TY  - CONF
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatovic, Ivan
AU  - Andrić, Sanja
AU  - Mirjanic, Tijana
AU  - Novaković, Ivana
AU  - Adžić, Miroslav
AU  - Marić, Nađa
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7157
C3  - Schizophrenia Bulletin
T1  - Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls
VL  - 43
SP  - S195
EP  - S195
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7157
ER  - 

@conference{
author = "Mihaljević, Marina and Franić, Dušanka and Soldatovic, Ivan and Andrić, Sanja and Mirjanic, Tijana and Novaković, Ivana and Adžić, Miroslav and Marić, Nađa",
year = "2017",
journal = "Schizophrenia Bulletin",
title = "Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls",
volume = "43",
pages = "S195-S195",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7157"
}

Mihaljević, M., Franić, D., Soldatovic, I., Andrić, S., Mirjanic, T., Novaković, I., Adžić, M.,& Marić, N.. (2017). Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls. in Schizophrenia Bulletin, 43, S195-S195.
https://hdl.handle.net/21.15107/rcub_vinar_7157

Mihaljević M, Franić D, Soldatovic I, Andrić S, Mirjanic T, Novaković I, Adžić M, Marić N. Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls. in Schizophrenia Bulletin. 2017;43:S195-S195.
https://hdl.handle.net/21.15107/rcub_vinar_7157 .

Mihaljević, Marina, Franić, Dušanka, Soldatovic, Ivan, Andrić, Sanja, Mirjanic, Tijana, Novaković, Ivana, Adžić, Miroslav, Marić, Nađa, "Allele-Specific and Trauma-Related Epigenetic Changes in the Fkbp5 Gene: Differences Between Psychotic Patients and Healthy Controls" in Schizophrenia Bulletin, 43 (2017):S195-S195,
https://hdl.handle.net/21.15107/rcub_vinar_7157 .

TY  - CONF
AU  - Marić, Nađa
AU  - Mihaljević, Marina
AU  - Franić, Dušanka
AU  - Soldatovic, Ivan
AU  - Andrić, Sanja
AU  - Lukić, Iva
AU  - Mirjanic, Tijana
AU  - Stankovic, Biljana
AU  - Zukic, Branka
AU  - Dobricic, Valerija
AU  - Novaković, Ivana
AU  - Pavlović, Sonja
AU  - Adžić, Miroslav
PY  - 2017
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7156
C3  - Schizophrenia Bulletin
T1  - The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation
VL  - 43
SP  - S66
EP  - S66
UR  - https://hdl.handle.net/21.15107/rcub_vinar_7156
ER  - 

@conference{
author = "Marić, Nađa and Mihaljević, Marina and Franić, Dušanka and Soldatovic, Ivan and Andrić, Sanja and Lukić, Iva and Mirjanic, Tijana and Stankovic, Biljana and Zukic, Branka and Dobricic, Valerija and Novaković, Ivana and Pavlović, Sonja and Adžić, Miroslav",
year = "2017",
journal = "Schizophrenia Bulletin",
title = "The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation",
volume = "43",
pages = "S66-S66",
url = "https://hdl.handle.net/21.15107/rcub_vinar_7156"
}

Marić, N., Mihaljević, M., Franić, D., Soldatovic, I., Andrić, S., Lukić, I., Mirjanic, T., Stankovic, B., Zukic, B., Dobricic, V., Novaković, I., Pavlović, S.,& Adžić, M.. (2017). The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation. in Schizophrenia Bulletin, 43, S66-S66.
https://hdl.handle.net/21.15107/rcub_vinar_7156

Marić N, Mihaljević M, Franić D, Soldatovic I, Andrić S, Lukić I, Mirjanic T, Stankovic B, Zukic B, Dobricic V, Novaković I, Pavlović S, Adžić M. The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation. in Schizophrenia Bulletin. 2017;43:S66-S66.
https://hdl.handle.net/21.15107/rcub_vinar_7156 .

Marić, Nađa, Mihaljević, Marina, Franić, Dušanka, Soldatovic, Ivan, Andrić, Sanja, Lukić, Iva, Mirjanic, Tijana, Stankovic, Biljana, Zukic, Branka, Dobricic, Valerija, Novaković, Ivana, Pavlović, Sonja, Adžić, Miroslav, "The Signature of Trauma in Psychosis: a Preliminary Genetic and Epigenetic Analyses of Fk506-Binding Protein 5 Regulation" in Schizophrenia Bulletin, 43 (2017):S66-S66,
https://hdl.handle.net/21.15107/rcub_vinar_7156 .

TY  - JOUR
AU  - Lukić, Iva
AU  - Mitić, Miloš
AU  - Soldatovic, Ivan
AU  - Jovičić, Milica
AU  - Marić, Nađa
AU  - Radulović, Jelena
AU  - Adžić, Miroslav
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/445
AB  - We have previously shown that patients with the major depressive disorder (MDD) exhibited elevated phosphorylation of the lymphocyte glucocorticoid receptor (GR) at serine 226 (S226). Here, we further analyse potential alterations of GR signalization in lymphocytes of MDD patients, i.e. the cytoplasmic/nuclear distribution of GR, levels of FK506-binding protein 5 (FKBP5) and glucocorticoid-induced leucine zipper (GILZ). The FKBP5 acts as an important regulator of GR activation, by decreasing ligand binding and impeding translocation of the receptor to the nucleus, while GILZ mediates glucocorticoid anti-inflammatory effects. Our result showed that the depressed patients had significantly higher GR levels in the cytoplasm compared to controls, which was accompanied by higher FKBP5 levels. Linear regression model demonstrated significantly higher correlation between FKBP5 and cytoplasmic GR than the presence of MDD itself or phosphorylation of nuclear GR at S226. There were no differences in the levels of GILZ isoforms. Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients.
T2  - Journal of Molecular Neuroscience
T1  - Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients
VL  - 55
IS  - 4
SP  - 951
EP  - 958
DO  - 10.1007/s12031-014-0451-z
ER  - 

@article{
author = "Lukić, Iva and Mitić, Miloš and Soldatovic, Ivan and Jovičić, Milica and Marić, Nađa and Radulović, Jelena and Adžić, Miroslav",
year = "2015",
abstract = "We have previously shown that patients with the major depressive disorder (MDD) exhibited elevated phosphorylation of the lymphocyte glucocorticoid receptor (GR) at serine 226 (S226). Here, we further analyse potential alterations of GR signalization in lymphocytes of MDD patients, i.e. the cytoplasmic/nuclear distribution of GR, levels of FK506-binding protein 5 (FKBP5) and glucocorticoid-induced leucine zipper (GILZ). The FKBP5 acts as an important regulator of GR activation, by decreasing ligand binding and impeding translocation of the receptor to the nucleus, while GILZ mediates glucocorticoid anti-inflammatory effects. Our result showed that the depressed patients had significantly higher GR levels in the cytoplasm compared to controls, which was accompanied by higher FKBP5 levels. Linear regression model demonstrated significantly higher correlation between FKBP5 and cytoplasmic GR than the presence of MDD itself or phosphorylation of nuclear GR at S226. There were no differences in the levels of GILZ isoforms. Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients.",
journal = "Journal of Molecular Neuroscience",
title = "Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients",
volume = "55",
number = "4",
pages = "951-958",
doi = "10.1007/s12031-014-0451-z"
}

Lukić, I., Mitić, M., Soldatovic, I., Jovičić, M., Marić, N., Radulović, J.,& Adžić, M.. (2015). Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients. in Journal of Molecular Neuroscience, 55(4), 951-958.
https://doi.org/10.1007/s12031-014-0451-z

Lukić I, Mitić M, Soldatovic I, Jovičić M, Marić N, Radulović J, Adžić M. Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients. in Journal of Molecular Neuroscience. 2015;55(4):951-958.
doi:10.1007/s12031-014-0451-z .

Lukić, Iva, Mitić, Miloš, Soldatovic, Ivan, Jovičić, Milica, Marić, Nađa, Radulović, Jelena, Adžić, Miroslav, "Accumulation of Cytoplasmic Glucocorticoid Receptor Is Related to Elevation of FKBP5 in Lymphocytes of Depressed Patients" in Journal of Molecular Neuroscience, 55, no. 4 (2015):951-958,
https://doi.org/10.1007/s12031-014-0451-z . .

TY  - JOUR
AU  - Simić, Iva
AU  - Adžić, Miroslav
AU  - Marić, Nađa
AU  - Savić, Danka A.
AU  - Đorđević, Jelena D.
AU  - Mihaljević, Marina
AU  - Mitić, Miloš
AU  - Pavlović, Zorana
AU  - Soldatovic, Ivan
AU  - Krstić-Demonacos, Marija
AU  - Jasovic-Gasic, Miroslava
AU  - Radoičić, Marija B.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5753
AB  - The mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
T2  - Psychiatry Research
T1  - A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults
VL  - 209
IS  - 3
SP  - 658
EP  - 664
DO  - 10.1016/j.psychres.2013.02.002
ER  - 

@article{
author = "Simić, Iva and Adžić, Miroslav and Marić, Nađa and Savić, Danka A. and Đorđević, Jelena D. and Mihaljević, Marina and Mitić, Miloš and Pavlović, Zorana and Soldatovic, Ivan and Krstić-Demonacos, Marija and Jasovic-Gasic, Miroslava and Radoičić, Marija B.",
year = "2013",
abstract = "The mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.",
journal = "Psychiatry Research",
title = "A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults",
volume = "209",
number = "3",
pages = "658-664",
doi = "10.1016/j.psychres.2013.02.002"
}

Simić, I., Adžić, M., Marić, N., Savić, D. A., Đorđević, J. D., Mihaljević, M., Mitić, M., Pavlović, Z., Soldatovic, I., Krstić-Demonacos, M., Jasovic-Gasic, M.,& Radoičić, M. B.. (2013). A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. in Psychiatry Research, 209(3), 658-664.
https://doi.org/10.1016/j.psychres.2013.02.002

Simić I, Adžić M, Marić N, Savić DA, Đorđević JD, Mihaljević M, Mitić M, Pavlović Z, Soldatovic I, Krstić-Demonacos M, Jasovic-Gasic M, Radoičić MB. A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. in Psychiatry Research. 2013;209(3):658-664.
doi:10.1016/j.psychres.2013.02.002 .

Simić, Iva, Adžić, Miroslav, Marić, Nađa, Savić, Danka A., Đorđević, Jelena D., Mihaljević, Marina, Mitić, Miloš, Pavlović, Zorana, Soldatovic, Ivan, Krstić-Demonacos, Marija, Jasovic-Gasic, Miroslava, Radoičić, Marija B., "A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults" in Psychiatry Research, 209, no. 3 (2013):658-664,
https://doi.org/10.1016/j.psychres.2013.02.002 . .