TY  - JOUR
AU  - El Barbary, Magdy A.
AU  - Saad, Alaa Eldin M.
AU  - Attia, Fadia M.
AU  - Mandour, Magda I.
AU  - Haidara, Mohamed A.
AU  - Dallak, Mohammad M.
AU  - Isenović, Esma R.
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3932
AB  - A total of 30 patients with chronic hepatitis C (HCV) thrombocytopenia (TP) and 20 healthy controls were studied. Both groups were subjected to complete medical history, clinical examination in addition to assessment of hepatitis markers: level of thrombopoietin (Tpo), Geimsa-stained bone marrow smears, and in vitro short-term megakaryocytic progenitors culture (CFU-MK). Serum Tpo level was significantly elevated in patients with TP HCV. Short-term CFU-MK showed an evident depression in the colony-forming unit-megakaryocyte (CFU-meg). There is a positive correlation between the number of CFU-meg and the platelet count and between serum Tpo level and prothrombin time, transaminase, albumin, and the Child Pugh score of liver disease; a negative correlation between serum Tpo level and the number of CFU-meg and between serum Tpo level and the platelet count. Thus, the level of Tpo could be an indicator of intact functional response of the hepatocytes.
T2  - Angiology
T1  - Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation
VL  - 61
IS  - 3
SP  - 304
EP  - 313
DO  - 10.1177/0003319709343178
ER  - 

@article{
author = "El Barbary, Magdy A. and Saad, Alaa Eldin M. and Attia, Fadia M. and Mandour, Magda I. and Haidara, Mohamed A. and Dallak, Mohammad M. and Isenović, Esma R.",
year = "2010",
abstract = "A total of 30 patients with chronic hepatitis C (HCV) thrombocytopenia (TP) and 20 healthy controls were studied. Both groups were subjected to complete medical history, clinical examination in addition to assessment of hepatitis markers: level of thrombopoietin (Tpo), Geimsa-stained bone marrow smears, and in vitro short-term megakaryocytic progenitors culture (CFU-MK). Serum Tpo level was significantly elevated in patients with TP HCV. Short-term CFU-MK showed an evident depression in the colony-forming unit-megakaryocyte (CFU-meg). There is a positive correlation between the number of CFU-meg and the platelet count and between serum Tpo level and prothrombin time, transaminase, albumin, and the Child Pugh score of liver disease; a negative correlation between serum Tpo level and the number of CFU-meg and between serum Tpo level and the platelet count. Thus, the level of Tpo could be an indicator of intact functional response of the hepatocytes.",
journal = "Angiology",
title = "Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation",
volume = "61",
number = "3",
pages = "304-313",
doi = "10.1177/0003319709343178"
}

El Barbary, M. A., Saad, A. E. M., Attia, F. M., Mandour, M. I., Haidara, M. A., Dallak, M. M.,& Isenović, E. R.. (2010). Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation. in Angiology, 61(3), 304-313.
https://doi.org/10.1177/0003319709343178

El Barbary MA, Saad AEM, Attia FM, Mandour MI, Haidara MA, Dallak MM, Isenović ER. Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation. in Angiology. 2010;61(3):304-313.
doi:10.1177/0003319709343178 .

El Barbary, Magdy A., Saad, Alaa Eldin M., Attia, Fadia M., Mandour, Magda I., Haidara, Mohamed A., Dallak, Mohammad M., Isenović, Esma R., "Thrombocytopenia in Patients With Chronic Hepatitis C: A Possible Role of HCV on Platelet Progenitor Cell Maturation" in Angiology, 61, no. 3 (2010):304-313,
https://doi.org/10.1177/0003319709343178 . .