TY  - JOUR
AU  - Selmani, A.
AU  - Coha, I.
AU  - Magdić, K.
AU  - Čolović, Božana M.
AU  - Jokanović, Vukoman R.
AU  - Segota, S.
AU  - Gajovic, S.
AU  - Gajovic, A.
AU  - Jurasin, D.
AU  - Sikirić, Dutour M.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/805
AB  - The influence of monomeric and micellar concentrations of the cationic monomeric, dodecyltrimethylammonium bromide (DTAB), and the corresponding dimeric, bis(N, N-dimethyl-N-dodecyl) ethylene-1,2-diammonium dibromide (12-2-12), surfactants on the formation and transformation of amorphous calcium phosphate (ACP) was investigated. The combination of microscopy (AFM and TEM) and light scattering techniques (size and zeta potential measurements) enabled, for the first time, the simultaneous monitoring of the effect that additives exert on different length scales during CaP formation in solution - from prenucleation clusters and ACP particles to the crystalline phase. Depending on their aggregation state (monomers or micelles) and the geometry of the aggregate (spherical or elongated micelles), DTAB and 12-2-12 have exhibited different effects on the rate of ACP transformation, as well as on the morphology of the amorphous and crystalline phases. It was shown that the effect of surfactants on the precipitation process observed on the microscale could be a result of different pathways on the nanoscale. The obtained results may have implications for the understanding of the general mechanism of inorganic-organic interactions underlying the biomineralization processes, as well as for materials science.
T2  - CrystEngComm
T1  - Multiscale study of the influence of cationic surfactants on amorphous calcium phosphate precipitation
VL  - 17
IS  - 44
SP  - 8529
EP  - 8548
DO  - 10.1039/c5ce01516b
ER  - 

@article{
author = "Selmani, A. and Coha, I. and Magdić, K. and Čolović, Božana M. and Jokanović, Vukoman R. and Segota, S. and Gajovic, S. and Gajovic, A. and Jurasin, D. and Sikirić, Dutour M.",
year = "2015",
abstract = "The influence of monomeric and micellar concentrations of the cationic monomeric, dodecyltrimethylammonium bromide (DTAB), and the corresponding dimeric, bis(N, N-dimethyl-N-dodecyl) ethylene-1,2-diammonium dibromide (12-2-12), surfactants on the formation and transformation of amorphous calcium phosphate (ACP) was investigated. The combination of microscopy (AFM and TEM) and light scattering techniques (size and zeta potential measurements) enabled, for the first time, the simultaneous monitoring of the effect that additives exert on different length scales during CaP formation in solution - from prenucleation clusters and ACP particles to the crystalline phase. Depending on their aggregation state (monomers or micelles) and the geometry of the aggregate (spherical or elongated micelles), DTAB and 12-2-12 have exhibited different effects on the rate of ACP transformation, as well as on the morphology of the amorphous and crystalline phases. It was shown that the effect of surfactants on the precipitation process observed on the microscale could be a result of different pathways on the nanoscale. The obtained results may have implications for the understanding of the general mechanism of inorganic-organic interactions underlying the biomineralization processes, as well as for materials science.",
journal = "CrystEngComm",
title = "Multiscale study of the influence of cationic surfactants on amorphous calcium phosphate precipitation",
volume = "17",
number = "44",
pages = "8529-8548",
doi = "10.1039/c5ce01516b"
}

Selmani, A., Coha, I., Magdić, K., Čolović, B. M., Jokanović, V. R., Segota, S., Gajovic, S., Gajovic, A., Jurasin, D.,& Sikirić, D. M.. (2015). Multiscale study of the influence of cationic surfactants on amorphous calcium phosphate precipitation. in CrystEngComm, 17(44), 8529-8548.
https://doi.org/10.1039/c5ce01516b

Selmani A, Coha I, Magdić K, Čolović BM, Jokanović VR, Segota S, Gajovic S, Gajovic A, Jurasin D, Sikirić DM. Multiscale study of the influence of cationic surfactants on amorphous calcium phosphate precipitation. in CrystEngComm. 2015;17(44):8529-8548.
doi:10.1039/c5ce01516b .

Selmani, A., Coha, I., Magdić, K., Čolović, Božana M., Jokanović, Vukoman R., Segota, S., Gajovic, S., Gajovic, A., Jurasin, D., Sikirić, Dutour M., "Multiscale study of the influence of cationic surfactants on amorphous calcium phosphate precipitation" in CrystEngComm, 17, no. 44 (2015):8529-8548,
https://doi.org/10.1039/c5ce01516b . .

TY  - JOUR
AU  - Jokanović, Vukoman R.
AU  - Čolović, Božana M.
AU  - Sikirić, Dutour M.
AU  - Trajković, Vladimir S.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5166
AB  - Mesoporous silica materials have already proved to be non-toxic and biocompatible, and also to have large pore volume and very high specific surface area suitable for loading of small molecules. Having this in mind and the fact that silicon dioxide (SiO2) powders can be so designed to obtain particle structures organized at multi levels, SiO2 was chosen as a potential carrier for metronidazole, an antibiotic drug. SiO2 powder was synthesized in two stages: first silica sol was prepared by hydrothermal synthesis and second the sol was converted into powder by dry spraying with simultaneous incorporation of the antibiotic into its structure. Scanning and transmission electron microscopy study revealed very complex structure and sub-structure of SiO2 particles. Cell viability tests were used for estimation of cytotoxicity of so synthesized SiO2. The drug release data showed that the system can provide drug release for a long time. Also, the device behavior is fully predictable, according to our theoretical model of multilevel structure design, and gives many opportunities for model investigations of drug release and its kinetics. The pore sizes and their distribution were observed as a limiting factor of drug release kinetics. Therefore, as the pore sizes are given as a set of discrete values, the kinetics of drug release might also be given as a set of corresponding discrete values. (c) 2012 Elsevier B.V. All rights reserved.
T2  - Ultrasonics Sonochemistry
T1  - A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying
VL  - 20
IS  - 1
SP  - 535
EP  - 545
DO  - 10.1016/j.ultsonch.2012.08.015
ER  - 

@article{
author = "Jokanović, Vukoman R. and Čolović, Božana M. and Sikirić, Dutour M. and Trajković, Vladimir S.",
year = "2013",
abstract = "Mesoporous silica materials have already proved to be non-toxic and biocompatible, and also to have large pore volume and very high specific surface area suitable for loading of small molecules. Having this in mind and the fact that silicon dioxide (SiO2) powders can be so designed to obtain particle structures organized at multi levels, SiO2 was chosen as a potential carrier for metronidazole, an antibiotic drug. SiO2 powder was synthesized in two stages: first silica sol was prepared by hydrothermal synthesis and second the sol was converted into powder by dry spraying with simultaneous incorporation of the antibiotic into its structure. Scanning and transmission electron microscopy study revealed very complex structure and sub-structure of SiO2 particles. Cell viability tests were used for estimation of cytotoxicity of so synthesized SiO2. The drug release data showed that the system can provide drug release for a long time. Also, the device behavior is fully predictable, according to our theoretical model of multilevel structure design, and gives many opportunities for model investigations of drug release and its kinetics. The pore sizes and their distribution were observed as a limiting factor of drug release kinetics. Therefore, as the pore sizes are given as a set of discrete values, the kinetics of drug release might also be given as a set of corresponding discrete values. (c) 2012 Elsevier B.V. All rights reserved.",
journal = "Ultrasonics Sonochemistry",
title = "A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying",
volume = "20",
number = "1",
pages = "535-545",
doi = "10.1016/j.ultsonch.2012.08.015"
}

Jokanović, V. R., Čolović, B. M., Sikirić, D. M.,& Trajković, V. S.. (2013). A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying. in Ultrasonics Sonochemistry, 20(1), 535-545.
https://doi.org/10.1016/j.ultsonch.2012.08.015

Jokanović VR, Čolović BM, Sikirić DM, Trajković VS. A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying. in Ultrasonics Sonochemistry. 2013;20(1):535-545.
doi:10.1016/j.ultsonch.2012.08.015 .

Jokanović, Vukoman R., Čolović, Božana M., Sikirić, Dutour M., Trajković, Vladimir S., "A new approach to the drug release kinetics of a discrete system: SiO2 system obtained by ultrasonic dry spraying" in Ultrasonics Sonochemistry, 20, no. 1 (2013):535-545,
https://doi.org/10.1016/j.ultsonch.2012.08.015 . .