru potential metallodrug in human urine by MALDI-TOF mass spectrometry: Validation and options to enhance the sensitivity
VL  - 222
SP  - 121551
DO  - 10.1016/j.talanta.2020.121551
ER  - 

@article{
author = "Nunes, Nadia and Popović, Iva and Abreu, Elder and Maciel, Dina and Rodrigues, João and Soto, Juan and Algarra, Manuel and Petković, Marijana",
year = "2021",
abstract = "We studied the possibility of detection of [Ru(η5-C5H5)(PPh3)2Cl] (abbreviated by RuCp) complex as a model system for Ru-based metallodrugs in human urine by using matrix-assisted laser desorption/ionization time-of- flight mass spectrometry (MALDI-TOF MS) without previous purification or removal of inorganic salts. Inorganic salts might prevent the detection of RuCp by MALDI-TOF MS, most likely through the increased number and intensity of background/organic matrix signals. This problem might be overcome by the acquisition of matrix- free spectra and the addition of nanoparticles, such as carbon dots, to the urine solution. Our results suggest that RuCp is easily detectable by MALDI-TOF MS in all acquisition conditions, with the CHCA matrix being the best for acquisition in phosphate-containing solutions, whereas in urine, DHB and matrix-free approach demonstrated the highest sensitivity, precision, and reproducibility. The sensitivity of matrix-free MALDI detection of RuCp could be increased by the addition of carbon dots to the urine. Based on theoretical calculations for all matrix/analyte combinations, the model for the interaction of RuCp with carbon dots was established, and higher sensitivity explained.",
journal = "Talanta",
title = "Detection of Ru potential metallodrug in human urine by MALDI-TOF mass spectrometry: Validation and options to enhance the sensitivity",
volume = "222",
pages = "121551",
doi = "10.1016/j.talanta.2020.121551"
}

Nunes, N., Popović, I., Abreu, E., Maciel, D., Rodrigues, J., Soto, J., Algarra, M.,& Petković, M.. (2021). Detection of Ru potential metallodrug in human urine by MALDI-TOF mass spectrometry: Validation and options to enhance the sensitivity. in Talanta, 222, 121551.
https://doi.org/10.1016/j.talanta.2020.121551

Nunes N, Popović I, Abreu E, Maciel D, Rodrigues J, Soto J, Algarra M, Petković M. Detection of Ru potential metallodrug in human urine by MALDI-TOF mass spectrometry: Validation and options to enhance the sensitivity. in Talanta. 2021;222:121551.
doi:10.1016/j.talanta.2020.121551 .

Nunes, Nadia, Popović, Iva, Abreu, Elder, Maciel, Dina, Rodrigues, João, Soto, Juan, Algarra, Manuel, Petković, Marijana, "Detection of Ru potential metallodrug in human urine by MALDI-TOF mass spectrometry: Validation and options to enhance the sensitivity" in Talanta, 222 (2021):121551,
https://doi.org/10.1016/j.talanta.2020.121551 . .

TY  - JOUR
AU  - Perestrelo, Rosa
AU  - Petković, Marijana
AU  - Silva, Catarina Luís
PY  - 2021
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13326
AB  - Altered lipid metabolism has been associated with the progression of various cancers, and aberrant expression of enzymes involved in the lipid metabolism has been detected in different stages of cancer. Breast cancer (BC) is one of the cancer types known to be associated with alterations in the lipid metabolism and overexpression of enzymes involved in this metabolism. It has been demonstrated that inhibition of the activity of certain enzymes, such as that of phospholipase A2 in BC cell lines sensitizes these cells and decreases the IC50 values for forthcoming therapy with traditional drugs, such as doxorubicin and tamoxifen. Moreover, other phospholipases, such as phospholipase C and D, are involved in intracellular signal transduction, which emphasizes their importance in cancer development. Finally, BC is assumed to be dependent on the diet and the composition of lipids in nutrients. Despite their importance, analytical approaches that can associate the activity of phospholipases with changes in the lipid composition and distribution in cancer tissues are not yet standardized. In this review, an overview of various analytical platforms that are applied on the study of lipids and phospholipase activity in BC tissues will be given, as well as their association with cancer diagnosis and tumor progression. The methods that are applied to tissues obtained from the BC patients will be emphasized and critically evaluated, regarding their applicability in oncology
T2  - Metabolites
T1  - Analytical Platforms for the Determination of Phospholipid Turnover in Breast Cancer Tissue: Role of Phospholipase Activity in Breast Cancer Development
VL  - 11
IS  - 1
SP  - 32
DO  - 10.3390/metabo11010032
ER  - 

@article{
author = "Perestrelo, Rosa and Petković, Marijana and Silva, Catarina Luís",
year = "2021",
abstract = "Altered lipid metabolism has been associated with the progression of various cancers, and aberrant expression of enzymes involved in the lipid metabolism has been detected in different stages of cancer. Breast cancer (BC) is one of the cancer types known to be associated with alterations in the lipid metabolism and overexpression of enzymes involved in this metabolism. It has been demonstrated that inhibition of the activity of certain enzymes, such as that of phospholipase A2 in BC cell lines sensitizes these cells and decreases the IC50 values for forthcoming therapy with traditional drugs, such as doxorubicin and tamoxifen. Moreover, other phospholipases, such as phospholipase C and D, are involved in intracellular signal transduction, which emphasizes their importance in cancer development. Finally, BC is assumed to be dependent on the diet and the composition of lipids in nutrients. Despite their importance, analytical approaches that can associate the activity of phospholipases with changes in the lipid composition and distribution in cancer tissues are not yet standardized. In this review, an overview of various analytical platforms that are applied on the study of lipids and phospholipase activity in BC tissues will be given, as well as their association with cancer diagnosis and tumor progression. The methods that are applied to tissues obtained from the BC patients will be emphasized and critically evaluated, regarding their applicability in oncology",
journal = "Metabolites",
title = "Analytical Platforms for the Determination of Phospholipid Turnover in Breast Cancer Tissue: Role of Phospholipase Activity in Breast Cancer Development",
volume = "11",
number = "1",
pages = "32",
doi = "10.3390/metabo11010032"
}

Perestrelo, R., Petković, M.,& Silva, C. L.. (2021). Analytical Platforms for the Determination of Phospholipid Turnover in Breast Cancer Tissue: Role of Phospholipase Activity in Breast Cancer Development. in Metabolites, 11(1), 32.
https://doi.org/10.3390/metabo11010032

Perestrelo R, Petković M, Silva CL. Analytical Platforms for the Determination of Phospholipid Turnover in Breast Cancer Tissue: Role of Phospholipase Activity in Breast Cancer Development. in Metabolites. 2021;11(1):32.
doi:10.3390/metabo11010032 .

Perestrelo, Rosa, Petković, Marijana, Silva, Catarina Luís, "Analytical Platforms for the Determination of Phospholipid Turnover in Breast Cancer Tissue: Role of Phospholipase Activity in Breast Cancer Development" in Metabolites, 11, no. 1 (2021):32,
https://doi.org/10.3390/metabo11010032 . .

TY  - JOUR
AU  - Bonet-San-Emeterio, Marta
AU  - Algarra, Manuel
AU  - Petković, Marijana
AU  - del Valle, Manel
PY  - 2020
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/13327
AB  - Nitrogen and sulphur-doped Carbons Dots (N-CDs and S-CDs) were synthesized by a hydrothermal method and incorporated as surface electrode modifiers to evaluate their properties for electrochemical sensing. The first task was to characterize the synthesized materials, for which different spectroscopies, scanning microscopes, mass spectrometry and elementary analysis were performed. Next, a glassy carbon electrode (GCE) was surface-modified with the doped CDs and applied to check the electrochemical signal of different organic compounds corresponding to different families. Water solubility of the doped carbon dots forced us to incorporate them in a graphite-polystyrene ink to complete the modification of electrodes. This modification needed a first activation to obtain a properly conductive surface. The organic compounds examined were salicylic acid, cysteine and ascorbic acid. The modified GCEs exhibited an enhanced sensitivity, probably caused by the increase of active surface, but in addition, signals of salicylic acid were shifted ca. 200 mV to lower potentials, what is a proof of the increase of the heterogeneous electron transfer rate, and a demonstration of an enhanced catalytic response.
T2  - Talanta
T1  - Modification of electrodes with N-and S-doped carbon dots. Evaluation of the electrochemical response
VL  - 212
SP  - 120806
DO  - 10.1016/j.talanta.2020.120806
ER  - 

@article{
author = "Bonet-San-Emeterio, Marta and Algarra, Manuel and Petković, Marijana and del Valle, Manel",
year = "2020",
abstract = "Nitrogen and sulphur-doped Carbons Dots (N-CDs and S-CDs) were synthesized by a hydrothermal method and incorporated as surface electrode modifiers to evaluate their properties for electrochemical sensing. The first task was to characterize the synthesized materials, for which different spectroscopies, scanning microscopes, mass spectrometry and elementary analysis were performed. Next, a glassy carbon electrode (GCE) was surface-modified with the doped CDs and applied to check the electrochemical signal of different organic compounds corresponding to different families. Water solubility of the doped carbon dots forced us to incorporate them in a graphite-polystyrene ink to complete the modification of electrodes. This modification needed a first activation to obtain a properly conductive surface. The organic compounds examined were salicylic acid, cysteine and ascorbic acid. The modified GCEs exhibited an enhanced sensitivity, probably caused by the increase of active surface, but in addition, signals of salicylic acid were shifted ca. 200 mV to lower potentials, what is a proof of the increase of the heterogeneous electron transfer rate, and a demonstration of an enhanced catalytic response.",
journal = "Talanta",
title = "Modification of electrodes with N-and S-doped carbon dots. Evaluation of the electrochemical response",
volume = "212",
pages = "120806",
doi = "10.1016/j.talanta.2020.120806"
}

Bonet-San-Emeterio, M., Algarra, M., Petković, M.,& del Valle, M.. (2020). Modification of electrodes with N-and S-doped carbon dots. Evaluation of the electrochemical response. in Talanta, 212, 120806.
https://doi.org/10.1016/j.talanta.2020.120806

Bonet-San-Emeterio M, Algarra M, Petković M, del Valle M. Modification of electrodes with N-and S-doped carbon dots. Evaluation of the electrochemical response. in Talanta. 2020;212:120806.
doi:10.1016/j.talanta.2020.120806 .

Bonet-San-Emeterio, Marta, Algarra, Manuel, Petković, Marijana, del Valle, Manel, "Modification of electrodes with N-and S-doped carbon dots. Evaluation of the electrochemical response" in Talanta, 212 (2020):120806,
https://doi.org/10.1016/j.talanta.2020.120806 . .