TY  - JOUR
AU  - Gluvić, Zoran
AU  - Tica, Jelena
AU  - Vujović, Marina
AU  - Rašić-Milutinović, Zorica
AU  - Popović-Radinović, Vesna
AU  - Lačković, Milena
AU  - Obradović, Milan M.
AU  - Isenović, Esma R.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10321
AB  - Hiponatrijemija je čest elektrolitski poremećaj kod hospitalizovanih bolesnika. Nakon potvrđivanja laboratorijskog nalaza, potrebno je pojavu hiponatrijemiju etiološki razjasniti. Prikaz bolesnika: Bolesnica stara 56 godina, hospitalizovana je zbog evaluacije grčeva nogu i malaksalosti. U biohemijskim nalazima se registruje hipotona hiponatrijemija, te je posumnjano na SIADH (engl. Syndrome of Inappropriate Antidiuretic Hormone Secretion). Evaluacijom SIADH-a, nije nađen uzrok hiponatrijemije. Primenom simptomatske terapije i korekcijom hiponatrijemije, pacijentkinja je otpuštena lako poboljšana. Četiri meseca nakon hospitalizacije, javlja se konfuzna, sa gušenjem, sindromom hiperglikemije i teškim opštem stanjem. Pored toga, kod pacijentkinjw su laboratorijski potvrđene hipotone hiponatrijemije, ultrasonografijom abdomena su viđene metastatske promene na jetri. Ubrzo nakon prijema, dolazi do smrtnog ishoda. Rodbina je odbila obdukciju, te primarno ishodište malignoma nije utrvđeno. Hipotona hiponatrijemija zahteva ozbiljnu kliničku evaluaciju. SIADH je najčešći uzrok hipotone hiponatrijemije, a najvažniji uzrok SIADH-a je maligna bolest. Pažljiva korekcija hiponatrijemije i lečenje osnovne bolesti je osnova lečenja SIADH-a.
AB  - Hyponatremia is a common electrolyte disorder in hospitalized patients. In the case of repetitive biochemically confirmed hyponatremia, it is necessary to find its cause. Case report: a 56-year-old woman was admitted to hospital due to leg cramps and malaise. Routine biochemical analysis revealed hypotonic hyponatremia and Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) was suspected. The cause of hyponatremia was not discovered by means of evaluating SIADH. The patient was simptomatically treated, and discharged in better general condition, with partially corrected hyponatremia. She was advised to restrict water intake and to repeat serum electrolytes and BUN regularly. Four months later, she presented with dyspnea and hyperglycemic syndrome, she was confused and her life was threatened. Beside severe hyponatremia and hyperglycemia, an urgent abdominal ultrasonography showed liver secondaries. Shortly after admission, the patient passed away. Unfortunately, the patient's family refused an autopsy, so the origin of neoplasia has remained unknown. It is necessary to do a thorough clinical evaluation of hypotonic hyponatremia. SIADH, as the most frequent cause of hypotonic hyponatremia, is often a paraneoplastic syndrome. Careful correction of hypotonic hyponatremia and management of the underlying disease is the mainstay of SIADH treatment.
T2  - Medicinska istraživanja
T1  - Malignomom uzrokovana hiponatrijemija - prikaz slučaja
T1  - Malignancy-related hyponatremia: Case report
VL  - 47
IS  - 2
SP  - 49
EP  - 53
DO  - 10.5937/MedIst1302049G
ER  - 

@article{
author = "Gluvić, Zoran and Tica, Jelena and Vujović, Marina and Rašić-Milutinović, Zorica and Popović-Radinović, Vesna and Lačković, Milena and Obradović, Milan M. and Isenović, Esma R.",
year = "2013",
abstract = "Hiponatrijemija je čest elektrolitski poremećaj kod hospitalizovanih bolesnika. Nakon potvrđivanja laboratorijskog nalaza, potrebno je pojavu hiponatrijemiju etiološki razjasniti. Prikaz bolesnika: Bolesnica stara 56 godina, hospitalizovana je zbog evaluacije grčeva nogu i malaksalosti. U biohemijskim nalazima se registruje hipotona hiponatrijemija, te je posumnjano na SIADH (engl. Syndrome of Inappropriate Antidiuretic Hormone Secretion). Evaluacijom SIADH-a, nije nađen uzrok hiponatrijemije. Primenom simptomatske terapije i korekcijom hiponatrijemije, pacijentkinja je otpuštena lako poboljšana. Četiri meseca nakon hospitalizacije, javlja se konfuzna, sa gušenjem, sindromom hiperglikemije i teškim opštem stanjem. Pored toga, kod pacijentkinjw su laboratorijski potvrđene hipotone hiponatrijemije, ultrasonografijom abdomena su viđene metastatske promene na jetri. Ubrzo nakon prijema, dolazi do smrtnog ishoda. Rodbina je odbila obdukciju, te primarno ishodište malignoma nije utrvđeno. Hipotona hiponatrijemija zahteva ozbiljnu kliničku evaluaciju. SIADH je najčešći uzrok hipotone hiponatrijemije, a najvažniji uzrok SIADH-a je maligna bolest. Pažljiva korekcija hiponatrijemije i lečenje osnovne bolesti je osnova lečenja SIADH-a., Hyponatremia is a common electrolyte disorder in hospitalized patients. In the case of repetitive biochemically confirmed hyponatremia, it is necessary to find its cause. Case report: a 56-year-old woman was admitted to hospital due to leg cramps and malaise. Routine biochemical analysis revealed hypotonic hyponatremia and Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) was suspected. The cause of hyponatremia was not discovered by means of evaluating SIADH. The patient was simptomatically treated, and discharged in better general condition, with partially corrected hyponatremia. She was advised to restrict water intake and to repeat serum electrolytes and BUN regularly. Four months later, she presented with dyspnea and hyperglycemic syndrome, she was confused and her life was threatened. Beside severe hyponatremia and hyperglycemia, an urgent abdominal ultrasonography showed liver secondaries. Shortly after admission, the patient passed away. Unfortunately, the patient's family refused an autopsy, so the origin of neoplasia has remained unknown. It is necessary to do a thorough clinical evaluation of hypotonic hyponatremia. SIADH, as the most frequent cause of hypotonic hyponatremia, is often a paraneoplastic syndrome. Careful correction of hypotonic hyponatremia and management of the underlying disease is the mainstay of SIADH treatment.",
journal = "Medicinska istraživanja",
title = "Malignomom uzrokovana hiponatrijemija - prikaz slučaja, Malignancy-related hyponatremia: Case report",
volume = "47",
number = "2",
pages = "49-53",
doi = "10.5937/MedIst1302049G"
}

Gluvić, Z., Tica, J., Vujović, M., Rašić-Milutinović, Z., Popović-Radinović, V., Lačković, M., Obradović, M. M.,& Isenović, E. R.. (2013). Malignomom uzrokovana hiponatrijemija - prikaz slučaja. in Medicinska istraživanja, 47(2), 49-53.
https://doi.org/10.5937/MedIst1302049G

Gluvić Z, Tica J, Vujović M, Rašić-Milutinović Z, Popović-Radinović V, Lačković M, Obradović MM, Isenović ER. Malignomom uzrokovana hiponatrijemija - prikaz slučaja. in Medicinska istraživanja. 2013;47(2):49-53.
doi:10.5937/MedIst1302049G .

Gluvić, Zoran, Tica, Jelena, Vujović, Marina, Rašić-Milutinović, Zorica, Popović-Radinović, Vesna, Lačković, Milena, Obradović, Milan M., Isenović, Esma R., "Malignomom uzrokovana hiponatrijemija - prikaz slučaja" in Medicinska istraživanja, 47, no. 2 (2013):49-53,
https://doi.org/10.5937/MedIst1302049G . .

TY  - CHAP
AU  - Sudar, Emina
AU  - Soskić, Sanja S.
AU  - Zarić, Božidarka
AU  - Rašić-Milutinović, Zorica
AU  - Smiljanić, Katarina
AU  - Radak, Đorđe J.
AU  - Mikhailidis, Dimitri P.
AU  - Rizzo, Manfredi
AU  - Isenović, Esma R.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8685
AB  - Cardiovascular disease (CVD) is common cause of death in humans and its major underlying pathology is atherosclerosis. Atherosclerosis is a chronic inflammatory disease that predisposes to coronary artery disease (CAD), stroke and peripheral arterial disease, responsible for most of the cardiovascular morbidity and mortality. This inflammatory process, triggered by the presence of lipids in the vascular wall, and encompasses a complex interaction among inflammatory cells, vascular elements, and lipoproteins through the expression of several adhesion molecules and cytokines. Obesity is a risk factor for CVD but this association is not fully understood. Altered levels of obesity related peptides such as ghrelin may play an important role in this pathophysiology. Recent evidence indicates that ghrelin features several cardiovascular activities, including increased myocardial contractility, vasodilatation and protection from myocardial infarction. Recent data demonstrate that ghrelin can influence important key events in atherogenesis and thus they may play a role in atherosclerosis. In this review we present the latest data from recent animal and clinical studies which focus on a novel approach to ghrelin as a potential therapeutic agent in the treatment of a complex disease like atherosclerosis. Thus, ghrelin may become a new therapeutic target for the treatment of CVD. Further studies are necessary to investigate the potential mechanisms involved in the effects of ghrelin on the cardiovascular system.
T2  - Ghrelin: Production, Action Mechanisms and Physiological Effects
T1  - Ghrelin, obesity and atherosclerosis
SP  - 111
EP  - 126
UR  - https://hdl.handle.net/21.15107/rcub_vinar_8685
ER  - 

@inbook{
author = "Sudar, Emina and Soskić, Sanja S. and Zarić, Božidarka and Rašić-Milutinović, Zorica and Smiljanić, Katarina and Radak, Đorđe J. and Mikhailidis, Dimitri P. and Rizzo, Manfredi and Isenović, Esma R.",
year = "2012",
abstract = "Cardiovascular disease (CVD) is common cause of death in humans and its major underlying pathology is atherosclerosis. Atherosclerosis is a chronic inflammatory disease that predisposes to coronary artery disease (CAD), stroke and peripheral arterial disease, responsible for most of the cardiovascular morbidity and mortality. This inflammatory process, triggered by the presence of lipids in the vascular wall, and encompasses a complex interaction among inflammatory cells, vascular elements, and lipoproteins through the expression of several adhesion molecules and cytokines. Obesity is a risk factor for CVD but this association is not fully understood. Altered levels of obesity related peptides such as ghrelin may play an important role in this pathophysiology. Recent evidence indicates that ghrelin features several cardiovascular activities, including increased myocardial contractility, vasodilatation and protection from myocardial infarction. Recent data demonstrate that ghrelin can influence important key events in atherogenesis and thus they may play a role in atherosclerosis. In this review we present the latest data from recent animal and clinical studies which focus on a novel approach to ghrelin as a potential therapeutic agent in the treatment of a complex disease like atherosclerosis. Thus, ghrelin may become a new therapeutic target for the treatment of CVD. Further studies are necessary to investigate the potential mechanisms involved in the effects of ghrelin on the cardiovascular system.",
journal = "Ghrelin: Production, Action Mechanisms and Physiological Effects",
booktitle = "Ghrelin, obesity and atherosclerosis",
pages = "111-126",
url = "https://hdl.handle.net/21.15107/rcub_vinar_8685"
}

Sudar, E., Soskić, S. S., Zarić, B., Rašić-Milutinović, Z., Smiljanić, K., Radak, Đ. J., Mikhailidis, D. P., Rizzo, M.,& Isenović, E. R.. (2012). Ghrelin, obesity and atherosclerosis. in Ghrelin: Production, Action Mechanisms and Physiological Effects, 111-126.
https://hdl.handle.net/21.15107/rcub_vinar_8685

Sudar E, Soskić SS, Zarić B, Rašić-Milutinović Z, Smiljanić K, Radak ĐJ, Mikhailidis DP, Rizzo M, Isenović ER. Ghrelin, obesity and atherosclerosis. in Ghrelin: Production, Action Mechanisms and Physiological Effects. 2012;:111-126.
https://hdl.handle.net/21.15107/rcub_vinar_8685 .

Sudar, Emina, Soskić, Sanja S., Zarić, Božidarka, Rašić-Milutinović, Zorica, Smiljanić, Katarina, Radak, Đorđe J., Mikhailidis, Dimitri P., Rizzo, Manfredi, Isenović, Esma R., "Ghrelin, obesity and atherosclerosis" in Ghrelin: Production, Action Mechanisms and Physiological Effects (2012):111-126,
https://hdl.handle.net/21.15107/rcub_vinar_8685 .