TY  - JOUR
AU  - Simić, Iva
AU  - Adžić, Miroslav
AU  - Marić, Nađa
AU  - Savić, Danka A.
AU  - Đorđević, Jelena D.
AU  - Mihaljević, Marina
AU  - Mitić, Miloš
AU  - Pavlović, Zorana
AU  - Soldatovic, Ivan
AU  - Krstić-Demonacos, Marija
AU  - Jasovic-Gasic, Miroslava
AU  - Radoičić, Marija B.
PY  - 2013
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/5753
AB  - The mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
T2  - Psychiatry Research
T1  - A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults
VL  - 209
IS  - 3
SP  - 658
EP  - 664
DO  - 10.1016/j.psychres.2013.02.002
ER  - 

@article{
author = "Simić, Iva and Adžić, Miroslav and Marić, Nađa and Savić, Danka A. and Đorđević, Jelena D. and Mihaljević, Marina and Mitić, Miloš and Pavlović, Zorana and Soldatovic, Ivan and Krstić-Demonacos, Marija and Jasovic-Gasic, Miroslava and Radoičić, Marija B.",
year = "2013",
abstract = "The mechanism of maladaptive chronic stress response involves altered phosphorylation of the glucocorticoid receptor (GR). In this study, we investigated if important depressogenic vulnerability factors, such as neuroticism and self-reports of negative affective states, may be associated with alterations in levels of the GR and GR phosphoisoforms in peripheral blood mononuclear cells (PBMC) of healthy adults. In 21 women and 16 men we evaluated PMBC levels of total GR (tGR), GR phosphorylated at serine 211 (pGR-S211) and serine 226 (pGR-S226) and correlated these data with personality traits and current reports of stress, anxiety and depression. Also, we assessed plasma cortisol levels in all tested subjects. Our results showed that in women nuclear pGR-S226 was positively correlated with neuroticism and current reports of depression, anxiety and stress, while the ratio of nuclear pGR-S211/pGR-S226 was negatively correlated with reports of depression. None of the aforementioned correlations were significant in men. No significant relations between cortisol levels and any of GR parameters were observed. These preliminary findings highlight the value of GR phosphorylation-related research in identifying molecular biomarkers of depressogenic vulnerability, at least in women. (C) 2013 Elsevier Ireland Ltd. All rights reserved.",
journal = "Psychiatry Research",
title = "A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults",
volume = "209",
number = "3",
pages = "658-664",
doi = "10.1016/j.psychres.2013.02.002"
}

Simić, I., Adžić, M., Marić, N., Savić, D. A., Đorđević, J. D., Mihaljević, M., Mitić, M., Pavlović, Z., Soldatovic, I., Krstić-Demonacos, M., Jasovic-Gasic, M.,& Radoičić, M. B.. (2013). A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. in Psychiatry Research, 209(3), 658-664.
https://doi.org/10.1016/j.psychres.2013.02.002

Simić I, Adžić M, Marić N, Savić DA, Đorđević JD, Mihaljević M, Mitić M, Pavlović Z, Soldatovic I, Krstić-Demonacos M, Jasovic-Gasic M, Radoičić MB. A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults. in Psychiatry Research. 2013;209(3):658-664.
doi:10.1016/j.psychres.2013.02.002 .

Simić, Iva, Adžić, Miroslav, Marić, Nađa, Savić, Danka A., Đorđević, Jelena D., Mihaljević, Marina, Mitić, Miloš, Pavlović, Zorana, Soldatovic, Ivan, Krstić-Demonacos, Marija, Jasovic-Gasic, Miroslava, Radoičić, Marija B., "A preliminary evaluation of leukocyte phospho-glucocorticoid receptor as a potential biomarker of depressogenic vulnerability in healthy adults" in Psychiatry Research, 209, no. 3 (2013):658-664,
https://doi.org/10.1016/j.psychres.2013.02.002 . .