TY  - JOUR
AU  - Cvijic, Gordana
AU  - Lakić, Iva
AU  - Vujovic, R.
AU  - Jasnic, N.
AU  - Djurasevic, S.
AU  - Dronjak, Slađana
AU  - Đorđević, Jelena D.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5603
AB  - The aim of this study was to examine whether the thermogenic potential of rat interscapular brown adipose tissue (IBAT) changes in response to acute and/or chronic exposure to non-thermal stressors (immobilization and isolation), by measuring the uncoupling protein 1 (UCP-1) content, MAO-A, SOD and CAT activities, as well as the number of IBAT sympathetic noradrenaline-containing nerve fibers. Both acute immobilization (2 h) and chronic isolation (21 days), as well as their combined effects, significantly increased the IBAT UCP-1 content in comparison to non-stressed animals. When applied individually, stressors increased the number of sympathetic fibers in comparison to controls, whereas in combination they decreased it. The activity of IBAT monoamine oxidase-A (MAO-A) decreased under the influence of each stressor independent of its type or duration. SOD activity coincided with MAO-A decrement, whereas CAT activity had an opposite pattern of changes. We conclude that acute and chronic exposure to non-thermal stressors, immobilization and isolation, respectively, affect the metabolic potential of rat IBAT, judging by the increase in UCP-1 content and sympathetic outflow. However, when acute immobilization was applied as a novel stressor to previously chronically isolated animals, an increase in the UCP-1 content was accompanied by a lower IBAT sympathetic outflow, suggesting that IBAT metabolic function under various stress condition is not solely dependent on SNS activity.
T2  - Archives of Biological Sciences
T1  - Single and Combined Effects of Acute and Chronic Non-Thermal Stressors on Rat Interscapular Brown Adipose Tissue Metabolic Activity
VL  - 65
IS  - 3
SP  - 919
EP  - 927
DO  - 10.2298/ABS1303919C
ER  - 

@article{
author = "Cvijic, Gordana and Lakić, Iva and Vujovic, R. and Jasnic, N. and Djurasevic, S. and Dronjak, Slađana and Đorđević, Jelena D.",
year = "2013",
abstract = "The aim of this study was to examine whether the thermogenic potential of rat interscapular brown adipose tissue (IBAT) changes in response to acute and/or chronic exposure to non-thermal stressors (immobilization and isolation), by measuring the uncoupling protein 1 (UCP-1) content, MAO-A, SOD and CAT activities, as well as the number of IBAT sympathetic noradrenaline-containing nerve fibers. Both acute immobilization (2 h) and chronic isolation (21 days), as well as their combined effects, significantly increased the IBAT UCP-1 content in comparison to non-stressed animals. When applied individually, stressors increased the number of sympathetic fibers in comparison to controls, whereas in combination they decreased it. The activity of IBAT monoamine oxidase-A (MAO-A) decreased under the influence of each stressor independent of its type or duration. SOD activity coincided with MAO-A decrement, whereas CAT activity had an opposite pattern of changes. We conclude that acute and chronic exposure to non-thermal stressors, immobilization and isolation, respectively, affect the metabolic potential of rat IBAT, judging by the increase in UCP-1 content and sympathetic outflow. However, when acute immobilization was applied as a novel stressor to previously chronically isolated animals, an increase in the UCP-1 content was accompanied by a lower IBAT sympathetic outflow, suggesting that IBAT metabolic function under various stress condition is not solely dependent on SNS activity.",
journal = "Archives of Biological Sciences",
title = "Single and Combined Effects of Acute and Chronic Non-Thermal Stressors on Rat Interscapular Brown Adipose Tissue Metabolic Activity",
volume = "65",
number = "3",
pages = "919-927",
doi = "10.2298/ABS1303919C"
}

Cvijic, G., Lakić, I., Vujovic, R., Jasnic, N., Djurasevic, S., Dronjak, S.,& Đorđević, J. D.. (2013). Single and Combined Effects of Acute and Chronic Non-Thermal Stressors on Rat Interscapular Brown Adipose Tissue Metabolic Activity. in Archives of Biological Sciences, 65(3), 919-927.
https://doi.org/10.2298/ABS1303919C

Cvijic G, Lakić I, Vujovic R, Jasnic N, Djurasevic S, Dronjak S, Đorđević JD. Single and Combined Effects of Acute and Chronic Non-Thermal Stressors on Rat Interscapular Brown Adipose Tissue Metabolic Activity. in Archives of Biological Sciences. 2013;65(3):919-927.
doi:10.2298/ABS1303919C .

Cvijic, Gordana, Lakić, Iva, Vujovic, R., Jasnic, N., Djurasevic, S., Dronjak, Slađana, Đorđević, Jelena D., "Single and Combined Effects of Acute and Chronic Non-Thermal Stressors on Rat Interscapular Brown Adipose Tissue Metabolic Activity" in Archives of Biological Sciences, 65, no. 3 (2013):919-927,
https://doi.org/10.2298/ABS1303919C . .

TY  - JOUR
AU  - Lakić, Iva
AU  - Drenca, Tamara
AU  - Đorđević, Jelena D.
AU  - Vujovic, P.
AU  - Jasnic, N.
AU  - Djurasevic, S.
AU  - Dronjak, Slađana
AU  - Cvijic, Gordana
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4466
AB  - Interscapular brown adipose tissue (IBAT) is an energy storing organ involved in the maintenance of homeostasis in stress conditions when the balance of energy supplies is disturbed. The major regulator of IBAT activity is the sympathetic nervous system (SNS). Since genetic background is responsible for the individual differences in neuroendocrine stress responsivity, spontaneously hypertensive rats (SHR) that have a genetically increased general sympathetic output are a useful model for studying adaptive processes in stress conditions. Our aim was to test the effect of acute and/or chronic exposure to various stressors (thermal-cold, psychophysical-immobilization and psychosocial-isolation) on IBAT SNS and the metabolic activity in SHR, by measuring the number of monoamine-containing nerve endings and uncoupling protein-1 (UCP-1) content. The obtained results show that the IBAT SNS activity of unstressed SHR was stimulated by the administration of a single acute or chronic stressor and was independent of the duration or type of stressor, while chronic pre-stress of isolation suppressed further the SNS reaction to novel acute stress exposure. The IBAT UCP-1 content followed SNS changes, suggesting that this system is dominant in the regulation of IBAT metabolic rate in SHR.
T2  - Archives of Biological Sciences
T1  - Novel Acute Stressor Effects on Interscapular Brown Adipose Tissue Sympathetic Inervation and Ucp-1 Content in Chronically Isolated and Spontaneously Hypertensive Rats
VL  - 63
IS  - 3
SP  - 589
EP  - 596
DO  - 10.2298/ABS1103589L
ER  - 

@article{
author = "Lakić, Iva and Drenca, Tamara and Đorđević, Jelena D. and Vujovic, P. and Jasnic, N. and Djurasevic, S. and Dronjak, Slađana and Cvijic, Gordana",
year = "2011",
abstract = "Interscapular brown adipose tissue (IBAT) is an energy storing organ involved in the maintenance of homeostasis in stress conditions when the balance of energy supplies is disturbed. The major regulator of IBAT activity is the sympathetic nervous system (SNS). Since genetic background is responsible for the individual differences in neuroendocrine stress responsivity, spontaneously hypertensive rats (SHR) that have a genetically increased general sympathetic output are a useful model for studying adaptive processes in stress conditions. Our aim was to test the effect of acute and/or chronic exposure to various stressors (thermal-cold, psychophysical-immobilization and psychosocial-isolation) on IBAT SNS and the metabolic activity in SHR, by measuring the number of monoamine-containing nerve endings and uncoupling protein-1 (UCP-1) content. The obtained results show that the IBAT SNS activity of unstressed SHR was stimulated by the administration of a single acute or chronic stressor and was independent of the duration or type of stressor, while chronic pre-stress of isolation suppressed further the SNS reaction to novel acute stress exposure. The IBAT UCP-1 content followed SNS changes, suggesting that this system is dominant in the regulation of IBAT metabolic rate in SHR.",
journal = "Archives of Biological Sciences",
title = "Novel Acute Stressor Effects on Interscapular Brown Adipose Tissue Sympathetic Inervation and Ucp-1 Content in Chronically Isolated and Spontaneously Hypertensive Rats",
volume = "63",
number = "3",
pages = "589-596",
doi = "10.2298/ABS1103589L"
}

Lakić, I., Drenca, T., Đorđević, J. D., Vujovic, P., Jasnic, N., Djurasevic, S., Dronjak, S.,& Cvijic, G.. (2011). Novel Acute Stressor Effects on Interscapular Brown Adipose Tissue Sympathetic Inervation and Ucp-1 Content in Chronically Isolated and Spontaneously Hypertensive Rats. in Archives of Biological Sciences, 63(3), 589-596.
https://doi.org/10.2298/ABS1103589L

Lakić I, Drenca T, Đorđević JD, Vujovic P, Jasnic N, Djurasevic S, Dronjak S, Cvijic G. Novel Acute Stressor Effects on Interscapular Brown Adipose Tissue Sympathetic Inervation and Ucp-1 Content in Chronically Isolated and Spontaneously Hypertensive Rats. in Archives of Biological Sciences. 2011;63(3):589-596.
doi:10.2298/ABS1103589L .

Lakić, Iva, Drenca, Tamara, Đorđević, Jelena D., Vujovic, P., Jasnic, N., Djurasevic, S., Dronjak, Slađana, Cvijic, Gordana, "Novel Acute Stressor Effects on Interscapular Brown Adipose Tissue Sympathetic Inervation and Ucp-1 Content in Chronically Isolated and Spontaneously Hypertensive Rats" in Archives of Biological Sciences, 63, no. 3 (2011):589-596,
https://doi.org/10.2298/ABS1103589L . .