TY  - JOUR
AU  - Lavtar, Polona
AU  - Rudolf, Gorazd
AU  - Maver, Aleš
AU  - Hodžić, Alenka
AU  - Starčević Čizmarević, Nada
AU  - Živković, Maja
AU  - Jazbec, Sasa Sega
AU  - Klemenc-Ketiš, Zalika
AU  - Kapović, Miljenko
AU  - Dinčić, Evica
AU  - Raičević, Ranko
AU  - Sepčić, Juraj
AU  - Lovrečić, Luca
AU  - Stanković, Aleksandra
AU  - Ristić, Smiljana
AU  - Peterlin, Borut
PY  - 2018
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/1913
AB  - Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.5.10(-5); CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35-2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13-1.73, P = 0.002). The results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis.
T2  - PLOS One
T1  - Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis
VL  - 13
IS  - 1
SP  - e0190601
DO  - 10.1371/journal.pone.0190601
ER  - 

@article{
author = "Lavtar, Polona and Rudolf, Gorazd and Maver, Aleš and Hodžić, Alenka and Starčević Čizmarević, Nada and Živković, Maja and Jazbec, Sasa Sega and Klemenc-Ketiš, Zalika and Kapović, Miljenko and Dinčić, Evica and Raičević, Ranko and Sepčić, Juraj and Lovrečić, Luca and Stanković, Aleksandra and Ristić, Smiljana and Peterlin, Borut",
year = "2018",
abstract = "Prevalence of multiple sclerosis varies with geographic latitude. We hypothesized that this fact might be partially associated with the influence of latitude on circadian rhythm and consequently that genetic variability of key circadian rhythm regulators, ARNTL and CLOCK genes, might contribute to the risk for multiple sclerosis. Our aim was to analyse selected polymorphisms of ARNTL and CLOCK, and their association with multiple sclerosis. A total of 900 Caucasian patients and 1024 healthy controls were compared for genetic signature at 8 SNPs, 4 for each of both genes. We found a statistically significant difference in genotype (ARNTL rs3789327, P = 7.5.10(-5); CLOCK rs6811520 P = 0.02) distributions in patients and controls. The ARNTL rs3789327 CC genotype was associated with higher risk for multiple sclerosis at an OR of 1.67 (95% CI 1.35-2.07, P = 0.0001) and the CLOCK rs6811520 genotype CC at an OR of 1.40 (95% CI 1.13-1.73, P = 0.002). The results of this study suggest that genetic variability in the ARNTL and CLOCK genes might be associated with risk for multiple sclerosis.",
journal = "PLOS One",
title = "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis",
volume = "13",
number = "1",
pages = "e0190601",
doi = "10.1371/journal.pone.0190601"
}

Lavtar, P., Rudolf, G., Maver, A., Hodžić, A., Starčević Čizmarević, N., Živković, M., Jazbec, S. S., Klemenc-Ketiš, Z., Kapović, M., Dinčić, E., Raičević, R., Sepčić, J., Lovrečić, L., Stanković, A., Ristić, S.,& Peterlin, B.. (2018). Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. in PLOS One, 13(1), e0190601.
https://doi.org/10.1371/journal.pone.0190601

Lavtar P, Rudolf G, Maver A, Hodžić A, Starčević Čizmarević N, Živković M, Jazbec SS, Klemenc-Ketiš Z, Kapović M, Dinčić E, Raičević R, Sepčić J, Lovrečić L, Stanković A, Ristić S, Peterlin B. Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis. in PLOS One. 2018;13(1):e0190601.
doi:10.1371/journal.pone.0190601 .

Lavtar, Polona, Rudolf, Gorazd, Maver, Aleš, Hodžić, Alenka, Starčević Čizmarević, Nada, Živković, Maja, Jazbec, Sasa Sega, Klemenc-Ketiš, Zalika, Kapović, Miljenko, Dinčić, Evica, Raičević, Ranko, Sepčić, Juraj, Lovrečić, Luca, Stanković, Aleksandra, Ristić, Smiljana, Peterlin, Borut, "Association of circadian rhythm genes ARNTL/BMAL1 and CLOCK with multiple sclerosis" in PLOS One, 13, no. 1 (2018):e0190601,
https://doi.org/10.1371/journal.pone.0190601 . .

TY  - JOUR
AU  - Babić Božović, Ivana
AU  - Stanković, Aleksandra
AU  - Živković, Maja
AU  - Vraneković, Jadranka
AU  - Kapović, Miljenko
AU  - Brajenović-Milić, Bojana
PY  - 2015
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/564
AB  - Down syndrome (DS, also known as trisomy 21) most often results from chromosomal nondisjunction during oogenesis. Numerous studies sustain a causal link between global DNA hypomethylation and genetic instability. It has been suggested that DNA hypomethylation might affect the structure and dynamics of chromatin regions that are critical for chromosome stability and segregation, thus favouring chromosomal nondisjunction during meiosis. Maternal global DNA hypomethylation has not yet been analyzed as a potential risk factor for chromosome 21 nondisjunction. This study aimed to asses the risk for DS in association with maternal global DNA methylation and the impact of endogenous and exogenous factors that reportedly influence DNA methylation status. Global DNA methylation was analyzed in peripheral blood lymphocytes by quantifying LINE-1 methylation using the MethyLight method. Levels of global DNA methylation were significantly lower among mothers of children with maternally derived trisomy 21 than among control mothers (P = 0.000). The combination of MTHFR C677T genotype and diet significantly influenced global DNA methylation (R-2 = 4.5%, P = 0.046). The lowest values of global DNA methylation were observed in mothers with MTHFR 677 CT+TT genotype and low dietary folate. Although our findings revealed an association between maternal global DNA hypomethylation and trisomy 21 of maternal origin, further progress and final conclusions regarding the role of global DNA methylation and the occurrence of trisomy 21 are facing major challenges.
T2  - PLOS One
T1  - Altered LINE-1 Methylation in Mothers of Children with Down Syndrome
VL  - 10
IS  - 5
DO  - 10.1371/journal.pone.0127423
ER  - 

@article{
author = "Babić Božović, Ivana and Stanković, Aleksandra and Živković, Maja and Vraneković, Jadranka and Kapović, Miljenko and Brajenović-Milić, Bojana",
year = "2015",
abstract = "Down syndrome (DS, also known as trisomy 21) most often results from chromosomal nondisjunction during oogenesis. Numerous studies sustain a causal link between global DNA hypomethylation and genetic instability. It has been suggested that DNA hypomethylation might affect the structure and dynamics of chromatin regions that are critical for chromosome stability and segregation, thus favouring chromosomal nondisjunction during meiosis. Maternal global DNA hypomethylation has not yet been analyzed as a potential risk factor for chromosome 21 nondisjunction. This study aimed to asses the risk for DS in association with maternal global DNA methylation and the impact of endogenous and exogenous factors that reportedly influence DNA methylation status. Global DNA methylation was analyzed in peripheral blood lymphocytes by quantifying LINE-1 methylation using the MethyLight method. Levels of global DNA methylation were significantly lower among mothers of children with maternally derived trisomy 21 than among control mothers (P = 0.000). The combination of MTHFR C677T genotype and diet significantly influenced global DNA methylation (R-2 = 4.5%, P = 0.046). The lowest values of global DNA methylation were observed in mothers with MTHFR 677 CT+TT genotype and low dietary folate. Although our findings revealed an association between maternal global DNA hypomethylation and trisomy 21 of maternal origin, further progress and final conclusions regarding the role of global DNA methylation and the occurrence of trisomy 21 are facing major challenges.",
journal = "PLOS One",
title = "Altered LINE-1 Methylation in Mothers of Children with Down Syndrome",
volume = "10",
number = "5",
doi = "10.1371/journal.pone.0127423"
}

Babić Božović, I., Stanković, A., Živković, M., Vraneković, J., Kapović, M.,& Brajenović-Milić, B.. (2015). Altered LINE-1 Methylation in Mothers of Children with Down Syndrome. in PLOS One, 10(5).
https://doi.org/10.1371/journal.pone.0127423

Babić Božović I, Stanković A, Živković M, Vraneković J, Kapović M, Brajenović-Milić B. Altered LINE-1 Methylation in Mothers of Children with Down Syndrome. in PLOS One. 2015;10(5).
doi:10.1371/journal.pone.0127423 .

Babić Božović, Ivana, Stanković, Aleksandra, Živković, Maja, Vraneković, Jadranka, Kapović, Miljenko, Brajenović-Milić, Bojana, "Altered LINE-1 Methylation in Mothers of Children with Down Syndrome" in PLOS One, 10, no. 5 (2015),
https://doi.org/10.1371/journal.pone.0127423 . .

TY  - JOUR
AU  - Živković, Maja
AU  - Starčević Čizmarević, Nada
AU  - Lovrečić, Luca
AU  - Klupka-Saric, Inge
AU  - Stanković, Aleksandra
AU  - Gasparovic, Iva
AU  - Lavtar, Polona
AU  - Dinčić, Evica
AU  - Stojković, Ljiljana S.
AU  - Rudolf, Gorazd
AU  - Jazbec, Sasa Sega
AU  - Perkovic, Olivio
AU  - Sinanovic, Osman
AU  - Sepčić, Juraj
AU  - Kapović, Miljenko
AU  - Peterlin, Borut
AU  - Ristić, Smiljana
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5963
AB  - Background. Previous studies have shown impaired fibrinolysis in multiple sclerosis (MS) and implicated extracellular proteolytic enzymes as important factors in demyelinating neuroinflammatory disorders. Tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) are key molecules in both fibrinolysis and extracellular proteolysis. In the present study, an association of the TPA Alu I/D and PAI-1 4G/5G polymorphisms with MS was analyzed within the Genomic Network for Multiple Sclerosis (GENoMS). Methods. The GENoMS includes four populations (Croatian, Slovenian, Serbian, and Bosnian and Herzegovinian) sharing the same geographic location and a similar ethnic background. A total of 885 patients and 656 ethnically matched healthy blood donors with no history of MS in their families were genotyped using PCR-RFLP. Results. TPA DD homozygosity was protective (OR = 0.79, 95% CI 0.63-0.99, P = 0.037) and PAI 5G5G was a risk factor for MS (OR = 1.30, 95% CI 1.01-1.66, P = 0.038). A significant effect of the genotype/carrier combination was detected in 5G5G/I carriers (OR = 1.39 95% CI 1.06-1.82, P = 0.017). Conclusions. We found a significantly harmful effect of the combination of the PAI-1 5G/5G genotype and TPA I allele on MS susceptibility, which indicates the importance of gene-gene interactions in complex diseases such as MS.
T2  - Disease Markers
T1  - The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis
DO  - 10.1155/2014/362708
ER  - 

@article{
author = "Živković, Maja and Starčević Čizmarević, Nada and Lovrečić, Luca and Klupka-Saric, Inge and Stanković, Aleksandra and Gasparovic, Iva and Lavtar, Polona and Dinčić, Evica and Stojković, Ljiljana S. and Rudolf, Gorazd and Jazbec, Sasa Sega and Perkovic, Olivio and Sinanovic, Osman and Sepčić, Juraj and Kapović, Miljenko and Peterlin, Borut and Ristić, Smiljana",
year = "2014",
abstract = "Background. Previous studies have shown impaired fibrinolysis in multiple sclerosis (MS) and implicated extracellular proteolytic enzymes as important factors in demyelinating neuroinflammatory disorders. Tissue-type plasminogen activator (t-PA) and its inhibitor (PAI-1) are key molecules in both fibrinolysis and extracellular proteolysis. In the present study, an association of the TPA Alu I/D and PAI-1 4G/5G polymorphisms with MS was analyzed within the Genomic Network for Multiple Sclerosis (GENoMS). Methods. The GENoMS includes four populations (Croatian, Slovenian, Serbian, and Bosnian and Herzegovinian) sharing the same geographic location and a similar ethnic background. A total of 885 patients and 656 ethnically matched healthy blood donors with no history of MS in their families were genotyped using PCR-RFLP. Results. TPA DD homozygosity was protective (OR = 0.79, 95% CI 0.63-0.99, P = 0.037) and PAI 5G5G was a risk factor for MS (OR = 1.30, 95% CI 1.01-1.66, P = 0.038). A significant effect of the genotype/carrier combination was detected in 5G5G/I carriers (OR = 1.39 95% CI 1.06-1.82, P = 0.017). Conclusions. We found a significantly harmful effect of the combination of the PAI-1 5G/5G genotype and TPA I allele on MS susceptibility, which indicates the importance of gene-gene interactions in complex diseases such as MS.",
journal = "Disease Markers",
title = "The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis",
doi = "10.1155/2014/362708"
}

Živković, M., Starčević Čizmarević, N., Lovrečić, L., Klupka-Saric, I., Stanković, A., Gasparovic, I., Lavtar, P., Dinčić, E., Stojković, L. S., Rudolf, G., Jazbec, S. S., Perkovic, O., Sinanovic, O., Sepčić, J., Kapović, M., Peterlin, B.,& Ristić, S.. (2014). The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis. in Disease Markers.
https://doi.org/10.1155/2014/362708

Živković M, Starčević Čizmarević N, Lovrečić L, Klupka-Saric I, Stanković A, Gasparovic I, Lavtar P, Dinčić E, Stojković LS, Rudolf G, Jazbec SS, Perkovic O, Sinanovic O, Sepčić J, Kapović M, Peterlin B, Ristić S. The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis. in Disease Markers. 2014;.
doi:10.1155/2014/362708 .

Živković, Maja, Starčević Čizmarević, Nada, Lovrečić, Luca, Klupka-Saric, Inge, Stanković, Aleksandra, Gasparovic, Iva, Lavtar, Polona, Dinčić, Evica, Stojković, Ljiljana S., Rudolf, Gorazd, Jazbec, Sasa Sega, Perkovic, Olivio, Sinanovic, Osman, Sepčić, Juraj, Kapović, Miljenko, Peterlin, Borut, Ristić, Smiljana, "The Role of TPA I/D and PAI-1 4G/5G Polymorphisms in Multiple Sclerosis" in Disease Markers (2014),
https://doi.org/10.1155/2014/362708 . .

TY  - JOUR
AU  - Stanković, Aleksandra
AU  - Dinčić, Evica
AU  - Ristić, Smiljana
AU  - Lovrečić, Luca
AU  - Starčević Čizmarević, Nada
AU  - Đurić, Tamara
AU  - Sepčić, Juraj
AU  - Kapović, Miljenko
AU  - Raičević, Ranko
AU  - Peterlin, Borut
AU  - Alavantić, Dragan
AU  - Živković, Maja
PY  - 2010
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/4004
AB  - The interleukin 7 receptor alpha single nucleotide polymorphism rs6897932 was identified as a multiple sclerosis susceptibility-modifying polymorphism in genome-wide and gene scan studies, mainly in populations in western countries. The aim of this study was to investigate the association of interleukin 7 receptor alpha rs6897932 with multiple sclerosis in populations from the Western Balkans: Serbia, Croatia, and Slovenia. A total of 678 unrelated white patients and 597 unrelated, ethnically matched healthy controls were included in the study. Genotyping was performed by real-time polymerase chain reaction. We found no significant difference in genotype or allele frequencies between controls and patients with multiple sclerosis either separately in Serbian, Croatian, and Slovenian populations or in the whole sample from the Western Balkans. The odds ratio for multiple sclerosis in this study was 1.04 (0.86-1.25) for the C allele. It is known that demographic as well as environmental factors have a substantial role in multiple sclerosis development, as well as population genetic background. The results of this study indicate that other types of genome variants should be required for the development and/or progression of multiple sclerosis, which may vary among populations.
T2  - Multiple Sclerosis Journal
T1  - Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans
VL  - 16
IS  - 5
SP  - 533
EP  - 536
DO  - 10.1177/1352458509360548
ER  - 

@article{
author = "Stanković, Aleksandra and Dinčić, Evica and Ristić, Smiljana and Lovrečić, Luca and Starčević Čizmarević, Nada and Đurić, Tamara and Sepčić, Juraj and Kapović, Miljenko and Raičević, Ranko and Peterlin, Borut and Alavantić, Dragan and Živković, Maja",
year = "2010",
abstract = "The interleukin 7 receptor alpha single nucleotide polymorphism rs6897932 was identified as a multiple sclerosis susceptibility-modifying polymorphism in genome-wide and gene scan studies, mainly in populations in western countries. The aim of this study was to investigate the association of interleukin 7 receptor alpha rs6897932 with multiple sclerosis in populations from the Western Balkans: Serbia, Croatia, and Slovenia. A total of 678 unrelated white patients and 597 unrelated, ethnically matched healthy controls were included in the study. Genotyping was performed by real-time polymerase chain reaction. We found no significant difference in genotype or allele frequencies between controls and patients with multiple sclerosis either separately in Serbian, Croatian, and Slovenian populations or in the whole sample from the Western Balkans. The odds ratio for multiple sclerosis in this study was 1.04 (0.86-1.25) for the C allele. It is known that demographic as well as environmental factors have a substantial role in multiple sclerosis development, as well as population genetic background. The results of this study indicate that other types of genome variants should be required for the development and/or progression of multiple sclerosis, which may vary among populations.",
journal = "Multiple Sclerosis Journal",
title = "Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans",
volume = "16",
number = "5",
pages = "533-536",
doi = "10.1177/1352458509360548"
}

Stanković, A., Dinčić, E., Ristić, S., Lovrečić, L., Starčević Čizmarević, N., Đurić, T., Sepčić, J., Kapović, M., Raičević, R., Peterlin, B., Alavantić, D.,& Živković, M.. (2010). Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans. in Multiple Sclerosis Journal, 16(5), 533-536.
https://doi.org/10.1177/1352458509360548

Stanković A, Dinčić E, Ristić S, Lovrečić L, Starčević Čizmarević N, Đurić T, Sepčić J, Kapović M, Raičević R, Peterlin B, Alavantić D, Živković M. Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans. in Multiple Sclerosis Journal. 2010;16(5):533-536.
doi:10.1177/1352458509360548 .

Stanković, Aleksandra, Dinčić, Evica, Ristić, Smiljana, Lovrečić, Luca, Starčević Čizmarević, Nada, Đurić, Tamara, Sepčić, Juraj, Kapović, Miljenko, Raičević, Ranko, Peterlin, Borut, Alavantić, Dragan, Živković, Maja, "Interleukin 7 receptor alpha polymorphism rs6897932 and susceptibility to multiple sclerosis in the Western Balkans" in Multiple Sclerosis Journal, 16, no. 5 (2010):533-536,
https://doi.org/10.1177/1352458509360548 . .