TY  - JOUR
AU  - Jovanovic-Santa, S
AU  - Petrović, Julijana
AU  - Sakac, M
AU  - Žakula, Zorica
AU  - Isenović, Esma R.
AU  - Ribarac-Stepić, Nevena B.
PY  - 2006
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/3007
AB  - Since many of newly synthesised D-secoestratriene derivatives showed antiestrogenic effect, with almost a total loss of estrogenic activity, we studied the effects of some of these compounds on estrogen receptors (ER), the translocation of the estrogen-ER complexes formed in presence of competing substances into the nucleus, as well as the binding of these complexes to DNA. The results of uterotrophic effects of analysed derivatives are in agreement with the influence of these compounds on activity and binding parameters of estrogen receptors. Namely, compounds that show relatively high antiestrogenic activity predominantly increase K-d and inhibit translocation to nuclei of radioactive complexes formed in their presence. On the other hand, compounds that do not significantly change binding parameters of estrogen receptors do not show antiestrogenic effect in in vivo experiments.
T2  - Collection of Czechoslovak Chemical Communications
T1  - The influence of 17-oxo- and 17-hydroxy-16,17-secoestratriene derivatives on estrogen receptor
VL  - 71
IS  - 4
SP  - 532
EP  - 542
DO  - 10.1135/cccc20060532
ER  - 

@article{
author = "Jovanovic-Santa, S and Petrović, Julijana and Sakac, M and Žakula, Zorica and Isenović, Esma R. and Ribarac-Stepić, Nevena B.",
year = "2006",
abstract = "Since many of newly synthesised D-secoestratriene derivatives showed antiestrogenic effect, with almost a total loss of estrogenic activity, we studied the effects of some of these compounds on estrogen receptors (ER), the translocation of the estrogen-ER complexes formed in presence of competing substances into the nucleus, as well as the binding of these complexes to DNA. The results of uterotrophic effects of analysed derivatives are in agreement with the influence of these compounds on activity and binding parameters of estrogen receptors. Namely, compounds that show relatively high antiestrogenic activity predominantly increase K-d and inhibit translocation to nuclei of radioactive complexes formed in their presence. On the other hand, compounds that do not significantly change binding parameters of estrogen receptors do not show antiestrogenic effect in in vivo experiments.",
journal = "Collection of Czechoslovak Chemical Communications",
title = "The influence of 17-oxo- and 17-hydroxy-16,17-secoestratriene derivatives on estrogen receptor",
volume = "71",
number = "4",
pages = "532-542",
doi = "10.1135/cccc20060532"
}

Jovanovic-Santa, S., Petrović, J., Sakac, M., Žakula, Z., Isenović, E. R.,& Ribarac-Stepić, N. B.. (2006). The influence of 17-oxo- and 17-hydroxy-16,17-secoestratriene derivatives on estrogen receptor. in Collection of Czechoslovak Chemical Communications, 71(4), 532-542.
https://doi.org/10.1135/cccc20060532

Jovanovic-Santa S, Petrović J, Sakac M, Žakula Z, Isenović ER, Ribarac-Stepić NB. The influence of 17-oxo- and 17-hydroxy-16,17-secoestratriene derivatives on estrogen receptor. in Collection of Czechoslovak Chemical Communications. 2006;71(4):532-542.
doi:10.1135/cccc20060532 .

Jovanovic-Santa, S, Petrović, Julijana, Sakac, M, Žakula, Zorica, Isenović, Esma R., Ribarac-Stepić, Nevena B., "The influence of 17-oxo- and 17-hydroxy-16,17-secoestratriene derivatives on estrogen receptor" in Collection of Czechoslovak Chemical Communications, 71, no. 4 (2006):532-542,
https://doi.org/10.1135/cccc20060532 . .