TY  - JOUR
AU  - Haidara, Mohamed A.
AU  - Assiri, Abdullah S.
AU  - Yassin, Hanaa Z.
AU  - Ammar, Hania I.
AU  - Obradović, Milan M.
AU  - Isenović, Esma R.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/716
AB  - Cardiovascular disease (CVD) is among the most major causes of morbidity and mortality worldwide. Great progress has been made in the management of CVD which has been influenced by the use of experimental animal models. These models provided information at cellular and molecular levels and allowed the development of treatment strategies. CVD models have been developed in many species, including large animals (e.g. pigs and dogs) and small animals (e.g. rats and mice). Although, no model can solely reproduce clinical HF, simulations of heart failure (HF) are available to experimentally tackle certain queries not easily resolved in humans. Induced HF may also be produced experimentally through myocardial infarction (MI), pressure loading, or volume loading. Volume loading is useful to look at hormone and electrolyte disturbances, while pressure loading models is helpful to study ventricular hypertrophy, cellular imbalance and vascular changes in HF. Coronary heart disease is assessed in MI animal models. In this review we describe various experimental models used to study the pathophysiology of HF.
T2  - Current Vascular Pharmacology
T1  - Heart Failure Models: Traditional and Novel Therapy
VL  - 13
IS  - 5
SP  - 658
EP  - 669
DO  - 10.2174/1570161113666150212151506
ER  - 

@article{
author = "Haidara, Mohamed A. and Assiri, Abdullah S. and Yassin, Hanaa Z. and Ammar, Hania I. and Obradović, Milan M. and Isenović, Esma R.",
year = "2015",
abstract = "Cardiovascular disease (CVD) is among the most major causes of morbidity and mortality worldwide. Great progress has been made in the management of CVD which has been influenced by the use of experimental animal models. These models provided information at cellular and molecular levels and allowed the development of treatment strategies. CVD models have been developed in many species, including large animals (e.g. pigs and dogs) and small animals (e.g. rats and mice). Although, no model can solely reproduce clinical HF, simulations of heart failure (HF) are available to experimentally tackle certain queries not easily resolved in humans. Induced HF may also be produced experimentally through myocardial infarction (MI), pressure loading, or volume loading. Volume loading is useful to look at hormone and electrolyte disturbances, while pressure loading models is helpful to study ventricular hypertrophy, cellular imbalance and vascular changes in HF. Coronary heart disease is assessed in MI animal models. In this review we describe various experimental models used to study the pathophysiology of HF.",
journal = "Current Vascular Pharmacology",
title = "Heart Failure Models: Traditional and Novel Therapy",
volume = "13",
number = "5",
pages = "658-669",
doi = "10.2174/1570161113666150212151506"
}

Haidara, M. A., Assiri, A. S., Yassin, H. Z., Ammar, H. I., Obradović, M. M.,& Isenović, E. R.. (2015). Heart Failure Models: Traditional and Novel Therapy. in Current Vascular Pharmacology, 13(5), 658-669.
https://doi.org/10.2174/1570161113666150212151506

Haidara MA, Assiri AS, Yassin HZ, Ammar HI, Obradović MM, Isenović ER. Heart Failure Models: Traditional and Novel Therapy. in Current Vascular Pharmacology. 2015;13(5):658-669.
doi:10.2174/1570161113666150212151506 .

Haidara, Mohamed A., Assiri, Abdullah S., Yassin, Hanaa Z., Ammar, Hania I., Obradović, Milan M., Isenović, Esma R., "Heart Failure Models: Traditional and Novel Therapy" in Current Vascular Pharmacology, 13, no. 5 (2015):658-669,
https://doi.org/10.2174/1570161113666150212151506 . .

TY  - JOUR
AU  - Haidara, Mohamed A.
AU  - Mikhailidis, Dimitri P.
AU  - Yassin, Hanaa Z.
AU  - Dobutović, Branislava
AU  - Smiljanić, Katarina
AU  - Soskić, Sanja S.
AU  - Mousa, Shaker A.
AU  - Rizzo, Manfredi
AU  - Isenović, Esma R.
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4662
AB  - The metabolic syndrome (MetS) is common, and its associated risk burdens of diabetes and cardiovascular disease (CVD) are a major public health problem. The hypothesis that main constituent parameters of the MetS share common pathophysiologic mechanisms provides a conceptual framework for the future research. Exercise and weight loss can prevent insulin resistance and reduce the risk of diseases associated with the MetS. Interrupting intracellular and extracellular reactive oxygen species (ROS) overproduction could also contribute to normalizing the activation of metabolic pathways leading to the onset of diabetes, endothelial dysfunction, and cardiovascular (CV) complications. On the other hand, it is difficult to counteract the development of CV complications by using conventional antioxidants. Indeed, interest has focused on strategies that enhance the removal of ROS using either antioxidants or drugs that enhance endogenous antioxidant defense. Although these strategies have been effective in laboratory experiments, several clinical trials have shown that they do not reduce CV events, and in some cases antioxidants have actually worsened the outcome. More research is needed in this field.
T2  - Current Pharmaceutical Design
T1  - Evaluation of the Possible Contribution of Antioxidants Administration in Metabolic Syndrome
VL  - 17
IS  - 33
SP  - 3699
EP  - 3712
DO  - 10.2174/138161211798220882
ER  - 

@article{
author = "Haidara, Mohamed A. and Mikhailidis, Dimitri P. and Yassin, Hanaa Z. and Dobutović, Branislava and Smiljanić, Katarina and Soskić, Sanja S. and Mousa, Shaker A. and Rizzo, Manfredi and Isenović, Esma R.",
year = "2011",
abstract = "The metabolic syndrome (MetS) is common, and its associated risk burdens of diabetes and cardiovascular disease (CVD) are a major public health problem. The hypothesis that main constituent parameters of the MetS share common pathophysiologic mechanisms provides a conceptual framework for the future research. Exercise and weight loss can prevent insulin resistance and reduce the risk of diseases associated with the MetS. Interrupting intracellular and extracellular reactive oxygen species (ROS) overproduction could also contribute to normalizing the activation of metabolic pathways leading to the onset of diabetes, endothelial dysfunction, and cardiovascular (CV) complications. On the other hand, it is difficult to counteract the development of CV complications by using conventional antioxidants. Indeed, interest has focused on strategies that enhance the removal of ROS using either antioxidants or drugs that enhance endogenous antioxidant defense. Although these strategies have been effective in laboratory experiments, several clinical trials have shown that they do not reduce CV events, and in some cases antioxidants have actually worsened the outcome. More research is needed in this field.",
journal = "Current Pharmaceutical Design",
title = "Evaluation of the Possible Contribution of Antioxidants Administration in Metabolic Syndrome",
volume = "17",
number = "33",
pages = "3699-3712",
doi = "10.2174/138161211798220882"
}

Haidara, M. A., Mikhailidis, D. P., Yassin, H. Z., Dobutović, B., Smiljanić, K., Soskić, S. S., Mousa, S. A., Rizzo, M.,& Isenović, E. R.. (2011). Evaluation of the Possible Contribution of Antioxidants Administration in Metabolic Syndrome. in Current Pharmaceutical Design, 17(33), 3699-3712.
https://doi.org/10.2174/138161211798220882

Haidara MA, Mikhailidis DP, Yassin HZ, Dobutović B, Smiljanić K, Soskić SS, Mousa SA, Rizzo M, Isenović ER. Evaluation of the Possible Contribution of Antioxidants Administration in Metabolic Syndrome. in Current Pharmaceutical Design. 2011;17(33):3699-3712.
doi:10.2174/138161211798220882 .

Haidara, Mohamed A., Mikhailidis, Dimitri P., Yassin, Hanaa Z., Dobutović, Branislava, Smiljanić, Katarina, Soskić, Sanja S., Mousa, Shaker A., Rizzo, Manfredi, Isenović, Esma R., "Evaluation of the Possible Contribution of Antioxidants Administration in Metabolic Syndrome" in Current Pharmaceutical Design, 17, no. 33 (2011):3699-3712,
https://doi.org/10.2174/138161211798220882 . .

TY  - JOUR
AU  - Bin-Jaliah, Ismaeel
AU  - Ammar, Hania I.
AU  - Mikhailidis, Dimitri P.
AU  - Dallak, Mohammed A.
AU  - Al-Hashem, Fahaid H.
AU  - Haidara, Mohamed A.
AU  - Yassin, Hanaa Z.
AU  - Bahnasi, Abeer A.
AU  - Rashed, Laila A.
AU  - Isenović, Esma R.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3883
AB  - The role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (Delta P/Delta t(max)) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P LT .001), RPP (P LT .001), and Delta P/Delta t(max) (P LT .001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechanisms.
T2  - Angiology
T1  - Cardiac Adaptive Responses After Hypoxia in an Experimental Model
VL  - 61
IS  - 2
SP  - 145
EP  - 156
DO  - 10.1177/0003319709352486
ER  - 

@article{
author = "Bin-Jaliah, Ismaeel and Ammar, Hania I. and Mikhailidis, Dimitri P. and Dallak, Mohammed A. and Al-Hashem, Fahaid H. and Haidara, Mohamed A. and Yassin, Hanaa Z. and Bahnasi, Abeer A. and Rashed, Laila A. and Isenović, Esma R.",
year = "2010",
abstract = "The role of vascular endothelial growth factor (VEGF) and erythropoietin (EPO) in mediating hypoxic preconditioning under the acute intermittent hypoxic condition (AIH) was investigated in this study. Male Wistar rats were randomly assigned and kept in normoxic conditions, (Nx) or in AIH conditions and subjected to brief cycles hypoxia/reoxygenation. Hearts were isolated, perfused, and subjected to in vitro global ischemia followed by reperfusion. During and at the end of reperfusion, left ventricular developed pressure (LVDP); LV end diastolic pressure (LVEDP); rate pressure product (RPP); peak left ventricular pressure rise (Delta P/Delta t(max)) and heart rate (HR) were measured. Hearts subjected to AIH displayed a significant higher LVDP (P LT .001), RPP (P LT .001), and Delta P/Delta t(max) (P LT .001). Expression of VEGF and EPO were significantly increased at 3, 8, and 24 hours after AIH. Hypoxic training could provide a new approach to enhance endogenous cardioprotective mechanisms.",
journal = "Angiology",
title = "Cardiac Adaptive Responses After Hypoxia in an Experimental Model",
volume = "61",
number = "2",
pages = "145-156",
doi = "10.1177/0003319709352486"
}

Bin-Jaliah, I., Ammar, H. I., Mikhailidis, D. P., Dallak, M. A., Al-Hashem, F. H., Haidara, M. A., Yassin, H. Z., Bahnasi, A. A., Rashed, L. A.,& Isenović, E. R.. (2010). Cardiac Adaptive Responses After Hypoxia in an Experimental Model. in Angiology, 61(2), 145-156.
https://doi.org/10.1177/0003319709352486

Bin-Jaliah I, Ammar HI, Mikhailidis DP, Dallak MA, Al-Hashem FH, Haidara MA, Yassin HZ, Bahnasi AA, Rashed LA, Isenović ER. Cardiac Adaptive Responses After Hypoxia in an Experimental Model. in Angiology. 2010;61(2):145-156.
doi:10.1177/0003319709352486 .

Bin-Jaliah, Ismaeel, Ammar, Hania I., Mikhailidis, Dimitri P., Dallak, Mohammed A., Al-Hashem, Fahaid H., Haidara, Mohamed A., Yassin, Hanaa Z., Bahnasi, Abeer A., Rashed, Laila A., Isenović, Esma R., "Cardiac Adaptive Responses After Hypoxia in an Experimental Model" in Angiology, 61, no. 2 (2010):145-156,
https://doi.org/10.1177/0003319709352486 . .

TY  - JOUR
AU  - Haidara, Mohamed A.
AU  - Yassin, Hanaa Z.
AU  - Žakula, Zorica
AU  - Mikhailidis, Dimitri P.
AU  - Isenović, Esma R.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4112
AB  - Numerous studies have shown that increased oxidative stress (OxS) is present in diabetic patients. There is evidence that this OxS can be increased before complications associated with diabetes mellitus (DM) occur. However, the role and influence of OxS in the initiation and progression of DM remains the subject of debate. It has been suggested that in DM, OxS is caused by increased production of reactive oxygen species (ROS), and associated with reduction in antioxidant defenses and altered cellular redox status. Acute and chronic OxS which could enhance the development of complications associated with DM. This review considers recent findings on the role of antioxidants in controlling OxS and the incidence of DM with emphasis on animal and human studies.
T2  - Current Vascular Pharmacology
T1  - Diabetes and Antioxidants: Myth or Reality?
VL  - 8
IS  - 5
SP  - 661
EP  - 672
UR  - https://hdl.handle.net/21.15107/rcub_vinar_4112
ER  - 

@article{
author = "Haidara, Mohamed A. and Yassin, Hanaa Z. and Žakula, Zorica and Mikhailidis, Dimitri P. and Isenović, Esma R.",
year = "2010",
abstract = "Numerous studies have shown that increased oxidative stress (OxS) is present in diabetic patients. There is evidence that this OxS can be increased before complications associated with diabetes mellitus (DM) occur. However, the role and influence of OxS in the initiation and progression of DM remains the subject of debate. It has been suggested that in DM, OxS is caused by increased production of reactive oxygen species (ROS), and associated with reduction in antioxidant defenses and altered cellular redox status. Acute and chronic OxS which could enhance the development of complications associated with DM. This review considers recent findings on the role of antioxidants in controlling OxS and the incidence of DM with emphasis on animal and human studies.",
journal = "Current Vascular Pharmacology",
title = "Diabetes and Antioxidants: Myth or Reality?",
volume = "8",
number = "5",
pages = "661-672",
url = "https://hdl.handle.net/21.15107/rcub_vinar_4112"
}

Haidara, M. A., Yassin, H. Z., Žakula, Z., Mikhailidis, D. P.,& Isenović, E. R.. (2010). Diabetes and Antioxidants: Myth or Reality?. in Current Vascular Pharmacology, 8(5), 661-672.
https://hdl.handle.net/21.15107/rcub_vinar_4112

Haidara MA, Yassin HZ, Žakula Z, Mikhailidis DP, Isenović ER. Diabetes and Antioxidants: Myth or Reality?. in Current Vascular Pharmacology. 2010;8(5):661-672.
https://hdl.handle.net/21.15107/rcub_vinar_4112 .

Haidara, Mohamed A., Yassin, Hanaa Z., Žakula, Zorica, Mikhailidis, Dimitri P., Isenović, Esma R., "Diabetes and Antioxidants: Myth or Reality?" in Current Vascular Pharmacology, 8, no. 5 (2010):661-672,
https://hdl.handle.net/21.15107/rcub_vinar_4112 .