TY  - JOUR
AU  - Spasojević, Nataša
AU  - Jovanović, Predrag
AU  - Spasojević-Tišma, Vera D.
AU  - Delic, N.
AU  - Dronjak, Slađana
PY  - 2011
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4467
AB  - It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.
T2  - Archives of Biological Sciences
T1  - Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine
VL  - 63
IS  - 3
SP  - 597
EP  - 601
DO  - 10.2298/ABS1103597S
ER  - 

@article{
author = "Spasojević, Nataša and Jovanović, Predrag and Spasojević-Tišma, Vera D. and Delic, N. and Dronjak, Slađana",
year = "2011",
abstract = "It is well known that antidepressants affect central monoaminergic neurotransmission and that they also modulate hormone release in peripheral tissues. Repeated maprotiline (a noradrenaline reuptake inhibitor) and fluoxetine (a serotonin reuptake inhibitor) treatment on gene expression of the catecholamine biosynthetic enzymes were examined in rat atria and ventricles in vivo. Maprotiline decreased the gene expression of tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) in the rat atrium. Fluoxetine increased gene expression of TH and DBH, but not of phenylethanolamine N-methyltransferase (PNMT). Chronic application of antidepressants did not change the expression of these enzymes in the ventricles. We conclude that repeated administration of fluoxetine enhances gene transcription of TH and DBH and subsequently stimulates noradrenaline synthesis in rat atria in vivo.",
journal = "Archives of Biological Sciences",
title = "Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine",
volume = "63",
number = "3",
pages = "597-601",
doi = "10.2298/ABS1103597S"
}

Spasojević, N., Jovanović, P., Spasojević-Tišma, V. D., Delic, N.,& Dronjak, S.. (2011). Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine. in Archives of Biological Sciences, 63(3), 597-601.
https://doi.org/10.2298/ABS1103597S

Spasojević N, Jovanović P, Spasojević-Tišma VD, Delic N, Dronjak S. Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine. in Archives of Biological Sciences. 2011;63(3):597-601.
doi:10.2298/ABS1103597S .

Spasojević, Nataša, Jovanović, Predrag, Spasojević-Tišma, Vera D., Delic, N., Dronjak, Slađana, "Differential in Vivo Regulation of Th and Dbh Mrna in Rat Atria By Maprotiline and Fluoxetine" in Archives of Biological Sciences, 63, no. 3 (2011):597-601,
https://doi.org/10.2298/ABS1103597S . .