TY  - JOUR
AU  - Sevaljevic, L
AU  - Dobric, S
AU  - Bogojevic, D
AU  - Petrović, M
AU  - Korićanac, Goran
AU  - Vulović, Mojca D.
AU  - Kanazir, DA
AU  - Ribarac-Stepić, Nevena B.
PY  - 2003
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2645
AB  - This work was aimed at the radioprotective efficacy of turpentine oil (TO), alpha(2)-Macroglobulin (alpha(2)-M), Amifostine (Ami) and/or dexamethasone (Dex). These agents were administrated, alone or in combination, prior to irradiation of rats with 6.7 Gy (LD50/30). The survival was recorded daily for 4 weeks after irradiation and body weight, peripheral leukocytes and thrombocytes were measured. The plasma concentration of alpha(2)-M and other acute phase proteins were determined by crossed immunoelectrophoresis. All rats receiving alpha(2)-M and Ami alone or in combination survived the radiation injury, whereas the rate of survival of TO-treated rats was 90%. Radiation and therapy-induced changes in the expression of acute phase protein genes were atypical for the acute phase reaction. Dex alone was lethal for 45% and 55% of control and irradiated rats, respectively. Pretreatment with 1mg Dex reduced radioprotective efficacy of TO and Ami to 30% and 40%, respectively. Given together TO and Ami provided 70% protection to rats receiving Dex. The TO and GYM enhanced the rate of survival from 50% to 90% and 100%, respectively. In the presence of 1 mg Dex the TO-induced radioprotectors and Ami exhibited radiosensitizing rather than radioprotecting activities.
T2  - Journal of Radiation Research
T1  - The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation
VL  - 44
IS  - 1
SP  - 59
EP  - 67
UR  - https://hdl.handle.net/21.15107/rcub_vinar_2645
ER  - 

@article{
author = "Sevaljevic, L and Dobric, S and Bogojevic, D and Petrović, M and Korićanac, Goran and Vulović, Mojca D. and Kanazir, DA and Ribarac-Stepić, Nevena B.",
year = "2003",
abstract = "This work was aimed at the radioprotective efficacy of turpentine oil (TO), alpha(2)-Macroglobulin (alpha(2)-M), Amifostine (Ami) and/or dexamethasone (Dex). These agents were administrated, alone or in combination, prior to irradiation of rats with 6.7 Gy (LD50/30). The survival was recorded daily for 4 weeks after irradiation and body weight, peripheral leukocytes and thrombocytes were measured. The plasma concentration of alpha(2)-M and other acute phase proteins were determined by crossed immunoelectrophoresis. All rats receiving alpha(2)-M and Ami alone or in combination survived the radiation injury, whereas the rate of survival of TO-treated rats was 90%. Radiation and therapy-induced changes in the expression of acute phase protein genes were atypical for the acute phase reaction. Dex alone was lethal for 45% and 55% of control and irradiated rats, respectively. Pretreatment with 1mg Dex reduced radioprotective efficacy of TO and Ami to 30% and 40%, respectively. Given together TO and Ami provided 70% protection to rats receiving Dex. The TO and GYM enhanced the rate of survival from 50% to 90% and 100%, respectively. In the presence of 1 mg Dex the TO-induced radioprotectors and Ami exhibited radiosensitizing rather than radioprotecting activities.",
journal = "Journal of Radiation Research",
title = "The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation",
volume = "44",
number = "1",
pages = "59-67",
url = "https://hdl.handle.net/21.15107/rcub_vinar_2645"
}

Sevaljevic, L., Dobric, S., Bogojevic, D., Petrović, M., Korićanac, G., Vulović, M. D., Kanazir, D.,& Ribarac-Stepić, N. B.. (2003). The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation. in Journal of Radiation Research, 44(1), 59-67.
https://hdl.handle.net/21.15107/rcub_vinar_2645

Sevaljevic L, Dobric S, Bogojevic D, Petrović M, Korićanac G, Vulović MD, Kanazir D, Ribarac-Stepić NB. The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation. in Journal of Radiation Research. 2003;44(1):59-67.
https://hdl.handle.net/21.15107/rcub_vinar_2645 .

Sevaljevic, L, Dobric, S, Bogojevic, D, Petrović, M, Korićanac, Goran, Vulović, Mojca D., Kanazir, DA, Ribarac-Stepić, Nevena B., "The radioprotective activities of turpentine-induced inflammation and alpha(2)-macroglobulin: The effect of dexamethasone on the radioprotective efficacy of the inflammation" in Journal of Radiation Research, 44, no. 1 (2003):59-67,
https://hdl.handle.net/21.15107/rcub_vinar_2645 .