TY  - CONF
AU  - Mitić, Miloš
AU  - Lukić, Iva
AU  - Božović, N.
AU  - Đorđević, Jelena D.
AU  - Adžić, Miroslav
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9191
AB  - A growing body of evidence indicates extracellular signal-regulated kinase
(ERK1/2) participates in various stress-induced responses which isconsider
to beinvolved in pathophysiology of depression. Surprisingly, the effect of
antidepressants on ERKs is almost unexplored, particularly from the
perspective of sexes.In the present study, we investigated the potential role
of cytoplasm-nuclear distribution of phospho-ERK1/2 in the hippocampus
of chronically stressed female and male Wistar rats and if those potential
changes could be attenuated with chronic fluoxetine treatment. In females,
stress induced cytosolic retention of phospho-ERKs, while in
malesitpromoted the nuclear translocation of phospho-ERK 1/2. The effect
of concomitant fluoxetine treatment was more pronounced in stressed
females, with main focus on normalization of its nuclear phospho-ERK 1/2
levels.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - Fluoxetine normalized nuclear phospho erk1/2 signaling in stressed females
VL  - F-11-P
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9191
ER  - 

@conference{
author = "Mitić, Miloš and Lukić, Iva and Božović, N. and Đorđević, Jelena D. and Adžić, Miroslav",
year = "2014",
abstract = "A growing body of evidence indicates extracellular signal-regulated kinase
(ERK1/2) participates in various stress-induced responses which isconsider
to beinvolved in pathophysiology of depression. Surprisingly, the effect of
antidepressants on ERKs is almost unexplored, particularly from the
perspective of sexes.In the present study, we investigated the potential role
of cytoplasm-nuclear distribution of phospho-ERK1/2 in the hippocampus
of chronically stressed female and male Wistar rats and if those potential
changes could be attenuated with chronic fluoxetine treatment. In females,
stress induced cytosolic retention of phospho-ERKs, while in
malesitpromoted the nuclear translocation of phospho-ERK 1/2. The effect
of concomitant fluoxetine treatment was more pronounced in stressed
females, with main focus on normalization of its nuclear phospho-ERK 1/2
levels.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "Fluoxetine normalized nuclear phospho erk1/2 signaling in stressed females",
volume = "F-11-P",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9191"
}

Mitić, M., Lukić, I., Božović, N., Đorđević, J. D.,& Adžić, M.. (2014). Fluoxetine normalized nuclear phospho erk1/2 signaling in stressed females. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., F-11-P.
https://hdl.handle.net/21.15107/rcub_vinar_9191

Mitić M, Lukić I, Božović N, Đorđević JD, Adžić M. Fluoxetine normalized nuclear phospho erk1/2 signaling in stressed females. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;F-11-P.
https://hdl.handle.net/21.15107/rcub_vinar_9191 .

Mitić, Miloš, Lukić, Iva, Božović, N., Đorđević, Jelena D., Adžić, Miroslav, "Fluoxetine normalized nuclear phospho erk1/2 signaling in stressed females" in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, F-11-P (2014),
https://hdl.handle.net/21.15107/rcub_vinar_9191 .

TY  - CONF
AU  - Brkić, Željka
AU  - Lukić, Iva
AU  - Mitić, Miloš
AU  - Božović, N.
AU  - Brašanac, Jelena
AU  - Đorđević, Jelena
AU  - Adžić, Miroslav
PY  - 2014
UR  - https://vinar.vin.bg.ac.rs/handle/123456789/9192
AB  - Systemic exposure to inflammatory challenges, such as lipopolysaccharide
(LPS), can induce a central neuroinflammation, which has been associated
with the development of major depressive disorder (MDD). Research data
emphasize not only sex as an important factor in the pathogenesis of MDD
but also point out a disturbance in cyclin-dependent kinase 5 (CDK5)
pathway. Therefore, in this study, we investigated the effects of LPS
treatment on depressive-like behavior as well as on the CDK5 and p35
levels in the cytosol and the nucleus of the prefrontal cortex of Wistar rats.
Our results showed that LPS causes a depressive-like behavior in both
sexes, as well as significant changes in the levels of CDK5 and p35, but
only in the males. Such differences of CDK5 activity could contribute to the
development of depressive-like behavior in males, while in females it seems
that some other mechanisms could be involved in the induction of this
behavior.
PB  - Society of Physical Chemists of Serbia
C3  - Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
T1  - Involvement of prefrontal cortex cdk5 pathway in lps-induced depressive-like behavior in male and female wistar rats
VL  - F-12-P
UR  - https://hdl.handle.net/21.15107/rcub_vinar_9192
ER  - 

@conference{
author = "Brkić, Željka and Lukić, Iva and Mitić, Miloš and Božović, N. and Brašanac, Jelena and Đorđević, Jelena and Adžić, Miroslav",
year = "2014",
abstract = "Systemic exposure to inflammatory challenges, such as lipopolysaccharide
(LPS), can induce a central neuroinflammation, which has been associated
with the development of major depressive disorder (MDD). Research data
emphasize not only sex as an important factor in the pathogenesis of MDD
but also point out a disturbance in cyclin-dependent kinase 5 (CDK5)
pathway. Therefore, in this study, we investigated the effects of LPS
treatment on depressive-like behavior as well as on the CDK5 and p35
levels in the cytosol and the nucleus of the prefrontal cortex of Wistar rats.
Our results showed that LPS causes a depressive-like behavior in both
sexes, as well as significant changes in the levels of CDK5 and p35, but
only in the males. Such differences of CDK5 activity could contribute to the
development of depressive-like behavior in males, while in females it seems
that some other mechanisms could be involved in the induction of this
behavior.",
publisher = "Society of Physical Chemists of Serbia",
journal = "Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry",
title = "Involvement of prefrontal cortex cdk5 pathway in lps-induced depressive-like behavior in male and female wistar rats",
volume = "F-12-P",
url = "https://hdl.handle.net/21.15107/rcub_vinar_9192"
}

Brkić, Ž., Lukić, I., Mitić, M., Božović, N., Brašanac, J., Đorđević, J.,& Adžić, M.. (2014). Involvement of prefrontal cortex cdk5 pathway in lps-induced depressive-like behavior in male and female wistar rats. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry
Society of Physical Chemists of Serbia., F-12-P.
https://hdl.handle.net/21.15107/rcub_vinar_9192

Brkić Ž, Lukić I, Mitić M, Božović N, Brašanac J, Đorđević J, Adžić M. Involvement of prefrontal cortex cdk5 pathway in lps-induced depressive-like behavior in male and female wistar rats. in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry. 2014;F-12-P.
https://hdl.handle.net/21.15107/rcub_vinar_9192 .

Brkić, Željka, Lukić, Iva, Mitić, Miloš, Božović, N., Brašanac, Jelena, Đorđević, Jelena, Adžić, Miroslav, "Involvement of prefrontal cortex cdk5 pathway in lps-induced depressive-like behavior in male and female wistar rats" in Physical chemistry 2014: 12th International Conference on Fundamental and Applied Aspects of Physical Chemistry, F-12-P (2014),
https://hdl.handle.net/21.15107/rcub_vinar_9192 .