TY  - JOUR
AU  - Adžić, Miroslav
AU  - Đorđević, Ana D.
AU  - Đorđević, Jelena D.
AU  - Nićiforović, Ana
AU  - Radojčić, Marija
PY  - 2009
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3750
AB  - In the present study, we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex and medulla in mature male Wistar rats subjected to three different stress types: acute, chronic, and combined, i.e., chronic followed by acute stress. These parameters were correlated with adrenal activity as judged from serum levels of corticosterone and catecholamines, respectively, as well as with serum levels of ACTH and glucose. Under all three conditions, we observed bilaterally asymmetric and stress-type-independent hypertrophy of whole adrenals, as well as adrenal cortices and medullas. Under acute and combined stress, adrenal hypertrophy was followed by increase of adrenal hormones in the blood serum. However, under chronic stress, both cortical and medullar activities as judged from low or unaltered levels of the respective hormones and glucose were compromised and disconnected from the input signal of ACTH. Since all of the studied adrenal activities could be restored by subsequent acute stress, it is concluded that chronic isolation can be viewed as partly maladaptive stress with characteristics resembling stress resistance rather than the stress exhaustion stage of the general adaptation syndrome.
T2  - Archives of Biological Sciences
T1  - Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats
VL  - 61
IS  - 2
SP  - 187
EP  - 194
DO  - 10.2298/ABS0902187A
ER  - 

@article{
author = "Adžić, Miroslav and Đorđević, Ana D. and Đorđević, Jelena D. and Nićiforović, Ana and Radojčić, Marija",
year = "2009",
abstract = "In the present study, we examined gross changes in the mass of whole adrenal glands and that of the adrenal cortex and medulla in mature male Wistar rats subjected to three different stress types: acute, chronic, and combined, i.e., chronic followed by acute stress. These parameters were correlated with adrenal activity as judged from serum levels of corticosterone and catecholamines, respectively, as well as with serum levels of ACTH and glucose. Under all three conditions, we observed bilaterally asymmetric and stress-type-independent hypertrophy of whole adrenals, as well as adrenal cortices and medullas. Under acute and combined stress, adrenal hypertrophy was followed by increase of adrenal hormones in the blood serum. However, under chronic stress, both cortical and medullar activities as judged from low or unaltered levels of the respective hormones and glucose were compromised and disconnected from the input signal of ACTH. Since all of the studied adrenal activities could be restored by subsequent acute stress, it is concluded that chronic isolation can be viewed as partly maladaptive stress with characteristics resembling stress resistance rather than the stress exhaustion stage of the general adaptation syndrome.",
journal = "Archives of Biological Sciences",
title = "Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats",
volume = "61",
number = "2",
pages = "187-194",
doi = "10.2298/ABS0902187A"
}

Adžić, M., Đorđević, A. D., Đorđević, J. D., Nićiforović, A.,& Radojčić, M.. (2009). Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats. in Archives of Biological Sciences, 61(2), 187-194.
https://doi.org/10.2298/ABS0902187A

Adžić M, Đorđević AD, Đorđević JD, Nićiforović A, Radojčić M. Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats. in Archives of Biological Sciences. 2009;61(2):187-194.
doi:10.2298/ABS0902187A .

Adžić, Miroslav, Đorđević, Ana D., Đorđević, Jelena D., Nićiforović, Ana, Radojčić, Marija, "Effect of Different Types of Stress on Adrenal Gland Parameters and Adrenal Hormones in the Blood Serum of Male Wistar Rats" in Archives of Biological Sciences, 61, no. 2 (2009):187-194,
https://doi.org/10.2298/ABS0902187A . .