TY  - JOUR
AU  - Pejić, Snežana
AU  - Todorović, Ana
AU  - Stojiljković, Vesna
AU  - Cvetković, Dragana
AU  - Lucic, Nenad
AU  - Radojicic, Ratko M.
AU  - Saičić, Zorica S.
AU  - Pajović, Snežana B.
PY  - 2008
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3520
AB  - Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes ill activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed With uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii. The results of our study have shown decreased SOD activities and unchanged SOD protein level in blood of all examined patients in comparison to healthy Subjects. Decrease of both SOD activity and level was Found in endometrium of patients with hyperplasia simplex, hyperplasia complex and adenocarcinoma in comparison to women with polypus or myoma. LOOH level was elevated in both tissues of patients with hyperplasia or adenocarcinoma in comparison to healthy Subjects or patients with benign diagnosis. Our findings suggest that the decrease in SOD activity and level, as well as the increase in LOOH level, in patients with gynecological disorders. render these patients more Susceptible to oxidative damage caused by reactive oxygen species (ROS). An imbalance in ROS formation and SOD level may be important in the pathogenesis and/or perpetuation of tissue damage in gynecological patients. Since evidence suggests that SOD may be a therapy target for cancer treatment, our findings provide a basis for further research and options for clinical applications.
T2  - Anais de Academia Brasileira de Ciencias
T1  - Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium
VL  - 80
IS  - 3
SP  - 515
EP  - 522
DO  - 10.1590/S0001-37652008000300011
ER  - 

@article{
author = "Pejić, Snežana and Todorović, Ana and Stojiljković, Vesna and Cvetković, Dragana and Lucic, Nenad and Radojicic, Ratko M. and Saičić, Zorica S. and Pajović, Snežana B.",
year = "2008",
abstract = "Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes ill activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxides (LOOH) in blood and endometrial tissue of patients diagnosed With uterine myoma, endometrial polypus, hyperplasia simplex, hyperplasia complex and adenocarcinoma endometrii. The results of our study have shown decreased SOD activities and unchanged SOD protein level in blood of all examined patients in comparison to healthy Subjects. Decrease of both SOD activity and level was Found in endometrium of patients with hyperplasia simplex, hyperplasia complex and adenocarcinoma in comparison to women with polypus or myoma. LOOH level was elevated in both tissues of patients with hyperplasia or adenocarcinoma in comparison to healthy Subjects or patients with benign diagnosis. Our findings suggest that the decrease in SOD activity and level, as well as the increase in LOOH level, in patients with gynecological disorders. render these patients more Susceptible to oxidative damage caused by reactive oxygen species (ROS). An imbalance in ROS formation and SOD level may be important in the pathogenesis and/or perpetuation of tissue damage in gynecological patients. Since evidence suggests that SOD may be a therapy target for cancer treatment, our findings provide a basis for further research and options for clinical applications.",
journal = "Anais de Academia Brasileira de Ciencias",
title = "Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium",
volume = "80",
number = "3",
pages = "515-522",
doi = "10.1590/S0001-37652008000300011"
}

Pejić, S., Todorović, A., Stojiljković, V., Cvetković, D., Lucic, N., Radojicic, R. M., Saičić, Z. S.,& Pajović, S. B.. (2008). Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. in Anais de Academia Brasileira de Ciencias, 80(3), 515-522.
https://doi.org/10.1590/S0001-37652008000300011

Pejić S, Todorović A, Stojiljković V, Cvetković D, Lucic N, Radojicic RM, Saičić ZS, Pajović SB. Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. in Anais de Academia Brasileira de Ciencias. 2008;80(3):515-522.
doi:10.1590/S0001-37652008000300011 .

Pejić, Snežana, Todorović, Ana, Stojiljković, Vesna, Cvetković, Dragana, Lucic, Nenad, Radojicic, Ratko M., Saičić, Zorica S., Pajović, Snežana B., "Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium" in Anais de Academia Brasileira de Ciencias, 80, no. 3 (2008):515-522,
https://doi.org/10.1590/S0001-37652008000300011 . .