TY  - JOUR
AU  - Arsić, Biljana
AU  - Petrović, Stefan
AU  - Mrmošanin, Jelena
AU  - Dimitrijević, Ivana
AU  - Tošić, Snežana
AU  - Stojanović, Gordana
AU  - Glišić, Sanja
AU  - Milićević, Jelena
PY  - 2024
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/12852
AB  - Pesticides commonly used in the Republic of Serbia (tebuconazole, pendimethalin, pyraclostrobin, propiconazole, and famoxadone) have high stability, so their potential toxicity to humans needs to be investigated. These pesticides are in use in the Republic of Serbia in various formulations. Their toxicity and interactions with acetylcholinesterase were thoroughly investigated in this study using computational tools. The ADMET (Adsorption, Distribution, Metabolism, Excretion, Toxicity) study showed that all of them are good oral compounds, and that pendimethalin was a mutagenic compound. Glide scores ranged from -18.41 kJ mol-1 (pendimethalin) to -27.61 kJ mol-1 (famoxadone) in Mus musculus, and from -19.58 kJ mol-1 (pendimethalin) to -24.31 kJ mol-1 (propiconazole) in Homo sapiens. In addition, the experimental stability of the pesticides solutions in methanol was studied using the fast GC-MS (retention times of the studied pesticides ranged from 14.47 min (pendimethalin) to 22 min (famoxadone)). They showed good stability over time, apart from pyraclostrobin which decomposed mainly into its des-methoxy derivative after 20 months. Based on the promising modeling results, pyraclostrobin and famoxadone emerge as potential candidates for further investigation in the treatment of Alzheimer's disease, taking care to increase their stability.
AB  - Пестициди који се често користе у Републици Србији (тебуконазол, пендиметалин, пираклостробин, пропиконазол, и фамоксадон) имају високу стабилност, тако да њихова потенцијална токсичност се мора проучити. Ови пестициди се користе у Републици Србији у различитим формулацијама. Њихова токсичност и интеракције са ацетихолинестеразом су детаљно изучене у овом истраживању коришћењем компјутерских алата. АДМЕТ (Адсорпција, Дистрибуција, Метаболизам, Екскреција, Токсичност) изучавање је показало да су сви они добра орална једињења, и да је пендиметалин мутагено једињење. Глајд скорови су били у опсегу од -18,41 kJ mol -1 (пендиметалин) до -27,61 kJ mol-1 (фамоксадон) код миша, и од -19,58 kJ mol-1 (пендиметалин) до -24,31 kJ mol-1 (пропиконазол) код човека. Осим тога, експериментална стабилност раствора пестицида у метанолу је проучавана коришћењем ГХ-МС (ретенциона времена проучаваних пестицида се кретала од 14.47 мин (пендиметалин) до 22 мин (фамоксадон)). Они показују добру стабилност током времена, осим пираклостробина који се углавном распада на свој дез-метокси дериват после 20 месеци. На основу обећавајућих резултата моделовања, пираклостробин и фамоксадон се појављују као потенцијални кандидати који се могу даље изучавати као третман за Алцхајмерову болест, водећи рачина да се повећа њихова стабилност.
T2  - Journal of the Serbian Chemical Society
T1  - Stability and computational analyses of selected pesticides in use in the Republic of Serbia
VL  - 89
IS  - 2
SP  - 259
EP  - 274
DO  - 10.2298/JSC230714102A
ER  - 

@article{
author = "Arsić, Biljana and Petrović, Stefan and Mrmošanin, Jelena and Dimitrijević, Ivana and Tošić, Snežana and Stojanović, Gordana and Glišić, Sanja and Milićević, Jelena",
year = "2024",
abstract = "Pesticides commonly used in the Republic of Serbia (tebuconazole, pendimethalin, pyraclostrobin, propiconazole, and famoxadone) have high stability, so their potential toxicity to humans needs to be investigated. These pesticides are in use in the Republic of Serbia in various formulations. Their toxicity and interactions with acetylcholinesterase were thoroughly investigated in this study using computational tools. The ADMET (Adsorption, Distribution, Metabolism, Excretion, Toxicity) study showed that all of them are good oral compounds, and that pendimethalin was a mutagenic compound. Glide scores ranged from -18.41 kJ mol-1 (pendimethalin) to -27.61 kJ mol-1 (famoxadone) in Mus musculus, and from -19.58 kJ mol-1 (pendimethalin) to -24.31 kJ mol-1 (propiconazole) in Homo sapiens. In addition, the experimental stability of the pesticides solutions in methanol was studied using the fast GC-MS (retention times of the studied pesticides ranged from 14.47 min (pendimethalin) to 22 min (famoxadone)). They showed good stability over time, apart from pyraclostrobin which decomposed mainly into its des-methoxy derivative after 20 months. Based on the promising modeling results, pyraclostrobin and famoxadone emerge as potential candidates for further investigation in the treatment of Alzheimer's disease, taking care to increase their stability., Пестициди који се често користе у Републици Србији (тебуконазол, пендиметалин, пираклостробин, пропиконазол, и фамоксадон) имају високу стабилност, тако да њихова потенцијална токсичност се мора проучити. Ови пестициди се користе у Републици Србији у различитим формулацијама. Њихова токсичност и интеракције са ацетихолинестеразом су детаљно изучене у овом истраживању коришћењем компјутерских алата. АДМЕТ (Адсорпција, Дистрибуција, Метаболизам, Екскреција, Токсичност) изучавање је показало да су сви они добра орална једињења, и да је пендиметалин мутагено једињење. Глајд скорови су били у опсегу од -18,41 kJ mol -1 (пендиметалин) до -27,61 kJ mol-1 (фамоксадон) код миша, и од -19,58 kJ mol-1 (пендиметалин) до -24,31 kJ mol-1 (пропиконазол) код човека. Осим тога, експериментална стабилност раствора пестицида у метанолу је проучавана коришћењем ГХ-МС (ретенциона времена проучаваних пестицида се кретала од 14.47 мин (пендиметалин) до 22 мин (фамоксадон)). Они показују добру стабилност током времена, осим пираклостробина који се углавном распада на свој дез-метокси дериват после 20 месеци. На основу обећавајућих резултата моделовања, пираклостробин и фамоксадон се појављују као потенцијални кандидати који се могу даље изучавати као третман за Алцхајмерову болест, водећи рачина да се повећа њихова стабилност.",
journal = "Journal of the Serbian Chemical Society",
title = "Stability and computational analyses of selected pesticides in use in the Republic of Serbia",
volume = "89",
number = "2",
pages = "259-274",
doi = "10.2298/JSC230714102A"
}

Arsić, B., Petrović, S., Mrmošanin, J., Dimitrijević, I., Tošić, S., Stojanović, G., Glišić, S.,& Milićević, J.. (2024). Stability and computational analyses of selected pesticides in use in the Republic of Serbia. in Journal of the Serbian Chemical Society, 89(2), 259-274.
https://doi.org/10.2298/JSC230714102A

Arsić B, Petrović S, Mrmošanin J, Dimitrijević I, Tošić S, Stojanović G, Glišić S, Milićević J. Stability and computational analyses of selected pesticides in use in the Republic of Serbia. in Journal of the Serbian Chemical Society. 2024;89(2):259-274.
doi:10.2298/JSC230714102A .

Arsić, Biljana, Petrović, Stefan, Mrmošanin, Jelena, Dimitrijević, Ivana, Tošić, Snežana, Stojanović, Gordana, Glišić, Sanja, Milićević, Jelena, "Stability and computational analyses of selected pesticides in use in the Republic of Serbia" in Journal of the Serbian Chemical Society, 89, no. 2 (2024):259-274,
https://doi.org/10.2298/JSC230714102A . .

TY  - CONF
AU  - Milićević, Jelena
AU  - Arsić, Biljana
AU  - Petrović, Stefan
AU  - Tošić, Snežana
AU  - Dimitrijević, Ivana
AU  - Stojanović, Gordana
AU  - Glišić, Sanja
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11585
PB  - Slovensko kemijsko društvo : Ljubljana, Slovenia
C3  - Slovenski kemijski dnevi
T1  - In silico and stability analyses of selected pesticides in use in Serbia
SP  - 133
UR  - https://hdl.handle.net/21.15107/rcub_vinar_11585
ER  - 

@conference{
author = "Milićević, Jelena and Arsić, Biljana and Petrović, Stefan and Tošić, Snežana and Dimitrijević, Ivana and Stojanović, Gordana and Glišić, Sanja",
year = "2023",
publisher = "Slovensko kemijsko društvo : Ljubljana, Slovenia",
journal = "Slovenski kemijski dnevi",
title = "In silico and stability analyses of selected pesticides in use in Serbia",
pages = "133",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11585"
}

Milićević, J., Arsić, B., Petrović, S., Tošić, S., Dimitrijević, I., Stojanović, G.,& Glišić, S.. (2023). In silico and stability analyses of selected pesticides in use in Serbia. in Slovenski kemijski dnevi
Slovensko kemijsko društvo : Ljubljana, Slovenia., 133.
https://hdl.handle.net/21.15107/rcub_vinar_11585

Milićević J, Arsić B, Petrović S, Tošić S, Dimitrijević I, Stojanović G, Glišić S. In silico and stability analyses of selected pesticides in use in Serbia. in Slovenski kemijski dnevi. 2023;:133.
https://hdl.handle.net/21.15107/rcub_vinar_11585 .

Milićević, Jelena, Arsić, Biljana, Petrović, Stefan, Tošić, Snežana, Dimitrijević, Ivana, Stojanović, Gordana, Glišić, Sanja, "In silico and stability analyses of selected pesticides in use in Serbia" in Slovenski kemijski dnevi (2023):133,
https://hdl.handle.net/21.15107/rcub_vinar_11585 .

TY  - JOUR
AU  - Petrović, Stefan
AU  - Arsić, Biljana
AU  - Zlatanović, Ivana
AU  - Milićević, Jelena S.
AU  - Glišić, Sanja
AU  - Mitić, Milan
AU  - Đurović-Pejčev, Rada
AU  - Stojanović, Gordana
PY  - 2023
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/11025
AB  - In this study, we considered some pesticides as active substances within formulations for the protection of plant-based food in the Republic of Serbia in silico, because these pesticides have not often been investigated in this way previously, and in an analytical way, because there are not very many available fast, cheap, and easy methods for their determination in real agricultural samples. Seven pesticides were detected in selected agricultural products (tomatoes, cucumbers, peppers, and grapes) using the QuEChERS methodology and HPLC-DAD. Standard curves for the investigated pesticides (chlorantraniliprole, methomyl, metalaxyl, thiacloprid, acetamiprid, emamectin benzoate, and cymoxanil) show good linearity, with R2 values from 0.9785 to 0.9996. The HPLC-DAD method is fast, and these pesticides can be determined in real spiked samples in less than 15 min. We further characterized the pesticides we found in food based on physicochemical properties and molecular descriptors to predict the absorption, distribution, metabolism, elimination, and toxicity (ADMET) of the compounds. We summarized the data supporting their effects on humans using various computational tools to determine their potential adverse effects. The results of our prediction study show that all of the selected pesticides considered in this study have good oral bioavailability, and those with high toxicity, therefore, could be harmful to human health. Chlorantraniliprole was shown in a molecular docking study as a good starting point for a new Alzheimer’s disease drug candidate.
T2  - International Journal of Molecular Sciences
T1  - In Silico Investigation of Selected Pesticides and Their Determination in Agricultural Products Using QuEChERS Methodology and HPLC-DAD
VL  - 24
IS  - 9
SP  - 8003
DO  - 10.3390/ijms24098003
ER  - 

@article{
author = "Petrović, Stefan and Arsić, Biljana and Zlatanović, Ivana and Milićević, Jelena S. and Glišić, Sanja and Mitić, Milan and Đurović-Pejčev, Rada and Stojanović, Gordana",
year = "2023",
abstract = "In this study, we considered some pesticides as active substances within formulations for the protection of plant-based food in the Republic of Serbia in silico, because these pesticides have not often been investigated in this way previously, and in an analytical way, because there are not very many available fast, cheap, and easy methods for their determination in real agricultural samples. Seven pesticides were detected in selected agricultural products (tomatoes, cucumbers, peppers, and grapes) using the QuEChERS methodology and HPLC-DAD. Standard curves for the investigated pesticides (chlorantraniliprole, methomyl, metalaxyl, thiacloprid, acetamiprid, emamectin benzoate, and cymoxanil) show good linearity, with R2 values from 0.9785 to 0.9996. The HPLC-DAD method is fast, and these pesticides can be determined in real spiked samples in less than 15 min. We further characterized the pesticides we found in food based on physicochemical properties and molecular descriptors to predict the absorption, distribution, metabolism, elimination, and toxicity (ADMET) of the compounds. We summarized the data supporting their effects on humans using various computational tools to determine their potential adverse effects. The results of our prediction study show that all of the selected pesticides considered in this study have good oral bioavailability, and those with high toxicity, therefore, could be harmful to human health. Chlorantraniliprole was shown in a molecular docking study as a good starting point for a new Alzheimer’s disease drug candidate.",
journal = "International Journal of Molecular Sciences",
title = "In Silico Investigation of Selected Pesticides and Their Determination in Agricultural Products Using QuEChERS Methodology and HPLC-DAD",
volume = "24",
number = "9",
pages = "8003",
doi = "10.3390/ijms24098003"
}

Petrović, S., Arsić, B., Zlatanović, I., Milićević, J. S., Glišić, S., Mitić, M., Đurović-Pejčev, R.,& Stojanović, G.. (2023). In Silico Investigation of Selected Pesticides and Their Determination in Agricultural Products Using QuEChERS Methodology and HPLC-DAD. in International Journal of Molecular Sciences, 24(9), 8003.
https://doi.org/10.3390/ijms24098003

Petrović S, Arsić B, Zlatanović I, Milićević JS, Glišić S, Mitić M, Đurović-Pejčev R, Stojanović G. In Silico Investigation of Selected Pesticides and Their Determination in Agricultural Products Using QuEChERS Methodology and HPLC-DAD. in International Journal of Molecular Sciences. 2023;24(9):8003.
doi:10.3390/ijms24098003 .

Petrović, Stefan, Arsić, Biljana, Zlatanović, Ivana, Milićević, Jelena S., Glišić, Sanja, Mitić, Milan, Đurović-Pejčev, Rada, Stojanović, Gordana, "In Silico Investigation of Selected Pesticides and Their Determination in Agricultural Products Using QuEChERS Methodology and HPLC-DAD" in International Journal of Molecular Sciences, 24, no. 9 (2023):8003,
https://doi.org/10.3390/ijms24098003 . .

TY  - JOUR
AU  - Arsić, Biljana
AU  - Barber, Jill
AU  - Čikoš, Ana
AU  - Kadirvel, Manikandan
AU  - Kostić, Emilija
AU  - McBain, Andrew J.
AU  - Milićević, Jelena S.
AU  - Oates, Angela
AU  - Regan, Andrew
PY  - 2022
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/10502
AB  - Although many antibiotics are active against Gram-positive bacteria, fewer also show activity against Gram-negative bacteria. Here, we present a combination of in silico (electron ion-interaction potential, molecular docking, ADMET), NMR, and microbiological investigations of selected macrolides (14-membered, 15-membered, and 16-membered), aiming to discover the pattern of design for macrolides active against Gram-negative bacteria. Although the conformational studies of 14-membered and 15-membered macrolides are abundant in the literature, 16-membered macrolides, and their most prominent representative tylosin A, have received relatively little research attention. We therefore report the complete 1H and 13C NMR assignment of tylosin A in deuterated chloroform, as well as its 3D solution structure determined through molecular modelling (conformational search) and 2D ROESY NMR. Additionally, due to the degradation of tylosin A in deuterated chloroform, other species were also detected in 1D and 2D NMR spectra. We additionally studied the anti-bacterial activity of tylosin A and B against selected Gram-positive and Gram-negative bacteria.
T2  - Molecules
T1  - Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform
VL  - 27
IS  - 21
SP  - 7280
DO  - 10.3390/molecules27217280
ER  - 

@article{
author = "Arsić, Biljana and Barber, Jill and Čikoš, Ana and Kadirvel, Manikandan and Kostić, Emilija and McBain, Andrew J. and Milićević, Jelena S. and Oates, Angela and Regan, Andrew",
year = "2022",
abstract = "Although many antibiotics are active against Gram-positive bacteria, fewer also show activity against Gram-negative bacteria. Here, we present a combination of in silico (electron ion-interaction potential, molecular docking, ADMET), NMR, and microbiological investigations of selected macrolides (14-membered, 15-membered, and 16-membered), aiming to discover the pattern of design for macrolides active against Gram-negative bacteria. Although the conformational studies of 14-membered and 15-membered macrolides are abundant in the literature, 16-membered macrolides, and their most prominent representative tylosin A, have received relatively little research attention. We therefore report the complete 1H and 13C NMR assignment of tylosin A in deuterated chloroform, as well as its 3D solution structure determined through molecular modelling (conformational search) and 2D ROESY NMR. Additionally, due to the degradation of tylosin A in deuterated chloroform, other species were also detected in 1D and 2D NMR spectra. We additionally studied the anti-bacterial activity of tylosin A and B against selected Gram-positive and Gram-negative bacteria.",
journal = "Molecules",
title = "Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform",
volume = "27",
number = "21",
pages = "7280",
doi = "10.3390/molecules27217280"
}

Arsić, B., Barber, J., Čikoš, A., Kadirvel, M., Kostić, E., McBain, A. J., Milićević, J. S., Oates, A.,& Regan, A.. (2022). Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform. in Molecules, 27(21), 7280.
https://doi.org/10.3390/molecules27217280

Arsić B, Barber J, Čikoš A, Kadirvel M, Kostić E, McBain AJ, Milićević JS, Oates A, Regan A. Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform. in Molecules. 2022;27(21):7280.
doi:10.3390/molecules27217280 .

Arsić, Biljana, Barber, Jill, Čikoš, Ana, Kadirvel, Manikandan, Kostić, Emilija, McBain, Andrew J., Milićević, Jelena S., Oates, Angela, Regan, Andrew, "Computational Studies on Selected Macrolides Active against Escherichia coli Combined with the NMR Study of Tylosin A in Deuterated Chloroform" in Molecules, 27, no. 21 (2022):7280,
https://doi.org/10.3390/molecules27217280 . .

TY  - JOUR
AU  - Mladenović, Milan P.
AU  - Arsić, Biljana
AU  - Stanković, Nevena M.
AU  - Mihović, Nezrina
AU  - Ragno, Rino
AU  - Regan, Andrew C.
AU  - Milićević, Jelena S.
AU  - Trtić-Petrović, Tatjana M.
AU  - Micić, Ružica J.
PY  - 2018
UR  - http://www.mdpi.com/1420-3049/23/9/2192
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/7862
AB  - Commercially available pesticides were examined as Mus musculus and Homo sapiens acetylcholinesterase (mAChE and hAChE) inhibitors by means of ligand-based (LB) and structure-based (SB) in silico approaches. Initially, the crystal structures of simazine, monocrotophos, dimethoate, and acetamiprid were reproduced using various force fields. Subsequently, LB alignment rules were assessed and applied to determine the inter synaptic conformations of atrazine, propazine, carbofuran, carbaryl, tebufenozide, imidacloprid, diuron, monuron, and linuron. Afterwards, molecular docking and dynamics SB studies were performed on either mAChE or hAChE, to predict the listed pesticides’ binding modes. Calculated energies of global minima (Eglob_min) and free energies of binding (∆Gbinding) were correlated with the pesticides’ acute toxicities (i.e., the LD50 values) against mice, as well to generate the model that could predict the LD50s against humans. Although for most of the pesticides the low Eglob_min correlates with the high acute toxicity, it is the ∆Gbinding that conditions the LD50 values for all the evaluated pesticides. Derived pLD50 = f(∆Gbinding) mAChE model may predict the pLD50 against hAChE, too. The hAChE inhibition by atrazine, propazine, and simazine (the most toxic pesticides) was elucidated by SB quantum mechanics (QM) DFT mechanistic and concentration-dependent kinetic studies, enriching the knowledge for design of less toxic pesticides.
T2  - Molecules
T1  - The Targeted Pesticides as Acetylcholinesterase Inhibitors: Comprehensive Cross-Organism Molecular Modelling Studies Performed to Anticipate the Pharmacology of Harmfulness to Humans In Vitro
VL  - 23
IS  - 9
SP  - 2192
DO  - 10.3390/molecules23092192
ER  - 

@article{
author = "Mladenović, Milan P. and Arsić, Biljana and Stanković, Nevena M. and Mihović, Nezrina and Ragno, Rino and Regan, Andrew C. and Milićević, Jelena S. and Trtić-Petrović, Tatjana M. and Micić, Ružica J.",
year = "2018",
abstract = "Commercially available pesticides were examined as Mus musculus and Homo sapiens acetylcholinesterase (mAChE and hAChE) inhibitors by means of ligand-based (LB) and structure-based (SB) in silico approaches. Initially, the crystal structures of simazine, monocrotophos, dimethoate, and acetamiprid were reproduced using various force fields. Subsequently, LB alignment rules were assessed and applied to determine the inter synaptic conformations of atrazine, propazine, carbofuran, carbaryl, tebufenozide, imidacloprid, diuron, monuron, and linuron. Afterwards, molecular docking and dynamics SB studies were performed on either mAChE or hAChE, to predict the listed pesticides’ binding modes. Calculated energies of global minima (Eglob_min) and free energies of binding (∆Gbinding) were correlated with the pesticides’ acute toxicities (i.e., the LD50 values) against mice, as well to generate the model that could predict the LD50s against humans. Although for most of the pesticides the low Eglob_min correlates with the high acute toxicity, it is the ∆Gbinding that conditions the LD50 values for all the evaluated pesticides. Derived pLD50 = f(∆Gbinding) mAChE model may predict the pLD50 against hAChE, too. The hAChE inhibition by atrazine, propazine, and simazine (the most toxic pesticides) was elucidated by SB quantum mechanics (QM) DFT mechanistic and concentration-dependent kinetic studies, enriching the knowledge for design of less toxic pesticides.",
journal = "Molecules",
title = "The Targeted Pesticides as Acetylcholinesterase Inhibitors: Comprehensive Cross-Organism Molecular Modelling Studies Performed to Anticipate the Pharmacology of Harmfulness to Humans In Vitro",
volume = "23",
number = "9",
pages = "2192",
doi = "10.3390/molecules23092192"
}

Mladenović, M. P., Arsić, B., Stanković, N. M., Mihović, N., Ragno, R., Regan, A. C., Milićević, J. S., Trtić-Petrović, T. M.,& Micić, R. J.. (2018). The Targeted Pesticides as Acetylcholinesterase Inhibitors: Comprehensive Cross-Organism Molecular Modelling Studies Performed to Anticipate the Pharmacology of Harmfulness to Humans In Vitro. in Molecules, 23(9), 2192.
https://doi.org/10.3390/molecules23092192

Mladenović MP, Arsić B, Stanković NM, Mihović N, Ragno R, Regan AC, Milićević JS, Trtić-Petrović TM, Micić RJ. The Targeted Pesticides as Acetylcholinesterase Inhibitors: Comprehensive Cross-Organism Molecular Modelling Studies Performed to Anticipate the Pharmacology of Harmfulness to Humans In Vitro. in Molecules. 2018;23(9):2192.
doi:10.3390/molecules23092192 .

Mladenović, Milan P., Arsić, Biljana, Stanković, Nevena M., Mihović, Nezrina, Ragno, Rino, Regan, Andrew C., Milićević, Jelena S., Trtić-Petrović, Tatjana M., Micić, Ružica J., "The Targeted Pesticides as Acetylcholinesterase Inhibitors: Comprehensive Cross-Organism Molecular Modelling Studies Performed to Anticipate the Pharmacology of Harmfulness to Humans In Vitro" in Molecules, 23, no. 9 (2018):2192,
https://doi.org/10.3390/molecules23092192 . .

TY  - JOUR
AU  - Perović, Milan
AU  - Gojnic, Miroslava
AU  - Arsić, Biljana
AU  - Pantic, Igor
AU  - Stefanovic, Tomislav
AU  - Kovacevic, Gordana
AU  - Kovacevic, Milica
AU  - Garalejic, Eliana
AU  - Dugalic, Stefan
AU  - Radakovic, Jovana
AU  - Babic, Uros
AU  - Isenović, Esma R.
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/603
AB  - BackgroundThe aim of the present study was to investigate the relationship between mid-trimester ultrasound fetal liver length (FLL) and gestational diabetes mellitus (GDM) in a high-risk population. MethodsA prospective study was performed in 331 women with singleton pregnancies who were at high risk of GDM and were undergoing a mid-trimester ultrasound examination. The ultrasound scan at 23 weeks gestation was followed by a 100-g oral glucose tolerance test (OGTT) at 24 weeks gestation. Correlations between FLL and OGTT results at different time points were tested. Receiver operating characteristic (ROC) analysis of FLL as a potential prognostic factor for GDM was also performed. ResultsIn GDM patients, there was a significant positive correlation (P LT 0.01) between FLL and OGTT glycemia immediately before and 60, 120, and 180min after glucose intake. Mean FLL in GDM was significantly higher than in healthy subjects (41.04 vs 31.09mm, respectively; P LT 0.001). When tested as a potential prognostic factor for GDM, fetal liver measurements showed excellent diagnostic performance. The ROC analysis established a cut-off value of FLL of 39mm for the prediction GDM, with sensitivity of 71.76%, specificity 97.56%, positive predictive value 91.0%, and negative predictive value 90.9%. The usefulness of FLL measurements was supported by a high area under the ROC curve (90.5%). ConclusionIn conclusion, there is a strong correlation between FLL and OGTT results, with FLL possibly serving as a valid marker for the prediction of GDM in high-risk populations.
T2  - Journal of Diabetes
T1  - Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus
VL  - 7
IS  - 4
SP  - 497
EP  - 505
DO  - 10.1111/1753-0407.12207
ER  - 

@article{
author = "Perović, Milan and Gojnic, Miroslava and Arsić, Biljana and Pantic, Igor and Stefanovic, Tomislav and Kovacevic, Gordana and Kovacevic, Milica and Garalejic, Eliana and Dugalic, Stefan and Radakovic, Jovana and Babic, Uros and Isenović, Esma R.",
year = "2015",
abstract = "BackgroundThe aim of the present study was to investigate the relationship between mid-trimester ultrasound fetal liver length (FLL) and gestational diabetes mellitus (GDM) in a high-risk population. MethodsA prospective study was performed in 331 women with singleton pregnancies who were at high risk of GDM and were undergoing a mid-trimester ultrasound examination. The ultrasound scan at 23 weeks gestation was followed by a 100-g oral glucose tolerance test (OGTT) at 24 weeks gestation. Correlations between FLL and OGTT results at different time points were tested. Receiver operating characteristic (ROC) analysis of FLL as a potential prognostic factor for GDM was also performed. ResultsIn GDM patients, there was a significant positive correlation (P LT 0.01) between FLL and OGTT glycemia immediately before and 60, 120, and 180min after glucose intake. Mean FLL in GDM was significantly higher than in healthy subjects (41.04 vs 31.09mm, respectively; P LT 0.001). When tested as a potential prognostic factor for GDM, fetal liver measurements showed excellent diagnostic performance. The ROC analysis established a cut-off value of FLL of 39mm for the prediction GDM, with sensitivity of 71.76%, specificity 97.56%, positive predictive value 91.0%, and negative predictive value 90.9%. The usefulness of FLL measurements was supported by a high area under the ROC curve (90.5%). ConclusionIn conclusion, there is a strong correlation between FLL and OGTT results, with FLL possibly serving as a valid marker for the prediction of GDM in high-risk populations.",
journal = "Journal of Diabetes",
title = "Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus",
volume = "7",
number = "4",
pages = "497-505",
doi = "10.1111/1753-0407.12207"
}

Perović, M., Gojnic, M., Arsić, B., Pantic, I., Stefanovic, T., Kovacevic, G., Kovacevic, M., Garalejic, E., Dugalic, S., Radakovic, J., Babic, U.,& Isenović, E. R.. (2015). Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus. in Journal of Diabetes, 7(4), 497-505.
https://doi.org/10.1111/1753-0407.12207

Perović M, Gojnic M, Arsić B, Pantic I, Stefanovic T, Kovacevic G, Kovacevic M, Garalejic E, Dugalic S, Radakovic J, Babic U, Isenović ER. Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus. in Journal of Diabetes. 2015;7(4):497-505.
doi:10.1111/1753-0407.12207 .

Perović, Milan, Gojnic, Miroslava, Arsić, Biljana, Pantic, Igor, Stefanovic, Tomislav, Kovacevic, Gordana, Kovacevic, Milica, Garalejic, Eliana, Dugalic, Stefan, Radakovic, Jovana, Babic, Uros, Isenović, Esma R., "Relationship between mid-trimester ultrasound fetal liver length measurements and gestational diabetes mellitus" in Journal of Diabetes, 7, no. 4 (2015):497-505,
https://doi.org/10.1111/1753-0407.12207 . .