TY  - CONF
AU  - Cvetković, Stefana
AU  - Đukanović, S.
AU  - Mitić-Ćulafić, Dragana
AU  - Nastasijević, Branislav J.
AU  - Knežević-Vukčević, Jelena
AU  - Nikolić, Biljana
PY  - 2019
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/8627
AB  - During high-temperature cooking of protein rich foods, especially meat and fish, heterocyclic aromatic amines can be formed. These amines are a class of potent mutagens that can cause alterations in the structure of DNA and chromosomes. In recent decades, research has been focused on investigating plants and their phytochemicals as potential antimutagens. The aim of this study was to examine the anti-genotoxic effect of methanolic root and leaf extracts of Gentiana lutea against the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) produced in thermally processed meat. To determine the protective potential of extracts, the alkaline comet assay was applied. The results obtained indicated strong anti-genotoxic effect of both extracts against the tested mutagens. The highest inhibition of IQ-induced genotoxicity was recorded for leaf extract (72%). Regarding PhiP, root extract achieved inhibition of 80% of DNA damage, so was more successful than leaf extract. The data obtained in this study stimulates further research of G. lutea extracts and its constituents as potential dietary supplements in improving human health. © Published under licence by IOP Publishing Ltd.
C3  - IOP Conference Series: Earth and Environmental Science
T1  - Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat
VL  - 333
IS  - 1
SP  - UNSP 012052
DO  - 10.1088/1755-1315/333/1/012052
ER  - 

@conference{
author = "Cvetković, Stefana and Đukanović, S. and Mitić-Ćulafić, Dragana and Nastasijević, Branislav J. and Knežević-Vukčević, Jelena and Nikolić, Biljana",
year = "2019",
abstract = "During high-temperature cooking of protein rich foods, especially meat and fish, heterocyclic aromatic amines can be formed. These amines are a class of potent mutagens that can cause alterations in the structure of DNA and chromosomes. In recent decades, research has been focused on investigating plants and their phytochemicals as potential antimutagens. The aim of this study was to examine the anti-genotoxic effect of methanolic root and leaf extracts of Gentiana lutea against the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) produced in thermally processed meat. To determine the protective potential of extracts, the alkaline comet assay was applied. The results obtained indicated strong anti-genotoxic effect of both extracts against the tested mutagens. The highest inhibition of IQ-induced genotoxicity was recorded for leaf extract (72%). Regarding PhiP, root extract achieved inhibition of 80% of DNA damage, so was more successful than leaf extract. The data obtained in this study stimulates further research of G. lutea extracts and its constituents as potential dietary supplements in improving human health. © Published under licence by IOP Publishing Ltd.",
journal = "IOP Conference Series: Earth and Environmental Science",
title = "Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat",
volume = "333",
number = "1",
pages = "UNSP 012052",
doi = "10.1088/1755-1315/333/1/012052"
}

Cvetković, S., Đukanović, S., Mitić-Ćulafić, D., Nastasijević, B. J., Knežević-Vukčević, J.,& Nikolić, B.. (2019). Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat. in IOP Conference Series: Earth and Environmental Science, 333(1), UNSP 012052.
https://doi.org/10.1088/1755-1315/333/1/012052

Cvetković S, Đukanović S, Mitić-Ćulafić D, Nastasijević BJ, Knežević-Vukčević J, Nikolić B. Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat. in IOP Conference Series: Earth and Environmental Science. 2019;333(1):UNSP 012052.
doi:10.1088/1755-1315/333/1/012052 .

Cvetković, Stefana, Đukanović, S., Mitić-Ćulafić, Dragana, Nastasijević, Branislav J., Knežević-Vukčević, Jelena, Nikolić, Biljana, "Protective effect of Gentiana lutea root and leaf extracts against heterocyclic aromatic amines IQ and PhIP produced in thermally processed meat" in IOP Conference Series: Earth and Environmental Science, 333, no. 1 (2019):UNSP 012052,
https://doi.org/10.1088/1755-1315/333/1/012052 . .

TY  - JOUR
AU  - Ribarac-Stepić, Nevena B.
AU  - Isenović, Esma R.
AU  - Naumovic, R
AU  - Korićanac, Goran
AU  - Vulović, Mojca D.
AU  - Žakula, Zorica
AU  - Blagojevic, R
AU  - Djukanovic, L
PY  - 2001
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/2514
AB  - The glucocorticoid receptors in lymphocytes of patients treated with glucocorticoids after kidney transplantation have been studied in order to determine whether abnormalities in corticosteroid binding and trans-activation of steroid-receptor complexes, i.e., their translocation into nuclei, may contribute to the resistance of patients to glucocorticoid therapy. The patients were divided into two groups, according to graft stability: patients with stable graft function and those with chronic allograft rejection. The study revealed changes in both level and binding affinity of glucocorticoid receptors in peripheral blood lymphocytes from patients with chronic graft rejection, compared with control level, as well as with values of patients with stable graft function. Those data indicate that sensitivity to glucocorticoids depends, at least in part, on the alterations of glucocorticoid receptors. The receptor translocation into nuclei indicates that unknown post-receptor events might also be involved in glucocorticoid resistance that seriously impair successive glucocorticoid therapy after organ transplantation. Further examination of glucocorticoid receptors in cases of organ transplantation seems warranted.
T2  - Clinical and Experimental Medicine
T1  - Glucocorticoid receptors in lymphocytes and stability of kidney graft function
VL  - 1
IS  - 4
SP  - 179
EP  - 186
DO  - 10.1007/s102380100001
ER  - 

@article{
author = "Ribarac-Stepić, Nevena B. and Isenović, Esma R. and Naumovic, R and Korićanac, Goran and Vulović, Mojca D. and Žakula, Zorica and Blagojevic, R and Djukanovic, L",
year = "2001",
abstract = "The glucocorticoid receptors in lymphocytes of patients treated with glucocorticoids after kidney transplantation have been studied in order to determine whether abnormalities in corticosteroid binding and trans-activation of steroid-receptor complexes, i.e., their translocation into nuclei, may contribute to the resistance of patients to glucocorticoid therapy. The patients were divided into two groups, according to graft stability: patients with stable graft function and those with chronic allograft rejection. The study revealed changes in both level and binding affinity of glucocorticoid receptors in peripheral blood lymphocytes from patients with chronic graft rejection, compared with control level, as well as with values of patients with stable graft function. Those data indicate that sensitivity to glucocorticoids depends, at least in part, on the alterations of glucocorticoid receptors. The receptor translocation into nuclei indicates that unknown post-receptor events might also be involved in glucocorticoid resistance that seriously impair successive glucocorticoid therapy after organ transplantation. Further examination of glucocorticoid receptors in cases of organ transplantation seems warranted.",
journal = "Clinical and Experimental Medicine",
title = "Glucocorticoid receptors in lymphocytes and stability of kidney graft function",
volume = "1",
number = "4",
pages = "179-186",
doi = "10.1007/s102380100001"
}

Ribarac-Stepić, N. B., Isenović, E. R., Naumovic, R., Korićanac, G., Vulović, M. D., Žakula, Z., Blagojevic, R.,& Djukanovic, L.. (2001). Glucocorticoid receptors in lymphocytes and stability of kidney graft function. in Clinical and Experimental Medicine, 1(4), 179-186.
https://doi.org/10.1007/s102380100001

Ribarac-Stepić NB, Isenović ER, Naumovic R, Korićanac G, Vulović MD, Žakula Z, Blagojevic R, Djukanovic L. Glucocorticoid receptors in lymphocytes and stability of kidney graft function. in Clinical and Experimental Medicine. 2001;1(4):179-186.
doi:10.1007/s102380100001 .

Ribarac-Stepić, Nevena B., Isenović, Esma R., Naumovic, R, Korićanac, Goran, Vulović, Mojca D., Žakula, Zorica, Blagojevic, R, Djukanovic, L, "Glucocorticoid receptors in lymphocytes and stability of kidney graft function" in Clinical and Experimental Medicine, 1, no. 4 (2001):179-186,
https://doi.org/10.1007/s102380100001 . .