@conference{
author = "Joksić, Gordana and Spasojević-Tišma, Vera D. and Leskovac, Andreja",
year = "2005",
abstract = "U radu su prikazani rezultati ispitivanja nutraceutika Gonebazola (“Bofarm” Beograd). Gonebazol sadrži vitamine (A, E, C, B3, B6) ekstrakt Echincea purpurea, polen, propolis, Ca, Mg, i aminokiseline u medu. Preparat je ispitan in vitro na ozračenim humanim limfocitima i in vivo na grupi volontera, zdravstvenih radnika, kojima je zbog hematološkog i nalaza hromozomskih aberacija stavljena privremena zabrana rada u zoni jonizujućeg zračenja. U in vitro uslovima smanjena je učestalost mikronukleusa za 69%, stepen lipidne peroksidacije za 50%, pri čemu je 25% ozračenih leukocita eliminisano apoptozom. In vivo ispitivanja su pokazala veliku sličnost sa in vitro efektima: vreme za regeneraciju kostne srži i perzistencija hromozomskih aberacija u limfocitima periferne krvi značajno je smanjeno. Iako preliminarni, rezultati in vivo ispitivanja su veoma ohrabrujući jer značajno smanjuju posledice kumulativnog efekta jonizujućeg zračenja., The results of investigation of benefitial radioprotective properties of nutraceutical Gonebazol-«Biofarm» Belgrade are presented in this study. Gonebazol is consisted of propolis, extracts of Phaseophycea digitata Khorbi, Ecninacea purpurea pulvis, Ca++, Mg++, vitamins B3, B6, A, E and C, amino acids, all conserved in honey. Nutraceutical was examined in vitro, on human irradiated lymphocytes, as well as in vivo on volunters, radiation technicians occupationally overexposed to ionizing radiation. In vitro investigations have shown remarkable radioprotective effects of Gonebazol: yield of radiation-induced micronuclei was reduced for 69%, which as followed with reduction of (MDA) for 50% and enhancement of apoptosis of leukocytes up to 25%. Although preliminary, results obtained in vivo have shown a great extent of similarity with in vitro effects: the incidence of chromosomal aberrations was lowered for less than 3 weeks. Baseline level of micronuclei was significantly reduced. Obtained results confirmed that supplementation with these carefully selected vitamins and minerals significantly improve genomic stability, which could used to avoid adverse effects of ionizing radiation.",
publisher = "Beograd : Institut za nuklearne nauke "Vinča" : Društvo za zaštitu od zračenja Srbije i Crne Gore",
journal = "23. simpozijum DZZSCG : zbornik radova; Sep 26-28, Donji Milanovac",
title = "Protektivni efekti: in vitro-in vivo, Radioprotective effects: in vitro-in vivo",
pages = "269-272",
url = "https://hdl.handle.net/21.15107/rcub_vinar_11694"
}