TY  - JOUR
AU  - Halliday, J. S.
AU  - Đorđević, Jelena D.
AU  - Lust, M.
AU  - Culver, E. L.
AU  - Braden, B.
AU  - Travis, S. P. L.
AU  - Chapman, R. W. G.
PY  - 2012
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4731
AB  - Background and aims: A distinct clinical phenotype has been demonstrated for ulcerative colitis with concomitant primary sclerosing cholangitis (PSC). The course and behaviour of Crohns disease (CD) with PSC has, in contrast, never been defined. We aimed to define the characteristics of patients with concomitant PSC and CD. Methods: The Oxford PSC and IBD databases were abstracted for: PSC subtype, date of diagnosis, symptom onset, smoking history, Mayo Clinic PSC score and outcomes (hepatic failure, liver transplantation, Montreal CD classification, treatment, cancer and death). Patients with PSC/CD were matched 1:2 to two control groups: one with PSC/UC and one with isolated CD. Results: 240 patients with PSC were identified; 32 (13%) with CD, 129 (54%) with co-existing UC, and 79 had PSC without IBD. For PSC/CD vs. CD controls, isolated ileal CD was less common (6% vs. 31%, p=0.03). Smoking was less common in PSC/CD (13% vs. 34%, p=0.045). No difference in the distribution of CD, or treatment required was observed. For PSC/CD vs. PSC/UC controls, more patients with PSC/CD were female (50% vs. 28%, p=0.021). 22% of PSC/CD patients had small duct PSC compared with 6% with PSC/UC, (p=0.038). Major event-free survival was prolonged in the PSC/CD group compared with PSC/UC, (Cox regression p=0.04). Conclusion: Unlike PSC/UC, patients with PSC/CD were as likely to be female as male, more commonly had small duct PSC and less commonly progressed to cancer, liver transplantation, or death. Compared to patients with isolated CD, patients with PSC/CD were less likely to smoke or have ileal disease. (C) 2011 European Crohns and Colitis Organisation. Published by Elsevier B.V. All rights reserved.
T2  - Journal of Crohns and Colitis
T1  - A unique clinical phenotype of primary sclerosing cholangitis associated with Crohns disease
VL  - 6
IS  - 2
SP  - 174
EP  - 181
DO  - 10.1016/j.crohns.2011.07.015
ER  - 

@article{
author = "Halliday, J. S. and Đorđević, Jelena D. and Lust, M. and Culver, E. L. and Braden, B. and Travis, S. P. L. and Chapman, R. W. G.",
year = "2012",
abstract = "Background and aims: A distinct clinical phenotype has been demonstrated for ulcerative colitis with concomitant primary sclerosing cholangitis (PSC). The course and behaviour of Crohns disease (CD) with PSC has, in contrast, never been defined. We aimed to define the characteristics of patients with concomitant PSC and CD. Methods: The Oxford PSC and IBD databases were abstracted for: PSC subtype, date of diagnosis, symptom onset, smoking history, Mayo Clinic PSC score and outcomes (hepatic failure, liver transplantation, Montreal CD classification, treatment, cancer and death). Patients with PSC/CD were matched 1:2 to two control groups: one with PSC/UC and one with isolated CD. Results: 240 patients with PSC were identified; 32 (13%) with CD, 129 (54%) with co-existing UC, and 79 had PSC without IBD. For PSC/CD vs. CD controls, isolated ileal CD was less common (6% vs. 31%, p=0.03). Smoking was less common in PSC/CD (13% vs. 34%, p=0.045). No difference in the distribution of CD, or treatment required was observed. For PSC/CD vs. PSC/UC controls, more patients with PSC/CD were female (50% vs. 28%, p=0.021). 22% of PSC/CD patients had small duct PSC compared with 6% with PSC/UC, (p=0.038). Major event-free survival was prolonged in the PSC/CD group compared with PSC/UC, (Cox regression p=0.04). Conclusion: Unlike PSC/UC, patients with PSC/CD were as likely to be female as male, more commonly had small duct PSC and less commonly progressed to cancer, liver transplantation, or death. Compared to patients with isolated CD, patients with PSC/CD were less likely to smoke or have ileal disease. (C) 2011 European Crohns and Colitis Organisation. Published by Elsevier B.V. All rights reserved.",
journal = "Journal of Crohns and Colitis",
title = "A unique clinical phenotype of primary sclerosing cholangitis associated with Crohns disease",
volume = "6",
number = "2",
pages = "174-181",
doi = "10.1016/j.crohns.2011.07.015"
}

Halliday, J. S., Đorđević, J. D., Lust, M., Culver, E. L., Braden, B., Travis, S. P. L.,& Chapman, R. W. G.. (2012). A unique clinical phenotype of primary sclerosing cholangitis associated with Crohns disease. in Journal of Crohns and Colitis, 6(2), 174-181.
https://doi.org/10.1016/j.crohns.2011.07.015

Halliday JS, Đorđević JD, Lust M, Culver EL, Braden B, Travis SPL, Chapman RWG. A unique clinical phenotype of primary sclerosing cholangitis associated with Crohns disease. in Journal of Crohns and Colitis. 2012;6(2):174-181.
doi:10.1016/j.crohns.2011.07.015 .

Halliday, J. S., Đorđević, Jelena D., Lust, M., Culver, E. L., Braden, B., Travis, S. P. L., Chapman, R. W. G., "A unique clinical phenotype of primary sclerosing cholangitis associated with Crohns disease" in Journal of Crohns and Colitis, 6, no. 2 (2012):174-181,
https://doi.org/10.1016/j.crohns.2011.07.015 . .